"Pathogen-triggered programmed cell death in plants: metacaspase 1-dependent pathways"

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Wednesday 07 March 2018, 11:00 - 12:30


Bacterial recognition by the plant host often triggers an hypersensitive response (HR) cell death at the site of attempted invasion, amplifying the response and probably contributing to systemic acquired resistance. Despite its importance, very little is known about how it is regulated or what its executioners are. Based on our previous results that identified the metacaspase AtMC1 as a positive regulator of HR in Arabidopsis, we are now characterizing a network of cell death regulators in the context of pathogen-triggered cell death. This data will hopefully widen our knowledge on immune-triggered cell death regulation, contributing to the design of staggered strategies to durably deploy resistance in the field.

In addition, we will describe our findings regarding the pro-survival role of AtMC1 and protein aggregate dynamics in Arabidopsis. AtMC1 helps with the clearance of protein aggregates through an unknown protein quality control mechanism that acts in parallel to autophagy. Our findings suggest that this pro-survival role of AtMC1 may reflect an ancient function that represents the evolutionary origin of this family of proteins, later diversified to perform both pro- and anti-death roles.

In plants, protein quality control compartments are very ill defined, although they are essential for protein homeostasis and to respond to stress. We will also present data showing the in planta dynamics of some stress-induced protein quality control compartments comparing wild-type plants with mutants that present altered aggregate dynamics due to defects in proteostasis regulators. These findings may help defining the protein quality control compartment/protein aggregate landscape in plants, which may contribute to the generation engineered plant genomes with better capacity to withstand stress.

Location Jozef Schell Seminar Room
Contact Prof Nuria Sanchez Coll
Centre for Research in Agricultural Genomics (CRAG)