CLUSTAL W (1.82) multiple sequence alignment ENST00000308572 ----------------MARISFSYLCPASWYFTV-----PTVSPFLRQRVAFLGLFFISC ENSMUST00000026198 GPGPGRAVQRDERASGFPRISFSYLCPASWYFTV-----PTVSPFLRQRVAFLGLFFIPC SINFRUP00000130070 ------------------------------------------------------------ ENSMUST00000022653 ----------------MGRIGISCLFPASWHFSISPVGCPRILNTNLRQIVVISILAAAV ENST00000314007 ----------------MGRIGISCLFPASWHFSISPVGCPRILNTNLRQIMVISVLAAAV SINFRUP00000129387 -------------------INFSCLLPASWHFSLSSQMIPRLLTPFPRQLLFIGLVLCLV ENST00000260756 ------------------------------------------------------------ ENSMUST00000052388 -----------------------------TTASRDSKNKKHPRQTREEEGNKKLPLMEDI ENSMUST00000047687 ------------------------------------MFTVMTRQPCEQAG---------- ENST00000301825 ------------------------------------MFTVLTRQPCEQAG---------- SINFRUP00000158369 ------------------------------------------------------------ ENSMUST00000028328 ------------------------------------------------------------ ENST00000312665 ------------------------------------------------------------ SINFRUP00000163975 ------------------------------------------------------------ CG3059-RD ------------------------------------------------------------ ENST00000308572 LLLLMLIIDFRHWSASLPRDRQYERYLARVGELEATDTEDPNLNYGLVVDCGSSGSRIFV ENSMUST00000026198 VLLLLLIMDLRHWATSLPRDRQYERYLARVGDLEATNTEDPNLNYGLVVDCGSSGSRIFV SINFRUP00000130070 ------------------------------------------------------------ ENSMUST00000022653 SLLYFSVVIIRSKYGWLSKDKKFQRYLARVTDVEATDTNNPSVNYGIVVDCGSSGSRIFV ENST00000314007 SLLYFSVVIIRNKYGRLTRDKKFQRYLARVTDIEATDTNNPNVNYGIVVDCGSSGSRVFV SINFRUP00000129387 GLLYLLTATGAGPGGWIRTD-HFHRRLARVTDVDATDTSNPNLNYGLVVDCGSSGSRVFV ENST00000260756 -ESNVKTFCSKNILAILGFSSIIAVIALLAVGLTQNKALPENVKYGIVLDAGSSHTSLYI ENSMUST00000052388 KDSKVKRFCSKNILIILGFTSILAVIALIAVGLTQNKPLPENVKYGIVLDAGSSHTNLYI ENSMUST00000047687 --FRALSRTPAIVTLVVLLVSIVVLVTLTLIQIRHPQVLPPGLKYGVVLDAGSSRTTVYV ENST00000301825 --LKALYRTPTIIALVVLLVSIVVLVSITVIQIHKQEVLPPGLKYGIVLDAGSSRTTVYV SINFRUP00000158369 ------------------------------------------LQYGIVIDAGSSRSNLYV ENSMUST00000028328 -----MAGKLVSLVPPLLLAAVGLAGLLLLCVPTQDVREPPALKYGIVLDAGSSHTSMFV ENST00000312665 -----MAGKVRSLLPPLLLAAAGLAGLLLLCVPTRDVREPPALKYGIVLDAGSSHTSMFI SINFRUP00000163975 ------------------------------------------------------------ CG3059-RD ------------------------------------------------------------ : : ::: : : ENST00000308572 YFWPRHNGNPHDLLDIKQMRDRNSQPVVKKIKPGISAMADTPE---HASDYLRPLLSFAA ENSMUST00000026198 YFWPRHNGNPHDLLDIKQMRDRNSQPVVKKIKPGISAMADTPE---HASDYLRPLLSFAA SINFRUP00000130070 ---------------------------------GISTLAQTPS---HASDYLSPLLSFAA ENSMUST00000022653 YCWPRHNGNPHDLLDIRQMRDKNRKPVVMKIKPGISEFATSPE---KVSDYISPLLSFAA ENST00000314007 YCWPRHNGNPHDLLDIRQMRDKNRKPVVMKIKPGISEFATSPE---KVSDYISPLLNFAA SINFRUP00000129387 YCWPRHNGNLHELLNIQQMRDQHRKPVVMKIKPGISELAKSPE---RASDYISPLLSFAA ENST00000260756 YKWPAEKENDTGVVHQVEECRVKG--------PGISKFVQKVN---EIGIYLTDCMERAR ENSMUST00000052388 YKWPAEKENDTGVVQQLEECQVKG--------PGISKYAQKTD---EIGAYLAECMELST ENSMUST00000047687 YQWPAEKENNTGVVSQTFRCSVKG--------KGGRRPGRGMG---SYFPILCQQGPGRG ENST00000301825 YQWPAEKENNTGVVSQTFKCSVKG--------SGISSYGNNPQ---DVPRAFEECMQKVK SINFRUP00000158369 YEWPGEKENETGVVTESLNCRVPG--------DGISDMEIDPGKNNTLWERFQECVDKAM ENSMUST00000028328 YKWPADKENDTGIVGQHSSCDVRG--------GGISSYANDPS---RAGQSLVECLEQAL ENST00000312665 YKWPADKETTQALCGQHSSCDVPG--------GGISSYADNPS---GASQSLVGCLEQAL SINFRUP00000163975 ------------------------------------------------------------ CG3059-RD ------------------------------------------------------------ : : ENST00000308572 AHVPVKKHKETP-LYILCTAGMRLLPERKQLAILADLVKDLPLEFDFLFSQSQAEVISGK ENSMUST00000026198 AHVPVKKHRETP-LYILCTAGMRLLPERQQLAILADLVKDLPLEFDFLFSQSQAEVISGK SINFRUP00000130070 AHVPQSKHKETP-VYILCTAGMRLLPESQQAAILEDLVNDIPLEFDFLFSRSHAEVISGK ENSMUST00000022653 EHVPRAKHKETP-LYILCTAGMRVLPESQQKAILEDLLTDIPVHYDFLFSDSHAEVISGK ENST00000314007 EHVPRAKHKETP-LYILCTAGMRILPESQQKAILEDLLTDIPVHFDFLFSDSHAEVISGK SINFRUP00000129387 QHIPRSKHQETP-LYILCTAGMRVLPESQQEAILEDLRTDIPVHFNFLFSDSHVEVISGK ENST00000260756 EVIPRSQHQETP-VYLGATAGMRLLRMESEELADRVLDVVERSLSNYPFDFQGARIITGQ ENSMUST00000052388 ELIPTSKHHQTP-VYLGATAGMRLLRMESEQSADEVLAAVSTSLKSYPFDFQGAKIITGQ ENSMUST00000047687 CFLAKGIDGRPPRLCAQPLVFCALHRLQNETAAREVLESIQSYFKSQPFDFRGAQIISGQ ENST00000301825 GQVPSHLHGSTP-IHLGATAGMRLLRLQNETAANEVLESIQSYFKSQPFDFRGAQIISGQ SINFRUP00000158369 KVIPAEKHKSTP-LFLGATAGMRLLHMTDEQRSNNIMKSLKQFLNSLPFDFKNASIISGQ ENSMUST00000028328 RDVPKDRYASTP-LYLGATAGMRLLNLTSPEATAKVLEAVTQTLTRYPFDFRGARILSGQ ENST00000312665 QDVPKERHAGTP-LYLGATAGMRLLNLTNPEASTSVLMAVTHTLTQYPFDFRGARILSGQ SINFRUP00000163975 ----------------------------------------------YPFDYRGASVLSGQ CG3059-RD --------------------------------------------------MDAVEIMDGT : : : : : . :: * ENST00000308572 QEGVYAWIGINFVLGRFDHEDESD------AEATQEL--AAGRRRTVGILDMGGASLQIA ENSMUST00000026198 QEGVYAWIGINFVLGRFDHEDESD------SDTSVDS--AAGRRRTVGILDMGGASLQIA SINFRUP00000130070 QEGVYAWIGINFVLGRFDHADEVE------VMTGSQSQQPISRRRTVGIIDMGGASLQIA ENSMUST00000022653 QEGVYAWIGINFVLGRFEHIEEDDEAVVEVNIPGSESSEAIVRKRTAGVLDMGGVSTQIA ENST00000314007 QEGVYAWIGINFVLGRFEHIEDDDEAVVEVNIPGSESSEAIVRKRTAGILDMGGVSTQIA SINFRUP00000129387 QEGVYAWIGINFVLGRFNHVENDEDAAVEQHVPDGGRPGTRVRQRTAGVLDMGGVSTQIA ENST00000260756 EEGAYGWITINYLLGKFSQK----------TRWFSIVPYETNNQETFGALDLGGASTQVT ENSMUST00000052388 EEGAYGWITINYLLGRFTQE----------QSWLSLIS-DSQKQETFGALDLGGASTQIT ENSMUST00000047687 EEGVYGWITANYIMGNFLEK----------NLWHMWVH--PHGVDTTGALDLGGASTQIS ENST00000301825 EEGVYGWITANYLMGNFLEK----------NLWHMWVH--PHGVETTGALDLGGASTQIS SINFRUP00000158369 EEGLYGWVTVNYLMGNFLEK----------NLWNAYIR--PEGSKTVGSMDLGGASTQIA ENSMUST00000028328 DEGVFGWVTANYLLENFIKY----------GWVGRWIR---PRKGTLGAMDLGGASTQIT ENST00000312665 EEGVFGWVTANYLLENFIKY----------GWVGRWFR---PRKGTLGAMDLGGASTQIT SINFRUP00000163975 EEGAYGWVTVNYLSENFIKY----------GFVGHWLS---PSRPTVGALDFGGASTQIT CG3059-RD DEGIFSWFTVNFLLGRLSKT------------------------NQAAALDLGGGSTQVT :** :.*. *:: .: . . :*:** * *:: ENST00000308572 YEVPTSTSVLPAKQEEAAKILLAEFNLGCDVQHTEHVYRVYVTTFLGFGGNFARQRYEDL ENSMUST00000026198 YEVPTSASDLPPKQEEAAKILLAEFNLGCDVQHTEHVYRVYVTTFLGFGGNFARQRYEDL SINFRUP00000130070 YEVPSAITFSSPQEEEAGKSVLAEFNLGCDVEHTQHVYRVYVTTFLGFGGNMARQRYEDQ ENSMUST00000022653 YEVPQTVSFASSQQEEVAKNLLAEFNLGCDVHQTEHVYRVYVATFLGFGGNAARQRYEDR ENST00000314007 YEVPKT--------EEVAKNLLAEFNLGCDVHQTEHVYRVYVATFLGFGGNAARQRYEDR SINFRUP00000129387 YEVPKSVSFASPQQEEVAKNLLAEFNLGCDAHRTEHVYRVYVSTFLGFGGNAARQRYEKS ENST00000260756 FVPQNQ--------------TIESPDNALQFRLYGKDYNVYTHSFLCYGKDQALWQKLAK ENSMUST00000052388 FVPQNS--------------TIESPENSLQFRLYGEDYTVYTHSFLCYGKDQALWQKLAK ENSMUST00000047687 FVAGEK--------------MEPNASDTVQVSLYGYTYTLYTHSFQCYGQNEAEKKFLAM ENST00000301825 FVAGEK--------------MDLNTSDIMQVSLYGYVYTLYTHSFQCYGRNEAEKKFLAM SINFRUP00000158369 FDVQDE--------------LTG--PDYMHVKLYGYPYNVYTHSFLCYGKNEAEKMILDA ENSMUST00000028328 FETTSP--------------SEDP-DNEVHLRLYGQHYRVYTHSFLCYGRDQVLQRLLAS ENST00000312665 FETTSP--------------AEDR-ASEVQLHLYGQHYRVYTHSFLCYGRDQVLQRLLAS SINFRUP00000163975 FETRDK--------------IEDD-TDMIKLRLYGYEYSVYTHSFLCYGQGQVLKRLLAH CG3059-RD FSPTDP------------DQVPVYDKYMHEVVTSSKKINVFTHSYLGLGLMAARHAVFTH : . ::. :: * . ENST00000308572 VLNETLN------KNRLLGQKTGLSPDNPFLDPCLPVGLTDVVERNSQVLHVRGRGDWVS ENSMUST00000026198 VLNETLN------KNRLLGQKTGLSPDNPFLDPCLPVGLTDMVKRNNQVLHFRGKGDWAS SINFRUP00000130070 LVNATLA------DTRVL-----TSLDKPYLDPCLPAGLSDSVVRDNHTIQLRGQGDWTR ENSMUST00000022653 LFASTVQ------KNRLLGKQTGLTPDAPLLDPCLPLDIKDEIQQNGQTLYLQGTGDFDL ENST00000314007 IFANTIQ------KNRLLGKQTGLTPDMPYLDPCLPLDIKDEIQQNGQTIYLRGTGDFDL SINFRUP00000129387 LLRNAST------RNRLLGQRVGETAETPVLDPCLPTDLQDEVGPS--RLHLRGTGDFDR ENST00000260756 DIQASASNEILRDPCFHPGYKKVVNVSDLYKTPCT--KRFEMTLPF-QQFEIQGIGNYQQ ENSMUST00000052388 DIQVSSG-GVLKDPCFNPGYEKVVNVSELYGTPCT--KRFEKKLPF-DQFRIQGTGDYEQ ENSMUST00000047687 LLQSPSTEANISNPCYPQGYSTAFTLGHVFGSLCTEKQRPESYNSS-KSVTFMGTGDPRL ENST00000301825 LLQNSPTKNHLTNPCYPRDYSISFTMGHVFDSLCTVDQRPESYNPN-DVITFEGTGDPSL SINFRUP00000158369 MVQASSDPSKINNPCYPEGFNTTIMASDIYETPCT--KKPQGYNPN-QKLFMVGSGNSDI ENSMUST00000028328 ALQIHR-----FHPCWPKGYSTQVLLREVYQSPCTMGQRPQTFNSS-ATVSLSGTSNAAL ENST00000312665 ALQTHG-----FHPCWPRGFSTQVLLGDVYQSPCTMAQRPQNFNSS-ARVSLSGSSDPHL SINFRUP00000163975 LLKGYSA--SIIHPCYPVGHSTNIKLDSIFDSPCSDKYKAQTYNSQ-STLSVRGSGHYEH CG3059-RD GYKKEDT---------------------VLESVCVNPIIANRTWTY-GNVQYKVSGKENG : * : . .. ENST00000308572 CGAMLSPLLARSNTSQASLNGIYQSPID-FNNSEFYGFSEFFYCTEDVLRIGG---RYHG ENSMUST00000026198 CRTLLSPLLARSNTSQASLNGIYQSPID-FNNSEFYGFSEFFYCTEDVLRIGG---HYHG SINFRUP00000130070 CLQVVRPFLGLHN-GTMSLGGVYQAPIN-FSNSEFYGFSEFFYCTEDVLRLGG---QYNS ENSMUST00000022653 CRETLQPFMNKTNETQTSLNGVYQPPIH-FQNSEFYGFSEFYYCTEDVLRMGG---DYNA ENST00000314007 CRETIQPFMNKTNETQTSLNGVYQPPIH-FQNSEFYGFSEFYYCTEDVLRMGG---DYNA SINFRUP00000129387 CRQILQPFLNRTNDTLTSLSGVYQPAID-YNRSQFYGFSEFYYCTEDVLRIGG---TYNA ENST00000260756 CHQSILELFNTSYCPYS-QCAFNGIFLP-PLQGDFGAFSAFYFVMKFLNLTSEK---VSQ ENSMUST00000052388 CHQSILELFNNSHCPYS-QCAFNGVFLP-PLHGSFGAFSAFYFVMDFFKKVAKNS-VISQ ENSMUST00000047687 CREKVASVFDFNACQEQDACSFDGIYQP-KVQGPFVAFAGFYYTASALNLSG----SFSL ENST00000301825 CKEKVASIFDFKACHDQETCSFDGVYQP-KIKGPFVAFAGFYYTASALNLSG----SFSL SINFRUP00000158369 CKTMVKSIFDFKSCSSQ-QCSFNGVEQP-PVSGDFLAYAGYFFVARALQINETSEITAEM ENSMUST00000028328 CRDLVSGLFNISSCPFS-QCSFNGVFQP-PVAGNFIAFSAFYYTVDFLKTVMGLP-VGTL ENST00000312665 CRDLVSGLFSFSSCPFS-RCSFNGVFQP-PVAGNFVAFSAFFYTVDFLRTSMGLP-VATL SINFRUP00000163975 CLGNVSEIFSFDNCSFS-QCSFDNVFQP-NVTGSFVAFSAFFYLHSFLERITGIR-VITP CG3059-RD KSSAEQPIVDFDACLELVKSKVMPLVKPKPFTLKQHAVAAFSYYFERAIESG------LV .. . . : : : ENST00000308572 PTFAKAAQD-YCGMAWSVLTQRFKNGLFSSHADEHRLKYQCFKSAWMYQVLHEGFHFP-Y ENSMUST00000026198 PTFAKAAQD-YCGMAWPVLAQRFKNGLFSSHADEHRLKYQCFKSAWMYEVLHEGFHFP-Y SINFRUP00000130070 QRFSKAAAD-YCATKWSTLKQRLENRLFSQHADIDRVKKQCFKSAWMFEVLHSGFRFP-T ENSMUST00000022653 ARFTQAAKD-YCATKWSILRERFDRGLYASHADLHRLKYQCFKSAWMFEVFHKGFSFP-V ENST00000314007 AKFTKAAKD-YCATKWSILRERFDRGLYASHADLHRLKYQCFKSAWMFEVFHRGFSFP-V SINFRUP00000129387 TEYARAAKARYCSTQWKTLRERFHSGLYASHADLHRLKYQCFKSAWMYEVLHSGFSFP-A ENST00000260756 EKVTEMMKK-FCAQPWEEIKTSYAG------VKEKYLSEYCFSGTYILSLLLQGYHFTAD ENSMUST00000052388 EKMTEITKN-FCSKSWEETKTSYPS------VKEKYLSEYCFSGAYILS-LLQGYNFTDS ENSMUST00000047687 TSFNDSSWD-FCRHTWSELPALLSR------FDETYARSYCFSAHYIYHLLVNGYKFTEE ENST00000301825 DTFNSSTWN-FCSQNWSQLPLLLPK------FDEVYARSYCFSANYIYHLFVNGYKFTEE SINFRUP00000158369 EEFTSSVRQ-FCETHWTVLKQEKSR------IADRYLKTYCFGAHYIYTLLADGYKFDKD ENSMUST00000028328 KQLEDATET-TCNQTWAELQARVP-------GQQTRLPDYCAVAMFIHQLLSRGYRFDER ENST00000312665 QQLEAAAVN-VCNQTWAQLQARVP-------GQRARLADYCAGAMFVQQLLSRGYGFDER SINFRUP00000163975 SLLDQAAKT-VCQMTYSQMLIRAP-------EDQARLQDYCAVSVFVKILMLRGYSFDET CG3059-RD DPLAGGETTVEAYRKKAQEICAIPN---------DEQPFMCFDLTFISTLLREGFGLN-- . * :: :: *: : ENST00000308572 DYPNLRTAQLVYDREVQWTLGAILYKTRFLPLRDLRQE--GVRQAHGSWFRLSFVYNHYL ENSMUST00000026198 DYPNLQTAQLVYDREVQWTLGAILYKTRFLPLRDLRQGQGGVRPAHGSWLRLSFVYNHYL SINFRUP00000130070 NYPSLKTAQLVYNKEVQWTLGAILFKTRFLPLRDLQQET--LRQSHSSWLRSSFVYNHHL ENSMUST00000022653 TYKNLKTALQVYDKEVQWTLGAILYRTRFLPLRDIRQEV--FRAGHAHWRGVSFVYNHYL ENST00000314007 NYKSLKTALQVYDKEVQWTLGAILYRTRFLPLRKIGMLI--IPCSGGCPKLCCAVWQPPP SINFRUP00000129387 GYKNLKTALLVYDKEVQWTLGAILYRTRFLPLRDIQQDS--LRGVHSHWRHSFFVNNHYL ENST00000260756 SWEHIHFIGKIQGSDAGWTLGYMLNLTNMIPAE--------QPLS-TPLSHSTYVFLMVL ENSMUST00000052388 SWEQIHFMGKIKDSNAGWTLGYMLNLTNMIPAE--------QPLS-PPLPHSTYIGLMVL ENSMUST00000047687 TWPQIRFEKEVGNSSIAWSLGYMLSLTNQIPAG--------SPLIHLPIQPPVFMGVLAF ENST00000301825 TWPQIHFEKEVGNSSIAWSLGYMLSLTNQIPAE--------SPLIRLPIEPPVFVGTLAF SINFRUP00000158369 NWKQIHFTKEV------------------------------------------------- ENSMUST00000028328 SFRGVVFEKKAADTAVGWALGYMLNLTNLIPAD--------LPGLRKGTHFSSWVALLLL ENST00000312665 AFGGVIFQKKAADTAVGWALGYILNLN-LIPAD--------PPGLRKGTDFSSWVVLLLL SINFRUP00000163975 TFPHISFQKKVGDASVGWALGYMLTLSNLLPAE--------MPATRKSLSVEVWGALLFL CG3059-RD DGKKIKLYKKIDGHEISWALG---CAYNVLTSD-------------EKFSNS-------- : : :: : ENST00000308572 FFACILVVLLAIFLYLLRLRRIHHRQTRASAPLDLLWLEEVVPMMGVQVGP ENSMUST00000026198 FFACTLVVLLAIVLYLLRIHRIHRRQTRASAPLDLLWIEQVVPMIGVQVGP SINFRUP00000130070 LSLCILVVLLAILLYILRLRRIHQREQRQAEALNLLWAEE----------- ENSMUST00000022653 FSGCFLVVLLSILLYLLRLRRIHRRAPRTGS----LWMEEGLPSQKGPGPL ENST00000314007 YG---------------ATKHLQCAAWN----------------------- SINFRUP00000129387 FLACFFIVLLSIILYVLRLRRIHRRSAQLYTPSSVPWLEAGLRSPTLP--- ENST00000260756 FSLVLFTVAIIGLLIFH------KPSYFWKDMV------------------ ENSMUST00000052388 FSLLLVAVAITGLFIYS------KPSYFWKEAV------------------ ENSMUST00000047687 FTAIALLCLAFLLYLCSSFRTKERSENAFDQAVDSD--------------- ENST00000301825 FTAAALLCLAFLAYLCSATRRKRHSEHAFDHAVDSD--------------- SINFRUP00000158369 --------------------------------------------------- ENSMUST00000028328 FTVLILAALVLLLRQVRSAKSPGAL-------------------------- ENST00000312665 FASALLAALVLLLRQVHSAKLPSTI-------------------------- SINFRUP00000163975 LVFLLVAVLLFTLLKV----------------------------------- CG3059-RD --------------------------------------------------- .