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"A chemical approach to clathrin-mediated endocytosis in plants: the ups and downs of small-molecule target identification”

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Friday 29 April 2016, 14:00 - 15:30

 
ABSTRACT

Clathrin-mediated endocytosis (CME) is a major pathway for the uptake of membrane proteins, lipids, and extracellular molecules into plant cells and is of vital importance for the plant development as multiple cellular processes, including nutrient uptake, signal transduction, and plant-microbe interactions, require CME. Classical genetic strategies for studying CME are faced with limitations, especially in plants, where knockouts of CME components are either lethal or have no phenotypes due to gene redundancy. Chemical inhibitors of CME are an attractive alternative to the current methods for disrupting protein function, but despite the available extensive structural and biochemical knowledge about CME in mammalian cells, the development of chemical tools to interfere with this process in different systems and especially plants is still limited. Our study is focused on the identification and characterization of novel compounds that target the endocytic protein clathrin in plants. The development of novel inhibitors will contribute to better molecular and functional dissection of CME in plants and to the increased understanding of many physiological processes that rely on CME.

Location Jozef Schell seminar room
Contact Prof Jenny Russinova
VIB
Dept. of Plant Systems Biology
Ghent University
Gent
BELGIUM