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“Sucrose regulated protein translation and the control of metabolism and growth in plants”

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Wednesday 08 June 2016, 11:00 - 12:30


A new paradigm in the control of plant metabolism has emerged involving sequence conserved (SC) peptides encoded by upstream open reading frames (uORF) of mRNAs. Over 40 SC-peptides have already been identified and recent results suggest that each peptide responds to a specific metabolite, which mainly are end products of metabolic pathways. The result of such Metabolite-Regulated Translation (MRT) is that metabolite concentration determines the level of translation of the main ORF (mORF) and thus the amount of protein produced. MRT involves stalling of ribosomes on the mRNA upstream region, which inhibits mORF translation. mORFs usually encode enzymes, transcription factors or signalling intermediates. The result is a direct and dynamic control over metabolism. We study MRT using sucrose control of translation of selected bZIP transcription factors. These bZIPs are major regulators of metabolism and their function in the central TOR – SnRK1 – T6P axis will be discussed.

Location Jozef Schell seminar room
Contact Prof Sjef Smeekens
Vice-Dean Faculty of Science & Chair of Molecular Plant Physiology
Utrecht University