Despite significant progress made in recent years, many questions still remain on how SnRK1 senses cellular energy and nutrient levels in plants, and how it translates this information to ensure optimal growth and survival. In this paper, the authors mapped a proteome-wide SnRK1 signaling network in Arabidopsis in relation to carbon availability. At the intersection of this targeted interactomics approach, the authors discovered a strong association of SnRK1 with class II T6P synthase-like proteins. They could show that these proteins function as negative regulators of SnRK1, and might have a role as carbon sensors that integrate T6P levels with SnRK1 activity.
