CLUSTAL W (1.82) multiple sequence alignment SINFRUP00000127520 ------------------------------------------------ME SINFRUP00000155421 -------------------------------------------------- SINFRUP00000154633 ------------------------------------------------MD O42322_Cyprinus_carpio -------------------------------------------------- SINFRUP00000149812 -------------------------------------------------- SINFRUP00000142755 -------------------------------------------------- ENSMUST00000026569 -------------------------------------------------- ENST00000258400 -----------------------------------------MALSYRVSE ENSMUST00000027431 -----------------------------------------MASSYKMSE Q8UUG8_Tetraodon_fluviatilis -------------------------------------------------- SINFRUP00000147089 -------------------------------------------------- ENST00000261668 ---------------------------------MDILCEENTSLSSTTNS ENSMUST00000036653 ---------------------------------MEILCEDNISLSSIPNS ENST00000276198 ----------------------------------------MVNLRNAVHS ENSMUST00000036303 ----------------------------------------MVNLGTAVRS SINFRUP00000135888 -------------------------------------------------- CG6919-RA MTLLQRLQAMSATTTRTILEGSISSFGGGTNEPLASKIPVLEESASHARY SINFRUP00000127520 LDNNSLDYFSSNFTDIPSNTTVAHWT-------EATLL------------ SINFRUP00000155421 ------------AANGSGNDTLG----------TPKLP------------ SINFRUP00000154633 LRATSSN--DSNATSGYSDTAAVDWDEGENATGSGSLPDPEL-------- O42322_Cyprinus_carpio ------------------------------MPANLTASSHST-------- SINFRUP00000149812 -------------------------------------------------- SINFRUP00000142755 ------------------------------------AAVAVA-------- ENSMUST00000026569 --------------MGNSSATEDGGLLAGRGPESLGTGAGLG-------- ENST00000258400 LQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQG-------- ENSMUST00000027431 -QSTTSEHILQKTCDHLILTNRSGLETDSVAEEMKQTVEGQG-------- Q8UUG8_Tetraodon_fluviatilis ----------------MFQAAVGPLQTN-----ISLPEETPG-------- SINFRUP00000147089 --------------------------------------ENPG-------- ENST00000261668 LMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLS ENSMUST00000036653 LMQLGDDSRLYPNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLS ENST00000276198 FLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGR-FKFPDG-------- ENSMUST00000036303 LLVHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDG-------- SINFRUP00000135888 -------------------------------------------------- CG6919-RA LKFIADGLIDEGLGSAVGSGSSIAVSVEDVVAGQAQDIQASEGSTDDADG : SINFRUP00000127520 ----GLQISVSVVLAIVTLATMLSNAFVIATIFLTRKLHTPANFLIGSLA SINFRUP00000155421 ----PRKILLTVTLFIVAVLTTFLNCLVITAIAVTRKLHHPANYLICSLA SINFRUP00000154633 ----SYQIITSLFLGALILCSIFGNSCVVAAIALERSLQNVANYLIGSLA O42322_Cyprinus_carpio ----NYNFPALIFGILLIVIIICGNVLVCLSVYTEKALKTTTNYFIVSLA SINFRUP00000149812 ---------ALVFGVLLIVVIICGNLLVCLSVLTEKALKTTTNYFIVSLA SINFRUP00000142755 ----HRNLPALICGILLIVTVASGNVLVCLSVYLEKALKTTTNYFIVSLA ENSMUST00000026569 ----GAGAAALVGGVLLIGLVLAGNSLVCVSVASERTLQTPTNYFIVSLA ENST00000258400 ----NKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLA ENSMUST00000027431 ----HTVHWAALLILAVIIPTIGGNILVILAVALEKRLQYATNYFLMSLA Q8UUG8_Tetraodon_fluviatilis ----LELNWAALLIVMVIIPTIGGNILVILAVWLEKKLQNATNFFLMSLA SINFRUP00000147089 ----LELNWAALLIVMVIIPTIGGNILVILAVWLERKLQNATNFFLMSLA ENST00000261668 LLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLA ENSMUST00000036653 ILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLA ENST00000276198 -----VQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLA ENSMUST00000036303 -----VQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLA SINFRUP00000135888 -------------------------------------------------- CG6919-RA SSHLALVFVKCFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLA . : : : : :: : SINFRUP00000127520 VTDMLVSILVMPISIVYTVSK-TWSLGQIVCDIWLSSDITFCTASILHLC SINFRUP00000155421 VTDLLVAVLVMPFSIVYIQKE-TWVMGQVMCTIWLSVDVTCCTCSILHLA SINFRUP00000154633 VTDLMVSVLVLPMAALYQVLN-KWTLGQDICDLFIALDVLCCTSSILHLC O42322_Cyprinus_carpio VADLLLAVLVLPLFVYAEFQDGVWSLNMTLCDGLMTMDVMLCTASIFNLC SINFRUP00000149812 VADLMLAVLVLPLFVYSEFQDGVWPLSSTICDYLMTMDVMLCTASIFNLC SINFRUP00000142755 FADLLLAVLVLPLFVYAEFQGGVWTLNVLMCDGLMTMDVMLCTASIFNLC ENSMUST00000026569 AADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLC ENST00000258400 VADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLC ENSMUST00000027431 IADLLVGLFVMPIALLTIMFEAIWPLPLALCPAWLFLDVLFSTASIMHLC Q8UUG8_Tetraodon_fluviatilis VADLLVGLLVMPIALITILYDSDWPLPEPLCPIWLFLDVLFSTASIMHLC SINFRUP00000147089 VADLLVGLLVMPIALITILYDADWPLPEPLCPIWLFLDVLFSTASIMHLC ENST00000261668 IADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLC ENSMUST00000036653 IADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLC ENST00000276198 IADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLC ENSMUST00000036303 IADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLC SINFRUP00000135888 -----------PPLVLCLFPDYAWPLPNALCPIWIYLDVLFSTASIMHLC CG6919-RA VADMLVALCAMTFNASVMISG-KWMFGSVMCDMWNSFDVYFSTASIMHLC ::: . :. * : :* *: .*.**::*. SINFRUP00000127520 VIALDRYWAITDALEYSKRRTMRRAAVMVAVVWVISISISMPPLFW---- SINFRUP00000155421 AIAIDRYRAITDAVEYSRKRTGAMAGQMVAVVWLLSILISLPPLLW---- SINFRUP00000154633 AIALDRYWAITDPIDYVNKRTPRRAAVLISVTWLIGFSISIPPMLG---- O42322_Cyprinus_carpio AISIDRFIAVSIPLNYNRKHVGQRQIVLLSATWILASAVASPVMFG---- SINFRUP00000149812 AISVDRFIAVLIPLNYNRKHVDLRQAVLLSATWILALAVASPIIFG---- SINFRUP00000142755 AISVDRFIAVSVPLNYNRKHVDHRQLVLLSATWLLALAVASPVIFG---- ENSMUST00000026569 AISVDRFVAVTVPLRYNQQ--GQCQLLLIAATWLLSAAVASPVVCG---- ENST00000258400 AISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIET ENSMUST00000027431 AISLDRYIAIKKPIQANQCNSRATAFIKITVVWLISIGIAIPVPIKGIET Q8UUG8_Tetraodon_fluviatilis AISLDRYIAIKKPIQHSQYKSRAKVMLKIALVWLISICIAIPIPIKGLRN SINFRUP00000147089 AISLDRYIAIKKPIQHSQYKSRPKVMLKIALVWLISICIAIPIPIKGLRN ENST00000261668 AISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQD ENSMUST00000036653 AISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQD ENST00000276198 AISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRD ENSMUST00000036303 AISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRD SINFRUP00000135888 AISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIGVSMPIPVIGLHN CG6919-RA CISVDRYYAIVQPLDYPLIMTQRRVFIMLLMVWLSPALLSFLPICSGWYT *::**: *: .: : .* :: SINFRUP00000127520 ---RQAKAHEELK-ECMVNTDQISYTLYSTFGAFYVPTVLLIILYGRIYV SINFRUP00000155421 ---RHFTEDSEQEDQCIIIHHHIAFTLYSTFGAFYIPLLLILILYYKIYR SINFRUP00000154633 ---WRSAEDRANPDACIISQD-PGYTIYSTFGAFYIPLILMLVLYGRIFK O42322_Cyprinus_carpio ---INNVPNRDHSECKLEDNN---YVVYSSVCSFFVPCPIMLLLYCGMFR SINFRUP00000149812 ---INNMPGRDPRECKLENND---YVLYSSVCSFFIPCPIMLLLYCGMFR SINFRUP00000142755 ---INNVPDRDPSACKLEDNN---YVVYSSVCSFFIPCPIMVLLYFGVFR ENSMUST00000026569 ---LNDVPGRDPAVCCLENRD---YVVYSSVCSFFLPCPLMLLLYWATFR ENST00000258400 -----DVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIH ENSMUST00000027431 -----DVINPHNVTCELTKDRFGSFMVFGSLAAFFAPLTIMVVTYFLTIH Q8UUG8_Tetraodon_fluviatilis YPHPNNITFTSNHTCVLKTDTFQEFIIFGSLVAFFIPLTIMMIIYFLTVR SINFRUP00000147089 HPHPNNITFNSNHTCLLKPDTFQEFIIFGSLVAFFIPLTIMMIIYLLTVR ENST00000261668 ----DSKVFKE-GSCLLADD---NFVLIGSFVSFFIPLTIMVITYFLTIK ENSMUST00000036653 ----DSKVFKE-GSCLLADD---NFVLIGSFVAFFIPLTIMVITYFLTIK ENST00000276198 ----EEKVFVNNTTCVLNDP---NFVLIGSFVAFFIPLTIMVITYCLTIY ENSMUST00000036303 ----ESKVFVNNTTCVLNDP---NFVLIGSFVAFFIPLTIMVITYFLTIY SINFRUP00000135888 ----EDKVFVN-GSCVLNEE---RFMLIGSFVAFFIPLVIMVVTYCLTIQ CG6919-RA TTENYKYLKSNPHICEFKVNK--AYAIVSSSMSFWIPGIVMLSMYYRIYQ : : : .: :*: * ::: * SINFRUP00000127520 AARSRIFKTPSYSGKRFTTAQLIQTSAGSSLCSLN---------SASNQE SINFRUP00000155421 AAQTLYMRR--------------EASRASRHSCMT---------NGSMIP SINFRUP00000154633 AARFRIRKTVKKTEKAKASDMCLTLSPAVFHKRANGDAVSAEWKRGYKFK O42322_Cyprinus_carpio GLRNWEEARKAKLRSSMQACRKLQEAAAS--LQPLSG-----LPPPLPPV SINFRUP00000149812 GLRRWEEARKAKLRNSIQACRKLQEAAAT--LPPLAS-----LPPPLPPI SINFRUP00000142755 GLKRWEETRKVKLRSSIEACRKLQHAAVSTTLPPLAAAIPGPLPMALPRV ENSMUST00000026569 GLRRWEAARHTKLHSRAPRRPSGPGPPVS---DPTQGPFFPDCPPPLP-S ENST00000258400 ALQKKAYLVKNK----PPQRLTWLTVSTVFQRDETPCSS-PEK------- ENSMUST00000027431 TLQKKAYLVKNK----PPQRLTRWTVPTVFLREDSSFSS-PEK------- Q8UUG8_Tetraodon_fluviatilis VLRKKVYLLRSK----VTQRFSYPIISTVFQREQAANPPQPEQPDSTGNS SINFRUP00000147089 VLRKKVYLLRSK----ATQRFSYSIISTVFQREQAANPAQPEQPHTTDSS ENST00000261668 SLQKEATLCVSD-------LGTRAKLASFSFLPQSSLSS----------- ENSMUST00000036653 SLQKEATLCVSD-------LSTRAKLSSFSFLPQSSLSS----------- ENST00000276198 VLRRQALMLLHGHTEEPP-GLSLDFLKCCKRNTAEEENS----------- ENSMUST00000036303 VLRRQTLMLLRGHTEEELRNISLNFLKCCCKKGDEEENA----------- SINFRUP00000135888 S-RRNTLSCLKG--AEPGMLLSVSTPDSLSIIPGSEVGS----------- CG6919-RA EADRQERLVYRS---------KVAALLLEKHLQISQIPK----------- SINFRUP00000127520 AHLHSGAGGEGGGSPLF---------------------VNSVKVKLADNV SINFRUP00000155421 STYPAGDGDLDGGP------------------------RSPEPLSPAENQ SINFRUP00000154633 PSSPCANGAVRHGEEMESLEIIEVNSNSKTHLPLPNTPQSSSHENINEKT O42322_Cyprinus_carpio IKKDLTDITLEELEQDPDSPEP--------VCMLAYPGGTYHEHRNQN-- SINFRUP00000149812 IEREPTET-LDEMSNFP-SPEPPFPS---SEYRAPVPAVSFAEIQFNPDP SINFRUP00000142755 IERDLAQSRLDDTDDDMQQEIP---------YPRQYRENSVPTVTFSHQL ENSMUST00000026569 LRTSPSDSSRPESELSQRPCSP-----------GCLLADAALPQPPEPSS ENST00000258400 -VAMLDGSRKDKALPNSG----------------------DETLMRRTST ENSMUST00000027431 -VAMLDGSHRDKILPNSS----------------------DETLMRRMSS Q8UUG8_Tetraodon_fluviatilis LARIQEKTDTDGMSSPTG----------------------DEKSFRRLST SINFRUP00000147089 LARTQEKTNTDAIISLTG----------------------DEKSFRRLST ENST00000261668 ----------EKLFQRS-------------------------IHREPGSY ENSMUST00000036653 ----------EKLFQRS-------------------------IHREPGSY ENST00000276198 ----------ANPNQDQ-----------------------NARRRKKKER ENSMUST00000036303 ----------PNPNPDQ-----------------------KPRR-KKKEK SINFRUP00000135888 ----------QLSSPATG----------------------TSRSDASGCH CG6919-RA --------------------------------------------PRPSIQ SINFRUP00000127520 LER-KRLCAARERKATKTLGIILGAFIICWLPFFVVTLVWAICKE-CSFD SINFRUP00000155421 FNQGPRISGSRERKAAYTLGLIIGAFIICWLPFFVKEVIVNTCNS-CYTS SINFRUP00000154633 TGTRRKIALARERKTVKTLGIIMGTFIFCWLPFFIVALVLPFCAENCYMP O42322_Cyprinus_carpio RQRKRAKINGRERKAMRVLPVVVGAFLFCWTPFFVVHTMRALCED-CYIP SINFRUP00000149812 RRRKRAKINSRERKAMKVLPVVVGAFLFCWTPFFVLHTLRARCED-CQIP SINFRUP00000142755 HGKKRAKINKRERKAMRVLPVVVGCFLFCWTPFFVVHTTRALCLT-CHIP ENSMUST00000026569 RRRRGAKITGRERKAMRVLPVVVGAFLVCWTPFFVVHITRALCPA-CFVS ENST00000258400 IGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCD-SCNQT ENSMUST00000027431 VGKRSAQTISNEQRASKALGVVFFLFLLMWCPFFITNLTLALCD-SCNQT Q8UUG8_Tetraodon_fluviatilis MGKKSMQTLTNEQRASKVLGIVFLLFVVMWCPFFITNITSALCG-PCDAN SINFRUP00000147089 MGKKSMQTLTNEQRASKVLGIVFLLFVVMWCPFFITNITSALCT-PCDAN ENST00000261668 TGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNED ENSMUST00000036653 AGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEN ENST00000276198 RPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQK ENSMUST00000036303 RPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQK SINFRUP00000135888 GRRGMMQAIKNERRASKVLGIVFFLFLIMWCPFFITNVTSVLCRGSCNES CG6919-RA VEQSTISTMRRERKAARTLGIIMSAFLICWLPFFLWYIVSSLCDS-CITP .*::: .* ::. *:. * ***: * * SINFRUP00000127520 PL--LFDVFTWLGYLNSLINPVIYTVFNDEFKQAFQKLIKFRR------- SINFRUP00000155421 VE--MADFLTWLGYINSLINPLIYTIFNEDFKKAFQRLV----------- SINFRUP00000154633 EW--LGAVINWLGYSNSLLNPIIYAYFNKDFQSAFKKILRCKFHRH---- O42322_Cyprinus_carpio SS--VTSIVTWLGYVNSALNPVIYTVFNTEFRKFFRKFLPTLPNCC---- SINFRUP00000149812 AA--LMSVVTWLGYVNSALNPVIYTIFNTEFRNLFKKLLH---RCC---- SINFRUP00000142755 PG--LMSTVTWLGYVNSALNPIIYTIFNTEFKKFFKKFFR---AGC---- ENSMUST00000026569 PR--LVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLR---LRC---- ENST00000258400 TLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKS-- ENSMUST00000027431 TLKTLLEIFVWIGYVSSGVNPLIYTLFNKTFREAFGRYITCNYRATKS-- Q8UUG8_Tetraodon_fluviatilis IIGRLMEIFSWVGYVSSGINPLVYTLFNKTFRQAFTRYITCNYRNFASKE SINFRUP00000147089 IIGRLMEIFVWVGYVSSGINPLVYTLFNKTFRQAFTRYITCNYKNISAQE ENST00000261668 VIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKK-- ENSMUST00000036653 VIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRK-- ENST00000276198 LMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKK-- ENSMUST00000036303 LMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKK-- SINFRUP00000135888 LLHDLLNVFVWVGYISSGVNPLVYTLFNKTYRRAFSSYIRCRY------- CG6919-RA RL--LVGILFWIGYFNSALNPIIYAYFNRDFRAAFKKTLKSLFPYAFYFC : . *:** * :**::*: ** :: * . SINFRUP00000127520 -------------------------------------------------- SINFRUP00000155421 -------------------------------------------------- SINFRUP00000154633 -------------------------------------------------- O42322_Cyprinus_carpio -------------------------------------------------- SINFRUP00000149812 -------------------------------------------------- SINFRUP00000142755 -------------------------------------------------- ENSMUST00000026569 -------------------------------------------------- ENST00000258400 ------VKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRL ENSMUST00000027431 ------VKALRKFSSTLCFGNSMVENSKFFTKHGIRNGINPAMYQSPMRL Q8UUG8_Tetraodon_fluviatilis QGRSFRASTVDRMLTHISPRSSVAENAKLFTKQEIKN--ETTDYRSPLGC SINFRUP00000147089 QGRSLRASTVDRMLTHISPRASLADNSKLGTKQETKN--GTTDYQSPSKG ENST00000261668 ----------PLQLILVNTIPALAYKSSQLQMGQKKN------SKQDAKT ENSMUST00000036653 ----------PLQLILVNTIPTLAYKSSQLQVGQKKN------SQEDAEP ENST00000276198 ----------PPVRQIP-RVAATALSGRELNVNIYRH------TNEPVIE ENSMUST00000036303 ----------PPVRQIP-RVAATALSGRELNVNIYRH------TNERVVR SINFRUP00000135888 -------------------------------------------------- CG6919-RA RRGRGRDDDRDLEFGGPSRRGTNGAQRTGSGSAEMANCVNSTASSEIHMS : SINFRUP00000127520 -------------------------------------------------- SINFRUP00000155421 -------------------------------------------------- SINFRUP00000154633 -------------------------------------------------- O42322_Cyprinus_carpio -------------------------------------------------- SINFRUP00000149812 -------------------------------------------------- SINFRUP00000142755 -------------------------------------------------- ENSMUST00000026569 -------------------------------------------------- ENST00000258400 RSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV----------------- ENSMUST00000027431 RSSTIQSSSIILLDT-LLTENDGDKAEEQVSYIAERAALIERGDEQDARA Q8UUG8_Tetraodon_fluviatilis LQPSAQTSTGVVLDKILLTHTENCKQEERVSCV----------------- SINFRUP00000147089 LRAPAQISTGAVLDTIALTQTESCKQEEHVNCV----------------- ENST00000261668 TDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV----------------- ENSMUST00000036653 TANDCSMVTLGNQHSEEMCTDNIETVNEKVSCV----------------- ENST00000276198 KASDNEPGIEMQVENLELPVNPSSVVSERISSV----------------- ENSMUST00000036303 KANDTEPGIEMQVENLELPVNPSNVVSERISSV----------------- SINFRUP00000135888 -------------------------------------------------- CG6919-RA VMRARQYAVNVTPTTDAQMQQLHPLYTN---------------------- : : SINFRUP00000127520 ------ SINFRUP00000155421 ------ SINFRUP00000154633 ------ O42322_Cyprinus_carpio ------ SINFRUP00000149812 ------ SINFRUP00000142755 ------ ENSMUST00000026569 ------ ENST00000258400 ------ ENSMUST00000027431 TWKGTE Q8UUG8_Tetraodon_fluviatilis ------ SINFRUP00000147089 ------ ENST00000261668 ------ ENSMUST00000036653 ------ ENST00000276198 ------ ENSMUST00000036303 ------ SINFRUP00000135888 ------ CG6919-RA ------