CLUSTAL W (1.82) multiple sequence alignment ENST00000323135 -------------------------MPPGVDCPMEFWTKE----ENQSVVVDFLLPTGVY ENST00000289153 -------------------MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIY ENST00000263967 -------------------------MPP-RPSSGELWGIH---LMPPRILVECLLPNGMI ENSMUST00000029201 -------------------------MPP-RPSSGELWGIH---LMPPRILVECLLPNGMI SINFRUP00000141882 -------------------------MPP-RPSSGELWGMH---LMPPSILVECLLPNGMI SINFRUP00000144436 -----------------------------------------------RILVDCLLPNGMI CG4141-RA MNMMDNRALAYVAHQPKYETPPEEAEPPCMRFSVNLWKNE----MLNWVDLICLLPNGFL : : : ***.*. ENST00000323135 LNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCD ENST00000289153 IQLEVPREATISYIKQMLWKQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCD ENST00000263967 VTLECLREATLITIKHELFKEARKYPLHQLLQDESSYIFVSVTQEAEREEFFDETRRLCD ENSMUST00000029201 VTLECLREATLVTIKHELFREARKYPLHQLLQDETSYIFVSVTQEAEREEFFDETRRLCD SINFRUP00000141882 LTLECLREATLITVKHELFKEARKYPLYHLLQEESSYIFVSVTQEAEREEFYDETRRLCD SINFRUP00000144436 LTLECLREATLITIKHELFKEARKYPLHHLLQEETSYIFVSVTQEAEREEFYDETRRLCD CG4141-RA LELRVNPANTIQVIKVEMVNQAKQMPLGYVIKEACEYQVYGISTFN-IEPYTDETKRLSE : : .: :* : ...: *: :: * . :. : ** :**.: ENST00000323135 VQPFLPVLRLVAREGDR---VKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCE ENST00000289153 VRPFLPVLKLVTRSCDP---GEK-LDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSE ENST00000263967 LRLFQPFLKVIEPVGNR---EEKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCK ENSMUST00000029201 LRLFQPFLKVIEPVGNR---EEKILNREIGFVIGMPVCEFDMVKDPEVQDFRRNILNVCK SINFRUP00000141882 LRLFQAFLKVIEPVGNR---EEKILNREIGFAIGMPICEFDLVKDPEVQDFRRNILNVCK SINFRUP00000144436 LRLFQPFLKVIEPVGNR---EEKILNREIGFAIGMPVCEFDLVKDPEVQDFRRNILNVCK CG4141-RA VQPYFGILSLGERTDTTSFSSDYELTKMVNGMIGTTFDHNRTHGSPEIDDFRLYMTQTCD :: : .* : . : :. ** . . .**:::** : : .. ENST00000323135 EAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGS----EESFT ENST00000289153 EKILSLVGLSWMDWLKQTYPPEHEPSIPEN--LEDKLYGGKLIVAVHFENC----QDVFS ENST00000263967 EAVDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVSPNNDKQKYT ENSMUST00000029201 EAVDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVSPNNDKQKYT SINFRUP00000141882 EAVDLRDCNGPHSRALYVYPPNVESSPELPRHIYNKLDKGQIIVVIWVIVSPTNDKQKYT SINFRUP00000144436 DSVELRDASGPHSRALYVYPPNVESSQELPKHIYSKLDKGQIIVVIWVIVSPNNDKQKYT CG4141-RA NIELERSAYTWQQRLLYEHPLRLANSTKMPELIRERHPTRTFLIVVKNEND----QSTFT : .* . * : ::: : :. :: ENST00000323135 FQVSTKDVPLALMACALRKKATVFRQPLV-------EQPEDYTLQVNGRHEYLYGSYPLC ENST00000289153 FQVSPNMNPIKVNELAIQKRLTIHGKEDE-------VSPYDYVLQVSGRVEYVFGDHPLI ENST00000263967 LKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYPLS ENSMUST00000029201 LKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYPLS SINFRUP00000141882 LKINHDYVPEQVIAEAIRKKTRSMLLSQEQLKMCVQEYQGKYILKVCGCDEYLLEKYPLS SINFRUP00000144436 LKINHDCVPEQVIAEAIRKKTRSMLLSPEQLKMCVQEYQGKYILKVCGCDEYLLEKHPIS CG4141-RA LSVNEQDTPFSLTESTLQKMNRSQMKMND--------RTSDYILKVSGRDEYLLGDYPLI :.:. . * : :::* : : : .* *:* * **. .:*: ENST00000323135 QFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAK--PPPIPAKKPSSVS ENST00000289153 QFQYIRNCVMNRALPHFILVECCKIKKMYEQEMIAIEAAINRNSSNLPLPLPPKKTRIIS ENST00000263967 QYKYIRSCIMLGRMPNLMLMAKESLYSQLPMDCFTMPSYSRRIST--ATPYMNGETSTKS ENSMUST00000029201 QYKYIRSCIMLGRMPNLMLMAKESLYSQLPIDSFTMPSYSRRIST--ATPYMNGETSTKS SINFRUP00000141882 QYKYVRSCIMLGRMPNLMLMAKDSLYSQLPMDIFTIPSYARRIST--ATPYMNGETATKA SINFRUP00000144436 QYKYIRSCIMLGRMPNLMLMAKDSLYSQLPTDNFVMPSYSRRIST--ATSYMNGEVAAKS CG4141-RA QFLYIQEMLSDSAVPNVVLQSVYRLESYINHHNEQAMVTKRPLPK----KRTVHLHKSIS *: *: . : *:. : : . . .. : ENST00000323135 -LWSLEQPFRIELIQGS--KVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWK ENST00000289153 HVWENNNPFQIVLVKGN--KLNTEETVKVHVRAGLFHGTELLCKTIVSSEVSGKNDHIWN ENST00000263967 -LWVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRVP-CSNPRWN ENSMUST00000029201 -LWVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRVP-CSNPRWN SINFRUP00000141882 -LWTINGTLRIKILCATYVNVNIRDIDKIYVRTGIYHGGEQLCDNVNTQRVP-CSNPRWN SINFRUP00000144436 -LWTINGTLRIRILCATYVNVNIRDIDKIYVRTGIYHGGEQMCDNVNTQRVP-CSNPRWN CG4141-RA SLWDMGNYFQLTLHSISNVNFDKTRALKVGVHVCLYHGDKKLCAQRSTDSPNGNFDTFLF :* ::: : . ::.: *: *:. ::** : :* :. : ENST00000323135 --QRLEFDINICDLPRMARLCFALYAVIEKAKKARSTK----------KKSKKADCPIAW ENST00000289153 --EPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGKVHYPVAW ENST00000263967 --EWLNYDIYIPDLPRAARLCLSICSVKGR------------------KGAKEEHCPLAW ENSMUST00000029201 --EWLNYDIYIPDLPRAARLCLSICSVKGR------------------KGAKEEHCPLAW SINFRUP00000141882 --EWLSYDMYIPDIPRAARLCLSICSVKGR------------------KGAKEEHCPLAW SINFRUP00000144436 --EWLTYDMYISDIPRAARLCLSICSVKGR------------------KGAKEEHCPLAW CG4141-RA NDLVMDFDIQMRNLPRMTRLCIVIFEVTKMSRSKKSSN----NKDIALKDVPYNKNPLAW : :*: : ::** :***: : * : . *:** ENST00000323135 ANLMLFDYKDQLKTGERCLYMWPSVPDEK-GELLNPTGTVRSNPNTDSAAALLICLPEVA ENST00000289153 VNTMVFDFKGQLRTGDIILHSWSSFPDEL-EEMLNPMGTVQTNPYTENATALHVKFPENK ENST00000263967 GNINLFDYTDTLVSGKMALNLWP-VPHGL-EDLLNPIGVTGSNPNKE-TPCLELEFDWFS ENSMUST00000029201 GNINLFDYTDTLVSGKMALNLWP-VPHGL-EDLLNPIGVTGSNPNKE-TPCLELEFDWFS SINFRUP00000141882 GNINMFDYTHTLVAGKMALNLWP-VPHGL-EDLLNPIGVTGSNPNKE-TPCLELEFEHFG SINFRUP00000144436 GNINLFDYTHTLVANKMALNLWP-VPHGL-EDLLNPIGVTGSNPNKE-TPCLELEFDHFS CG4141-RA VNTTIFDHKDILRTGRHTLYTWTYADDIQSVEVFHPLGTIEPNPRKEECALVDLTFLSSG * :**.. * :. * *. . ::::* *. .** .: . : : : ENST00000323135 PHPVYYPALEKILELG---RHSEC------VHVTEEE----------QLQLREILERRGS ENST00000289153 KQPYYYPPFDKIIEKAAEIASSDS------ANVSSRGGKKF------LPVLKEILDRDPL ENST00000263967 -SVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPL ENSMUST00000029201 -SVVKFPDMSVIEEHANWSVSREAGFSYSHTGLSNRLARDNELRENDKEQLRALCTRDPL SINFRUP00000141882 -CPVKYPDMTIIEEHANWNISRELGFNYCHTGLSSRLARDNPVTDADNDQLRQVCTRDPL SINFRUP00000144436 -SSVKYPDMNAVEDHASRTISREVGLNYTLSGQSNRAARDHILTEGDSEQLRQLTNRDPL CG4141-RA TGTVRYPSEEVVLQYAADREQVNR--------LQRQLAGPEKPIKELKELMANYTGLDKI :* : : . : : . : ENST00000323135 GELYEHEKDLVWKLR--HEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLS ENST00000289153 SQLCENEMDLIWTLR--QDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPRE ENST00000263967 SEITEQEKDFLWSHR---HYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQ ENSMUST00000029201 SEITEQEKDFLWSHRQVVHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQ SINFRUP00000141882 SEITEQEKDFLWRHR---QDCLNMPEILPKILLAVKWNSRDEIAQMYCLLKDWPAIRPEQ SINFRUP00000144436 SEITEQEKDFLWRNR---YYCMNIPEILPKILLAVKWNSRDEVAKMYCLLKEWPSIRPEQ CG4141-RA YEMVDQDRNAIWERR--NDILRELPEELSILLHCVYWKERDDVADMWYLLKQWPLISIER :: ::: : :* * :*: *. :* *:. :::*.: *: ** : ENST00000323135 ALELLDFSFPDCHVGSFAIKSLRK-LTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRA ENST00000289153 ALELLDFNYPDQYVREYAVGCLRQ-MSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERA ENST00000263967 AMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKA ENSMUST00000029201 AMELLDCNYPDPMVRSFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKA SINFRUP00000141882 AMELLDCNFPDPMIREFAVKCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNPLARFLLKRA SINFRUP00000144436 AMELLDCNYPDPMVRHFAVRCLDKYLTDDKLSQYLIQLVQVLKYEQYLDNPLVRFLLKKA CG4141-RA SLELLDYAYPDPAVRRFAIRCLHF-LKDEDLLLYLLQLVQAIKHESYLESDLVVFLLERA ::**** :** : :*: .* :.*:.* **:****.:*:* :*: * ***.:* ENST00000323135 LANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALND ENST00000289153 LGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLKTLNS ENST00000263967 LTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTD ENSMUST00000029201 LTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTD SINFRUP00000141882 LTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLSRQVEAMEKLINLTD SINFRUP00000144436 LTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLEAYCRACGMYLKHLSRQVEAMEKLINLTD CG4141-RA LRNQRIGHYFFWHLRSEMQTPSMQTRFGLLLEVYLKGCKHHVAPLRKQLHVLEKLKQGSL * *::**:::****:**:: :: :**::** * :.. :: * :* ..:.** . ENST00000323135 FVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMK ENST00000289153 LIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMDSKMK ENST00000263967 ILKQEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKR ENSMUST00000029201 ILKQEKKDETQKVQMKFLVEQMRQPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKR SINFRUP00000141882 LLKQEKKDEAQKVQMKFLVEQMRRPDYMDALQSFTSPLNPAHQLGNLRLEECRMMSSAKR SINFRUP00000144436 ILKQEKKDETQKVQMRFLVDQMKRPDYMDALQNFTSPLNPAHQLGNLRLDECRIMSSAKR CG4141-RA IAK----KGSKEKVKTMLQDFLRDQRNSAVFQNIQNPLNPSFRCSGVTPDRCKVMDSKMR : * . : : :: .:. : .**:*. . : :.* *.* : ENST00000323135 PLWIMYSNEEAGSGG---SVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYG ENST00000289153 PLWLVYNNKVFGED----SVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG ENST00000263967 PLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYG ENSMUST00000029201 PLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYG SINFRUP00000141882 PLWLNWENPDMMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYG SINFRUP00000144436 PLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIKIMENIWQNQGLDLRMLPYG CG4141-RA PLWVVFENADVNAS----DVHIIFKNGDDLRQDMLTLQMLRVMDQLWKRDGMDFRMNIYN ***: :.* :: . :****************::::*: :*:. *:*:** *. ENST00000323135 CLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNP-GEALDRAIE ENST00000289153 CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNS-GDDLDRAIE ENST00000263967 CLSIGDCVGLIEVVRNSHTIMQIQCKGG-LKGALQFNSHTLHQWLKDKNK-GEIYDAAID ENSMUST00000029201 CLSIGDCVGLIEVVRNSHTIMQIQCKGG-LKGALQFNSHTLHQWLKDKNK-GEIYDAAID SINFRUP00000141882 CLSIGDCVGLIEVVRNSHTIMQIQCKGG-LKGALQFNSHTLHQWLKDKNK-GEMYDQAID SINFRUP00000144436 CLSLGDCVGLIEVVRSSHTIMQIQCKGG-LKGALQFNSNTLHQWLRDKNK-GEMYDMAVD CG4141-RA CISMEKSLGMIEVVRHAETIANIQKEKGMFSATSPFKKGSLLSWLKEHNKPADKLNKAIN *:. . *:**** :.** :** : . . .: *:. :* .**:. * .: : *:: ENST00000323135 EFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFI ENST00000289153 EFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFI ENST00000263967 LFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFV ENSMUST00000029201 LFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFV SINFRUP00000141882 LFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFV SINFRUP00000144436 LFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFV CG4141-RA EFTLSCAGYCVATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFKEKLGVRRERVPFV ** ********:::**:.***..***:: **********:*.: * *:* .******: ENST00000323135 LTYDFVHVIQQG--KTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSC ENST00000289153 LTYDFIHVIQQG--KTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTS ENST00000263967 LTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQS ENSMUST00000029201 LTQDFLIVISKGAQEYTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQS SINFRUP00000141882 LTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQS SINFRUP00000144436 LTQDFLIVISKGSQECVKTKEFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQS CG4141-RA LTHDFVYVINKG-FNDRESKEFCHFQELCERAFLVLRKHGCLILSLFSMMISTGLPELSS ** **: **.:* : ::.:* :*: * *: :*:*. *:: **::* :*:*** . ENST00000323135 SKDIQYLKDSLALGKTEE-------------EALKHFRVKFNEALRESWKTKVNWLAHNV ENST00000289153 VKDIQYLKDSLALGKSEE-------------EALKQFKQKFDEALRESWTTKVNWMAHTV ENST00000263967 FDDIAYIRKTLALDKTEQ-------------EALEYFMKQMNDAHHGGWTTKMDWIFHTI ENSMUST00000029201 FDDIAYIRKTLALDKTEQ-------------EALEYFTKQMNDAHHGGWTTKMDWIFHTI SINFRUP00000141882 FDDIAYIRKTLALDKSEQ-------------EALDYFMKQMNDAHHGGWTTKMDWIFHTI SINFRUP00000144436 FDDIAYIRKTLALEKTEQAMMLFSFLISTHPEALDYFMKQMNDAHHGGWTTKMDWIFHTI CG4141-RA EKDLDYLRETLVLDYTEE-------------KAREHFRAKFSEALANSWKTSLNWASHNF .*: *::.:*.* :*: :* . * ::.:* .*.*.::* *.. ENST00000323135 SKDNRQ ENST00000289153 RKDYRS ENST00000263967 KQHALN ENSMUST00000029201 KQHALN SINFRUP00000141882 RQHAMN SINFRUP00000144436 RQHALN CG4141-RA SKNNKQ :. .