CLUSTAL W (1.82) multiple sequence alignment ENST00000271289 ------------------------------------------------------------ ENSMUST00000046316 ------------------------------------------------------------ SINFRUP00000134775 ------------------------------------------------------------ SINFRUP00000161345 ------------------------------------------------------------ ENST00000280336 ------------------------------------------------------------ ENSMUST00000032105 ------------------------------------------------------------ ENST00000273261 ------------------------------------------------------------ CG8434-RA MSWSRRRRRNNNNNNNSSSNNNNAASESRSNDNCNYSTTNDFNKINKLLLITYMLLITAA ENST00000271289 ------------------------------------------------------------ ENSMUST00000046316 ------------------------------------------------------------ SINFRUP00000134775 ------------------------------------------------------------ SINFRUP00000161345 ------------------------------------------------------------ ENST00000280336 ------------------------------------------------------------ ENSMUST00000032105 ------------------------------------------------------------ ENST00000273261 ------------------------------------------------------------ CG8434-RA TICQSAAQSPSSSNGNGVGGSGSTGGSPLSALLKSGGASYNQQLPQQQLFAMLTRNGGGS ENST00000271289 --------------------------------------------MAPAPLGVPEEQLLGC ENSMUST00000046316 --------------------------------------------MAAAPRGIWEQRRLGC SINFRUP00000134775 ------------------------------------------------------------ SINFRUP00000161345 ------------------------------------------------------------ ENST00000280336 ------------------------------------------------------------ ENSMUST00000032105 --------------------------------------------MARPGPGVLGAPRLAP ENST00000273261 --------------------------------------------MARPVRGGLGAPRRSP CG8434-RA SGPRSSGGNRGYTSARQHFMALSEDYSDADVDEEDMAALHYPLSASHPPAGVQGSSSSSG ENST00000271289 RSRVLSRLLF------------IAQTALLLLPAAGAGLCPAPCSCRIPLLDCSRRKLPAP ENSMUST00000046316 GLGPLARLLI------------LAQ-ALRLLPAARAGLCPAPCACRLPLLDCSRRKLPAP SINFRUP00000134775 ------------------------------------------------------------ SINFRUP00000161345 ------------------------------------------------------------ ENST00000280336 ------------------------------------------------------------ ENSMUST00000032105 RLLLWLLLLL------------LQWPESAGAQAGPRAPCAAACTCAGDSLDCSGRGLATL ENST00000273261 CLLLLWLLLL------------RLEPVTA--AAGPRAPCAAACTCAGDSLDCGGRGLAAL CG8434-RA ISIQSGSLETNGFVADDGGQYEHAQKALEAAAAAAKASNKYNIDCPKDCKCLNVLFDCDK : ENST00000271289 SWRALSGLLPPDTAILDFSHNRLSNWN--ISLESQTLQEVKMNYNELTEIPYFGEPTSNI ENSMUST00000046316 SWRALSGPLPSDISSLDLSHNRLSNWN--NTLESQTLQEVKMNYNELTEIPYFGEPTPNI SINFRUP00000134775 ------------------------------------------------------------ SINFRUP00000161345 ------------------------------------------------------------ ENST00000280336 ------------------------------------------------------------ ENSMUST00000032105 PR-----DLPSWTRSLNLSYNRLSEIDSAAFEDLTNLQEVYLNSNELTAIPSLGAASIGV ENST00000273261 PG-----DLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHV CG8434-RA LHLERVPVLPSYVQTLHLANNKLNDTTVLEIRNLLNLTKVSLKRNLLEVIPKFIGLSG-L : : : : : : : : : : : ENST00000271289 TLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPR-MQLKYLNLSNNRITT ENSMUST00000046316 TLLSLVHNLIPEINAEAFELYSALESLDLSSNIISEIKTSSFPR-MSLKYLNLSNNRIST SINFRUP00000134775 -----VHNRISDLFMHELQPYVSLETLDLTSNSISEIKAGSFPT-IQLKYLNLSNNKISV SINFRUP00000161345 ------------------------------------------------------------ ENST00000280336 ------------------------------------------------------------ ENSMUST00000032105 VSLFLQHNKILSVDGSQLKSYLSLEVLDLSSNNITEIRSSCFPNGLRIRELNLASNRISI ENST00000273261 VSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGT CG8434-RA KHLVLANNHITSISSESLAALPLLRTLDLSRNKLHTIELNSFPKSNNLVHLILSFNEITN : : : : : : : : : : : : : : : ENST00000271289 LEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTFQGLDSL ENSMUST00000046316 LEAGCFDNLSDSLLVVKLNRNRISMIPPKVFKLPHLQFLELKRNRIKIVEGLTFQGLDSL SINFRUP00000134775 LEPGCFENISSTLLVLKLNRNRLVVLPSRLFKLPQLQFLEMKRNKIKIVESLTFKGMDSL SINFRUP00000161345 ---------------------------------------ELSRNRVRRVEGLTFHGLHAL ENST00000280336 ------------------------------------------------------------ ENSMUST00000032105 LESGAFDGLSRSLLTLRLSKNRITQLPVKAFKLPRLTQLDLNRNRIRLIEGLTFQGLDSL ENST00000273261 LELGAFDGLSRSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSL CG8434-RA VNEHSFATLN-NLTDLELSNNRLSTLPIRVFKNLNQLKKLALNFNQLEINWSTFRGLESM : : : : : : : : : : : : : ENST00000271289 RSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIER ENSMUST00000046316 RSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTGVNKGWLYGLRMLQQLYMSQNAIEK SINFRUP00000134775 KSLKMQRNGITKLMDGAFFGLNNIEELELEYNNLTEINKGWLYGLRMLRILRISQNAVGI SINFRUP00000161345 RSLRMQRNGLSRLMDGALWGLSNMEVLQLDYNNLTEVNKGWLYGLLTLQQLHLSHNAISR ENST00000280336 ------------------------------------------------------------ ENSMUST00000032105 EVLRLQRNNISRLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSISR ENST00000273261 EVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIAR CG8434-RA KNLQLKSNKIRALQDGVFYVMHKIETIDLAMNQISSLSRQGLFNLTKLRHLNLSFNAISR : : : : : : : : : : : : : : : : : ENST00000271289 ISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNL ENSMUST00000046316 ISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNL SINFRUP00000134775 IRPDAWEFCQKLEELDLSFNHLTRLEETAFLGLGLLESLHLGENSISYLGEGVF------ SINFRUP00000161345 IQPDAWEFCQKLAELNLSSNHLSRLEESSFSGLSLLQELHVGNNRVSFIADGAFRGLSNL ENST00000280336 ----------------------MSLQGNAFSQMKKLQQLH-------------------- ENSMUST00000032105 IQRDGWSFCQKLHELILSFNNLTRLDEESLAELSSLSILRLSHNAISHIAEGAFKGLKSL ENST00000273261 IHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSL CG8434-RA IEVDTWEFTQSLEVLDLSNNAINEFKPQHLDCLHRLKTLNLAHNRLQYLQENTFDCVKNL : : : : : : :. : : *. *.: : : : : : ENST00000271289 QTLDLRNNEISWAIED--ASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNN ENSMUST00000046316 QTLDLRNNDISWAIED--ASEAFSGLKSLTKLILQGNRIKSVTQKAFIGLESLEYLDLNN SINFRUP00000134775 -----------------------SGLTSLFTFVLN------------------------- SINFRUP00000161345 QML--------------------RDPYVLSDLRLTAM----------------------- ENST00000280336 ------------------------------------------------------------ ENSMUST00000032105 RVLDLDHNEISGTIED--TSGAFTGLDNLSKLTLFGNKIKSVAKRAFSGLESLEHLNLGE ENST00000273261 RVLDLDHNEISGTIED--TSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGG CG8434-RA EELNLRRNRLSWIIEDQSAAAPFKGLRKLRRLDLHGNNLKQISTKAMSGLNNLEILNLGS : : : : : : : : : : : : : : : ENST00000271289 NAIMSIQENAFSQTH-LKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLA ENSMUST00000046316 NAIMSIQENAFSQTH-LKGLVLNTSSLLCDCHLKWLLQWLVDNNFHHSVNVSCAHPEWLA SINFRUP00000134775 -----------------------TSSLLCDCYMQWLGPWLTDNQFQQSVSAVCAHPANLF SINFRUP00000161345 ---------SLVRSS-ASDRRLNTSSLLCDCQLKWLPVWVAEQTFLPSVNASCAHPQMLK ENST00000280336 ---------------------LNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLK ENSMUST00000032105 NAIRSVQFDAFAKMKNLKELYISSESFLCDCQLKWLPPWLMGRMLQAFVTATCAHPESLK ENST00000273261 NAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLK CG8434-RA NALASIQVNAFEHMLRLNKLVFKSLNFICDCDLVWFQQWLKNRFPQQAEHAVCGYPEHLL : : : : : .::*** : *: *: . . *.:* * ENST00000271289 GQSILNVDLKDFVCDDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDS------PMSTV ENSMUST00000046316 GQSILNVDLKDFVCDDFLKPQIRTHPESTIALRGVNVTLTCTAVSSSDS------PMSTI SINFRUP00000134775 GRSVLSISPELFVCDDFPKPHITSHPETSVVLRGNNVTLSCVASSSSDS------PMTVA SINFRUP00000161345 GRSVFAVSQDEFVCDDFPKPQITVQPETQSALKGSNVTFICSAASSSDS------PMTFS ENST00000280336 GRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDS------PMTFA ENSMUST00000032105 GQSIFSVLPDSFVCDDFPKPQIITQPETTMAVVGKDIRFTCSAASSSSS------PMTFA ENST00000273261 GQSIFSVPPESFVCDDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSS------PMTFA CG8434-RA DRHLKSLSSSELVCVDSPKPRVEQEPDDMLAVNAANITLECIASSPTAASLAAADELKIK .: : : . :** * **:: .*: .: . :: : * * *.: : :. ENST00000271289 WRKDSEILYD-VDTENFVRYWQQAG-----EALEYTSILHLFNVNFTDEGKYQCIVTNHF ENSMUST00000046316 WRKDSEILYD-VDIENFVRYRQQDG-----EALEYTSVLRLFSVNFTDEGKYQCIVTNHF SINFRUP00000134775 WRKEGEVLYD-AEVHNYAQYQDRE--------LIYTTELHLLDVNFTDEGRYQCVVSNHF SINFRUP00000161345 WKKDNEVLNK-AEIHNQAHLRIQAGAGGDTEVTEYTTTLQLHTVDFSSEGKYQCVISNHF ENST00000280336 WKKDNELLHD-AEMENYAHLRAQGG-----EVMEYTTILRLREVEFASEGKYQCVISNHF ENSMUST00000032105 WKKDNEVLAN-ADMENFAHVRAQDG-----EVMEYTTILHLRHVTFGHEGRYQCIITNHF ENST00000273261 WKKDNEVLTN-ADMENFVHVHAQDG-----EVMEYTTILHLRQVTFGHEGRYQCVITNHF CG8434-RA WRHDNQHVQERPAVHDGASTETQIRHDLSTNQTSIYGYLRLTNVTYESAGRYQCVVSNAF *:::.: : . .: . : *:* * : *:***:::* * ENST00000271289 GSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAA ENSMUST00000046316 GSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLECAAEGHPTPQISWQKDGGTDFPAA SINFRUP00000134775 GSNYSTRAKLTVNEMPSFLKTPMDLTIRTGTMARLECAAEGHPSPQIAWQKDGGTDFPAA SINFRUP00000161345 GSSYSTKARLTVNMLPSFTKTPMDLSIRAGAVARLECAAVGHPSPQIAWQKDGGTDFPAA ENST00000280336 GSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAA ENSMUST00000032105 GSTYSHKARLTVNVLPSFTKIPHDIAIRTGTTARLECAATGHPNPQIAWQKDGGTDFPAA ENST00000273261 GSTYSHKARLTVNVLPSFTKTPHDITIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAA CG8434-RA GTTYAQKFKISIGIHPTFLQVPSNLTLDAGEMARLVCSASGDPTPEIALQKFGGSEFPAA *:.*: : ::::. *:* : * :::: : *** *:* *.* *:*: ** **::**** ENST00000271289 RERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNTAGGLSANASLTVLETPSFIRPLEDKT ENSMUST00000046316 RERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNIAGGLSANASLTVLETPSFIRPLEDKT SINFRUP00000134775 RERRMHVMPDDDIFFIANVKTEDMGVYSCTAQNTAGSLSANATLTVLETPSFMRPLEDRT SINFRUP00000161345 RERRMHVMPEDDEFFMVNVKTEDIGVYSCTAQNTAGAISANATLTVLETPLFLRPLVDRT ENST00000280336 RERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRT ENSMUST00000032105 RERRMHVMPDDDVFFITDVKIDDMGVYSCTAQNSAGSVSANATLTVLETPSLAVPLEDRV ENST00000273261 RERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNSAGSISANATLTVLETPSLVVPLEDRV CG8434-RA TERRLQVIREENAFLITNAKPSDSGIYTCTALSAAGEIKVNATLVVNDKPQPSIPLVHQE ***::*: ::: *::.:.* .* *:*:* * . ** :..**:*.* :.* ** .: ENST00000271289 VTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTC ENSMUST00000046316 VTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTC SINFRUP00000134775 VARGETAVLQCIAGGSPTPRLNWTKDDGPLILTERHFFAAANQLLIIVDAGPADAGKYTC SINFRUP00000161345 VAKGETAVLQCIAGGSPAPRLNWTKDDSPLVVTERHFFAAANQLLIIVDTTEADAGKYTC ENST00000280336 VTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTC ENSMUST00000032105 VTVGETVAFQCKATGSPTPRITWLKGGRPLSLTERHHFTPGNQLLVVQNVMIDDAGRYTC ENST00000273261 VSVGETVALQCKATGNPPPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTC CG8434-RA VVVGRTCVLQCLSETAN--------ADFELEHPHREWFKENKPIHISPTAPDGDQ----- * *.* .:** : : . * ..*. : : : : * ENST00000271289 IMSNTLGTERGHIYLNVISSPNCDSSQ---------SSIGHEDDGWTTVGIVIIVVVCCV ENSMUST00000046316 LMSNTLGTERGHIYLNVISSPNCDSSQ---------SSIGHEDDGWTTVGIVIIVVVCCV SINFRUP00000134775 IMSNTLGTERGHIYLSVSPSSTCDTG------------AIYDQDAWTTVGIVVIVVVCCV SINFRUP00000161345 EMSNTLGTERGNARLAVLPNPNCESGVQGGIRIGMVAGAGSDDDGWTTVGIVIIAVVCCV ENST00000280336 EMSNTLGTERGNVRLSVIPTPTCDS--------PQMTAPSLDDDGWATVGVVIIAVVCCV ENSMUST00000032105 EMSNPLGTERAHSQLSILPTPGCRKDG-------------------TTVGIFTIAVVCSI ENST00000273261 EMSNTLGTERAHSQLSVLPAAGCRKDG-------------------TTVGIFTIAVVSSI CG8434-RA -----LVVVKENLNWVVL-----------------------------LVGIITVTVICVV : * . : : : **:. :.*:. : ENST00000271289 VGTSLIWVIVIYHMRRKNEDYSITNTEELNLPADIPSYLSSQGTLSEPQEGYSNSEAGSH ENSMUST00000046316 VGTSLIWVIVIYHMRRKNEDYSITNTEELNLPADIPSYLSSQGTLSEPQEGYSNSEAGSH SINFRUP00000134775 VGTSLVWVIVIYHMRRKSEDYSITNT---------------------------------- SINFRUP00000161345 VGTSLVWVVIIYHTRRRNEDCSVTNTDETNLPADIPSYLSSQGTLADRQDGYMPSESGSS ENST00000280336 VGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIPSYLSSQGTLADRQDGYVSSESGSH ENSMUST00000032105 VLTSLVWVCIIYQTRKKSEEYSVTNTDETIVPPDVPSYLSSQGTLSDRQETVVRTEGGHQ ENST00000273261 VLTSLVWVCIIYQTRKKSEEYSVTNTDETVVPPDVPSYLSSQGTLSDRQETVVRTEGGPQ CG8434-RA VDCCIIWCTLRYQKKKLRMSLAAERHSTQLRPRSLADLGCSYDEANHRRLTVMSTPPSEQ * .::* : *: :: . : . : ENST00000271289 QQLMPPAN------GYIHKGTDGGTGTRVICSDCYDNANIYSRTREYCPYTYIAEEDVLD ENSMUST00000046316 QQLMPPAN------GYTHRGTDGGAGTRVICSDCYDNANIYSRTREYCPYTYIAEEDVLD SINFRUP00000134775 ------------------------------------------------------------ SINFRUP00000161345 HQYMASSV------SGFYLQPKDMNGLCQLDTGS--EADLEAAIDPLLCHYQGPMGSLLC ENST00000280336 HQFVTSSG------AGFFLPQHDSSGTCHIDNSS--EADVEAATDLFLCPFLGSTGPMYL ENSMUST00000032105 ANGHIESNGVCLRDPSLFPEVDIHSTTCRQPKLCVG--YTREPWKVTEKADRTAAPHTTA ENST00000273261 ANGHIESNGVCPRDASHFPEPDTHSVACRQPKLCAGSAYHKEPWKAMEKAEGTPGPHKME CG8434-RA RCLEQGLT-------LSYLRQTDLEAQQDHLSSKDSGTGSDAAVKRTLDDFEVAMPSHKH ENST00000271289 QTLSSLMVQMPKET----YLVHPPQDTTALESLIPSANREPSAFPTNHERISEKKLPSTQ ENSMUST00000046316 QALSSLMVQMPKET----FLSHPPQDAANLESLIPSAEREPAAFPTNHERMTEN-LPFSQ SINFRUP00000134775 ------------------------------------------------------------ SINFRUP00000161345 RDRMYPSDPSDDF----------------------------------------------- ENST00000280336 KGNVYGSDPFETYH----TGCSPDPRTVLMDHYEPSYIKKKECYPCSHPSEESCERSFSN ENSMUST00000032105 HSGSAVCSDCSTDT-------AYHPQPVPRDSGQPGTASSQELRQHDREYSPHHPYSGTA ENST00000273261 HGGRVVCSDCNTEVDCYSRGQAFHPQPVSRDSAQPSAPNGPEPGGSDQEHSPHHQCSRTA CG8434-RA HTDDEEEEEVEEVYE------ENEPPYIKHTYEVNYAEPEQHLFLQNNNHNYDGGGIGVA ENST00000271289 MSGETLQRPVWN------------------------INRELGLPHPPFSQQPVHESPQLH ENSMUST00000046316 RSSEIFQRPLWN------------------------MNRELGL--LPFSQQPVLESPELT SINFRUP00000134775 ------------------------------------------------------------ SINFRUP00000161345 ------------------------------------------------------------ ENST00000280336 ISWPSHVRKLLNTSYSHNEGPGMKNLCLNKSSLDFSANPEPASVASSNSFMGTFGKALRR ENSMUST00000032105 DGSHTLSGGSLYPSNHDRILPSLKNK--------AASADGNGDSSWTLAKLHEADCIDLK ENST00000273261 AGSCPECQGSLYPSNHDRMLTAVKKKP-------MASLDGKGDSSWTLARLYHPDSTELQ CG8434-RA GGVNKMVPNALLR------------------------KCSAGASGSNYSSIQQCTTVDI- ENST00000271289 QNEGLAGREPDCSASSMSCHRLQDHAFDFSRTRNIQDGSEGT------------------ ENSMUST00000046316 E------RDPNCSSP-VTCRRLHDHAFDFSRTRIIQDGTEGT------------------ SINFRUP00000134775 ------------------------------------------------------------ SINFRUP00000161345 ------------------------------------------------------------ ENST00000280336 PHLDAYSSFGQPSDCQPRAFYLKAHSSPDLDSGSEEDGKERTDFQEENHICTFKQTLENY ENSMUST00000032105 PSPTLASGSPELMEDAISTEAQHLLVSNGHLPKACDSSPESVPLKGQITGKRRGPLLLAP ENST00000273261 PASSLTSGSPE------RAEAQYLLVSNGHLPKACDASPESTPLTGQLPGKQRVPLLLAP CG8434-RA ------------------------------------------------------------ ENST00000271289 ------------ ENSMUST00000046316 ------------ SINFRUP00000134775 ------------ SINFRUP00000161345 ------------ ENST00000280336 RTPNFQSYDLDT ENSMUST00000032105 RS---------- ENST00000273261 KS---------- CG8434-RA ------------