CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000021898 ------------------------------------------------------------ ENST00000277153 -----------------------MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAA SINFRUP00000154123 -----------------------MLHRTKYNRFRNESVTSVDELLHGLPMN---PKVSAS ENST00000264554 ----------------------------RGPAAARAAGASGGADPQPEP----------- ENSMUST00000020560 --------------------------------AAMTQGPGGRAAPEPEAPTTFCALLPRM SINFRUP00000137453 ------------------------------------------------------------ SINFRUP00000145905 -----------------------LAPKTKYTHFRSESLSSTDETN------SNPSSVPPS ENSMUST00000060406 MRERSQDSQAGLTLYVGLFGHLGMLHRTKYSRFRNESITSLDEGSPGGSVGNKGSSPPPY ci0100139026 ------------------------------------------------------------ CG3715-RA ------------------------------------------------------------ : ENSMUST00000021898 ------------------------------------------------------------ ENST00000277153 RATPAAAPYLVSGEALRKAPDDGPGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARL- SINFRUP00000154123 PETSYTPPTEVQSFSTATASS-TPACLG-----SDHLE---DGGTTLCTLINKVSGLKF- ENST00000264554 -----AGPG----------------------GVPALAAAVLGACEPRCAAPCPLPALSR- ENSMUST00000020560 PQWKFAAPGSFLGRGPAATRVAGVAEAQPEPGVPALAA-VLGACEPRCAAPCPLPALGR- SINFRUP00000137453 ------------------------------------------------------------ SINFRUP00000145905 SPVSPLTPSPGMPSS--LSSSSLTPILPPCSPHPAENSPTTLCSFFPRMGSLRLGVSATL ENSMUST00000060406 PALAPHLPTEDATVSSQESPTALCTLIPRMASMKLANPITFLGLKTFCLGTKQVSRLKLQ ci0100139026 ------------------------------------------------------------ CG3715-RA ------------------------------------------------------------ ENSMUST00000021898 -------------------------------MSATRKSRAGDEPLPRPPRG----APHTS ENST00000277153 -------SGSCSAPSLAAPDGSAPSAPRAPAMSAARKGRPGDEPLPRPPRG----APHAS SINFRUP00000154123 -------SNSGSLLGIKG----LPSAVKDLAVSKLQVASSSG----GSACG----SHSVP ENST00000264554 -------CRGAGSRGSRGGRGAAGSGDAAAAAEWIRKGSFIH----KPAHG----WLHPD ENSMUST00000020560 -------CRGSGTRGAR--------VTPDVADEWVRKGGFIH----KPAHG----WLHPD SINFRUP00000137453 ------------------------------------------------------------ SINFRUP00000145905 LPSFKTASRPQNTRAPVELGGASRRARVEGGQLGGDEWTRHGSFVNKPTRG----WLHSD ENSMUST00000060406 ENQDQTPSRPASPESNLNRTGPAPAP--DPDQVGRRPTSLRPDTCPLPGPGEPSPRSKQD ci0100139026 ---------------------MMRRNKKLVEGDQTNEWRKSGSFVNKPQRG----WLHPD CG3715-RA --------------------------------MPKNGDAGNRSGSGTTSDG----CIYPD ENSMUST00000021898 D----QVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQVTREAISRVCEA----VPGAKG ENST00000277153 D----QVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQITREAISRVCEA----VPGAKG SINFRUP00000154123 C----SQLEPAVGMSKKSRLDELQLGRVEWNPGGGGALMSKPSRGWVHSSD---KISGPG ENST00000264554 A----RVLGPGVSYVVRYMGCIEVLRSMRSLDFNTRTQVTREAINRLHEA----VPGVRG ENSMUST00000020560 A----RVLGPGVSYIVRYMGCIEVLRSMRSLDFNTRTQVTREAINRLHEA----VPGVRG SINFRUP00000137453 ------------------------------------------------------------ SINFRUP00000145905 G----VVSTSGVSYTVRYMGCVEVLQSMRALDFSTRTQVTRFLYNVFIGI----SPQPCS ENSMUST00000060406 GPPLQHLLGNGLNYCVRYMGCIEVLQSMRSLDFGMRTQVTREAISRLCEA----VPGAHG ci0100139026 S----SVMGPGVVYSVQYLGCVEVRQSMRTLDFDMRTLATKEAIWRVLASTGMSPLPPAA CG3715-RA D----VIMGVGVAFNVRYTGCVEVKTSMKSLDFETRTQLARECINRVCEAAG-------- : : . ENSMUST00000021898 ALKKRKPPSKMLSSILG-KSNLQFAGMSISLTISTASLNLRTPDSKQIIANHHMRSISFA ENST00000277153 AFKKRKPPSKMLSSILG-KSNLQFAGMSISLTISTASLNLRTPDSKQIIANHHMRSISFA SINFRUP00000154123 VTYIVKPPSKTLSSILG-KSNLQFAGMSINLNISTSSLNLMTPDGKQIIANHHMQSISFA ENST00000264554 SWKK-KAPNKALASVLG-KSNLRFAGMSISIHISTDGLSLSVPATRQVIANHHMPSISFA ENSMUST00000020560 SWKK-KAPNKALASILG-KSNLRFAGMSISVNISVDGLNLSVPATRQIIANHHMQSISFA SINFRUP00000137453 --------NKALQTVMG-KSNLRFAGMSIAVNISIDGLSLLIPTTRQVIAHHPMQSISFA SINFRUP00000145905 SLQ---PSSRCLSSILG-KSNLQFAGMTISLTVSTSSLNLLACDCKQVRSDKCMI----- ENSMUST00000060406 AIKKRKAPVKFLTTVLG-KSNLQFSGMNIKLTVSTSSLTLMNLDNQQIIANHQMQSISFA ci0100139026 NRSGRKKPPKDVTRILGERPNLKFSQSFINLTISTASLTLVVSNTGQFIANHQMQSISFA CG3715-RA ---LKSAGKRRLTNFISDRPSMQHAGTNIIINVSSRALSLSNVETGEVIANHNMPRISFA : : .:. :..::.: * : :* .*.* :. :.: * : : ENSMUST00000021898 SGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQAFELRFKQYLQCP-SKV ENST00000277153 SGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQAFELRFKQYLQCP-TKI SINFRUP00000154123 SGGDPDTTDYVAYVAKDPVNRRACHILECSDGLAQDVIGTIGQAFDLRFQQYLQCPSSKI ENST00000264554 SGGDTDMTDYVAYVAKDPINQRACHILECCEGLAQSIISTVGQAFELRFKQYLHSP-PKV ENSMUST00000020560 SGGDTDMTDYVAYVAKDPINQRACHILECCEGLAQSVISTVGQAFELRFKQYLHSP-PKA SINFRUP00000137453 SGGDTDTPDYVAYVAKDPVNQRACHILECSDGLAQGVISTIGQAFELQFKQYLHSP-PKT SINFRUP00000145905 ---------YSVCVTLP----SACHILECSEGLAQEVISTIGQAFELRFKQYLKNP-PKL ENSMUST00000060406 SGGDPDTTDYVAYVAKDPVNQRACHILECRSGMAQDVISTIGQAFELRFKQYLKNP-S-- ci0100139026 SGGDPDTIDYVAYVAKDPINSRACHVLKCTDGLAQDVINTIGQAFELRFKEYLKNP-PKA CG3715-RA SGGDNDTLDFLAYIAKNEDEWRACYVLECAGGQSEDLIVTIGKAFALRFNALSRLNDPSA : . :: **::*:* * :: :* ::*:** *:*: : . ENSMUST00000021898 PALQDRMQSL---DEP-WTEEEGDGPDHP---YYNSVPTKMPPPGGFLDA--RLKGRPHA ENST00000277153 PALHDRMQSL---DEP-WTEEEGDGSDHP---YYNSIPSKMPPPGGFLDT--RLKPRPHA SINFRUP00000154123 SSPHDRVLNM---EELTWTEEEEESTEHP---YYNNIPGKMPPPGGIVDT--RLTNQNAA ENST00000264554 ALPPERLAGP---EESAWGDEE-DSLEHN---YYNSIPGKEPPLGGLVDS--RL------ ENSMUST00000020560 VVPPERLTGL---EELAWGDDD-AAADHN---YYNSIPGKEPPLGGLVDS--RL------ SINFRUP00000137453 LASVERSVRT---EEPIWGEEE-SFSDHN---YYNSIPGKEPPIGGVVDS--RLRGNGAL SINFRUP00000145905 VTPHDRMAPF---DGSAWEEEDEEPPPPPDVPYYNNFPGKQPPPGGLIDM--RTRPGATL ENSMUST00000060406 LNTWEREEVL---VDGAPEDRDHD--------YYNSIPGKQPPEGGISDV--RIQAQATD ci0100139026 VTPPDRTEPLFHDGKSRWGDDEPE--------YYNEIPGKLAPESGLK----RLDDGSKI CG3715-RA DCNINQSCKEN------------------VKEYYNDLPNKLPPEVPEPQQQQ-------- :: ***..* * .* ENSMUST00000021898 PEAAQFAGK--EQTYYQGRHLGDTFGEDWQRAPTRQGSLDIYS-TAEGKT--------HM ENST00000277153 PDTAQFAGK--EQTYYQGRHLGDTFGEDWQQTPLRQGSSDIYS-TPEGKL--------HV SINFRUP00000154123 QDGCQMGPGSIDQTYYQGRHCGENWGDDRKPIFIQQGSFDIIS-LPESK---------GQ ENST00000264554 --------------------------ALTQPCALTA--LDQVSLCPRGDG--------DR ENSMUST00000020560 --------------------------AVTQPCALAT--LGGLGQVPVG------------ SINFRUP00000137453 LG----------HIHSQLQGYTTTQVTLQTECLTSDGYLCADGQSAGGKD--------YE SINFRUP00000145905 PYG----------------QPGQ---NDIHKQPLP-------PLPEGG------------ ENSMUST00000060406 QMAYCPIRC-----EKLCYLPGNSTCSGVYKNCMGRSRPIGIPHERAGQGDTPSLRHFWR ci0100139026 DEG---------AVVYPNHHNSQEYINNGMQSECSAPTPTLSTPTPRRTPRNFEDHNYVN CG3715-RA ------------------------VQQPLHPHAPRVAQLNLKKPRDR------------- : ENSMUST00000021898 VPVGETPTYVNTQPVPPQVWPAATSSTE------------SSPRKDLFDMKPFEDALRNQ ENST00000277153 APTGEAPTYVNTQQIPPQAWPAAVSSAE------------SSPRKDLFDMKPFEDALKNQ SINFRUP00000154123 AQRAEMPAYVNTQQIDAQVLAALQAEGENVTKGLASAPAKESPQKDLFDMKPFEDAIQSE ENST00000264554 DAPAAAPPSAPCPSNTKTGCVSATGLQL-------------GAPRPCFPDGPFEDALKLH ENSMUST00000020560 ------------PEVTWS-----------------------------CPWGPFEDALKLH SINFRUP00000137453 EHQYVNTQNLDNLTSQGAEGPRAGRAPD-------------SPLKDIFDMRPFEDALKLH SINFRUP00000145905 --LFDDPSYVNVDKPRPRVASNGN------------------MHRDAFDMKPFDDALGVS ENSMUST00000060406 VDLFDDPCYVNTQALQSMHSYAGNQSSA-------------LPQGSPWHLGKAPETVQPG ci0100139026 TCVMPHGQEATPASVRPMASPQPTPVMS---------HELSSGGGGALAIAAAIGVSREH CG3715-RA ----LSSNLIDLNSPPPDQTTN-----------------------KLGHFDPLQATTAAN : : . ENSMUST00000021898 ----PLGPMLSKAASV-------ECISPVTPRAPDARMLEELNAEPWYQGEMSRKEAEAL ENST00000277153 ----PLGPVLSKAASV-------ECISPVSPRAPDAKMLEELQAETWYQGEMSRKEAEGL SINFRUP00000154123 GPEHSQAAGLHKAASV-------DNASPLLVRSLAFRAQEELEGQTWYHGIMSRREAEKL ENST00000264554 --ECSVAAGVTAAPLP----LEDQWPSPPTRRAPVAPTEEQLRQEPWYHGRMSRRAAERM ENSMUST00000020560 --ACSVAAGITAASPP----LEDQWPSPPTRRAPIAPTEEQLRQEPWYHGRMSRRAAEKL SINFRUP00000137453 E-ACAGAAGPTAAAAGGTQVLEDQWPSPPRRRAPVAPNEEQLRREPWYHSRMSRRDAERL SINFRUP00000145905 ----GHSGTSSASAAP--------------------PLVQQLQCEAWFHGGLSRKEAERL ENSMUST00000060406 ----ATAKPGSALALP--------------------HIRQQLWDEECFHGKLSRGAAEKL ci0100139026 TPTNQKRPSVDAFDMR-------PFANTLNPPATPTSATNALQSKPWFHGHVTRKEAEQL CG3715-RA ----SVLPSVRDVFDG---------------------PQCPLTAEVWFHAGISRPISERL * : ::. ::* :* : ENSMUST00000021898 LREDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIRTKDRVFDSISHLINYHLE ENST00000277153 LEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIRTKDRVFDSISHLINHHLE SINFRUP00000154123 LQDDGDFLVRKSTTNPGSYVLTGMHNGLAKHLLLVDPEGTVRTKDHVFDSILHLIGHHRD ENST00000264554 LRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEGVVRTKDVLFESISHLIDHHLQ ENSMUST00000020560 LRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEGVVRTKDVLFESISHLIDYHLK SINFRUP00000137453 LIRDGDFLVRESTTNPGQYVLTGMHCGLPKHLLLVDPEGVVRTKDMLFDSINHLIAYHLK SINFRUP00000145905 LTRDGDFLVRESGTTPGQYVLTGQQGGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMD ENSMUST00000060406 LVKDGDFLVRESVTSPGQFVLSGLQGGQAKHLLLVDPEGKVRTKDHVFDNVGHLIKYHMD ci0100139026 LSHDGDFLVRESTTTKGQFVLSGVQDGQYKHLLLVDPNGVVRTKDRQFDSVSHLISFHRD CG3715-RA LQQDGDFLVRESQGKRGQYVLTGLEGKTPKHLLLIDPEGVVRTKDRIFDSISHLINYHWA * *******.* . *.:**:* . *****:**:* :**** *:.: *** .* ENSMUST00000021898 SSLPIVSAGSELCLQQPVERKP------------- ENST00000277153 SSLPIVSAGSELCLQQPVERKQ------------- SINFRUP00000154123 NNLPILSAGSELFLLQPVGRKQ------------- ENST00000264554 NGQPIVAAESELHLRGVVSREP------------- ENSMUST00000020560 NGLPIVAAESELHLRGVVSRE-------------- SINFRUP00000137453 NELPIVAAESELHLKQAVRRKP------------- SINFRUP00000145905 NRLPIISAGSEVCLKQPVERR-------------- ENSMUST00000060406 NNLPIISSGSEVRLKQPIRKYDNTGLL-------- ci0100139026 NTLPIVSSGSVLLLRQPVTRQIER----------- CG3715-RA HALPIISEDSELVLRNPVRRPQQDQAASPITSASS **:: * : * : :