Seminar Prof Erika Isono

11:00 - 12:30

Jozef Schell seminar room

''Intracellular membrane trafficking – a ubiquitin point of view'' Intracellular trafficking is essential for plant growth, development, and environmental responses. Ubiquitin family proteins are small modifier proteins that are conjugated to proteins and lipids and serve as targeting signals in endosomal and autophagosomal trafficking processes. Thus, for the proper regulation of endosomal and autophagic protein degradation, the spatiotemporal regulation of ubiquitylating and deubiquitylating enzymes as well as ubiquitin-binding proteins is essential. Prof Isono her group is interested in the molecular mechanisms of the regulation and recognition of ubiquitin and ubiquitin-like proteins in intracellular trafficking. They have identified deubiquitylating enzymes (DUBs) that are important for fine-tuning the ubiquitin- and endosomal sorting complex required for transport (ESCRT)-dependent degradation of plasma membrane proteins. Furthermore, they have found proteins that interact with the ubiquitin-like protein ATG8 on autophagosomes and could be key for the recruitment of the ESCRT machinery to non-endosomal membranes. Invited by Prof Dirk Inzé and Prof Daniël Van Damme