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 Across the plant kingdom, the jasmonate hormone steers the delicate balance between growth and the activation of defence programs, such as the production of bioactive secondary metabolites. By using cutting-edge functional genomics tools, in combination with reverse genetics screenings, we aim to identify the essential components acting in the jasmonate signalling network, in medicinal plants and in the model plant Arabidopsis thaliana. |
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 The impressive plant metabolic machinery is still hardly exploited, mainly because of the limited molecular insight into plant (secondary) metabolism.To address the current shortcomings for designing effective plant metabolic engineering strategies, a functional genomics based technology platform has been created that enables comprehensive investigations and large-scale gene discovery programs in plant metabolism.
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 Jasmonates are plant-specific signalling molecules, found throughout the plant kingdom, that steer diverse physiological and developmental processes. |
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 Combinatorial biosynthesis has been successfully employed for e.g. carotenoid- and antibiotic polyketide-producing micro-organisms. It involves interchanging secondary metabolism genes between micro-organisms to create unnatural gene combinations or hybrid genes. Novel metabolites can be made due to the effect of new enzyme-metabolic pathway combinations or to the formation of proteins with new enzymatic properties. |
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 The generated technology, gene and plant culture platforms have set the base for the foundation of a new spin-off company, Solucel ( http://www.solucel.com/). Solucel offers an integrated approach for the elucidation and engineering of metabolite biosynthetic pathways to ensure a sustainable and economic production of high-value phytochemicals. |
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 To explore diatoms for biotechnological applications like sustainable production of fuels, pharmaceuticals, health foods, materials relevant to nanotechnology as well as for pollution mitigation and carbon dioxide abatement we are studying the metabolism of the pennate diatom Phaeodactylum tricornutum. |
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Information about the current and former group members
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Metabolites projects
