CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000017961 ----------------------------------------------MSGGRFDFDDGGAY ENST00000278973 ----------------------------------------------MSGGRFDFDDGGAY SINFRUP00000149143 ----------------------------------------------MSGGRFEFDDGGAY ENST00000220810 ----------------------------------------------MTGGRFDFDDGGTY ENSMUST00000038382 ----------------------------------------------MTGGRFDFDDGGTY SINFRUP00000161000 ----------------------------------------------MTGGRFDFDDGGTY SINFRUP00000129869 ----------------------------------------------MTGGRFDFDDGGTY ENST00000284262 ---------------------------------------------MSSGGRFNFDDGGSY SINFRUP00000134219 ---------------------------------------------MSTGGRFNFDDGGSY CG4405-RB MQQAGQLTPQQQQQQQQQLLQQQQQQNGGDLAAYAASQAAGGRRGPINGGRFDFEDGGTY .****:*:***:* ENSMUST00000017961 CGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGFEVAGVYTWPSGNTFEGYWSQGKRHGLGI ENST00000278973 CGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGFEVAGVYTWPSGNTFEGYWSQGKRHGLGI SINFRUP00000149143 CGGWEGGKAHGHGICTGPKGQGEFSGSWNYGFEVVGVYTWPSGNTFEGYWSQGKRHGLGV ENST00000220810 CGGWEEGKAHGHGICTGPKGQGEYSGSWSHGFEVVGGYTWPSGNTYQGYWAQGKRHGLGV ENSMUST00000038382 CGGWEEGKAHGHGICTGPKGQGEYSGSWSHGFEVVGVYTWPSGNTYQGYWAQGKRHGLGV SINFRUP00000161000 CGGWEDGKAHGHGICTGPKGQGEYAGSWSHGFEIVGVYTWPSGNTYKGYWSQGKRHGLGV SINFRUP00000129869 CGGWEDGKAHGHGVCTGPKGQGEYSGSWSSGFEVVGVYTWPSGNLYQGYWAQGKRHGLGV ENST00000284262 CGGWEDGKAHGHGVCTGPKGQGEYTGSWSHGFEVLGVYTWPSGNTYQGTWAQGKRHGIGL SINFRUP00000134219 CGGWEDGKAHGHGICTGPKGQGEYCGSWAHGFEVLGVYTWPSGNTYQGTWAQGKRHGAGV CG4405-RB CGGWDEGKAHGHGVCTGPKHQGAYAGAWNYGFEVSGSYIWPSGSHYEGQWQNGRRHGLGV ****: *******:***** ** : *:* ***: * * ****. ::* * :*:*** *: ENSMUST00000017961 ETKGRWLYKGEWT-HGFKGRYGIRQSTNSGAKYEGTWNNGLQDGYGTETYADG------- ENST00000278973 ETKGRWLYKGEWT-HGFKGRYGIRQSSSSGAKYEGTWNNGLQDGYGTETYADG------- SINFRUP00000149143 ETKGHWIYKGEWT-HGFKGRYGTRINAGSGAKYEGTWNNGLQDGYGTETYADG------- ENST00000220810 ETKGKWMYRGEWS-HGFKGRYGVRQSLCTPARYEGTWSNGLQDGYGVETYGDG------- ENSMUST00000038382 ETKGKWMYRGEWS-HGFKGRYGVRQSLCTPARYEGTWSNGLQDGYGVETYGDG------- SINFRUP00000161000 ENKGKWIYRGEWS-HGFKGRYGVRQSHNTPARYDGTWSNGLQDGYGIETYVDGALTDLST SINFRUP00000129869 ETKGRWIYRGEWT-HGFKGRYGVRQSQNTPARYEGTWSNGLQDGYGVETYGDG------- ENST00000284262 ESKGKWVYKGEWT-HGFKGRYGVRECAGNGAKYEGTWSNGLQDGYGTETYSDG------- SINFRUP00000134219 ENKGRWVYKGEWT-HGFKGRYGVRESMGMSGKYEGTWNNGLQDGYGTETYSDG------- CG4405-RB EQIGRQIYRGEWSKDGHKGRYGVRESTVSTAKYEGTWNEGYQDGSGCETYADG------- * *: :*:***: .*.***** * .:*:***.:* *** * *** ** ENSMUST00000017961 ---GTYQGQFTNGMRHGYGVRQSVPYGMAVVVRSP-LRTSLSSLR--SEHSNGTVAPDS- ENST00000278973 ---GTYQGQFTNGMRHGYGVRQSVPYGMAVVVRSP-LRTSLSSLR--SEHSNGTVAPDSP SINFRUP00000149143 ---GTFQGQFTGGMRHGYGVRQSVPYGMAAVVRSP-LRTSLTSLR--SEHSNGTVLQQDV ENST00000220810 ---GTYQGQWAGGMRHGYGVRQSVPYGMATVIRSP-LRTSLASLR--SEQSNGSVLHD-A ENSMUST00000038382 ---GTYQGQWAGGMRHGYGVRQSVPYGMATVIRSP-LRTSLASLR--SEQSNGSVLHEAA SINFRUP00000161000 CSSGTYQGQWMGGMRHGYGVRQSVPYGMATVIRSP-LRTSLASLR--SEQSNGTVLQD-L SINFRUP00000129869 ---GTYQGQWTGGMRHGYGVRQSVPYGMASVIRSP-LRTSLASLR--SEQSNGTILRD-- ENST00000284262 ---GTYQGQWVGGMRQGYGVRQSVPYGMAAVIRSP-LRTSINSLR--SEHTNGTALHPDA SINFRUP00000134219 ---GTFQGQWVGGMRHGYGIRQSVPYGMAAVIRSP-LRTSINSLRSGSEHSNGTALLDRT CG4405-RB ---GKYQGQWQEGKRHGYGIRTSAPFGLASHHRRKNLHASLSSLRS-GENGNAAKMVEK- *.:***: * *:***:* *.*:*:* * *::*: *** .*: *.: ENSMUST00000017961 --PAADGP----------------MLPSPPVP-RGGFALTLLATAEAAR--PQG--LFTR ENST00000278973 ASPASDGP----------------ALPSPAIP-RGGFALSLLANAEAAARAPKGGGLFQR SINFRUP00000149143 PIITATNASGEETPI---------ATPTQLGPSRGPFALTLHVDPEAVK--PKKKGLFRR ENST00000220810 AAAADS-----------------------PAGTRGGFVLNFHADAELAG--KKKGGLFRR ENSMUST00000038382 AAAADS-----------------------PAGTRGGFVLNFHADTELG---KKKGGLFRR SINFRUP00000161000 SSPAET-----------------------PTGSRGGFVLNFHSDTEVVT--GKKKGLFRR SINFRUP00000129869 -SLSDS-----------------------PAGTRGGFVLNFHSDGEGLE--KKKG-LFRR ENST00000284262 SPAVAG----------------------SPAVSRGGFVLVAHSDSEILKS-KKKG-LFRR SINFRUP00000134219 GAAVPGAPPVSATLTTSVSMCSTGSSGSSPAVSRGGFVLTALSESELLKG-KRKGGLFRR CG4405-RB -----------------------------AEEIRGGFVLTAKSDKLPVRR-NSLTDKTGK ** *.* : ENSMUST00000017961 GTLLGRLR---RSESRTSLGSQRSRLS-FLKSE--LSSGAS---DAASTGSLAEGAEGPD ENST00000278973 GALLGKLR---RAESRTSVGSQRSRVS-FLKSD--LSSGAS---DAASTASLGEAAEG-A SINFRUP00000149143 SSLLGKLK---KSESSTSLSSQKSKIS-FLRSESALSSNAS---DTNSTISIGDESLAGA ENST00000220810 GSLLGSMK-LRKSESKSSISSKRS----SVRSDAAMSRISS--SDANSTISFGD----VD ENSMUST00000038382 GSLLGSMK-LRKSESKSSISSKRS----SVRSDAAMSRISS--SDANSTISFGD----VD SINFRUP00000161000 GSLFGSLRQLRKTDSRTSISSKRS----SARSDATMSRISS--SDANSTISIGDG--ELP SINFRUP00000129869 GSIFGSLQRLRKSDSRSSISSKRS----SAHSDTTMSRISS--SDANSTISFGDG--DPG ENST00000284262 -SLLSGLK-LRKSESKSSLASQRSKQS-SFRSEAGMSTVSSTASDIHSTISLGE----AE SINFRUP00000134219 -SILSGLK-LRKSESRSSLASQRSKQS-SFRSEAGMSTVSSAASDINSTISLGD----AD CG4405-RB KGFLMNLK-MRKQRSTGDLEKRGTIASGSIRSTMSSASWIS-TGSEQSNLTTKSNHTESN :: :: : : * .: .: : :* : * . *. : . ENSMUST00000017961 DAAAPFDADIDATTTETYMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGRTTLPD ENST00000278973 DEAAPFEADIDATTTETYMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGCTTLPD SINFRUP00000149143 EDFPPVEADIDATTTEVYMGEWKNDKRSGYGISERSSGLKYEGEWLNNQRHGYGCTTFAE ENST00000220810 CDFCPVEDHVDATTTETYMGEWKNDKRNGFGVSERSNGMKYEGEWANNKRHGYGCTVFPD ENSMUST00000038382 CDFCPVEDHVDATTTETYMGEWKNDKRNGFGISERSNGMKYEGEWANNKRHGYGCTVFPD SINFRUP00000161000 DEDLPLEDHVDATTTETYMGEWKNDKRNGFGVSERSNGMKYEGEWLNNKRHGYGCTVFPD SINFRUP00000129869 DDYLTLEDNVDATTTESYMGEWKNDKRSGFGVSERSNGMKYEGEWLNNKRHGYGCTIFPD ENST00000284262 AELAVIEDDIDATTTETYVGEWKNDKRSGFGVSQRSDGLKYEGEWASNRRHGYGCMTFPD SINFRUP00000134219 ADLAAADDVVDATATEIYCGEWKNDKRTGFGVSRRSDGLQYEGEWLGNKRHGYGCTAFPD CG4405-RB ASFTMEDEQLDPTVVETYMGEWKKDKRCGHGVAERSDGLKYEGEWYNNRKHGYGVTTFRD : :*.*..* * ****:*** *.*::.**.*::***** .* :**** : : ENSMUST00000017961 GHREEGKYRHNVLVKG-TKRRVLPLKSSKVRQKVEHGVEGAQRAAAIARQKAEIAASRTS ENST00000278973 GHREEGKYRHNVLVKD-TKRRMLQLKSNKVRQKVEHSVEGAQRAAAIARQKAEIAASRTS SINFRUP00000149143 GGKEEGKYVNNMLVKA-MKKRVIQLKGNKIKHKVERAVEGAQRAAAIAKQKAEIASSRTT ENST00000220810 GSKEEGKYKNNILVRG-IRKQLIPIRHTKTREKVDRAIEGAQRAAAMARTKVEIANSRTA ENSMUST00000038382 GSKEEGKYKNNILVRG-IRKQLIPIRNTKTREKVDRAIEGAQRAAAMARTKVEIANSRTA SINFRUP00000161000 GTKEEGKYKNNVLVRG-IRKQLIPLKNPKTKEKVDRAVEGAQRVAAIARSKVEIAASR-- SINFRUP00000129869 GTKEEGKYKNNVLARG-IRKQLIPLKNAKTKQKVDRAIEGAVRAAAIARTKVEIAISRTS ENST00000284262 GTKEEGKYKQNILVGG-KRKNLIPLRASKIREKVDRAVEAAERAATIAKQKAEIAASRTS SINFRUP00000134219 GTKEEGKYKQNILVSG-KRKNLIPLRASKIREKVDRAVDGAQKAADVARKKVEIASSRTS CG4405-RB GTVEEGKYKNNILITSQKKKHLFLARSRKLRDRIAAALSSAQRALKMAMQRSDMAISRMA * ***** :*:* ::.:: : * :.:: .:..* :. :* : ::* ** ENSMUST00000017961 HAKAKAEAAEQAALAANQESNIARTLAKELAPDFYQ------------------PGPE-- ENST00000278973 HAKAKAEAAEQAALAANQESNIARTLARELAPDFYQ------------------PGPE-- SINFRUP00000149143 HAKAKADAAEQAAQASNSESSIARLVAKELSPSFYQ------------------PGPE-- ENST00000220810 HARAKADAADQAALAARQECDIARAVARELSPDFYQ------------------PGPD-- ENSMUST00000038382 HARAKADAADQAALAARQECDIARAVARELSPDFYQ------------------PGPD-- SINFRUP00000161000 ------------------------------------------------------------ SINFRUP00000129869 HARAKAEAADQAAHSANQDSDIGRTVARELSPSFHQ------------------PGPD-- ENST00000284262 HSRAKAEAALTAAQKAQEEARIARITAKEFSPSFQH------------------RENG-- SINFRUP00000134219 HAQGKAEAATAAAQKAQEESRVARRTAKQFSPSFQH------------------PGNG-- CG4405-RB TAAAKAQNADAAAEQARMDCENAVRMAREFAPDFKPSVLERFEKLRFRERERFRPGPAAA : : ENSMUST00000017961 ------------------------------------------------------------ ENST00000278973 ------------------------------------------------------------ SINFRUP00000149143 ------------------------------------------------------------ ENST00000220810 ------------------------------------------------------------ ENSMUST00000038382 ------------------------------------------------------------ SINFRUP00000161000 ------------------------------------------------------------ SINFRUP00000129869 ------------------------------------------------------------ ENST00000284262 ------------------------------------------------------------ SINFRUP00000134219 ------------------------------------------------------------ CG4405-RB SDASVKMGVGLQTQQQQQQQGQFSPTSSSGSDAYATQAQRQQQYLNMQQQQQQQRRMSQQ ENSMUST00000017961 ----------------------------------------------YQKRR-LLQEILEN ENST00000278973 ----------------------------------------------YQKRR-LLQEILEN SINFRUP00000149143 ----------------------------------------------YLKKR-VLQEVAEG ENST00000220810 ----------------------------------------------YVKQRFQEGVDAKE ENSMUST00000038382 ----------------------------------------------YIKQRCQEGGDIKE SINFRUP00000161000 ------------------------------------------------------------ SINFRUP00000129869 ----------------------------------------------YIQQKYNEPVEVKE ENST00000284262 ----------------------------------------------LEYQRPKRQTSCD- SINFRUP00000134219 ----------------------------------------------IEVQRPKRQVSSEV CG4405-RB KHESECPVPPSMYSQQLPVSPQTDLSGMVSQAQPSHAQVISAINQMYHQQQHQQQQQLNQ ENSMUST00000017961 SE-----------SLLEPPERGLG-TGLPERPRESPQLHERETPQPEGGPPSPAGTPPQP ENST00000278973 SE-----------SLLEPPDRGAGAAGLPQPPRESPQLHERETPRPEGGSPSPAGTPPQP SINFRUP00000149143 SENT---------DIVIHEPLLAEDEPLPTPP-ESPLMNELVSLMPD----SSSGRTPSP ENST00000220810 NPEE---------KVPEKPPTPKESPHFYRKGTTPP-----------RSPEASPKHSHSP ENSMUST00000038382 NPEE---------KVLEKPPSPKESPHFYRKGTTPP-----------RSPESSPKQSHSP SINFRUP00000161000 ------------------------------------------------------------ SINFRUP00000129869 VPLE---------EKNNKSATG--SPHFYRKGTTPT-----------QSPSGSPCPSPRA ENST00000284262 -DIE---------VLSTGTPLQQESPELYRKGTTPSDLTPDDSP--LQSFPTSPAATPPP SINFRUP00000134219 -EVE---------GLSS-SAGTADSPDLYGKSAASDDLSNDAATPDLSPPSSSPPHTPPP CG4405-RB QQSNPQMNPAYQFQQQQPPGQAKINPNLNANLKQNQAPNQNQTQMPFGSGTNQVTVSPQQ : ENSMUST00000017961 KRPRPGASKDGL--LSPGSWNGE-----------------------PGGEGSRPATPSDG ENST00000278973 KRPRPGVSKDGL--LSPGAWNGE-----------------------PSGEGSRSVTPSEG SINFRUP00000149143 SPGIISKEHPKL--LSPGSWNED-----------------------KISKGAGSRGNSK- ENST00000220810 -ASSPKPLKKQN--PSSGARLNQ-----------------------------------DK ENSMUST00000038382 QPSSPEPSKKQN--PSPGARLSQ-----------------------------------DK SINFRUP00000161000 ------------------------------------------------------------ SINFRUP00000129869 SPTTVKNTFNKI--PASVAAPEK-----------------------------------EN ENST00000284262 --APAARNKVAH--FSRQVSVDE-----------ERGGDIQMLLEGRAGDCARSSWGEEQ SINFRUP00000134219 PARPSQHRKTAR--FHRQSAVDHGDRGKYAGQLGEKGGEIQLLVEEGSVEGGGKGEQFKS CG4405-RB QQLLQQQQQQQQQQLLQQQQLQQQQQLQQQHQGLQQQPSLHASPTHNASNLLRRASQMQQ ENSMUST00000017961 AGRRSPARPASEHMAIEALQPPPAPSQEPE------------------------------ ENST00000278973 AGRRSPARPATERMAIEALQAPPAPSREPE------------------------------ SINFRUP00000149143 PNSRSSSRPSTPSTSAPTSAGPEGGGAPNG------------------------------ ENST00000220810 RSVADEQVTAIVNKPLMSKAPTKEAG---------------------------------- ENSMUST00000038382 QSLAEEQVTAFVNKPSMSKAPAKELG---------------------------------- SINFRUP00000161000 ------------------------------------------------------------ SINFRUP00000129869 KTPTPETLSAGIPKAASKLNQSQEVK---------------------------------- ENST00000284262 AGGSRGVRSGALRGGLLVDDFRTRGSGRKQ-PGNPKPRE--------------------- SINFRUP00000134219 SNLSEDKKKGLLSKGVVSGRKTNRANGHKHSPSNHKSREHGSSNHRQTKAN--------- CG4405-RB QQIQETAAAAAMAANAAAMAAAQQQQRSGRPPMLGQMGQQSSIDHFDHYKRPPSRDSSID ENSMUST00000017961 ---VAMYRGYHSYAVRTGPPEPPPLEDEQEPEP--------------------------- ENST00000278973 ---VALYQGYHSYAVRTTPPEPPPFEDQ-------------------------------- SINFRUP00000149143 ---RGPSRTPSQHTAKVTPKAPEPKLPVFKANQ--------------------------- ENST00000220810 -----AVVPQSKYSGRHHIPNPSNG----------------------------------- ENSMUST00000038382 -----ASV--SKYSGRHHVPNPSNG----------------------------------- SINFRUP00000161000 ------------------------------------------------------------ SINFRUP00000129869 -----QAQYPHSVKP-TLSSYPSNG----------------------------------- ENST00000284262 --RRTESPPVFTWTSHHRASNHSPGGSRLLELQ--------------------------- SINFRUP00000134219 --RWVQSSSSASWTSGQQSLQGRSG--QLLEQD--------------------------- CG4405-RB RYARAASRLSGAFAGSRQASLDRSGIADPVTNGGTSTPDGRPRAGSVFRGSTPQPGAGTS ENSMUST00000017961 ------------------------------------------------------------ ENST00000278973 ------------------------------------------------------------ SINFRUP00000149143 ------------------------------------------------------------ ENST00000220810 ------------------------------------------------------------ ENSMUST00000038382 ------------------------------------------------------------ SINFRUP00000161000 ------------------------------------------------------------ SINFRUP00000129869 ------------------------------------------------------------ ENST00000284262 ------------------------------------------------------------ SINFRUP00000134219 ------------------------------------------------------------ CG4405-RB TMTGNGSLPSGNGGGRLSRAGTPSLGAGGRAPSQGKTEPLFSSPNQPFEDVLLRQRTLGQ ENSMUST00000017961 ---EPEPEVRRSDSAPPSPVSATVPEEEPPAPR-SPVPAKQATLEPKPIVPKAEPKAKAR ENST00000278973 ----PEPEVSGSESAPSSPATAPLQAPTLRGP--EPARETPAKLEPKPIIPKAEPRAKAR SINFRUP00000149143 ---EPDALTPQGRGEPREGSRPSSKAEAKTFPRRQPSPAPPPKPAPPKPASKPEPKPAPH ENST00000220810 ----ELHSQYHGYYVKLNAPQHPPVDVEDGDGSSQSSSALVHKPSANKWSPS-KSVTKPV ENSMUST00000038382 ----ELHSQYHGYYVKLNTPQHPPEDREDDRGVSQSSSALVPRPSPNKWGPP-KSVTKPV SINFRUP00000161000 ------------------------------------------------------------ SINFRUP00000129869 ----QIHSQYHGYYVKAEVKVPPPEE---------------------------------- ENST00000284262 ---EEKLSNYRMEMKPLLRMETHPQKRRYSKGGACRGLGDDHRPEDRGFGVQ-RLRSKAQ SINFRUP00000134219 ---EEKISNYGMEMKPLQPRDSSTHK-AHGPGDKRRGHG--HR-EGGSSTGQ-RQRLKNR CG4405-RB DIIPSPSQPKRTESLYLPAKPATPVGMAMGGKGGGGGGGKKMKSVPINVTLQRKKSMPDF ENSMUST00000017961 KTEARGLS---KAGAKKKGRKE-VAQAKEAEVEVEEVPNTVLICMVILLN---------- ENST00000278973 KTEARGLT---KAGAKKKARKE-AALAAEAEVEVEEVPNTILICMVILLN---------- SINFRUP00000149143 PVEAKAAVEKPKAEPKQKVVISGPSSERGPELEELEGPNTIMICMVILLN---------- ENST00000220810 AKESKAEPKAKKSELAIPKNPASNDSCPALEKEANSGPNSIMIVLVMLLN---------- ENSMUST00000038382 AKESKTEPKAKKSELAIPKNPASNDTCPSLEKEANSGPNSIMIVLVMLLN---------- SINFRUP00000161000 ------------------------------------------------------------ SINFRUP00000129869 ------------------------------------------------------------ ENST00000284262 NKENFRPASSAEPAVQKLASLRLGGAEPRLLRWDLTFSPPQKSLPVALESDEENGDELKS SINFRUP00000134219 DGRDVREEKEAG---RERTSEKM---EPRAVRRDLTLPPPLQSSPMTLE----------- CG4405-RB QELPRATEAMSREEVSALGSARREAVRRQIEVNERLKANPLLYLVSPQVKDWFVR----- ENSMUST00000017961 ----------------IGLAILFVHLLT ENST00000278973 ----------------IGLAILFVHLLT SINFRUP00000149143 ----------------IGLAILFVHILS ENST00000220810 ----------------IGLAILFVHFLT ENSMUST00000038382 ----------------IGLAILFVHFLT SINFRUP00000161000 ---------------------------- SINFRUP00000129869 ---------------------------- ENST00000284262 STGSAPILVVMVILLNIGVAILFINFFI SINFRUP00000134219 ---------------------------- CG4405-RB -----QQLMLLVLIFNVALALLFVYMLT : : :::: ::