Applied Bioinformatics and Biostatistics

Although data analysis has always been an important part of scientific research, the scale has changed in recent years. With the introduction and adoption of High Throughput Sequencing (HTS) methods, a different approach to data analysis is now required. Before, most analyses in Life Sciences could be conducted on a personal PC. But the large amounts of data and the requirements of the HTS analysis algorithms call for dedicated servers and an optimized storage solution.

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Crop Genome Engineering Facility

CRISPR/Cas9 technology is revolutionizing life sciences, including plant breeding. Due to high efficiency and simple design, CRISPR/Cas9 has brought genome engineering (GE) in reach of small and medium enterprises in this area. Plant breeders can now use gene editing for increasing the genetic diversity in their germplasm or introducing novel traits in their species..

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Gateway Vectors

The Gateway™ (Invitrogen) technology provides a rapid method for cloning a DNA fragment into multiple expression vectors, regardless of its sequence. Using the Gateway format, we have constructed over 200 versatile vectors for functional gene analysis in Arabidopsis plants and other species. The plasmid accessions presented in these web pages comprise Gateway destination vectors, entry clones and intermediary plasmids for transgene construction. All plasmids are documented with a graphical map and the corresponding Vector NTI file.
You can order any of the plasmids online, once registered.

Compound Screening Facility

The application of small molecules to study a biological system is referred to as 'Chemical Biology'. Typically, these molecules interfere with the function of target proteins and consequently lead to disruption of biological processes. When these molecules are applied to cells or whole organisms, the consequences of this perturbation can be studied at the molecular level. As such, these chemical probes allow researchers to unravel the role of cellular and molecular components in a complex biological network, even inside living organisms. Next to the application as chemical probes, small molecules can also be used as starting points for the development of therapeutic agents to treat disease or, in the field of plant sciences, of plant-protective substances. 

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AP-MS Platform Service

We offer the plant research community and companies access to our protein complex purification platform. Purifications under research service agreement are performed based on well-established protocols for complex purification from either the Arabidopsis cell suspension cultures PSB-D/L or Col-0 seedlings. We have recently been able to show that our complex purification technology performs equally well in crop species such as corn or rice.

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Bio Imaging

The Transmission Electron Microscopy (TEM) facility located on the campus ‘Ledeganck’ of the UGent is providing expertise in the use and application of transmission electron microscopy to serve biological or biomedical sciences.
The facility was established in 2003 and uses the equipment of the UGent Department of Biology. Its aim is to support research projects of all scientific groups of VIB1 (IRC), including projects in cell biology, inflammation, glycobiology, virology, cancer biology, cell death, developmental biology, immunology… and VIB2 (PSB), including projects dealing with cell cycle, cell death, gene regulation, plant microbes, root development, secondary metabolites… 

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