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Dynamics of membrane-resident cell surface receptors & partners

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Tuesday 08 November 2016, 14:00 - 15:30

 
ABSTRACT

Considering the dense packing of proteins at the plasma membrane (PM) and the plethora of environmental stimuli that tissues need to perceive and to integrate simultaneously, cells evolved membrane-based substructures called membrane micro-domains (MDs). These compartments may serve as central hubs for the specific assembly of signalling complexes including receptors. Even though many individual proteins have been described to laterally segregate into MDs at the cell surface, it has been a long-standing question whether pathway-specific components indeed localize to the same MD. I will show evidence for this intriguing phenomenon, unravel essential molecular building blocks and the propose a sequence of events that are required and sufficient to maintain an infection-related MD in vivo.

Location Jozef Schell seminar room
Contact Prof Thomas Ott
University of Freiburg
Faculty of Biology, Cell Biology
GERMANY