CLUSTAL W (1.82) multiple sequence alignment


ENST00000216392         CPAAQRLRPHFQLSAQPAAQPAAPAMAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRH
ENSMUST00000021469      -------------------------MAKPLTDQEKRRQISIRGIVGVENVAELKKGFNRH
SINFRUP00000143844      -------------------------MAKPLTDQEKRKQISIRGIVEVENVAELKKGFNRH
ENST00000164139         -------------------------MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRH
ENSMUST00000035269      -------------------------MSRPLSDQDKRKQISVRGLAGVENVSELKKNFNRH
ENST00000216962         -------------------------MAKPLTDSEKRKQISVRGLAGLGDVAEVRKSFNRH
ENSMUST00000045441      -------------------------MAKPLTDSERQKQISVRGIAGL-DVAEVRKSFNRH
ci0100143704            --------------------------SKPVTDQEKRKQISVRGIASLEGVSDIKKSFNRH
CG7254-RA               -------------------------MSKPQSDADRRKQISVRGIAEVGNVTEVKKNFNRH
                                                 :::* :* ::::***:**:. : .*::::*.****

ENST00000216392         LHFTLVKDRNVATTRDYYFALAHTVRDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRT
ENSMUST00000021469      LHFTLVKDRNVATPRDYYFALAHTVRDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRT
SINFRUP00000143844      LHFTLVKDRNIATPRDYYFALAHTVRDHLVGRWIRTQQFYYETDPKRVYYLSLEFYMGRT
ENST00000164139         LHFTLVKDRNVATPRDYYFALAHTVRDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRT
ENSMUST00000035269      LHFTLVKDRNVATPRDYYFALAHTVRDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRT
ENST00000216962         LHFTLVKDRNVATPRDYFFALAHTVRDHLVGRWIRTQQHYYERDPKRIYYLSLEFYMGRT
ENSMUST00000045441      LHFTLVKDRNVATPRDYFFALAHTVRDHLVGRWIRTQQHYYERDPKRIYYLSLEFYMGRT
ci0100143704            LHYTLVKDRNVATGRDYYFALANTVRDQMVGRWIRTQQYYYEKDPKRVYYLSLEFYMGRA
CG7254-RA               LHYTLVKDRNVSTLRDYYFALANTVKDNMVGRWIRTQQHYYEKDPKRVYYLSLEYYMGRS
                        **:*******::* ***:****:**:*::*********.**:  ***:******:****:

ENST00000216392         LQNTMINLGLQNACDEAIYQLGLDIEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAA
ENSMUST00000021469      LQNTMINLGLQNACDEAIYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAA
SINFRUP00000143844      LQNTMINLGLQNACDEAIYQLGLDMEELEEMEEDAGLGNGGLGRLAACFLDSMATLGLAA
ENST00000164139         LQNTMVNLALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAA
ENSMUST00000035269      LQNTMVNLALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAA
ENST00000216962         LQNTMVNLGLQNACDEAIYQLGLDLEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAA
ENSMUST00000045441      LQNTMVNLGLQTACDEATYQLGLDLEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAA
ci0100143704            LQNTMLNLGIQSSCDEAMYQLGLDIEELEELEEDAGLGNGGLGRLAACFLDSMATLGLAS
CG7254-RA               LTNTMINLGIQSECEEAMYQLGLDIENLEEMEEDAGLGNGGLGRLAACFLDSMATLGLAA
                        * ***:**.::. *:** ******:*:***:****************************:

ENST00000216392         YGYGIRYEYGIFNQKIRDGWQVEEADDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTG--
ENSMUST00000021469      YGYGIRYEYGIFNQKIREGWQVEEADDWLRHGNPWEKARPEFMLPVHFYGRVEHTQTG--
SINFRUP00000143844      YGYGIRYEYGIFNQKIRGGWQVEEADDWLRHGNPWEKARPEYMLPVHFYGRVEETKSG--
ENST00000164139         YGYGIRYEFGIFNQKISGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGHVEHTSQG--
ENSMUST00000035269      YGYGIRYEFGIFNQKICGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQG--
ENST00000216962         YGYGIRYEFGIFNQKIVNGWQVEEADDWLRYGNPWEKARPEYMLPVHFYGRVEHTPDG--
ENSMUST00000045441      YGYGIRYEFGIFNQKIVNGWQVEEADDWLRYGNPWEKARPEYMLPVHFYGRVEHTPDG--
ci0100143704            YGYGIRYEYGIFNQKIREGWQVEEADDWLRYGNAWDKARPEYMVPVHFFGNVEHGPDGDW
CG7254-RA               YGYGIRYEYGIFAQKIKNGEQVEEPDDWLRYGNPWEKARPEFMLPVNFYGRVIDTPEG--
                        ********:*** ***  * *:**.*****:**.*:*:***: :**:*:*.* .   *  

ENST00000216392         ---TKWIDTQVVLALPYDTPVPGYMNNTVNTMRLWSARAPNDFNLRDFNVGDYIQAVLDR
ENSMUST00000021469      ---TKWVDTQVVLALPYDTPVPGYMNNTVNTMRLWSARAPNDFNLQDFNVGDYIQAVLDR
SINFRUP00000143844      ---SKWVDTQVVLAMPYDTPIPGYMNNTVNTMRLWSARAPNDFNLRDFNVGDYIQAVLDR
ENST00000164139         ---AKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLKDFNVGGYIQAVLDR
ENSMUST00000035269      ---AKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLKDFNVGGYIQAVLDR
ENST00000216962         ---VKWLDTQVVLAMPYDTPVPGYKNNTVNTMRLWSAKAPNDFKLQDFNVGDYIEAVLDR
ENSMUST00000045441      ---VLWLDTQVVLAMPYDTPVPGYKNNTVNTMRLWSAKAPNDFKLKDFNVGDYIEAVLDR
ci0100143704            SKPCKWVNSQVVFAMPYDTPTPGYGNNTVNTLRLYTAKSPNSFNLGVFNTGDYIQAVCDR
CG7254-RA               ---KKWVDTQRVFAMPYDNPIPGYNNNHVNTLRLWSAKSPIDFNLKFFNDGDYIQAVLDR
                             *:::* *:*:***.* *** ** ***:**::*::* .*:*  ** *.**:** **

ENST00000216392         NLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKASKFGSTRGAGTVFDAF
ENSMUST00000021469      NLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDVIRRFKASKFGSKDGMGTVFDAF
SINFRUP00000143844      NLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKTTKKESPG--RTSFEGF
ENST00000164139         NLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTNFDAF
ENSMUST00000035269      NLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGSRDPVRTNFDAF
ENST00000216962         NLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGCRDPVRTCFETF
ENSMUST00000045441      NLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSRFGCRDPVRTCFETF
ci0100143704            NLAENISRVLYPNDNFFEGKELRLKQEYFVVCATLQDIIRRFKSSIFGCRDPVRTSFDAF
CG7254-RA               NLAENISRVLYPNDNFFEGKELRLKQEYFMCAATLQDIIRRYKASKFGSREAVRNTFDHF
                        *****************************: .*****:***:*::   .     . *: *

ENST00000216392         PDQVAIQLNDTHPALAIPELMRIFVDIEKLPWSKAWELTQKTFAYTNHTVLPEALERWPV
ENSMUST00000021469      PDQVAIQLNDTHPALAIPELMRIFVDIEKLPWAKAWEITKKTFAYTNHTVLPEALERWPV
SINFRUP00000143844      PEKVAIQLNDTHPAMAIPELMRIFVDIEKLDWDTAWDLTRRTFAYTNHTVLPEALERWPV
ENST00000164139         PDKVAIQLNDTHPSLAIPELMRILVDLERMDWDKAWDVTVRTCAYTNHTVLPEALERWPV
ENSMUST00000035269      PDKVAIQLNDTHPSLAIPELMRILVDLERLDWDKAWDVTVKTCAYTNHTVLPEALERWPV
ENST00000216962         PDKVAIQLNDTHPALSIPELMRILVDVEKVDWDKAWEITKKTCAYTNHTVLPEALERWPV
ENSMUST00000045441      PDKVAIQLNDTHPALSIPELMRILVDVEKVDWDKAWEITKKTCAYTNHTVLPEALERWPV
ci0100143704            PDKVAIQLNDTHPSLAIPELMRLLIDIEEMEWDRAWKIVVNTCAYTNHTVLPEALERWPV
CG7254-RA               PDKVAIQLNDTHPSLAIPELMRILVDEEHLTWEKAWDITVRSCAYTNHTVLPEALERWPV
                        *::**********:::******:::* *.: *  **.:. .: *****************

ENST00000216392         DLVEKLLPRHLEIIYEINQKHLDRIVALFPKDVDRLRRMSLIEEEGSKRINMAHLCIVGS
ENSMUST00000021469      ELVEKLLPRHLEIIYEINQKHLDRIVALFPKDISRMRRMSLIEEEGGKRINMAHLCIVGC
SINFRUP00000143844      DLLETLLPRHLQIIYQINQIHLDRIAALYPEDMDKLRTMSLIEEDGCKRVNMAHLCIVGS
ENST00000164139         HLLETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGS
ENSMUST00000035269      HLMETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGS
ENST00000216962         SMFEKLLPRHLEIIYAINQRHLDHVAALFPGDVDRLRRMSVIEEGDCKRINMAHLCVIGS
ENSMUST00000045441      SMFEKLLPRHLEIIYAINQRHLDHVAALFPGDVDRLRRMSVIEEGDCKRINMAHLCVIGS
ci0100143704            HLMEKMLPRHLEIIYMINQKHIENISKHFPGDFDRLRRMSLVEEDGEKRINMAHLCIVGS
CG7254-RA               SLLESILPRHLQIIYHINFLHMENVKKKFPDDLDRMRRMSMVEEDGEKRINMAHLSIVGS
                         :.*.:*****:*** **  .::.:   :* *..::* **::**   **:*****.: *.

ENST00000216392         HAVNGVAKIHSDIVKTKVFKDFSEL-----EPDKFQNKTNGITPRRWLLLCNPGLAELIA
ENSMUST00000021469      HAVNGVAKIHSDIVKTQVFKDFSEL-----EPDKFQNKTNGITPRRWLLLCNPGLADLIA
SINFRUP00000143844      HAVNGVAEIHSNIIKTQVFRNFSDL-----EPKKFQNKTNGITPRRWLLLCNPGLAELIA
ENST00000164139         HAVNGVARIHSEILKKTIFKDFYEL-----EPHKFQNKTNGITPRRWLVLCNPGLAEVIA
ENSMUST00000035269      HAVNGVARIHSEILKKTIFKDFYEL-----EPHKFQNKTNGITPRRWLVLCNPGLAEVIA
ENST00000216962         HAVNGVARIHSEIVKQSVFKDFYEL-----EPEKFQNKTNGITPRRWLLLCNPGLADTIV
ENSMUST00000045441      HAVNGVARIHSEIVKQSVFKDFYEL-----EPEKFQNKTNGITPRRWLLLCNPGLAEIIV
ci0100143704            HAVNGVAAIHSKIIQDSVFKDFVELSEKMGEVNKFQNKTNGITPRRWLLLCNPGLADLIA
CG7254-RA               HAVNGVAAIHSQILKDSLFHDFYEM-----EPQKFQNKTNGITPRRWLLLCNPGLSDLIA
                        ******* ***.*::  :*::* ::     * .***************:******:: *.

ENST00000216392         EKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQENKLKFSQFLETEYKVKINPSSMFD
ENSMUST00000021469      EKIGEDYVKDLSQLTKLHSFVSDDIFLREIAKVKQENKLKFSQFLEKEYKVKINPSSMFD
SINFRUP00000143844      EVIGEDYVKELSQLQKLNDFVDDAAFIRDVSKVKQDNKVKFGQYLEQEYRVKINPASMFD
ENST00000164139         ERIGEDFISDLDQLRKLLSFVDDEAFIRDVAKVKQENKLKFAAYLEREYKVHINPNSLFD
ENSMUST00000035269      ERIGEDYISDLDQLRKLLSYVDDEAFIRDVAKVKQENKLKFSAYLEREYKVHINPNSLFD
ENST00000216962         EKIGEEFLTDLSQLKKLLPLVSDEVFIRDVAKVKQENKLKFSAFLEKEYKVKINPSSMFD
ENSMUST00000045441      ERIGEGFLTDLSQLKKLLSLVDDEAFIRDVAKVKQENKLKFSAQLEKEYKVKINPASMFD
ci0100143704            EKIGEDWPKNLDQLRELTPLIDNPTFIRSIGQVKQENKMKLARFIKKEWNIDVNVASMFD
CG7254-RA               EKIGDEWPVHLDQLVALKKWAKDPNFQRNVARVKQENKLKLAAILEKDYGVKINPSSMFD
                        * **: :  .*.**  *     :  * *.:.:***:**:*:.  :: :: :.:*  *:**

ENST00000216392         VQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFVPRTVIIGGKAAPGYHMAKMIIKLIT
ENSMUST00000021469      VHVKRIHEYKRQLLNCLHVITMYNRIKKDPKKFFVPRTVIIGGKAAPGYHMAKMIIKLIT
SINFRUP00000143844      VHVKRIHEYKRQLLNCLHIIVMYNRIRKNPAAPFVPRTVIIGGKAAPGYHMAKMIIKLIT
ENST00000164139         IQVKRIHEYKRQLLNCLHVITLYNRIKREPNKFFVPRTVMIGGKAAPGYHMAKMIIRLVT
ENSMUST00000035269      VQVKRIHEYKRQVLNCLHIITLYNRIKREPNRFMVPRTIMIGGKAAPGYHMAKMIIKLIT
ENST00000216962         VHVKRIHEYKRQLLNCLHVVTLYNRIKRDPAKAFVPRTVMIGGKAAPGYHMAKLIIKLVT
ENSMUST00000045441      VHVKRIHEYKRQLLNCLHIITLYNRIKKDPAKAFVPRTVMIGGKAAPGYHMAKMIIKLVT
ci0100143704            VQVKRIHEYKRQLMNALHIVVMYNRIKANPNKEFVPRTVMIGGKAAPGYHTAKMIIKLIN
CG7254-RA               IQVKRIHEYKRQLLNCLHIITLYNRIKKDPTANFTPRTIMIGGKAAPGYYVAKQIIKLIC
                        ::**********::*.**::.:****: :*   :.***::*********: ** **:*: 

ENST00000216392         SVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPATDLSEQISTAGTEASGTGNMKFMLN
ENSMUST00000021469      SVAEVVNNDPMVGSKLKVIFLENYRVSLAEKVIPATDLSEQISTAGTEASGTGNMKFMLN
SINFRUP00000143844      SVAEVVNNDPVVGNKLKVIFLENYRVSLAEKVIPATDLSEQISTAGTEASGTGNMKFMLN
ENST00000164139         AIGDVVNHDPAVGDRLRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLN
ENSMUST00000035269      AIGDVVNHDPAVGDRLRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLN
ENST00000216962         SIGDVVNHDPVVGDRLKVIFLENYRVSLAEKVIPAADLSQQISTAGTEASGTGNMKFMLN
ENSMUST00000045441      SIGDVVNHDPVVGDRLRVIFLENYRVSLAEKVIPAADLSQQISTAGTEASGTGNMKFMLN
ci0100143704            NIAAMVNHDPIVGDKLKVVYLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLN
CG7254-RA               AVGNVVNNDPIVGDKLKVIFLENYRVTLAEKIMPAADLSEQISTAGTEASGTGNMKFQLN
                         :. :**:** **.:*:*::******:****::**:***:***************** **

ENST00000216392         GALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVAALDKKGYEAKEYYEALPELKLVIDQ
ENSMUST00000021469      GALTIGTMDGANVEMAEEAGEENLFIFGMRVDDVAALDKKGYEAKEYYEALPELKLVIDQ
SINFRUP00000143844      GALTIGTMDGANVEMAEEAGEENLFIFGMRVEDVAELDKKGYDAMLYYSKIPELKQVMDQ
ENST00000164139         GALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVDKLDQRGYNAQEYYDRIPELRQVIEQ
ENSMUST00000035269      GALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVERLDQRGYNAQEYYDRIPELRQIIEQ
ENST00000216962         GALTIGTMDGANVEMAEEAGAENLFIFGLRVEDVEALDRKGYNAREYYDHLPELKQAVDQ
ENSMUST00000045441      GALTIGTMDGANVEMAEEAGEENLFIFGMRVEDVEALDQKGYNAREFYERLPELRQAVDQ
ci0100143704            GALTIGTLDGANVEMAEEMNGENIFIFGMKVHEVEELDKAGYNARQFYESVPELKTALDQ
CG7254-RA               GALTIGTLDGANVEMAEEMGLDNIFIFGMTVDEVEALKKKGYNAYDYYNANPEVKQVIDQ
                        *******:********** . :*:****: :.:*  *.: **:*  :*.  **::  ::*

ENST00000216392         IDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEAYVKCQDKVSQLYMNPKAWNTMVLKN
ENSMUST00000021469      IDNGFFSPNQPDLFKDIINMLFYHDRFKVFADYEAYVKCQEKVSQLYMNQKAWNTMVLKN
SINFRUP00000143844      ITSGFFCPKNPELFKDLTNMLFKHDRFKVFADF---------------------------
ENST00000164139         LSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEDYIKCQEKVSALYKNPREWTRMVIRN
ENSMUST00000035269      LSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEEYIKCQDKVSELYKNPREWTRMVIRN
ENST00000216962         ISSGFFSPKEPDCFKDIVNMLMHHDRFKVFADYEAYMQCQAQVDQLYRNPKEWTKKVIRN
ENSMUST00000045441      ISSGFFSPKDPDCFKDVVNMLMYHDRFKVFADYEAYIQCQAQVDRLYRNSKEWTKKVIRN
ci0100143704            ISSGYFNPMEADQFTHFVENLINHDRFKLLADFKAYVECQDRVSEAFKDTEKWTKMCLAN
CG7254-RA               IQGGFFSPGNPNEFKNIADILLKYDHYYLLADYDAYIKAQDLVSKTYQNQAKWLEMSINN
                        : .*:* * :.: *... : *: :*:: ::**:                           

ENST00000216392         IAASGKFSSDRTIKEYAQNIWNVEP-SDLKISLSNES-NKVNGN--
ENSMUST00000021469      IAASGKFSSDRTIKEYAKDIWNMEP-SDLKISLSNESSNGVSANGK
SINFRUP00000143844      ----------------------------------------------
ENST00000164139         IATSGKFSSDRTIAQYAREIWGVEP-SRQRLPAPDEAI--------
ENSMUST00000035269      IATSGKFSSDRTIAQYAREIWGVEP-SRQRLPAPDEKI--------
ENST00000216962         IACSGKFSSDRTITEYAREIWGVEP-SDLQIPPPNIPRD-------
ENSMUST00000045441      IACSGKFSSDRTITEYAREIWGVEP-SDLQIPPPNLPKD-------
ci0100143704            IAASGKFSSDRTISQYAREIWGVEPQPDLKIPAPHEPL--------
CG7254-RA               IASSGKFSSDRTIAEYAREIWGVEP-TWEKLPAPEDQPQN------