PSB/CMB Seminar Prof Jing Yang on Thursday, December 22 at 11 am

11:00 - 12:30

Jozef Schell seminar room

''Mapping the Cysteine Redoxome''

The nucleophilic thiol group (Cys-SH) allows cysteine to undergo a broad range of redox modifications, such as sulfenylation (Cys-SOH), sulfinylation (Cys-SO2H). Emerging evidence suggests that cysteine redox modifications are well-controlled, site-specific cellular events, which play important roles in regulating many biological processes, such as autophagy, cellular metabolism, inflammation, cell cycle and cell death under physiological and pathological contexts. Efforts to understand their underlying mechanisms have been hampered due to limitations of methods for globally analyzing site-specific protein targets and redox dynamics. We have recently developed several chemoproteomic approaches to globally map and to quantify Cys-SH, Cys-SOH and Cys-SO2H in complex proteomes, providing versatile opportunities to study cysteine-mediated redox networks in a range of biological processes and adaptive responses in physiology and pathophysiology.

Invited by Prof Dirk Inzé, Prof Frank Van Breusegem and Prof Kris Gevaert (VIB-CMB)