CLUSTAL W (1.82) multiple sequence alignment ENST00000270642 ---------------------------------MGQPYNRTTQLSERARRCAGHGHADMS ENSMUST00000013511 ------------------------------------------------------------ ENST00000306821 ------------------------------------------------------------ SINFRUP00000152202 ------------------------------------------------------------ SINFRUP00000136113 ------------------------------------------------------------ ENST00000297153 ------------------------------------------------------------ ENSMUST00000056422 ------------------------------------------------------------ ci0100138601 ------------------------------------------------------------ CG6669-RA ---------------------MNIISRSIRTGALAPPITAHASANANASGLRKSSQRRNR ENST00000273261 MARPVRGGLGAPRRSPCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLA ENST00000270642 QQYSKEEERMKMLTWWEEHQSPKAKEGLPLKKPELLEETEVPKMPEADTPPDRAGGLLSQ ENSMUST00000013511 -----------------------------------------------------SAGLLSQ ENST00000306821 ------------------------------------------------------------ SINFRUP00000152202 ---------------------------------------------APPTVRIIHPRQPCN SINFRUP00000136113 ---------------------------------------------APPTVRIIHSGHACN ENST00000297153 -----------------------MEVTCLLLLALIPFHCRGQGVYAPAQAQIVHAGQACV ENSMUST00000056422 ---------------------------MGHPNDVIGDGCS-LPAFTPAQAQIVHAGQACV ci0100138601 -------------------------------------------------MRVCILG-VPT CG6669-RA APLQMNCPILIVISLGWLLHAHAGSGGFAVEAAISNRGSNSRSMSNVQQSAVAASTLTAT ENST00000273261 ALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSL ENST00000270642 SLEF---------------NSPADNYTVCEGDNATLSCFIDEH-VTRVAWLN-------- ENSMUST00000013511 SLEF---------------SSPADNYTVCEGDNATLSCFIDEH-VTRVAWLN-------- ENST00000306821 ----------------------------CR-------CYLEDG-ASKGAWLN-------- SINFRUP00000152202 LQEE---------------RYTERVFTIREGATLELQCLVTGHPRPQVRWTK-------- SINFRUP00000136113 VEEE---------------RYTERVYTIREGETLELTCLVTGHPRPQVTVLL-------- ENST00000297153 VKED---------------NISERVYTIREGDTLMLQCLVTGHPRPQVRWTK-------- ENSMUST00000056422 VKED---------------NISERVYTIRESDTLVLQCLVTGHPRPQVRWTK-------- ci0100138601 VRIE---------------PNSDVVYNFKEYDDVVVICVATGHPMPSIRWTI-------- CG6669-RA LPRF---------------LSRGHTYRAVVGDTLVLPCQVENLGNFVLLWRR-------- ENST00000273261 FLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLEL * ENST00000270642 ------RSNILYAGNDRWTSDPRVRLLINTPEEFSILITEVGLGDEGLYTCSF-QTRHQP ENSMUST00000013511 ------RSNILYAGNDRWTSDPRVRLLINTPEEFSILITQVGLGDEGLYTCSF-QTRHQP ENST00000306821 ------RSSIIFAGGDKWSVDPRVSISTLNKRDYSLQIQNVDVTDDGPYTCSV-QTQHTP SINFRUP00000152202 ------TVGGASERQVGPPLHNETLKIGNISRHQGGRYYCKADNGLGSPAIHS-IRVDVY SINFRUP00000136113 ------STRMTGARSQGGSLP------PPFNTH--GFCLCPAD----------------- ENST00000297153 ------TAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKS-IRVDVQ ENSMUST00000056422 ------TAGSASDKFQETSVFNETLRIERIARTQGGRYYCKAENGVGVPAIKS-IRVDVQ ci0100138601 ------FGGELERRNLN--LRSSTLRIPNITRDENCRVSCRASNGIGNPAITS-KRINVL CG6669-RA ------GTNVLTASNIMVTRDER----VRLIDGYNLEISDLEPQDAGDYVCQISDKINRD ENST00000273261 GAFDGLSRSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVL ENST00000270642 YTTQVYLIVHVPARIVNISSPVTVNEGGNVNLLCLA--------------VGRPEPTVTW ENSMUST00000013511 YTTQVYLIVHVPARIVNISSPVAVNEGGNVNLLCLA--------------VGRPEPTVTW ENST00000306821 RTMQVHLTVQVPPKIYDISNDMTVNEGTNVTLTCLA--------------TGKPEPSISW SINFRUP00000152202 YLDDPVIWVHQS--VGEMKEQFYSER--TVFLRCAS--------------NGNPPVRYTW SINFRUP00000136113 -LDEPVVTVHQS--IGEAKEQFYYER--TVFLRCVA--------------NSNPPVRYSW ENST00000297153 YLDEPMLTVHQT--VSDVRGNFYQEK--TVFLRCTV--------------NSNPPARFIW ENSMUST00000056422 YLDEPVLTVHQT--VSDVRGNFYQEK--TVFLRCTV--------------SSNPPARFIW ci0100138601 YLDRPVLTAHLTNKWRMPSTSIWFEN--TVYLHCTV--------------TSNPAAVFTW CG6669-RA QVHTVEILVPPSVRAIPTSGQLQARKGGPITLECKG--------------SGNPVPSIYW ENST00000273261 KLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHR : . : ... ENST00000270642 R----------------------QLRGED----------PIPDGFTSEGEILEISDIQRG ENSMUST00000013511 R----------------------QLR----------------DGFTSEGEILEISDIQRG ENST00000306821 R----------------------HIS-------------PSAKPFEN-GQYLDIYGITRD SINFRUP00000152202 R----------------------RGREVLSQGSDAGVEIYEPFFTQGETKILKLKNLRPQ SINFRUP00000136113 H----------------------RGREVLTQGSDKGVEIYEPFFTQGETKILKLKNLRPQ ENST00000297153 K----------------------RGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQ ENSMUST00000056422 K----------------------RGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQ ci0100138601 L----------------------LNGTVIRPNEQNGKRIDA-YSKDTSTVILKIKDAQEK CG6669-RA T----------------------KKSGAN-----------KSTARIGDGPILTLEKLERQ ENST00000273261 KGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVL : ENST00000270642 QAGEYECVT-HNGVNSAPDSRRVLVTVN-------------------------------- ENSMUST00000013511 QAGEYECVT-HNGVNSAPDSRRVLVTVN-------------------------------- ENST00000306821 QAGEYECSA-ENDV-SFPDVRKVKVVVN-------------------------------- SINFRUP00000152202 DYAEYTCISSVRNICGIGDKSAHFSLTNLT------------------------------ SINFRUP00000136113 DYANYSCIASVRNVCGIPDRSVIFTLTNRT------------------------------ ENST00000297153 DYASYTCQVSVRNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGG ENSMUST00000056422 DYASYTCQVSVRNVCGIPDKAITFQLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGG ci0100138601 DFGDYRCQTSVVGFTTPPRIGRITPKLIKVNP---------------GGKVRIQCDIISG CG6669-RA QAGVYQCTADNGVGDPVTVDMRLDVLYP-------------------------------- ENST00000273261 DLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRS : ENST00000270642 --------------------YPPTITDVTSARTALGRAALLRCEAMAVP----------- ENSMUST00000013511 --------------------YPPTITDVTSARTALGRAALLRCEAMAVP----------- ENST00000306821 --------------------FAPTIQEIKSGTVTPGRSGLIRCEGAGVP----------- SINFRUP00000152202 ------------------------------------------------------------ SINFRUP00000136113 ------------------------------------------------------------ ENST00000297153 DPLPQLQWSHGPGPLPLGALAQGG--TLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLL ENSMUST00000056422 DPLPQLHWSHGPGPLPLGALAQGG--TLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLL ci0100138601 FPEPKIDWVTETGVFSERIVISKMRNILTIDGAMPQDSGNYYCTANNQVGTKVEKRTTVV CG6669-RA ---------------------PDIQVEKSWIHSGEGFEAKLVCIVFADP----------- ENST00000273261 VQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGRMLQAFVTATCAHPESLKGQSIF ENST00000270642 --------------------------------------------PADFQWYKDDRLLSSG ENSMUST00000013511 --------------------------------------------PADFQWYKDDRLLSSG ENST00000306821 --------------------------------------------PPAFEWYKGEKKLFNG SINFRUP00000152202 ------------------------------------------------------------ SINFRUP00000136113 ------------------------------------------------------------ ENST00000297153 VRS----MKNATFQITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMS ENSMUST00000056422 -------------------------------------------EKVNYQWFKNGKPARTS ci0100138601 VRD----IGPMTYWLTPDPLRDDRSFAVATDIKLTCHVDAAPYSELQYAWFKKVQTPCLS CG6669-RA --------------------------------------------VATVSWYQNSFPIQST ENST00000273261 SVPPESFVCDDFLKPQIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNA ENST00000270642 TAEGLK---VQT---ERTRSMLLFANVSARHYGNYTCRAAN------------------- ENSMUST00000013511 SAEGLK---VQT---ERTRSMLLFANVSARHYGNYTCRAAN------------------- ENST00000306821 -QQGII---IQN---FSTRSILTVTNVTQEHFGNYTCVAAN------------------- SINFRUP00000152202 ------------------------------------------------------------ SINFRUP00000136113 ------------------------------------------------------------ ENST00000297153 KRLLVT---RNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETV ENSMUST00000056422 KRLLVT---RNDPELPAVTSSLELIDLHFSDYGTYLCMASFPGSPVPDLSIEVNISSETV ci0100138601 IALGHT---TNQCYLLFLCSQLQIRRLTEDDYGTYVCSGKLPTLGPNGAESFAVITVSRE CG6669-RA DRRIMA---TRAN-----RHMLTIRHIQQEDFGNYSCVADN------------------- ENST00000273261 DMENFVHVHAQDGEVMEYTTILHLRQVTFGHEGRYQCVITNHFG-----STYSHKARLTV ENST00000270642 ------RLGASSASMRLLRPGSLENSAPRPPGLLA-------LLSALGWLWWRM------ ENSMUST00000013511 ------RLGASSASMRLLRPGSLENSAPRPPGPLT-------LLSALSWLWWRM------ ENST00000306821 ------KLGTTNASLPLNPPSTAQYGITGSADVLFSCWYLVLTLSSFTSIFYLKNAILQ- SINFRUP00000152202 ------------------------------------------------------------ SINFRUP00000136113 ------------------------------------------------------------ ENST00000297153 PPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGK ENSMUST00000056422 PPTISVPKGRAVVTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLALEETPDGK ci0100138601 SAPAKIEAIESRVVVTEGDPASLKCRTIGKPKPLVIWFRN--ENTTMPSGNMQEVTSGGV CG6669-RA ------SLGRSRKYMELSGRPGAAEFYSPKWGRSPDSYNLTWKIDSYPPLEEVRLLYRRV ENST00000273261 NVLPSFTKTPHDITIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARERRMHVMPDDD ENST00000270642 ------------------------------------------------------------ ENSMUST00000013511 ------------------------------------------------------------ ENST00000306821 ------------------------------------------------------------ SINFRUP00000152202 ------------------------------------------------------------ SINFRUP00000136113 ------------------------------------------------------------ ENST00000297153 LRLERVSRDMSGTYRCQTARYNGFNVRPR---EAQVQLNVQFPPEVEPSSQDVRQALGRP ENSMUST00000056422 LRLESVSRDMSGTYRCQTARYNGFNVRPR---EAQVQLTVHFPPEVEPSSQDVRQALGRP ci0100138601 LVINRTSREDADLYTCAPALYNGFSKHSRSQSDAVVELQVQYKPTVEPSYREIRRPLGSD CG6669-RA QMNETYQQPGRWHDFILTPEHRPASEPLTHIMSYTIKNLHPGGYYEAIVQAKNRYGWNEV ENST00000273261 VFFITDVKIDDAGVYSCTAQNSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCK ENST00000270642 ------------------------------------------------------------ ENSMUST00000013511 ------------------------------------------------------------ ENST00000306821 ------------------------------------------------------------ SINFRUP00000152202 ------------------------------------------------------------ SINFRUP00000136113 ------------------------------------------------------------ ENST00000297153 VLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVVP-AAAEAPDHAELRLDAVTRDSSGSYE ENSMUST00000056422 VLLRCSLLRGSPQRIASAVWRFKGQLLPPPPVLPAAAVETPDHAELRLDALTRDSSGNYE ci0100138601 VTLSCFVSDASPMIPITYVWKKE----------NVVQTSSSSGQHLVLQSIQVRDCGVYI CG6669-RA SDIFQFVVATNSQDIG---------------PEDAEVVASSKSRSNSASIGSLPGSTVLH ENST00000273261 ATGNPPPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAH ENST00000270642 ------------------------------------------------------------ ENSMUST00000013511 ------------------------------------------------------------ ENST00000306821 ------------------------------------------------------------ SINFRUP00000152202 ------------------------------------------------------------ SINFRUP00000136113 ------------------------------------------------------------ ENST00000297153 CSVSNDVGSAACLFQVSAKAYSPEFYFDTPNP----------TRSHKLSKNYSYVLQWTQ ENSMUST00000056422 CSVSNDVGSATCLFQVS------------------------------------------- ci0100138601 CEVTNAIGKARCALNVTAFAFKPEFLFTDVGEGEGDLTSTVFPQTKSDPGTFMYLLSWTQ CG6669-RA TALLLALALSNCQFDRRRLGLG-------------------------------------- ENST00000273261 SQLSVLPAAGCRKDGTTVGIFTIAVVSSIVLTSLVWVCIIYQTRKKSEEYSVTN-----T ENST00000270642 ------------------------------------------------------------ ENSMUST00000013511 ------------------------------------------------------------ ENST00000306821 ------------------------------------------------------------ SINFRUP00000152202 ------------------------------------------------------------ SINFRUP00000136113 ------------------------------------------------------------ ENST00000297153 REPDAVDPVLNYRLSIRQLNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVRLTPY ENSMUST00000056422 ------------------------------------------------------------ ci0100138601 KHPNAVDAVTEYRFSSCIFYNNIKLKYKSGILSYGQLLTYQISDLVKGVYQVEVTPKTIF CG6669-RA ------------------------------------------------------------ ENST00000273261 DETVVPPDVPSYLSSQGTLSDRQETVVRTEGGPQANGHIESNGVCPRDASHFPEPDTHSV ENST00000270642 ------------------------------------------------------------ ENSMUST00000013511 ------------------------------------------------------------ ENST00000306821 ------------------------------------------------------------ SINFRUP00000152202 ------------------------------------------------------------ SINFRUP00000136113 ------------------------------------------------------------ ENST00000297153 TTFGAGDMASRIIHYTEHNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGP- ENSMUST00000056422 ------------------------------------------------------------ ci0100138601 GYGDSNTREIYVRERNPSFFCQFNENDLCGFIQEKNPNMDTIDWTKNSARTQLRRTKNTG CG6669-RA ------------------------------------------------------------ ENST00000273261 ACRQPKLCAGSAYHKEPWKAMEKAEGTPGPHKMEHGGRVVCSDCNTEVDCYSRGQAFHPQ ENST00000270642 ------------------------------------------------------------ ENSMUST00000013511 ------------------------------------------------------------ ENST00000306821 ------------------------------------------------------------ SINFRUP00000152202 ------------------------------------------------------------ SINFRUP00000136113 ------------------------------------------------------------ ENST00000297153 ---PTDISGTPEGYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSL ENSMUST00000056422 ------------------------------------------------------------ ci0100138601 PSADHSTLTKEAGGYMYIEASLTTKGDRARLISPIIFDKSSSRQCLKFWYHMRGRHIG-- CG6669-RA ------------------------------------------------------------ ENST00000273261 PVSRDSAQPSAPNGPEPGGSDQEHSPHHQCSRTAAGSCPECQGSLYPSNHDRMLTAVKKK ENST00000270642 ------------------------------------------------------------ ENSMUST00000013511 ------------------------------------------------------------ ENST00000306821 ------------------------------------------------------------ SINFRUP00000152202 ------------------------------------------------------------ SINFRUP00000136113 ------------------------------------------------------------ ENST00000297153 NLLVRSRNKGALDTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGY--LGDIAI ENSMUST00000056422 ------------------------------------------------------------ ci0100138601 ILRVMTKKRGENETEIWRVSGDQGDKWNTGDITIQHTVPYQIIFEAVITYVDGYQGDIAI CG6669-RA ------------------------------------------------------------ ENST00000273261 PMASLDGKGDSSWTLARLYHPDSTELQPASSLTSGSPERAEAQYLLVSNGHLPKACDASP ENST00000270642 ------------------------------------------------------------ ENSMUST00000013511 ------------------------------------------------------------ ENST00000306821 ------------------------------------------------------------ SINFRUP00000152202 ------------------------------------------------------------ SINFRUP00000136113 ------------------------------------------------------------ ENST00000297153 DDVTLKKGECPRKQTDPNKVVVMPGSGAPCQSSPQLWGPMAIFLLALQR----------- ENSMUST00000056422 ------------------------------------------------------------ ci0100138601 DDVLLCINNIGKHRFIIIQLFVRLFKVHSNNSDSISFILFVNITFVQIVARWRQRKQVIN CG6669-RA ------------------------------------------------------------ ENST00000273261 ESTPLTGQLPGKQRVPLLLAPKS------------------------------------- ENST00000270642 ---- ENSMUST00000013511 ---- ENST00000306821 ---- SINFRUP00000152202 ---- SINFRUP00000136113 ---- ENST00000297153 ---- ENSMUST00000056422 ---- ci0100138601 ECEM CG6669-RA ---- ENST00000273261 ----