The study of gene networks and their dynamics has become the corner stone of molecular systems biology. Numerous studies have demonstrated that interactomics is one of the most powerful means to map gene networks. However, interactomics in plants is lagging behind compared to other model organisms. Hence, a major part of our current research is to develop such tools for plant research. At the same time, we apply them to gather knowledge on cell proliferation control in plants, and as such discover new approaches for the engineering of plant growth. Cell proliferation plays a key role in plant growth and development. The basic machinery controling progression through the cell cycle has been studied and unraveled during passed two decades. However, its dynamics and the signaling pathways that impinge on it remain elusive. It is our long term goal to map the gene networks involved in cell proliferation by system wide interactomic approaches, as described below.