Phosphatases and Kinases

Icon PhosphatasesKinasesWhile the knowledge on post-translational regulation through transient phosphorylation in plants is growing because of its crucial importance in plant molecular networks, it remains an underexplored and challenging area.

In Arabidopsis and major crop species, phosphorylation is controlled by a large number of protein kinases and phosphatase complexes (plantsp.genomics.purdue.edu/family/class.html; Dissmeyer and Schnittger 2011; Marshall et al. 2012). However, for the majority of cytoplasmic kinases, membrane-associated receptor kinases and phosphatases unraveling physiological and developmental roles and identifying substrates remain a challenge.

Recommended Reading

  • Marshall, A. Aalen, R.B., Audenaert, D., Beeckman, T., Broadley, M.R., Butenko, M.A., Caño-Delgado, A.I., de Vries, S., Dresselhaus, T., Felix, G., Graham, N.S., Foulkes, J., Granier, C., Greb, T., Grossniklaus, U., Hammond, J.P., Heidstra, R., Hodgman, C., Hothorn, M., Inzé, D., Østergaard, L., Russinova, E., Simon, R., Skirycz, A., Stahl, Y., Zipfel, C., & De Smet, I. (2012). Tackling drought stress: RECEPTOR-LIKE KINASES present new approaches. Plant Cell 24, 2262-2278.
  • Nakagami, H., Sugiyama, N., Ishihama, Y., & Shirasu, K. (2012). Shotguns in the front line: phosphoproteomics in plants. Plant Cell Physiol. 53, 118-124.
  • Bond, A. E., Row, P. E., & Dudley, E. (2011). Post-translation modification of proteins; methodologies and applications in plant sciences. Phytochemistry 72, 975-996.
  • Dissmeyer, N., & Schnittger, A. (2011). The age of protein kinases. Methods Mol. Biol. 779, 7-52.
  • Kline-Jonakin, K. G., Barrett-Wilt, G. A., & Sussman, M. R. (2011). Quantitative plant phosphoproteomics. Curr. Opin. Plant Biol. 14, 507-511.
  • de la Fuente van Bentem, S., & Hirt, H. (2007). Using phosphoproteomics to reveal signalling dynamics in plants. Trends Plant Sci. 12, 404-411.