CLUSTAL W (1.82) multiple sequence alignment ENST00000287722 MENYFQAEAYNLDKVLDEFEQNEDET--------------VSSTLLDTKWNKILDPPSHR SINFRUP00000165222 ------------------------------------------------------------ ENST00000313202 MDSYFKAAVSDLDKLLDDFEQNPDEQDYLQDVQNAYDSNHCSVSSELASSQRTSLLPKDQ ENSMUST00000022217 MDSYFKAAVSGLDKLLDDFEQNPDKQDYLP---DAYAFNQCSVSSESASPQ-LALLSKDQ SINFRUP00000145372 ------------------------------------------------------------ CG15667-RA ------MDLVDIDQVLDNLELS----------------------------------IAAD : : : :: : : : ENST00000287722 LSFNPTLASVNESAVSNESQPQLKVFS-LAHSAPLTTEEEDHCANGQDCNLNPEIATMWI SINFRUP00000165222 ------------------------------------------------------------ ENST00000313202 ECVNSCASSETSYG-TNESSLNEKTLKGLTSIQNEKNVTGLDLLSSVDGGTSDEIQPLYM ENSMUST00000022217 RCISTCASSEACCEDANETFLEGKIHEGLTSRPNEKNVAGLDLLSSVDASTSDEIQPSCM SINFRUP00000145372 ------------------------------------------------------------ CG15667-RA EQLSRNAAAAAAAGANPGRFLGDGASASISGVGAGAGVSGAAGVTPTPASG--------- . : : : ENST00000287722 DENAVAEDQLIKRN-------YSWDDQCSAVEVGEKKCGNLACLPDEKNVLVVAVMHNCD SINFRUP00000165222 ------------------------------------------------------------ ENST00000313202 GRCSKPICDLISDMGNLVHATNSEEDIKKLLPDDFKSNADSLIGLDLSSVSDTPCVSSTD ENSMUST00000022217 RRCSKPVCDLISDMGNLVHATNSEEDIKQLLPDDPKSSADTLITLDSSSVSEALTVSSVD SINFRUP00000145372 ------------------------------------------------------------ CG15667-RA ----------------------------------------------KSFVGVSQVFNSLD :: :: : : . ENST00000287722 K-----RTLQNDLQDCNNYNSQSLMDAFSCSLDNENRQTDQFSFSINESTEKDMNSEKQM SINFRUP00000165222 ------------------------------------------------------------ ENST00000313202 HDSDTVREQQNDISSELQNREIGGIKELGIKVDTTLSDSYNYSGTENLKDKKIFNQLESI ENSMUST00000022217 CGSNAVREEQNNINAGIKNRDIS-IKELGVKVDMALFDSCKYNRTENLKDKIISNELET- SINFRUP00000145372 ------------------------------------------------------------ CG15667-RA DYRENVKSLQVDAQLPSYDWQTEAEHEDDIHKFSEQASKNNGQTIVSSSESLTTSSCSTF : : ENST00000287722 DPLNRPKTEGRSVNHLCPTSSDSLASVCSPSQLKDDGSIGRDPSMSAITSLTVDSVISSQ SINFRUP00000165222 ------------------------------------------------------------ ENST00000313202 VDFNMSSALTRQSSKMFHAKDKLQHKSQPCGLLKDVGLVKEEVDVAVITAAECLKEEG-- ENSMUST00000022217 VDFDMPSVLMEQSSEMSNTKDNPQYKRLPCELLKDDGCLAEEKVAVAVNNTECLEEGGGS SINFRUP00000145372 ------------------------------------------------------------ CG15667-RA SSGPSPVSNGSHSEELATPPEDEKTSEVQVE----------------------------- : : : : ENST00000287722 GTDGCPAVKKQENYIPDEDLTGKISSPRTDLGSPNSFSHMSEGILMKKEPAEESTTEESL SINFRUP00000165222 ------------------------------------------------------------ ENST00000313202 KTSALTCSLPKNEDLCLNDSN----SRDENFKLPDFSFQEDKT--VIKQSAQEDSKSLDL ENSMUST00000022217 NTIAMPCKLPENEGISPSDPA----SKDENFKLPDFPLQENRTSVFMKQTVKEDSRNLDL SINFRUP00000145372 ------------------------------------------------------------ CG15667-RA --------------------------PKEQDQQPEQVKHEDQHQDQAVPPPTQSKQ---- : : ENST00000287722 RSG--------LPLLLKPDMPNGSGRNNDCERCSDCLVPNEVRADENEGYEHEETLGTTE SINFRUP00000165222 ------------------------------------------------------------ ENST00000313202 KDNDVIQDSSSALHVSSKDVPSSLSCLPASGSMCGSLIESKARGDFLPQHEHKDNIQDAV ENSMUST00000022217 KDN------NDIVHVSGDDVPPSLSCLSLSGSLCGSLIHNNEHSDILPPNESEGQNNDAV SINFRUP00000145372 ------------------------------------------------------------ CG15667-RA -------------TVEELAVGLSSISITASGTESQSLLPEEVTASSVLGQVLEELSEESS :: : : :: ENST00000287722 FLNMTEHFS-----------ESQDMTNWKLTKLNEMNDSQVNEEKEKFLQISQPEDTNGD SINFRUP00000165222 ------------------------------------------------------------ ENST00000313202 TIHEEIQNSVVLGGEPFKENDLLKQEKCKSILLQSLIEGMEDRKIDPDQTVIRAESLDGG ENSMUST00000022217 TIHEEIQKSDVLDG----ETDLSKKETCRSIFLQPVNEKKGEGKVEVEEMVISGESLESP SINFRUP00000145372 ------------------------------------------------------------ CG15667-RA PSRE----------------PETEMTNGIDVPLANLPASVAEVPVPKEMEQPVQTEEEDV :: : : : ENST00000287722 SGGQCVGLADAGLDLKGTCISESEECDFSTVIDTPAANYLSNGCDSYGMQDPGVS----- SINFRUP00000165222 ------------------------------------------------------------ ENST00000313202 D--TSSTVVESQEGLSGTHVPESSDCCEGFINTFSSNDMDGQDLDYFNIDEGAKSGPLIS ENSMUST00000022217 EDASSAAAAGSPVALSAASVPEAPGPCEGLT--FPSSDMDGQELDYFNIDESMRSGILIS SINFRUP00000145372 ------------------------------------------------------------ CG15667-RA ELPQEQHPRRSQPLTFCSTMDEISDTELDSMLQEMDADDNQADDQQMPDDEKSCSASPVT : : ENST00000287722 ------FVPKTLPSKEDSVTEEKEIEESKSECYSNIYEQRGNEATEGSGLLLNSTGDLMK SINFRUP00000165222 ----------------------------------------------GQAKLNN------- ENST00000313202 DAELDAFLTEQYLQTTNIKSFEENVNDSKSQMN-QIDMKGLDDGNINNIYFNAEAGAIGE ENSMUST00000022217 DAELDAFLKEQCLSNSNTMSAGENVNDSQLQMN-QITMKGLHDENAGDIYFNAEAGAAGE SINFRUP00000145372 ------------------------------------------------------------ CG15667-RA EEESVRILSDEQETTSNDQMNVDNFSQASTVEFADLKQPESTPVTAMG------------ :: . : : ENST00000287722 KNYLHNFCSQVPSVLGQSSPKVVASLPSISVPFGGARPKQPSNLKLQIPKPLSDHLQNDF SINFRUP00000165222 -----------------------AQLQPVSVPYGGARPKQPVSLKLQIPQTPVFQVQNLG ENST00000313202 SHGINIICEIVDKQNTIENGLSLGEKSTIPVQQGLPTSKSEITNQLSVSDINSQSVGGAR ENSMUST00000022217 NGGVG-NCETSDKENTENNGLSIGEKGAIPTERELSACQPDIRDELPVPSIKTQAVGGAR SINFRUP00000145372 ------------------------------------------------------------ CG15667-RA ----------------------------EDVASSFSSTESDSLSGRKLDGEVEVDREHED : : : ENST00000287722 PANSGNNTKNKNDILGKAKLGENSATNVCSPSLGNISNVDTNGEHLESYEAEISTRPCLA SINFRUP00000165222 PPALGS---NKNQEKQKSRNASPENTQVAP---------DPSKEGLNGDGGAHSP---LP ENST00000313202 PKQLFSLPSRTRSSKDLNKPDVPDTIESEPSTADTVVPITCAIDSTADPQVSFNSN-YID ENSMUST00000022217 PKQLLSLPPGTRSSKELNKPDVVDVPESEPCTANATAVSTCSADHIPDSQVSFNSN-YID SINFRUP00000145372 ------------------------------------------------------------ CG15667-RA ASLATDALETQEQRPQRPQTLNLNGCQAESSTPSQDENPEIQQETLQPTEVREGAAGVGV ENST00000287722 LAPDSPDND----LRAGQFGISARKPFTTLGEVAPVWVPDSQAPNCMKCEARFTFTKRRH SINFRUP00000165222 VPSESPDND----LQSGQRGAPGRKSTNSLGEVAPVWVPDSQAPVCMKCDVKFTFTKRRH ENST00000313202 IESNSEGGSSFVTANEDSVPENTCKEGLVLGQKQPTWVPDSEAPNCMNCQVKFTFTKRRH ENSMUST00000022217 IESNFEDGSSFVTANKDSLPENKRKESLVLGQKQPTWVPDSEAPNCMNCQVKFTFTKRRH SINFRUP00000145372 -----------------------------LGSRQPSWVPDSEAPNCMNCSQRFTFTKRRH CG15667-RA IPGEDDEES------PIYEAVGYSDPHANLGKVPPIWVPDNMAGQCMQCQQKFTMIKRRH : :: **. * ****. * **:*. :**: **** ENST00000287722 HCRACGKVFCASCCSLKCKLLYMDRKEARVCVICHSVLMNAQAWENMMSASS-------- SINFRUP00000165222 HCRACGKVFCAACCSLKCKLVYMERKEARVCVTCFSALTAAQSCETPVFASN-------- ENST00000313202 HCRACGKVFCGVCCNRKCKLQYLEK-EARVCVVCYETISKAQAFERMMSPTG-------- ENSMUST00000022217 HCRACGKVFCGVCCNRKCKLQYLEK-EARVCVICYETINKAQAFERMMSPGG-------- SINFRUP00000145372 HCRACGKVYCAVCCNRKCKLKYLEK-EARVCLICFDSINRAQALERMMSPVG-------- CG15667-RA HCRACGKVLCSVCCSQRFRLEFATEPESRVCVQCYMILSERQANGLNSESAPGSALPPTP ******** *. **. : :* : . *:***: *. : *: . ENST00000287722 -QSPNPNNPAEYCSTIPPLQQAQASGALSSPPPTVMVPVGVLKHP---------GAEVAQ SINFRUP00000165222 -QSPNPNNPAEYCSTIPPLQQAQASGVLSSPPPTVMVPVGVLKQA---------GNEAIL ENST00000313202 -SNLKSNH-SDECTTVQPPQENQTS----SIPSPATLPVSALKQP---------GVEGLC ENSMUST00000022217 -SCLKSNH-SNECATDQPLQETQTS----STPSPTTLPISALKQP---------NVEGPC SINFRUP00000145372 -PSPNPNIPSEYCSTIPPLQQARAAGTLNSPPPTVMVPVSVLKHP---------NDS--C CG15667-RA IRSPNPNNPMEYCSTIPPHRQVANSP--GAPPPSVIVPVGVLKKTDGSSSNSSSSDGQKG :.* : *:* * :: : : *... :*:..**:. . ENST00000287722 PREQRRVWFADGILPNGEVADAAKLTMNGTSSAG----------------TLAVSHDPVK SINFRUP00000165222 TREQRRVWFADGLLPNGDAAESSKPPAANLAPSQ----------------PSASTHS--- ENST00000313202 SKEQKRVWFADGILPNGEVADTTKLSSGSKRCSEDFSPLSPDVPMTVN--TVDHSHSTTV ENSMUST00000022217 SKEQKRVWFADGILPNGEVADTTKLSSGSKRCSDDFSPVLPDVPTMIN--KVDRTHSPTV SINFRUP00000145372 PREQKRVWFADGILPNGEVADTSKLSVTSRRDSQEFSSVTPDQPAVRAPIRTPQPHTHKV CG15667-RA QRKRKSVMFSDGIAPGSELASTMEQQWGESKHSRRGLSRSGSGAGQKPPTPATEEPPRSI :::: * *:**: *..: *.: : : ENST00000287722 -------------PVTTSPLPAETDICLFSG----------------------------- SINFRUP00000165222 ---------------TKSSTSEYTEVAHTP------------------------------ ENST00000313202 EKPNNETGDITRNEIIQSPISQVPSVEKLSMNTGNEGLPTSGSFTLDDDVFAETEEPSSP ENSMUST00000022217 EKPNNGLGDIIRSEISQSPTCHTAPVERLPGNTGTEGLPMPGPFTLEDDVFVDSEEPSTP SINFRUP00000145372 QKIN-----------YINPLIPPSSAELEGVDGGS----------------SCPEGPGAA CG15667-RA DTSSTLGLVAQLFRGSIPPSAAAATLSATETSAGR------------------------- . . : : : :: ENST00000287722 ------------------SITQVGSPVGSAMNLIPED--GLPPILISTGVKGD--YAVEE SINFRUP00000165222 -------------------VATVGSPVGSSISLIPED--GLPPILISTGVKGD--YAVEE ENST00000313202 TGVLVNSNLPIASISDYRLLCDINKYVCNKISLLPNDEDSLPPLLVASGEKGS-VPVVEE ENSMUST00000022217 TVVPANSGLPVASISDYRLLCSVAKCVCNNISLLPDDDIGLPPLLATSGEDGS-VPVVQE SINFRUP00000145372 EVVRP----PLSGPWDYALLCGLGSSVEKVPSLLPNNEEELPPLLIITGEDEAGDVLVEE CG15667-RA SSSQSQAQTSPRRKAESSRNRKLPPNGDAQGCYLPPEENGLPPICISSKEGGE--VDYKV : :* : ***: : : ENST00000287722 KPSQISVMQQLEDGGPDPLVFVLNANLLSMVKIVNYVNRKCWCFTTKGMHAVGQSEIVIL SINFRUP00000165222 RPSEMALMQQLEEGGPDPLVFVLNANLLAMVKLVNYVNRKCWYMSTKGMHAVGQAEVVIL ENST00000313202 HPSHEQIILLLEGESFHPVTFVLNANLLVNVKFIFYSSDKYWYFSTNGLHGLGQAEIIIL ENSMUST00000022217 RPSHEQIILLLEGEGFPPATFVLNANLLVNVKLVLYSSEKYWYFSTNGLHGLGQAEIIVL SINFRUP00000145372 NPAPCQILHLLAEGGPRPLTFALNANLLVNVKLVTCSGRQCWCFGSTGLQALGQKELVFL CG15667-RA VRNDGSLLDRLQNETLKFIIKNNFFVLVKIVNMSCCMNRWVLNFTTSGLHHMGSDELIIL :: * *: *:: . : :.*:: :*. *::.* ENST00000287722 LQCLP--------DEKCLPKDIFNHFVQLYRDALAGN--VVSNLGHSFFSQSFLGSKEHG SINFRUP00000165222 LQCLP--------DEKTIPKDIFTHFVQLYQEALSGN--VLSQLSHSFFTQRFLGSREHG ENST00000313202 LLCLP--------NEDTIPKDIFRLFITIYKDALKGK--YIENLDNITFTESFLSSKDHG ENSMUST00000022217 LQCLP--------NEDTVPKDIFRLFITIYKDALKGK--YIENLDNLTFTESFLNSKDHG SINFRUP00000145372 LECLP--------DEKVLPKDLFSLYLNIYQEAQKGK--FLEELDNVTFTSTFLGSKDHA CG15667-RA LEIKQPKQEEYVKGEVAIPKDLFQHLYEIYVEAEHARSGTHELAFTSPRNANFLGSREHG * .* :***:* :* :* .. . . **.*::*. ENST00000287722 GFLYVTSTYQSLQDLVLPTPPYLFGILIQKWETPWAKVFPIRLMLRLGAEYRLYPCPLFS SINFRUP00000165222 GFLYISPTFQSLQDLLLPNPPYLFGILIQKWETPWAKVFPIRLMLRLGAEYRFYPCPLFS ENST00000313202 GFLFITPTFQKLDDLSLPSNPFLCGILIQKLEIPWAKVFPMRLMLRLGAEYKAYPAPLTS ENSMUST00000022217 GFLFITPTFQNLDGLPVPRSPFLCGILIQKLEIPWAKVFPMRLMLRLGAEYKAYPAPLTS SINFRUP00000145372 GMLFFSPTYQPLDGLTLPSQPFLFGLLIQKLEVPWAKVFPIRLLLRLGAEYNVYPTPLIS CG15667-RA GFIFIRPTYQCLQGVIVPDNPYLVGVLIHRHEVPWAKVLPLRLILRLGAQYRYYPCPLIS *:::. .*:* *:.: :* *:* *:**:: * *****:*:**:*****:*. ** ** * ENST00000287722 VRFRKPLFGETGHTIMNLLADFRNYQYTLPVVQGLVVDMEVRKTSIKIPSNRYNEMMKAM SINFRUP00000165222 VRFRKPLFGETGHTIMNLLADFRNYQYTLPVVKGLVVDMEVKKTTIKIPSNRYNELMKAM ENST00000313202 IRGRKPLFGEIGHTIMNLLVDLRNYQYTLHNIDQLLIHMEMGKSCIKIPRKKYSDVMKVL ENSMUST00000022217 VRGRKPLFGEIGHTIMNLLVDLRNYQYTLHNIDQLLIHMEMGKSCIKIPRKKYSDVMKVI SINFRUP00000145372 VRFRESVFRETGHTIMNLLADLRNYQYSLS-VVEGLRHMEMGHIYIDIPKSSYSDMQRVV CG15667-RA VRGRESVYGEIAQTIINFLVDFRNYSYSLPAIRGLYIHMEDRQTTVIIPKYRQQDVIKAI :* *:.:: * .:**:*:*.*:***.*:* : .** : : ** .:: :.: ENST00000287722 NKSNEHVLAGGACFNEKADSHLVCVQNDD------GNYQTQAISIHNQPRKVTGASFFVF SINFRUP00000165222 SKSNDHVLAMGACFNDRADSHLVCIQNDD------GNYQTQAISIHHQPRKVTGACFFVF ENST00000313202 NSSNEHVISIGASFSTEADSHLVCIQND-------GIYETQANSATGHPRKVTGASFVVF ENSMUST00000022217 HSSNEHVISIGASFSTEADSHLVCVQSD-------GVYQTQANSATGQPRKVTGASFVVF SINFRUP00000145372 NVSNEHVISIGAHFSTEADSHLVCFQNEE------GNYQTQASSMPGKTRTVTGASFVVF CG15667-RA NNASDHILAFAGNFSKVADGHLVCMQNINDDRSEMYSYSTQAINIQGQPRKITGASFFVL :.:*::: .. *. **.****.*. *.*** . :.*.:***.*.*: ENST00000287722 SGALKSSSGYLAKSSIVEDGVMVQITAENMDSLRQALREMKDFTITCGKADAEEPQ-EHI SINFRUP00000165222 SGALKSSSGFLAKTSIVEDGVMIQITAETMESLRQALKDMKDFTITCGKADQEENQ-ELV ENST00000313202 NGALKTSSGFLAKSSIVEDGLMVQITPETMNGLRLALREQKDFKITCGKVDAVDLR-EYV ENSMUST00000022217 NGALKTSSGFLAKSSIVEDGLMVQITPETMEGLRLALREQKDFRIQCGKVDAVDLR-EYV SINFRUP00000145372 NGALKASSGFIAKSSIVEDGLMVQIPPETMESLRTALREQTDFHIPCGRNDGGEVR-ENV CG15667-RA NEALKSSSGLSGKCSIVEDGLMVQIMPAKMEEVRQALRNQNDIDIVCGPIDATDDQSEIV . ***:*** .* ******:*:** . .*: :* **:: .*: * ** * : : * : ENST00000287722 HIQWVDDDKNVSKGVVSPIDGKSMETITNVKIFHGSEYKANGK--VIRWTEVFFLENDDQ SINFRUP00000165222 HIQWTEDDHDFNKGVISPIDGKSMESITSVKIFHGSEFKANGK--VIRWTEVFFLQSEDY ENST00000313202 DICWVDAEEKGNKGVISSVDGISLQGFPSEKIKLEADFETDEK--IVKCTEVFYFLKDQD ENSMUST00000022217 DICWVDSEERKNKGVISSVDGMSVEGFPSEKIKLETDFETEEK--TVKCTEVFYFLKDQD SINFRUP00000145372 TVRWVDWSSPVNRGKTSGVDGRPLDGVRSVRVLQDTDFESDGR--TIRCTEVFYQLKTLD CG15667-RA SIKWVDNNRDINVGVKSPIDDQPMDGISNMRVLKWASFNYSNTNYAIRLSDIYIIKCEDW : *.: . . * * :*. .:: . . :: :.:: . :: :::: ENST00000287722 HNC-LSDPADHSRLTEHVAKAFCLALCPHLKLLKEDGMTKLGLRVTLDSDQVGYQAGSNG SINFRUP00000165222 PGG-LSDPADHSRLTENVARAFCVALLPHLKLLKEDGMAKLGLRVTLDSDQV-------- ENST00000313202 ----LSILSTSYQFAKEIAMACSAALCPHLKTLKSNGMNKIGLRVSIDTDMVEFQAGSEG ENSMUST00000022217 ----ISILSSSYQFAKEIAVACSAALCPHLRTLKSNRMNKIGLRVSIDTDMVEFQAGCEG SINFRUP00000145372 RSL-ESVLSSCSGFQKEIALAACSALTPHLAVLASAGINSLSLRISTQADMVEYQAGCGG CG15667-RA YATNGGNCEEITRIAEQLARSASMALLPLLDLLAAAGINKLGLRATLDQDNVGYEAGARG . : :.:* : . ** * * * : .:.** : : * * ENST00000287722 QPLPSQYMNDLDSALVPVIHGGACQLSEGPVVMELIFYILENIV- SINFRUP00000165222 --------------------------------------------- ENST00000313202 QLLPQHYLNDLDSALIPVIHGG-TSNSSLPLEIELVFFIIEHLF- ENSMUST00000022217 QLLPQHYLNDLDSALIPVIHGG-TSNSSLPLEIELAFFILENLSE SINFRUP00000145372 RLLPQ-YMNELDGALIPVIHGGSASVPQTAMDMEFTFYI------ CG15667-RA SKLPPLYMNALDNHLIATLHGE-SSGIQEPIILELIFYILNA--- : : : :: : : : : : :: :