CLUSTAL W (1.82) multiple sequence alignment ENST00000323550 MDEPPFSEAALEQALGEPCDLDAALLTDIEDMLQLINNQDSDFPGLFD-PPYAGSGAGGT ENSMUST00000020846 MDELAFGEAALEQTLAEMCELDTAVLNDIEDMLQLINNQDSDFPGLFD-APYAGGETGDT SINFRUP00000141113 ------------------------------DMLQLINNQEMEFGGLFDNPPYTGLPTPQE ENSMUST00000023100 ------------------------------EMLQFVSNQVGEFPDLFSEQLCSSFPGGGS ENST00000263250 -MDDSGELGGLETMETLTELGDELTLGDIDEMLQFVSNQVGEFPDLFSEQLCSSFPGSG- CG8522-RA ---------------------------MDTTLMNLIDAPLDESMDLFKAEDVFEP----- : : : :::::. : .**. ENST00000323550 DPASPDTSSPGSLSPPPATLSSSLEAFLSGPQAAPSPLSPPQPAPTPLKMYPSMPAFSPG ENSMUST00000020846 GPSSPGANSPESFS--SASLASSLEAFLGGPKVTPAPLSPPPSAPAALKMYPSVSPFSPG SINFRUP00000141113 LPSLTQGVSPAPPTITTAAPPSSSSSILSSSPHLDALLGPPIIRTSSNSFQHPTFQQSPL ENSMUST00000023100 NGGS-GNNSSGRGNNGGATDPAVQRSFS---QVPLSTFSPSAASPQAPALQVKVSPTPPR ENST00000263250 ---------------GSAVDPSVQRSFT---QVTLPSFSPSAASPQAPTLQVKVSPTSVP CG8522-RA --------------FDADLHSDMLDIILNDMDLAPTQMYNMLLDEPRTHTQQTQSVDQQP . : . : ENST00000323550 PGIKEESVPLSILQTPTPQP-LPGALLPQSFPAPA-PPQFSSTPVLGYPSPPGGFSTGSP ENSMUST00000020846 PGIKEEPVPLTILQPAAPQP-SPGTLLPPSFPAP--PVQLSPAPVLGYSSLPSGFS-GTL SINFRUP00000141113 TQVSSPTQRQQTATPKVPSVEQPKTNLSPSSPVQASCPHGSPGPNPGVTSTPHGVFTSPA ENSMUST00000023100 ATPVLQPRPQPQPQPPAQLQ-QQTVMITPT---------FSTAPQTRIIQQPLIYQNAAT ENST00000263250 TTPRATP--------------ILTVMITPT---------FSTTPQTRIIQQPLIYQNAAT CG8522-RA QSVEQQPHVKSEHSSPVHIKEELHQQQQQSPLLVYKPDPLIATSYNCPQQQPTGLLKAAQ . : . . . * .. ENST00000323550 PGN---TQQPLPGLPLASPPG-VPP-VSLHTQVQSVVPQQLLTVTAAPTAA----PVTTT ENSMUST00000020846 PGN---TQQPPSSLPLAPAPG-VLPTPALHTQVQSLASQQPLPASAAP--------RTNT SINFRUP00000141113 PQIGSPSTVTQTTLSLSSSPSNVQPAVTVQTQLQGLTTTSPLLATSTS-------MPTQT ENSMUST00000023100 SFQ----VLQPQVQSLVTSPQ-VQP-VTIQQQVQTVQAQRVLTQTANGTLQTLAPATVQT ENST00000263250 SFQ----VLQPQVQSLVTSSQ-VQP-VTIQQQVQTVQAQRVLTQTANGTLQTLAPATVQT CG8522-RA PTAT---IHHMDAQRMPPNTAVYPPSLGSSFVYQSMSPPTSPVESANQNVN-----VMQP . : . . * * : . :: . ENST00000323550 VTS-QIQQVPVLLQPHFIKADSLLLTAMKTDG-ATVKAAGLSPLVSGTT-VQTGPLPT-- ENSMUST00000020846 VTS-QVQQVPVVLQPHFIKADSLLLTAVKTDAGATVKTAGISTLAPGTA-VQAGPLQT-- SINFRUP00000141113 ITS-HVQQVPVLLQPQFIKAESVLLTTLKHDPCMVTTVA-----TTTTP-VQSTSLQA-- ENSMUST00000023100 VAAPQVQQVPVLVQPQIIKTDSLVLTTLKTDGSPVMAAVQNPALTALTAPIQTAALQVPT ENST00000263250 VAAPQVQQVPVLVQPQIIKTDSLVLTTLKTDGSPVMAAVQNPALTALTTPIQTAALQVPT CG8522-RA VAATPAPASAPLPQQSYPQPFITYNSKAGMTSDEAMYFLLQPTVASPTPSPPVAPPPT-- ::: . : * :. : . :.. *. . . ENST00000323550 LVSG-GTILATVPLVVDAEKLPINRLAAGSKAPASAQSRGEKRTAHNAIEKRYRSSINDK ENSMUST00000020846 LVSG-GTILATVPLVVDTDKLPIHRLAAGSKALGSAQSRGEKRTAHNAIEKRYRSSINDK SINFRUP00000141113 FMGG-GTILTTVPLMVDTDKLPINRIAIAGKLAGQP-HKGEKRTAHNAIEKRYRSSINDK ENSMUST00000023100 LVGSNGTILTTMPVMMGQEKVPIKQVPGGVKQLDPP-KEGERRTTHNIIEKRYRSSINDK ENST00000263250 LVGSSGTILTTMPVMMGQEKVPIKQVPGGVKQLEPP-KEGERRTTHNIIEKRYRSSINDK CG8522-RA STGSRASKVRVAPLAPSPAAMEVQGKVP--INRVQPKVKEVKRSAHNAIERRYRTSINDK .. .: : . *: . : :: . . :*::** **:***:***** ENST00000323550 IIELKDLVVGTEAKLNKSAVLRKAIDYIRFLQHSNQKLKQENLSLRTAVHKS---KSLKD ENSMUST00000020846 IVELKDLVVGTEAKLNKSAVLRKAIDYIRFLQHSNQKLKQENLTLR-SAHKS---KSLKD SINFRUP00000141113 IIELKDLVAGTEAKLNKSAVLKKAIDYIRYMQQTNQKLKQENMALKMAAQKN---KSLKD ENSMUST00000023100 IIELKDLVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLKLANQKN---KLLKG ENST00000263250 IIELKDLVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLKLANQKN---KLLKG CG8522-RA INELKNLVVGEQAKLNKSAVLRKSIDKIRDLQRQNHDLKAELQRLQRELMARDGSKVKDL * ***:** * :**::**.**:*:** *: :*: *:.*: * *: * . ENST00000323550 LVSACGSGGNTDVLMEGVKTEVEDTLTPPPSDAGSPFQSSPLSLGSRGSGSGGSGSDSEP ENSMUST00000020846 LVSACGSGGGTDVSMEGMKPEVVETLTPPPSDAGSPSQSSPLSFGSRASSSGGS--DSEP SINFRUP00000141113 LV---------AMEVDNVTDEKNVLPTPPASDVG-----SPTSFSQCGS-------DSEP ENSMUST00000023100 IDLGSLVDSDVDLKIDDFN-QNVLLMSPPASDSGSQAGFSPYSID------------SEP ENST00000263250 IDLGSLVDNEVDLKIEDFN-QNVLLMSPPASDSGSQAGFSPYSID------------SEP CG8522-RA LQLGTRPGRASKKRRESSQTFTTDAGLTPPRSDESDPSLSPMHSDISLPPSPYG--GSTA : :. .*. . ** . * . ENST00000323550 DSPVFEDSKAKPEQRPSLHSRGMLDRSRLALCTLVFLCLSCNPLASLLGARGLPSPSD-- ENSMUST00000020846 DSPAFEDSQVKAQRLPS-HSRGMLDRSRLALCVLAFLCLTCNPLASLFG-WGILTPSD-- SINFRUP00000141113 DSPMAEDTKVN-------FAGGMLDRTRMALCAFTFFFLSLNPLATLFFSSGSSSSAEGA ENSMUST00000023100 GSPLLDDAKVKDEPDSPPVALGMVDRSRILLCVLTFLGLSFNPLTSLLQWGGAHNTDQ-- ENST00000263250 GSPLLDDAKVKDEPDSPPVALGMVDRSRILLCVLTFLCLSFNPLTSLLQWGGAHDSDQ-- CG8522-RA SCSSGSSSSNEEPLVVPSSMRGMATHSRLGLCMFMFAILAVNPFKTFLQRGHYDSNDD-- ... ..:. : ** ::*: ** : * *: **: ::: : ENST00000323550 TTSVYHSPGRNVLGTE-SRDGPGWAQWLLP-PVVWLLNGLLVLVSLVLLFVYGEPVTRPH ENSMUST00000020846 ATGTHRSSGRSMLEAE-SRDGSNWTQWLLP-PLVWLANGLLVLACLALLFVYGEPVTRPH SINFRUP00000141113 ASVSTHHAGRTMLGVDVAADSWGWMDWMLPTILVWLLNGVLVSGVLIRLLVYGEPVTRPH ENSMUST00000023100 --HPYSGSGRSVLSLE--SGAGGWFDWMVPTLLLWLVNGVIVLSVFVKLLVHGEPVIRPH ENST00000263250 --HPHSGSGRSVLSFE--SGSGGWFDWMMPTLLLWLVNGVIVLSVFVKLLVHGEPVIRPH CG8522-RA --LGDMSGQRRILSYD--VEGEGFAVWQQS-SWIWLLNFTLMLGCLVKLLVYGDPQLDAQ * :* : . .: * . :** * :: : *:*:*:* .: ENST00000323550 SGPAVYFWRHRKQADLDLARGDFAQAAQQLWLALRALGRPLPTSHLDLACSLLWNLIRHL ENSMUST00000020846 SGPAVHFWRHRKQADLDLARGDFPQAAQQLWLALQALGRPLPTSNLDLACSLLWNLIRHL SINFRUP00000141113 SGSSVLFWRHRKQADRDLARGDFAQASQNLWTCLKALGRPLPTSQLDLACAALWSLLRFC ENSMUST00000023100 SRPSVTFWRHRKQADLDLAKGDFAAAAANLQTCLSVLGRALPTSRLDLACSLSWNVIRYS ENST00000263250 SRSSVTFWRHRKQADLDLARGDFAAAAGNLQTCLAVLGRALPTSRLDLACSLSWNVIRYS CG8522-RA TD---AYCQHRQRADFYFSQGQSSQAYAGYLNCLHMFGLSLPASRLECYLQTTWQFLRFL : : : :**::** :::*: . * .* :* .**:*.*: *..:*. ENST00000323550 LQRLWVGRWLAGRAGGLQ-----QDCALRVDASASARDAALVYHKLHQLHTMGKH-TGGH ENSMUST00000020846 LQRLWVGRWLAGQAGGLL-----RDRGLRKDARASARDAAVVYHKLHQLHAMGKY-TGGH SINFRUP00000141113 LQRLWVGRWLATRAGRLR-----SDRPLQEDACKSNRDAALVYHRLHQLHMTGKL-NGSH ENSMUST00000023100 LQKLRLVRWLLKKVFQRWRATPATAAGFEDEAKSSARDAALAYHRLHQLHITGKLPAGSA ENST00000263250 LQKLRLVRWLLKKVFQCRRATPATEAGFEDEAKTSARDAALAYHRLHQLHITGKLPAGSA CG8522-RA FHRLWLGRVLSRRSGGLFS-----NAASRKQALASARELALLFNRLNQLQLTGNG-SRGD :::* : * * : . :* * *: *: :::*:**: *: . ENST00000323550 LTATNLALSALNLAECAGDAVSVATLAEIYVAAALRVKTSLPRALH-FLTRFFLSSARQA ENSMUST00000020846 LAASNLALSALNLAECAGDAISMATLAEIYVAAALRVKTSLPRALH-FLTRFFLSSARQA SINFRUP00000141113 LSAMHMALSAVNLAECAGSCLPVASLAEVYVSAALRVKASLPRILH-FTSRVFLSSGRQV ENSMUST00000023100 CSDVHMALCAVNLAECAEEKILPSTLIEIHLTAAMGLKTRCGGKLG-FLASYFLNRAQSL ENST00000263250 CSDVHMALCAVNLAECAEEKIPPSTLVEIHLTAAMGLKTRCGGKLG-FLASYFLSRAQSL CG8522-RA MNGIMMALFASNMAEVAHNLLTPRETICIHVMTALRMKRSAPKWLQQLFARYYMSRARQE :** * *:** * . : ::: :*: :* * : : ::. .:. ENST00000323550 CLAQ-SGSVPPAMQWLCHPVGHRFFVDGDWS---VLSTPWESLYSLAGNPVDPLAQVTQL ENSMUST00000020846 CLAQ-SGSVPLAMQWLCHPVGHRFFVDGDWA---VHGAPPESLYSVAGNPVDPLAQVTRL SINFRUP00000141113 CLSA-SGSVPPAMQWLCHPLGHRFFVAQLLR---ITHVN-----ASGTFPVDPLAQVTQA ENSMUST00000023100 CGPE-HSTVPDSLRWLCHPLGQKFFMERSWS---IKSAAKESLYCAQRSPADPIAQVHQA ENST00000263250 CGPE-HSAVPDSLRWLCHPLGQKFFMERSWS---VKSAAKESLYCAQRNPADPIAQVHQA CG8522-RA CGLTRATEQTQELRWAFTAYGYRYCATHVFTYDLSDSGEQDGFFTRLRNPCDPAAHVIKQ * . ::* . * :: : * ** *:* : ENST00000323550 FREHLLERALNCVTQPNPSPGSADGDKE---FSDALGYLQLLNSCSDAAGAPAYSFSISS ENSMUST00000020846 FREHLLERALNCIAQ--PSPGAADGDRE---FSDALGYLQLLNSCSDAAGAPACSFSVSS SINFRUP00000141113 FREHLLEKALYCMAQPCGDKNTNPGKGE---YADALEYLQLLISASDAAGATSQSFAIGS ENSMUST00000023100 FCKNLLERAVESLVKPQAKKKAGDQEEESCEFSSALEYLKLLHSFVDSVGFVTSPFSSSS ENST00000263250 FCKNLLERAIESLVKPQAKKKAGDQEEESCEFSSALEYLKLLHSFVDSVGVMSPPLSRSS CG8522-RA YREHLLFKAIQCLVGAGHKSGGLPTSSVS---GEAEQLQQQQHSGTIVSNVLKYTSLLKD : ::** :*: .:. . . ..* : * . . . ENST00000323550 SMATTTG-VDPVAKWWASLTAVVIHWLRRDEEAAERLCPLVEHLPRVLQES--ERPLPRA ENSMUST00000020846 SMAATTG-PDPVAKWWASLTAVVIHWLRRDEEAAERLYPLVEHIPQVLQDT--ERPLPRA SINFRUP00000141113 NMATVTGKLRSPLQWWSSIVVVIINWLQGDDAAAERLYPTVEHLPRSLLNA--ESLLPKA ENSMUST00000023100 VLRSALG-PDVICRWWTSAVTMAISWLQGDDAAVRSRFTEVERVPKALEVT--ESPLVKA ENST00000263250 VLKSALG-PDIICRWWTSAITVAISWLQGDDAAVRSHFTKVERIPKALEVT--ESPLVKA CG8522-RA TLWADEDERDTNVVWWADVLETAVHWLLGEDTLAEQLYGRIKQMPTQLQQCGENDHLPKA : : . **:. : ** :: .. ::::* * : * :* ENST00000323550 ALHSFKAARALLGCA----KAESGPASLTICEKASGYLQDSLATTP--ASSSIDKAVQLF ENSMUST00000020846 ALYSFKAARALLDHR----KVESSPASLAICEKASGYLRDSLASTP--TGSSIDKAMQLL SINFRUP00000141113 SLNIFRAVRALLS------KPENCQLSLSYSDKASALLRDSLNLGPHCHSSSLDKVVQLL ENSMUST00000023100 VFYTCRAMHASLSG-----KADGQQNSFCHCERASGHLWSSLNVSGTTSDPSLNHVIQLF ENST00000263250 IFHACRAMHASLPG-----KADGQQSSFCHCERASGHLWSSLNVSGATSDPALNHVVQLL CG8522-RA LHAVLRAKMILLKNNGNALDKSLKQLVNILCDESSVELQECLTVNRITDAKGIKLLFQLL :* * . . .:.:* * ..* .:. .**: ENST00000323550 LCDLLLVVRTSLWRQQQPPAPAPAAQGTSSRPQASALELRGFQRDLSSLRRLAQSFRPAM ENSMUST00000020846 LCDLLLVARTSLWQRQQSPASVQVAHGTSNGPQASALELRGFQHDLSSLRRLAQSFRPAM SINFRUP00000141113 LCDLLLVMRTNVWRLQQQGAKQPGSSCPSGVHQASPLELQGFQQDLSSLRKLAHSFRPAV ENSMUST00000023100 TCDLLLSLRTALWQKQAS-----ASQLLGETYHASGTELAGFQRDLGSLRRLAHSFRPAY ENST00000263250 TCDLLLSLRTALWQKQAS-----ASQAVGETYHASGAELAGFQRDLGSLRRLAHSFRPAY CG8522-RA TCDWLLETRTALWELEHMN------MEDDGFYQVPGEVLEKFQTDLNSLRNIVENIPNAQ ** ** ** :*. : . :.. * ** **.***.:...: * ENST00000323550 RRVFLHEATARLMAGASPTRTHQLLDRSLRRRAGPGGKGGAVAELEPR---PTRREHAEA ENSMUST00000020846 RRVFLHEATARLMAGASPARTHQLLDRSLRRRAGSSGKGGTTAELEPR---PTWREHTEA SINFRUP00000141113 RRLFLHEATARLMAGASPTRTHQLLDRSLRRRATPGAK---TDECEMR---PGQREQAEA ENSMUST00000023100 RKVFLHEATVRLMAGASPTRTHQLLEHSLRRRPTQNTK---HGEVDTW---PGQRERATA ENST00000263250 RKVFLHEATVRLMAGASPTRTHQLLEHSLRRRTTQSTK---HGEVDAW---PGQRERATA CG8522-RA SRIYLYEAVCRLMAGASPCPTQQLLDRSLRSRNAHSSIFCGSKDRRQQNFVGGERERASA :::*:**. ******** *:***::*** * . : **:: * ENST00000323550 LLLASCYLPPGFLSAPGQRVGMLAEAARTLEKLGDRRLLHDCQQMLMRLGGGTTVTSS ENSMUST00000020846 LLLASCYLPPAFLSAPGQRMSMLAEAARTVEKLGDHRLLLDCQQMLLRLGGGTTVTSS SINFRUP00000141113 VMLACRYLPPSFLSAPGQRVGMLADAARTLEKLGDKRTLHDCQQMIIKLGSGTTVTNS ENSMUST00000023100 ILLACRHLPLSFLSSPGQRAVLLAEAARTLEKVGDRRSCSDCQQMIVKLGGGTAIAAS ENST00000263250 ILLACRHLPLSFLSSPGQRAVLLAEAARTLEKVGDRRSCNDCQQMIVKLGGGTAIAAS CG8522-RA MYVACKYLPPALLSSPGERAGMLAEAAKTLEKVGDKRKLKECYQLMKSLGNGIGSVKA : :*. :** .:**:**:* :**:**:*:**:**:* :* *:: **.* . :