CLUSTAL W (1.82) multiple sequence alignment ENST00000320781 QAVPARGEPQQDCCVKTELLGEETPMAADEGSAEKQAGEAHMAADGETNGSCENSDASSH ENSMUST00000046227 --------------MKTELLREDTPMAADEGSTEKQEGETPMAADGETNGSCEKSGDPSH SINFRUP00000130617 ------------------------------------------------------------ ENST00000259865 --------------MAAAAGAAAAAAAEGEAPAEMGALLLEKETRGATERVHGSLGDTPR ENSMUST00000043876 --------------MAAAAGAAAAAAAEGEAPAEMGALLLEKEPRGAAERVHSSLGDTPQ CG7462-RC ------------------------MVTENGAQGDGNTSFLRAARAGNLERVLEHLKNNID : : ENST00000320781 ANAAKHTQDSARVNPQDGTNTLTRIAENGVSERDSEAAKQNHVTAD-DFVQTSVIGSNGY ENSMUST00000046227 LNAPKHTQENTRASPQEGTNRVSRVAENGVSERDTEVGKQNHVTAD-DFMQTSVIGSNGY SINFRUP00000130617 ------------------------------------------------------------ ENST00000259865 SEETLPKATPDSLEPAGPSSPASVTVTVGDEGADTPVGATPLIGDESENLEGDGDLRGGR ENSMUST00000043876 SEETLPKANPDSLEPAGPSSPASVTVTVGDEGADTPVGAASLIGDEPESLEGD----GGR CG7462-RC INTSN----------ANGLNALHLASKDGHIHVVSELLRRGAIVDSATKKGNTALHIASL : ENST00000320781 ILNKPALQAQPLRTTSTLASSLPGHAAKTLPGGAGKGRTPSAFPQTPAAPPATLGEGSAD ENSMUST00000046227 FLNKPALQGQPLRTPNILTSSLPGHAAKTLPGGASKCRTLSALPQTPTTAPTVPGEGSAD SINFRUP00000130617 ------------------------------------------------------------ ENST00000259865 ILLGHATKSFPS--SPSKGGSCPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAAAAG ENSMUST00000043876 IVLGHATKSFPS--SPSKGGACPSRAKMSMTGAGKSPPSVQSLAMRLLSMPGAQGAATAG CG7462-RC AGQEEVVKLLLEHNASVNVQSQNGFTPLYMAAQENHDAVVRLLLSNGANQSLATEDGFTP : : ENST00000320781 TEDRKLPAPG--ADVKVHRARKTMPKSVVGLHAASKDPREVREARDHKEPKEEINKNISD ENSMUST00000046227 TEDRKPTASG--TDVRVHRARKTMPKSILGLHAASKDHR---EVQDHKEPKEDINRNISE SINFRUP00000130617 ------------------------------------------------------------ ENST00000259865 SEPPPATTSP-EGQPKVHRARKTMSKPGNGQPPVPEKRPPEIQHFRMSDDVHSLGKVTSD ENSMUST00000043876 PEPSPATTAAQEGQPKVHRARKTMSKPSNGQPPIPEKRPPEVQHFRMSDDMH-LGKVTSD CG7462-RC ------------LAVAMQQGHDKVVAVLLESDTRGKVRLPALHIAAKKDDVKAATLLLDN : : ENST00000320781 FGRQQLLPPFPSLHQSLPQNQCYMATTKSQTACLPFVLAAAVSRKKKRRMGTYSLVPKKK ENSMUST00000046227 CGRQQLLPTFPALHQSLPQNQCYMATTKSQTACLPFVLAAAVSRKKKRRMGTYSLVPKKK SINFRUP00000130617 ------------------------------------------------------------ ENST00000259865 LAKRRKLNSGGGLSEELG---------------------------SARRSGEVTLTKGDP ENSMUST00000043876 VAKRRKLNSGS-LSEDLG---------------------------SAGGSGDIILEKGEP CG7462-RC DHNPDVTSKSGFTPLHIAS------------------------HYGNQNIANLLIQKGAD : : : ::: : : ENST00000320781 TKVLKQRTVIEMFKSITHSTVGSKGEKDLGASSLHVNGESLEMDSDEDDSEELEEDDGHG ENSMUST00000046227 TKVLKQRTVIEMFKSITHSTVGAKGEKALDDSALHVNGESLEMDSEDEDSDELEDDEDHG SINFRUP00000130617 ------------------------------------------------------------ ENST00000259865 GSLEEWETVVG------------------DDFSLYYDSYSVDERVDSDSKSEVEALTEQL ENSMUST00000043876 RPLEEWETVVG------------------DDFSLYYDAYSVDERVDSDSKSEVEALAEQL CG7462-RC VNYSAKHNISP-----------------LHVAAKWGKTNMVSLLLEKGGNIEAKTR---- : :: : : : : ENST00000320781 AEQAAAFPTEDSRTSKESMSEADRAQKMDGESEEEQESVDTGEEEEGGDESDLSSESSIK ENSMUST00000046227 AEQAAAFPTEDSRTSKESMSETDRAAKMDGDSEEEQESPDTGEDEDGGDESDLSSESSIK SINFRUP00000130617 ------------------------------------------------------------ ENST00000259865 SEE-----------------EEEEEEEEEEEEEEEEEEEEEE-DEESGNQSDRSGSSGRR ENSMUST00000043876 SEE-----------------EEEEEEEEEEEEEEEEEEEEEEEDEESGNQSDRSGSSGRR CG7462-RC ----------------------DGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAP : : ENST00000320781 KKFLKRKGKTDSPWIKPARKRRRRSRKKPSGALGSESYKSSAGSAEQTAPGDSTGYMEVS ENSMUST00000046227 KKFLKRRGKTDSPWIKPARKRRRRSRKKPSSMLGSEACKSSPGSMEQAALGDSAGYMEVS SINFRUP00000130617 ------------------------------------------------------------ ENST00000259865 K--AKKKWRKDSPWVKPSRKRRKREPPRAKEPRGVNGVGSS----------GPSEYMEVP ENSMUST00000043876 K--AKKKWRKDSPWVKPSRKRRKREPPRAKEPR--------------------------- CG7462-RC LHMAAQGEHVDAARILLYHR---------------------------------------- : : : : ENST00000320781 LDSLDLRVKGILSSQA--EGLANGPDVLETD-GLQEVPLCSCRMETPKSREITTLANNQC ENSMUST00000046227 LDSLDLRVRGILSSQTENEGLASGPDVLGTD-GLQEVPLCSCRMETPKSREISTLANNQC SINFRUP00000130617 ----------------------------------QELPLCSCRMETPKSREILTLADRKC ENST00000259865 LGSLELPSEGTLSPNH--AGVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKC ENSMUST00000043876 -------------------GVSNDTSSLETERGFEELPLCSCRMEAPKIDRISERAGHKC CG7462-RC ----------------------APVDEVTVDYLTALHVAAHCGHVRVAKLLLDRNADANA : : : : : : . * : *. :. ENST00000320781 MATESVDHELGRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNF ENSMUST00000046227 MATESVDHELGRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNF SINFRUP00000130617 MATESIDGQLIRCQGAILKHEMMRPSNSVQLLVLCEDHRNGMVKHQCCPGCGFFCRAGTF ENST00000259865 MATESVDGELSGCNAAILKRETMRPSSRVALMVLCETHRARMVKHHCCPGCGYFCTAGTF ENSMUST00000043876 MATESVDGELLGCNAAILKRETMRPSSRVALMVLCEAHRARMVKHHCCPGCGYFCTAGTF CG7462-RC RALNGFTPLHIACKKNRLKVVELLLRHGASISATTESG-LTPLHVAAFMGCMNIVIYLLQ * :.. * :* : . : . * :: . ** : ENST00000320781 MECQPESSISHRFHKDCASRVNNASYCPHCGEESSKAKEVTIAKADTTSTVT--PVPGQE ENSMUST00000046227 MECQPESSISHRFHKDCASRVNNASYCPHCGEEASKAKEVTIAKADTTSTVT--LAPGQE SINFRUP00000130617 MECQPDISISHRFHRACASVLKGQSFCPHCGEEASKAKEVTIAKADTTSTVPPVVVHGGA ENST00000259865 LECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDASEAQEVTIPRGDGVTPPAGTAAPAPP ENSMUST00000043876 LECHPDFRVAHRFHKACVSQLNGMVFCPHCGEDASEAQEVTIPRGDGGTPPIGTAAPALP CG7462-RC HDASPDVPTVRGETPLHLAARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDI :. *: : : . : . :. . : ENST00000320781 -KGSALEGRADTTTGSAAGPPLSEDDKLQGAASHV---PEGFDPTGPAGLGRPTPGLSQG ENSMUST00000046227 -KSLAAEGRADTTTGSIAGAP--EDERSQSTAPQA---PECFDPAGPAGLVRPTSGLSQG SINFRUP00000130617 -TAAVPEGRADTTTDIKAEHFL--PDRLHISPLPG---SSSFTLVPPRSGTTEQAPVPAG ENST00000259865 PLSQDVPGRADTSQPSARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPLG ENSMUST00000043876 PLAHDAPGRADTSQPSARMRGHGEPRRPPCDPLADTIDSSGPSLTLPNGGCLSAVGLPPG CG7462-RC VMLLLQHGAQVDATTKDMYTALHIAAKEGQDEVAAVLIENGAALDAATKKGFTPLHLTAK * : : . . :. ENST00000320781 PGKETLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKR ENSMUST00000046227 PGKETLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQSKR SINFRUP00000130617 PPRETLESILVALDTEKPKKLRFHPKQLYHSAKQGELKKVFLMLVDGIDPNFKMESQNKR ENST00000259865 PGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKR ENSMUST00000043876 PGREALEKALVIQESERRKKLRFHPRQLYLSVKQGELQKVILMLLDNLDPNFQSDQQSKR CG7462-RC YGHIKVAQLLLQKEADVDAQGKNGVTPLHVACHYNNQQVALLLLEKGASP--HATAKNGH : : . *: ::: : : *: : : .: : .:*:* .. .* :: :. : ENST00000320781 SPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDP ENSMUST00000046227 SPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLDAVKYLIKAGAQVDP SINFRUP00000130617 TPLHAAAEGGHSDICHMLVQAGANLDICDDDHRTPLMEACENNHMATVLYLLRAGANATQ ENST00000259865 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYS ENSMUST00000043876 TPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQLGGCVYS CG7462-RC TPLHIAARKNQMDIATTLLEYGALANAESKAGFTPLHLSSQEGHAEISNLLIEHKAAVNH :*** **. . :*. *:: ** : .. *** : :.* ::. . . ENST00000320781 KDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLS ENSMUST00000046227 KDAEGSTCLHLAAKKGHYDVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVELVKLLLS SINFRUP00000130617 KDVEGFTCLHLAAKSGHYAIVEHLLLTGLININCQDDGGWTPMIWATEYKHVDQVKLLLS ENST00000259865 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT ENSMUST00000043876 KEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIDVIRMLLT CG7462-RC PAKNGLTPMHLCAQEDNVNVAEILEKNG-ANIDMATKAGYTPLHVASHFGQANMVRFLLQ :* * :* .*: .: :.. * .* ::: ..*:**: *:.. : : :::** ENST00000320781 KGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDC ENSMUST00000046227 KGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDC SINFRUP00000130617 KGADISIRDKEENICLHWAAFSGCVDIAVLLLDANCDMHAVNIHGDSPLHIAARENRLEC ENST00000259865 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDC ENSMUST00000043876 RGADVTLTDNEENICLHWASFTGSAAIAEVLLNAQCDLHAVNYHGDTPLHIAARESYHDC CG7462-RC NGANVDAATSIGYTPLHQTAQQGHCHIVNLLLEHKANANAQTVNGQTPLHIARKLGYISV .*::: . ** :: * *. :** ..: :* . :*::***** : . . ENST00000320781 VVLF--LSRDSDVTLKNKEGETPLQCASLNSQVWSALQMSKALQDSAPDRPSPVERIVSR ENSMUST00000046227 VVLF--LSRDSDVTLKNKEGETPLQCASLSSQVWSALQMSKALRDSAPDKPVAVEKTVSR SINFRUP00000130617 VTLF--LSQGANVFLRNREGETPPDCCGHNSKAWAVLQASRKERGSNSSMDKAEEKVLHS ENST00000259865 VLLF--LSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAIRTEKIICR ENSMUST00000043876 VLLF--LSRGANPELRNKEGDTAWDLTPERSDVWFALQLNRKLRLGVGNRAVRTEKIICR CG7462-RC LDSLKTITKEDETAAAPSQAEEKYRVVAPEAMHESFMSDSEEEGGEDNMLSDQPYRYLTV : : ::: : :.: : :. .. : : ENST00000320781 DIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSN ENSMUST00000046227 DIARGYERIPIPCVNAVDSELCPTNYKYVSQNCVTSPMNIDRNITHLQYCVCVDDCSSST SINFRUP00000130617 DIALGHERVPIPCVNSVDSEPYPEGYKYIPENCVTSPMNIDRNITHMQYCVCKENCSTSI ENST00000259865 DVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSN ENSMUST00000043876 DVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSN CG7462-RC DEMKSLGDDSLPIDVTRDERMDSNRMTQSAEYASGVPPTIGEEVISPHKTQVYGSSPKAT * . .:* * . . . .: . . .*..:: : ....: ENST00000320781 CMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRN--------------- ENSMUST00000046227 CMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRN--------------- SINFRUP00000130617 CMCGQLSLRCWYDKTGRLLPEFCREEPPLIFECNHACSCWRTCKN--------------- ENST00000259865 CLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKN--------------- ENSMUST00000043876 CLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRSCKN--------------- CG7462-RC VDGVYIANGSGHDEPPHVGRKLSWKSFLVSFLVDARGGAMRGCRHSGVRMIIPSRSTCQP :: . :*: :: :: . : * : .. * *:: ENST00000320781 -RVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDS--EADVREEDSYL ENSMUST00000046227 -RVVQNGLRARLQLYRTQDMGWGVRSLQDIPLGTFVCEYVGELISDS--EADVREEDSYL SINFRUP00000130617 -RVVQNGLRTKLQLFRTSKKGWGVRAHQDIPQGTFVCEYVGEIISEA--EAEMRQNDAYL ENST00000259865 -RVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDA--EADVREDDSYL ENSMUST00000043876 -RVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDA--EADVREDDSYL CG7462-RC TRVTCRYVKPQRTMHPPQLMEGEALASRVLELGPCSTKFIGPVVMEVPHFASLRGKEREI **. :: : :. . . : : : *. :::* :: : *.:* .: : ENST00000320781 FDLDNKISSA-------------------------------------------------- ENSMUST00000046227 FDLDNKDGEVYCIDARFYGN--VSRFINHHCEPN----------LVPVRVFMSHQDLRFP SINFRUP00000130617 FSLDDKPQDLYCIDARFYGN--ISRFLNHMCEPN----------LFACRVFTTHQDLRFP ENST00000259865 FDLDNKDGEVYCIDARYYGN--ISRFINHLCDPN----------IIPVRVFMLHQDLRFP ENSMUST00000043876 FDLDNKDGEVYCIDARYYGN--ISRFINHLCDPN----------IIPVRVFMLHQDLRFP CG7462-RC IILRSDNGETWREHTIDNSEEIIHDVLQQCFEPEEIAQLEEQAGNHVCRFVTYDFPQYFA : * .. . ENST00000320781 ------------------------------------------------------------ ENSMUST00000046227 RIAFFSTRLIQAGEQLGFDYGERFWDVKGKLFSCRCGSSKCRHSSAALAQRQASAAQEPQ SINFRUP00000130617 HIAFFASENIKAGEELGFDYGSHFWEVKSKVFNCECGSSKCRYSSAAMATLQADSTPEDQ ENST00000259865 RIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDP ENSMUST00000043876 RIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARLDP CG7462-RC VVSRIRQEVHAIGPEGGMVSSTVVPQVQAVFPQGALTKKIKVGLQVNLFKPRKGVAPEKL ENST00000320781 ------------------ ENSMUST00000046227 ENGLPDTSSAAAADPL-- SINFRUP00000130617 QQPSASPDTSSS------ ENST00000259865 HPELLPELGSLPPVNT-- ENSMUST00000043876 HPELLPDLSSLPPINT-- CG7462-RC RKISVNHVPKKKRFSLIW