CLUSTAL W (1.82) multiple sequence alignment


ENST00000265903         -MSQLRLLPSRLGVQAARLLAAHDVPVFG----------WRSRSSGPPATFPSSKGGGGS
ENSMUST00000022480      -MSQLRLLPFRLGPRATKLLATRAIPVFS----------GCRRSSGPPTTIPRSRSGVSS
SINFRUP00000148054      ------------------------------------------------------------
ENST00000309514         -MFHLRTCAAKLRPLTASQTVKTFSQNRP----AAARTFQQIRCYSAPVAAEPFLSGTSS
ENSMUST00000003461      -MFHLRTCAAKLRPLTASQTVKTFSQNKP----AAIRTFQQIRCYSAPVAAEPFLSGTSS
SINFRUP00000153892      -MHRLRTCAARLRPLTAAQAAQTVGQQRPVTFTGGTRTFQPLRSYTTPVASEPFLNGTSS
SINFRUP00000145347      ------------------------------------------------------------
CG11661-RC              MHRAHTAFSLALSPMAHKNFATWLLKSSSSQQMAKVTAAAAVRTYN-SAAAEPFANGSTA
                                   :                                                

ENST00000265903         SYMEEMYFAWLENPQSVHKSWDSFFREASEEAFSGSAQPR-------PPSVVHESRSAVS
ENSMUST00000022480      SYVEEMYFAWLENPQSVHKSWDSFFQRASKEASVGPAQPQ-------LPAVLQESRTSVS
SINFRUP00000148054      ------------------------------------------------------------
ENST00000309514         NYVEEMYCAWLENPKSVHKSWDIFFRNTNAGAPPGTAYQSPLPLSRGSLAAVAHAQSLVE
ENSMUST00000003461      NYVEEMYCAWLENPKSVHKSWDIFFRNTNAGAPPGTAYQSPLSLSRSSLATMAHAQSLVE
SINFRUP00000153892      NYVEEMYYAWLENPKSVHKSWDVFFRNANAGAPPGAAYQSPLGLS-----AAPQLSSLVG
SINFRUP00000145347      ------------------------------------------------------------
CG11661-RC              SYVEEMYNAWLRDPTSVHTSWDAYFRSNSYVSPPNLAPVQAN----TLPLTAFNFGGAVA
                          :  :    :     :       :                                 : 

ENST00000265903         SRTKTSKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSFVPSDLITTIDKLAFY
ENSMUST00000022480      SCTKTSKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSFVPSDLITTIDKLAFY
SINFRUP00000148054      -----------------LLLSPQIRGHQVAQLDPLGILEADLDSFVPSDLITSIDKLGYY
ENST00000309514         AQPNVDKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSSVPADIISSTDKLGFY
ENSMUST00000003461      AQPNVDKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSSVPADIISSTDKLGFY
SINFRUP00000153892      AQPNVEKLVEDHLAVQSLIRAYQIRGHQVAQLDPLGIMDADLDSCVPTDIITSSDKLGFY
SINFRUP00000145347      ------------------------------------------------------------
CG11661-RC              GAAPDSKTIDDHLAVQAIIRSYQIRGHNIAHLDPLEINTPELPGNSSTKSIYAN-----F
                                :   : :  ::    :    :  :  : :    :        :     :   

ENST00000265903         DLQEADLDKEFQLPTTTFIGGSENTLSLREIIRRLENTYCQHIGLEFMFINDVEQCQWIR
ENSMUST00000022480      DLQEADLDKEFRLPTTTFIGGPENTLSLREIIRRLESTYCQHIGLEFMFINDVEQCQWIR
SINFRUP00000148054      DLKESDLDRSFQLPSTTFIGGEDSTLPLREIIRRLETAYCGHIGVEFMFINNVDQCQWIR
ENST00000309514         GLDESDLDKVFHLPTTTFIGGQESALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWIR
ENSMUST00000003461      GLHESDLDKVFHLPTTTFIGGQEPALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWIR
SINFRUP00000153892      GLDESDLDKVFRLPTTTFIGGSESVLPLKEIIRRLEMSYCQHIGVEFMFINDLEQCQWIR
SINFRUP00000145347      ---------------------------------------------EFMFINDVQQCHWIR
CG11661-RC              SFGEQDMDRQFKLPSTTFIGGDEASLPLKEILNRLENVYCNKIGVEFMFINSLEQCNWIR
                         :    :   : :    ::      : :  ::  :       : :******.::**:***

ENST00000265903         QKFETPGVMQFSSEEKRTLLARLVRSMRFEDFLARKWSSEKRFGLEGCEVMIPALKTIID
ENSMUST00000022480      QKFETPGVMQFSVEEKRTLLARLVRSMRFEDFLARKWSSEKRFGLEGCEVMIPALKTIID
SINFRUP00000148054      QKIETPGIMRLTDVDKRTLLARLIRSTRFEDFLARKWSSEKRFGLEGCEVLIPALKTIID
ENST00000309514         QKFETPGIMQFTNEEKRTLLARLVRSTRFEEFLQRKWSSEKRFGLEGCEVLIPALKTIID
ENSMUST00000003461      QKFETPGIMQFTNEEKRTLLARLVRSTRFEEFLQRKWSSEKRFGLEGCEVLIPALKTIID
SINFRUP00000153892      QKFETPGIMQFTLEEKRTLLARMIRSTRFEEFLQKKWSAEKRFGLEGCESLIPALKTIID
SINFRUP00000145347      EKFETPGIMKFSLEEKRTLXGRVIRSTRFEEFLQKKWSSEKRFGLEGCESLIPALKTIID
CG11661-RC              KRFETPGVLNFSPEEKRLILARLTRATGFEAFLAKKYSSEKRFGLEGCEIMIPALKEIID
                        :::****::.::  :** : .*: *:  ** ** :*:*:********** :***** ***

ENST00000265903         KSSEMGIENVILGMPHRGRLNVLANVIRKDLEQIFCQFDPKLEAADEGSGDVKYHLGMYH
ENSMUST00000022480      KSSEMGIENVILGMPHRGRLNVLANVIRKDLEQIFCQFDPKLEAADEGSGDVKYHLGMYH
SINFRUP00000148054      ESSTAGVDSVIMGMPHRGRLNVLANVIRKDLDQIFCQFDPKLEAADEGSGDVKYHLGMYH
ENST00000309514         KSSENGVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAADEGSGDVKYHLGMYH
ENSMUST00000003461      MSSANGVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAADEGSGDMKYHLGMYH
SINFRUP00000153892      KSSEKGVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAADEGPGDVKYHLGMYH
SINFRUP00000145347      ISSQSGVESIIMGMPHRGRLNVLANVIRKELDQIFCQVDSKLEAADEGSGDVKYHLGMYH
CG11661-RC              VSTELGVESVIMGMPHRGRLNTLANVCRKPLNQIFTQFAG-LEAADDGSGDVKYHLGTYI
                         *:  *:: :*:*********.**** ** *:*** *.   *****:*.**:***** * 

ENST00000265903         ERINRVTNRNITLSLVANPSHLEAVDPVVQGKTKAEQFYRGDAQGKKVMSILVHGDAAFA
ENSMUST00000022480      ERINRVTNRNITLSLVANPSHLEAVDPVVQGKTKAEQFYRGDAQGRKVMSILVHGDAAFA
SINFRUP00000148054      ERINRKTDKNIMLSLMANPSHLEAVDPVVQGKTKAEQFYRGDSEGKKVMSILIHGDAAFA
ENST00000309514         RRINRVTDRNITLSLVANPSHLEAADPVVMGKTKAEQFYCGDTEGKKVMSILLHGDAAFA
ENSMUST00000003461      RRINRVTDRNITLSLVANPSHLEAADPVVMGKTKAEQFYCGDTEGKKVMSILLHGDAAFA
SINFRUP00000153892      RRINRVTDRNITLSLVANPSHLEAADPVVQGKTKAEQFYCGDNDGKRVMSILLHGDAAFA
SINFRUP00000145347      RWLNRVSNKYITMSLMANPSHLEAVDPVVQGKTKAEQFYSGDAEGKRVMSILLHGDAAFA
CG11661-RC              ERLNRVTNKNIRLAVVANPSHLEAVDPVVQGKTRAEQFYRGDQEGKKVMSILIHGDAAFC
                        . :** ::: * ::::********.**** ***:***** ** :*::*****:******.

ENST00000265903         GQGVVYETFHLSDLPSYTTNGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHV
ENSMUST00000022480      GQGVVYETFHLSDLPSYTTNGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHV
SINFRUP00000148054      GQGVVYETFHLSELPSYSTHGTIHVVVNNQIGFTTDPRVARSSPYPTDVARVVNAPIFHV
ENST00000309514         GQGIVYETFHLSDLPSYTTHGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHV
ENSMUST00000003461      GQGIVYETFHLSDLPSYTTHGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHV
SINFRUP00000153892      GQGIVYETFHLSDLPSYTTHGTVHVVVNNQIGFTTDPRVARSSPYPTDVARVVNAPIFHV
SINFRUP00000145347      GQGIVYETFHLSDLPSYTTHGTIHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHV
CG11661-RC              GQGVVYETMHLSDLPDYTTHGTIHVVANNQIGFTTDPRFSRSSPYCTDVARVVNAPIFHV
                        ***:****:***:**.*:*:**:***.***********.:***** **************

ENST00000265903         NADDPEAVIYVCSVAAEWRNTFNKDVVVDLVCYRRRGHNEMDEPMFTQPLMYKQIHRQVP
ENSMUST00000022480      NADDPEAVIYVCSVAAEWRNTFNKDVVVDLVCYRRRGHNEMDEPMFTQPLMYKQIHKQVP
SINFRUP00000148054      NADDPEAVVYVCQIAAEWRSTFNKDVVIDLVSYRRFGHNEMDEPMFTQPLMYKVIRRQEH
ENST00000309514         NSDDPEAVMYVCKVAAEWRSTFHKDVVVDLVCYRRNGHNEMDEPMFTQPLMYKQIRKQKP
ENSMUST00000003461      NSDDPEAVMYVCKVAAEWRNTFHKDVVVDLVCYRRNGHNEMDEPMFTQPLMYKQIRKQKP
SINFRUP00000153892      NADDPEAVIYVCKVAAEWRNTFHKDVVVDLVCYRRMGHNEMDEPMFTQPLMYKQIKKQKP
SINFRUP00000145347      NADDPEAVMYVCKVAAEWRNTFHKDVVVDLVCYRRNGHNEMDEPMFTQPLMYKKIKKQKG
CG11661-RC              NADDPEAVMHVCKVAAEWRATFHKDCVIDLVGYRRNGHNEIDEPMFTQPLMYQKIRKHKN
                        *:******::**.:***** **:** *:*** *** ****:***********: *:::  

ENST00000265903         VLKKYADKLIAEGTVTLQEFEEEIAKYDRICEEAYGRSKDKKILHIKHWLDSPWPGFFNV
ENSMUST00000022480      VLKKYADKLIAEGTVTLQEFEEEIAKYDRICEEAYGRSKDKKILHIKHWLDSPWPGFFNV
SINFRUP00000148054      VLKKYSDRLIAERVVTLQEYEEEVAKYDKICEEAYASSKDEKILHIRHWLDSPWPDFFTA
ENST00000309514         VLQKYAELLVSQGVVNQPEYEEEISKYDKICEEAFARSKDEKILHIKHWLDSPWPGFFTL
ENSMUST00000003461      VLQKYAELLVSQGVVNQPEYEEEISKYDKICEEAFTRSKDEKILHIKHWLDSPWPGFFTL
SINFRUP00000153892      VLQKYAEKLIAEGAVSRQEYEEEIAKYDKICEEAYARSKDEKILHIKHWLDSPWPGFFTL
SINFRUP00000145347      VLKIYVEKLIAEGVITLQEYQEEVAKYDKICEDAYSRSKDEKILHIKHWLDSPWPDFFTL
CG11661-RC              CLDLYADKLIAEGTVTAEEVKSVAAKYENICEEAFALAKTETHVKYKDWLDSPWSGFFEG
                         *. * : *::: .:.  * :.  :**:.***:*:  :* :. :: :.******..**  

ENST00000265903         DGEPKSMTCPATGIPEDMLTHIGSVASSVP--LEDFKIHTGLSRILRGRADMTKNRTVDW
ENSMUST00000022480      DGEPKSMTCPTTGIPEEMLTHIGSVASSVP--LEDFKIHTGLSRILRGRADMTKKRTVDW
SINFRUP00000148054      DGEPKTMSYIPTGLDEEILQHIGKEASSVP--LEDFNIHPGVSRILRGRADLVKKRQVDW
ENST00000309514         DGQPRSMSCPSTGLTEDILTHIGNVASSVP--VENFTIHGGLSRILKTRGEMVKNRTVDW
ENSMUST00000003461      DGQPRSMTCPSTGLEEDVLFHIGKVASSVP--VENFTIHGGLSRILKTRRELVTNRTVDW
SINFRUP00000153892      EGQPKSMSCPSTGLTEENLTHIGQVASSVP--VEDFTIHGGLSRILKARAEMVRNRVVDW
SINFRUP00000145347      DGQPKTMSCNSTGIPEEQLCHIGSIASSVP--LKDFTIHGGLTRILKSRANMVSQRVCDW
CG11661-RC              KD---PLKVAPTGVKEETLIHIGNRFSSPPPNAAEFVIHKGLLRVLAARKAMVDEKVADW
                        ..   .:.  .**: *: * ***.  ** *    :* ** *: *:*  *  :. ::  **

ENST00000265903         ALAEYMAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHDQEVDRRTCVPMNHLWPDQAPY
ENSMUST00000022480      ALAEYMAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHDQEVDRRTCVPMNHLWPDQAPY
SINFRUP00000148054      ALGEYMAFGSLLKDGIHVRLSGQDVERGTFSHRHHVLHDQEVDKRICVPMNHLWSNQAPY
ENST00000309514         ALAEYMAFGSLLKEGIHIRLSGQDVERGTFSHRHHVLHDQNVDKRTCIPMNHLWPNQAPY
ENSMUST00000003461      ALAEYMAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHDQNVDKRTCIPMNHLWPNQAPY
SINFRUP00000153892      ALGEYMAFGSLLKEGTHIRLSGQDVERGTFSHRHHVLHDQNVDKRICIPMNHLAPDQAPY
SINFRUP00000145347      ALGEYMAFGSLLQDGIHVRLSGQDVERGTFSHRHHVLHDQNVDKRICIPMNHISTSQAPY
CG11661-RC              ALGEAMAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHHQLVDKATYNSLQHMYPDQAPY
                        **.* *******::* *:********************.* **:    .::*: ..****

ENST00000265903         TVCNSSLSEYGVLGFELGYAMASPNALVLWEAQFGDFHNTAQCIIDQFISTGQAKWVRHN
ENSMUST00000022480      TVCNSSLSEYGVLGFELGYAMASPNALVLWEAQFGDFHNTAQCIIDQFISTGQAKWVRHN
SINFRUP00000148054      TVCNSSLSEYGVLGFELGFAMASPNALILWEAQFGDFHNTAQCIIDQFISSGQAKWVRNN
ENST00000309514         TVCNSSLSEYGVLGFELGFAMASPNALVLWEAQFGDFHNTAQCIIDQFICPGQAKWVRQN
ENSMUST00000003461      TVCNSSLSEYGVLGFELGFAMASPNALVLWEAQFGDFNNMAQCIIDQFICPGQAKWVRQN
SINFRUP00000153892      TVCNSSLSEYGVLGFELGFAMASPNALILWEAQFGDFHNTAQCIIDQFICPGQAKWVRQN
SINFRUP00000145347      TVCNSSLSEYGVLGFELGFAMASPNALVLWEAQFGDFHNTAQCIIDQFISPGQAKWVRQN
CG11661-RC              SVSNSSLSEYAVLGFEHGYSMTNPNALVLWEAQFGDFSNTAQSIIDQFISSGQSKWVRQS
                        :*.*******.***** *::*:.****:********* * **.******..**:****:.

ENST00000265903         GIVLLLPHGMEGMGPEHSSARPERFLQMSNDDSDAYPAFT-KDFEVSQLYDCNWIVVNCS
ENSMUST00000022480      GIVLLLPHGMEGMGPEHSSARPERFLQMSNDDSDAYPVFT-EDFEVSQLYDCNWIVVNCS
SINFRUP00000148054      GIVLLLPHGMEGMGPEHSSARPERFLQMSNDDPDHFPEFS-GDFEVEQLYDCNWIVVNCS
ENST00000309514         GIVLLLPHGMEGMGPEHSSARPERFLQMCNDDPDVLPDLKEANFDINQLYDCNWVVVNCS
ENSMUST00000003461      GIVLLLPHGMEGMGPEHSSARPERFLQMCNDDPDVLPDLQEENFDINQLYDCNWIVVNCS
SINFRUP00000153892      GIVLLLPHGMEGMGPEHSSARPERFLQMCNDDPDVMPVIS-DDFTVRQLYDCNWIVVNCS
SINFRUP00000145347      GIVLLLPHGMEGMGPEHSSARPERFLQMCNDDPDASPIVT-EDFAVHQLFDCNWIVVNCS
CG11661-RC              GLVMLLPHGMEGMGPEHSSCRVERFLQMSSDDPDYFPPES-DEFGVRQLHDINWIVANCS
                        *:*:***************.* ******..**.*  *     :* : **.* **:*.***

ENST00000265903         TPANYFHVLRRQILLPFRKPLIIFTPKSLLRHPEAKSSFDQMVSGTSFQRVIPEDGAAAR
ENSMUST00000022480      TPASYFHVLRRQILLPFRKPLIVFTPKSLLRHPDAKSSFDQMVSGTSFQRLIPEDGPAAH
SINFRUP00000148054      TPANYCHVLRRQVLLPFRKPLVVFTPKSLLRHPDARSSFDELTTGTKFKRLIPDDGPAAQ
ENST00000309514         TPGNFFHVLRRQILLPFRKPLIIFTPKSLLRHPEARSSFDEMLPGTHFQRVIPEDGPAAQ
ENSMUST00000003461      TPGNFFHVLRRQILLPFRKPLIVFTPKSLLRHPEARTSFDEMLPGTHFQRVIPENGPAAQ
SINFRUP00000153892      NPANYFHVLRRQILLPFR-PLIIFTPKSLLRHPEARSSFDDMLPGTHFQSLIPEDGTAAQ
SINFRUP00000145347      TPANYFHVLRRQILLPFRKPLIVFTPKSLLRHPEAKSSFDDMLPGTHFKRIIPDDGPTTV
CG11661-RC              TPANYYHILRRQIALPFRKPLILCTPKSLLRHPEAKSPFSEMSEGSEFQRIIPDNGPAGQ
                        .*..: *:****: **** **:: *********:*::.*.::  *: *: :**::*.:  

ENST00000265903         APEQVQRLIFCTGKVYYDLVKERSSQDLEEKVAITRLEQISPFPFDLIKQEAEKYPGAEL
ENSMUST00000022480      SPEQVQRLIFCTGKVYYDLVKERSSQGLEQQVAITRLEQISPFPFDLIMREAEKYSGAEL
SINFRUP00000148054      DPARVKRVIFCSGKVYYDLAKERKQQNLEREVAIIRLEQISPFPFDLVRTEAEMYAEAEL
ENST00000309514         NPENVKRLLFCTGKVYYDLTRERKARDMVGQVAITRIEQLSPFPFDLLLKEVQKYPNAEL
ENSMUST00000003461      DPHKVKRLLFCTGKVYYDLTRERKARNMEEEVAITRIEQLSPFPFDLLLKEAQKYPNAEL
SINFRUP00000153892      HPEEVKRLIFCN-KVFYELIKERKTRGMDASVAISRIEQLSPFPFDQVKAEVDRFPKADL
SINFRUP00000145347      DPQKVKRVVFCTGKVYYELIRERKNRGMDDAVAVVRIEQLSPFPFDLVKAEIDQYINADL
CG11661-RC              NPSNVKKVVFCSGRVYYDLTKTRREKQLEGEIAIVRVEQISPFPFDLVKEQANLYKNAEL
                         * .*::::**. :*:*:* : *  : :   :*: *:**:****** :  : : :  *:*

ENST00000265903         AWCQEEHKNMGYYDYISPRFMTILRRARPIWYVGRDPAAAPATGNRNTHLVSLKKFLDTA
ENSMUST00000022480      VWCQEEHKNMGYYDYISPRFMTLLGHSRPIWYVGRDPAAAPATGNKNAHLVSLRRFLDTA
SINFRUP00000148054      VWCQEEHKNMGYYDYVRPRFLTVLANRKPIWYVGREPAAAPATGNKFTH-----------
ENST00000309514         AWCQEEHKNQGYYDYVKPRLRTTISRAKPVWYAGRDPAAAPATGNKKTHLTELQRLLDTA
ENSMUST00000003461      AWCQEEHKNQGYYDYVKPRLRTTIDRAKPVWYAGRDPAAAPATGNKKTHLTELQRFLDTA
SINFRUP00000153892      VWCQEEHKNQGYYDYVKPRIRTTIQRAKPVWYAGRDPAAAPATGNKNTH-----------
SINFRUP00000145347      VWCQEEHKNQGYYDYVKPRISNTTQHRRPVWYVGREPAAAPATGNKHTHLVELQHFLDTA
CG11661-RC              VWAQEEHKNQGSWTYVQPRFLTALNHSRDVSYVGRACGASTATGSKAQHIRELNALLNDA
                        .*.****** * : *: **: .   . : : *.**  .*:.***.:  *:  :  ::   

ENST00000265903         FNLQAFEGKTF
ENSMUST00000022480      FNLKAFEGKTF
SINFRUP00000148054      -----------
ENST00000309514         FDLDVFKNFS-
ENSMUST00000003461      FDLDAFKKFS-
SINFRUP00000153892      -----------
SINFRUP00000145347      FDLEAF-----
CG11661-RC              IST--------
                        :    :    :