Publication Information
Linster et al., 2015
Abstract
Nat Commun. 2015 Jul 17;6:7640. doi: 10.1038/ncomms8640.
Downregulation of N-terminal acetylation triggers ABA-mediated drought responses
in Arabidopsis.
Linster E(1), Stephan I(2), Bienvenut WV(3), Maple-Grødem J(4), Myklebust LM(5),
Huber M(1), Reichelt M(6), Sticht C(7), Møller SG(8), Meinnel T(3), Arnesen
T(9), Giglione C(3), Hell R(2), Wirtz M(2).
Author information:
(1)1] Centre for Organismal Studies, University of Heidelberg, Heidelberg 69120,
Germany [2] Hartmut Hoffmann-Berling International Graduate School, University
of Heidelberg, Heidelberg 69120, Germany.
(2)Centre for Organismal Studies, University of Heidelberg, Heidelberg 69120,
Germany.
(3)Institute of Integrative Biology of the Cell (I2BC), CEA, CNRS, Université
Paris-Sud, Bâtiment 21, 1 avenue de la Terrasse, Gif-sur-Yvette F-91198, France.
(4)Center for Organelle Research, University of Stavanger, Stavanger N-4036,
Norway.
(5)Department of Molecular Biology, University of Bergen, Bergen N-5020, Norway.
(6)Max Planck institute for Chemical Ecology, Jena 07745, Germany.
(7)Center for Medical Research, Mannheim 68167, Germany.
(8)1] Center for Organelle Research, University of Stavanger, Stavanger N-4036,
Norway [2] Department of Biological Sciences, St John's University, New York,
New York 11439, USA [3] Norwegian Centre for Movement Disorders, Stavanger
University Hospital, Stavanger 4068, Norway.
(9)1] Department of Molecular Biology, University of Bergen, Bergen N-5020,
Norway [2] Department of Surgery, Haukeland University Hospital, Bergen N-5021,
Norway.
Comment in
Trends Plant Sci. 2015 Oct;20(10):599-601.
N-terminal acetylation (NTA) catalysed by N-terminal acetyltransferases (Nats)
is among the most common protein modifications in eukaryotes, but its
significance is still enigmatic. Here we characterize the plant NatA complex and
reveal evolutionary conservation of NatA biochemical properties in higher
eukaryotes and uncover specific and essential functions of NatA for development,
biosynthetic pathways and stress responses in plants. We show that NTA decreases
significantly after drought stress, and NatA abundance is rapidly downregulated
by the phytohormone abscisic acid. Accordingly, transgenic downregulation of
NatA induces the drought stress response and results in strikingly drought
resistant plants. Thus, we propose that NTA by the NatA complex acts as a
cellular surveillance mechanism during stress and that imprinting of the
proteome by NatA is an important switch for the control of metabolism,
development and cellular stress responses downstream of abscisic acid.
DOI: 10.1038/ncomms8640
PMCID: PMC4530475
PMID: 26184543 [Indexed for MEDLINE]
