Integration and Specificity of Brassinosteroid Signaling

integrationRecent studies revealed that brassinosteroid signaling interacts and shares components (signaling hubs) with a number of other signaling pathways.

The BRI1 co-receptor BAK1 integrates brassinosteroid signaling and MAMP-triggered immunity as it associates with the flagellin receptor, FLS2. The GSK3-type kinase BIN2 phosphorylates and inactivates the MAPKK YODA (YDA) and the bHLH factor SPEECHLESS (SPCH), both components of the ERECTA (ER) signaling pathway that regulates stomatal development. BIN2 directly interacts with the transcriptional repressor ARF2 and provides a mechanistic explanation for the crosstalk between brassinosteroids and auxin. Brassinosteroid signaling is also highly integrated with the light and gibberellin pathways through the direct interactions BZR1-PIF4 and BZR1-DELLA. The aim of the project is to combine genetics, proteomics and molecular cell biology to study the mechanisms of brassinosteroid signaling interaction at the level of BIN2 to eventually answer the question how specificity is achieved in brassinosteroid signaling.

Selected publications

  • Gudesblat GE, Betti C, Russinova E. (2012).Brassinosteroids tailor stomatal production to different environments. Trends Plant Sci. 17: 685-687.
  • Gudesblat GE, Schneider-Pizon J, Betti C, Mayerhofer J, Vanhoutte I, van Dongen W, Boeren S, Zhiponova M, de Vries S, Jonak C, Russinova E. (2012). SPEECHLESS integrates brassinosteroid and stomata signalling pathways. Nat Cell Biol. 14: 548-554.