CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000003544 --------------------------------------------------------PQLP ENST00000281474 ------------------------------------------------------------ SINFRUP00000140623 ------------------------------------------------------------ SINFRUP00000151872 ------------------------------------------------------------ ci0100137969 ------------------------------------------------------------ ci0100134183 ---------------------------------------------------------MDS CG3493-RA MFANLKNKLIEEVKASPSKFQQFANAAQAAVSSSSSTTPNSETNTSNNENFFSITEEDTP ENSMUST00000003544 AGPQGALPIIHQALFFSIFIFIPICFSFSLLLCVYLRHPAMAAEEALKTVDQYKTEIERL ENST00000281474 ----------------------------------------MAAEEVLQTVDHYKTEIERL SINFRUP00000140623 ------------------------------------------------------------ SINFRUP00000151872 -------------------------------MSMEEQECADAVLVTEAGPQWLRAEVDRL ci0100137969 --------------------------------------------------------IVRL ci0100134183 PRTGGESTPPQSNTPRKLDTMSHEDLVKGYKRQMLLLQKLKAKCDEFQTKLKAKADYDDI CG3493-RA QNSPYRIQKLPATSASALRGRSTQSLNGATSRTRKLSNSSMASDVSFRLPTYEAPAVYHL : : : ENSMUST00000003544 TKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDGLKQELEQLREAFG------ ENST00000281474 TKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQELEQLKEAFG------ SINFRUP00000140623 -------------------------------------------------RQAFG------ SINFRUP00000151872 TRELRETTHEKIQAAEYGLAVLEEKQQLKQRFDELETDYEAVRHELDQLKEAFG------ ci0100137969 TGELEDAQLEKVQAAEYGLQVLEEKRQLQHQCEELESQLEMTQRELENARHEFD------ ci0100134183 KGELTSSKQKYDELLTQNESLKSTEALLKKGNNAMNEELECLRMKQDTLLSSMQYLQEDH CG3493-RA QSDLDETSSEFDDSASTARLDVITKDQLYDAYKKSLDRYHKYRCRYTDLAKKYKELERDS : : ENSMUST00000003544 QSFSIHRKVAEDGETREETLLQESASKEAYYLNKILEMQ--------NELKQSRAVVTNV ENST00000281474 QSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQ--------NELKQSRAVVTNV SINFRUP00000140623 QAYSNQRKVAKDGETTEETLLQESACKEAYYMGRLLELQ--------TEVTISRSVASNA SINFRUP00000151872 QAYSTHRKVAADGESREESLILESASKEALYQQKLLEQQ--------NELRQAKASFTSV ci0100137969 LSTKT-KKAFCEGELREDSLEKQCKDVEERLIQVEKERD--------IESSQSKIAVANA ci0100134183 AAVSASNKELAEQSEKSQIALKDVQAEKIELADQIQDQL--------HQISDLKSHIKNL CG3493-RA SKARSVLVETQDKALRRISELREQCTLEQQAKAHLEEALRVEMDDMSCKMQAYQTKLQLL : : : : : : ENSMUST00000003544 QAENERLSAVVQELK-------------------------ENNEMVELQRIRMKDEIREY ENST00000281474 QAENERLTAVVQDLK-------------------------ENNEMVELQRIRMKDEIREY SINFRUP00000140623 QAENERLSTLMQELR-------------------------EANETLELQRTRMREEIKEY SINFRUP00000151872 QAENERLASIILDMR-------------------------ENSELAELQRGQLRDDIREY ci0100137969 QEEADRLTILNNELN-------------------------MSVQALDQQRIALRRDLKEL ci0100134183 SSEHAKLEELTGENKTLKKELAAMKMTVNMFKTQKKPDQTEKIEELNLKVEELNEEVKLL CG3493-RA GENPENITAALERSGQQLESEQLIDLEESIGKSPLSTNGSSGVSDLQRLLKERDEQLKSV : .: . : ::: ENSMUST00000003544 KFREARLLQDY---------------TELEEENITLQKLVSTLKQNQVEYEGLKHEIKRF ENST00000281474 KFREARLLQDY---------------TELEEENITLQKLVSTLKQNQVEYEGLKHEIKRF SINFRUP00000140623 KFRETRLLQDY---------------TELEEENITLQKLVSTLKQSQVEYEGLKHEIKVL SINFRUP00000151872 KVREARLLQDY---------------SELEEENISLQKQVSVLRQNQVEFEGLKHEIRRL ci0100137969 KSREAHLMADY---------------SELEEENCSLQKQVSVLRQSQAEYEGFKHEIRRL ci0100134183 ETQSVKLNEDREAERSNHKQMCVDLETELHASVKHQSEVESELESSKTEVTDLKEKLIQL CG3493-RA TEKYEAVRKQEEENVLLLAQTKQAIHTELELKDTEVRKLQEKLKQLESQRESHNNEVKEQ : : : :**. . : . *.. : : . :.:: ENSMUST00000003544 EE--------------ETVLLNSQLEDAIRLKEIAEHQLEEALETLKNERE--------- ENST00000281474 EE--------------ETVLLNSQLEDAIRLKEIAEHQLEEALETLKNERE--------- SINFRUP00000140623 EE--------------ETVLLNSQLEDALRLKDISEGQLEEALDALKGERE--------- SINFRUP00000151872 EE--------------DSQCLHSQLEEAVRLREISERQLTEALETIKTERE--------- ci0100137969 EE--------------EAEFLNSQLEEALKLKDLLEHQLDDAHETIAKERE--------- ci0100134183 QE--------------IHTAKITAMNETISDEIEQSKTLTETLENIKSTKADLEEKLLKL CG3493-RA FKKLQATKQEVDAKLMATEHLLNTLKESYAIKEQQVVTLEAQLEAIRVENEQKVKDLQKQ : . :::: . * : : . ENSMUST00000003544 ----------------QKNNLRKELSQYINLSDS------HISISVD---GLKFAEDGSE ENST00000281474 ----------------QKNNLRKELSQYISLNDN------HISISVD---GLKFAEDGSE SINFRUP00000140623 ----------------QKNNLRKELAHHLSLSDSVYGAGAHLALTVTGVEGIKFHEESNA SINFRUP00000151872 ----------------QKATLRKELSHYMTIGGSVYNG--SFSISID---NLKLHEDPSA ci0100137969 ----------------LKLSLKRELSQHMNVICIFYTR--SVNIKCD-FAPWKANIRRAD ci0100134183 ETENSDLNSTITTLQAEQENRKESDTEKADLLKELSEANKQLTIQTDAISRLTSENEEIK CG3493-RA NED-------------RNTQASDSSEQLKKLQAAVQDAESQLLSKDQLLESLRSEQAAKE : . . : . ENSMUST00000003544 P-------------------------NNDD--KMNGHIHG--PLGKLNGDYRTPTTRKGE ENST00000281474 P-------------------------NNDD--KMNGHIHG--PLVKLNGDYRTPTLRKGE SINFRUP00000140623 SNVTNGSAI------------PVANGNSEDSTRRNGHLHTGNGMTKINGEYRPG--WKGE SINFRUP00000151872 ATEP----------------------DNDD--LIRGFENG---LLKASEDDDDNKRLEAF ci0100137969 FHVD----------------------NGDD--ELDHPLIR-----HITSDLLHSTPSKRL ci0100134183 SSAKDLLEQKDLASLDLEKERERVKCLTESENKLFQKMTQKESEIQILEEKFKDLQTKAH CG3493-RA QQLKHLKEQLG----------KLKQENENYLDKLRENKKSSDSQTNEAQDQQKKLQAAKD : : : ENSMUST00000003544 SLHP----VSDLFSELN--------------------------------------ISEIQ ENST00000281474 SLNP----VSDLFSELN--------------------------------------ISEIQ SINFRUP00000140623 NMHP----VPDLFSELN--------------------------------------LSEIQ SINFRUP00000151872 KPAPSL--VDDLLSELN--------------------------------------ICEIQ ci0100137969 SSESK---GEDLLSELN--------------------------------------LCEVT ci0100134183 EFEQRSKDVENISSQNNQLGEKLAEAKSKIDSQAQEMNSLSED--------KKQLSAEVM CG3493-RA EAESKLLATEELLHSLRNDYKAQEEKVALLEDKLKTLSKENDVNVEKLHHINEQREAQST . :: . . .: ENSMUST00000003544 KLKQQLIQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQNSKEI ENST00000281474 KLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKEL SINFRUP00000140623 KLKQQLLQVECEKTALLMRLQESQTQLQHTQGALSEQNERVHRLTEHVNTIKCLNGDKEL SINFRUP00000151872 KLKQQLMQVEREKVVLINSLQESQKQLEQAYGTVSEQKETVNRLTENLSAMRKLQASKER ci0100137969 KLKQQLSQIENENLVLINTVKEQEKLLKNAQGELTHKTETVGLLLRVILYKRELFYPHRN ci0100134183 DLKEQLSNSTCESETVLKKYTEENVTLQNAISQLESDKEEINANKESLQADLEDVKQELS CG3493-RA DSQQKINELRAAKDEAEAKLLSTEHSLNALQAALSAKEEQAASLEQSLNALKTESEHSLQ . :::: : . . : *: . : . * . : ENSMUST00000003544 KAELDCEKG----RNSAEEAHDYEVDKNGLEILECKYRVAVTEVIDLKAEIKALKEKYNK ENST00000281474 KAELDGEKG----RDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNK SINFRUP00000140623 DDPQESEKADA-ASSSPPANGHHELDISGFEILECKYKVAVTEVIDLKAELKALKEKYNQ SINFRUP00000151872 QSALDSEKD----RDSHDDGDYYELDINGPEILQCKYTVAMSEAGELRQELKTLKGKYEK ci0100137969 LTKQPNKAN------AISMSDXKIMHVYIPALNEVKYLDLVSECERLKEDLKTIRDEQAE ci0100134183 VLRTENESFKASIESNNGAVHQLAEQVEKNDSMMAQITDLNTEVEAASKEIEVLKEKLKN CG3493-RA DLRLHNDQLLE-IVQRHQQNDWEAQLARAREELAAIQSQRELHALELEKSLEMERESVAA . . .:: : . ENSMUST00000003544 SVENYTEEKTKYESKIQMYD---EQVTNLEKTSKESGEKMAHMEKELQKMTGIANENHNT ENST00000281474 SVENYTDEKAKYESKIQMYD---EQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHST SINFRUP00000140623 TVEGQGENHD--DGRAQALS---EQVIHLERCYRETRERVAGLEAELRAATHTATESQGM SINFRUP00000151872 CRNQYEEEQARLEGDVQELR---SKLQTVEKISQLDKAQMARLEKELRLVSEAAGESLGS ci0100137969 RKDAQ-------KKSEIALK---ESKSKQMMLTQRNQALVEEIESSNHALSCRVKDAR-- ci0100134183 QDELVNEKEVLAEKCSQYSNNCRELQEKVEVLEKELKEYVDQVLTKVADTNQAAEEKVRE CG3493-RA LNSEKASQEEQHRLKLEQLQR--EIQILQDQHANSESETVAALKGQLEALSQDLATSQAS . . . : : . . ENSMUST00000003544 LNTAQDELVTFSEELAQLYHHVCLCNN---------ETPNRVMLDYYRQSRVTRSGSLKG ENST00000281474 LNTAQDELVTFSEELAQLYHHVCLCNN---------ETPNRVMLDYYRQSRVTRSGSLKG SINFRUP00000140623 LNTAQDELVTFSEELAQLYHHVCLCNN---------ETPNRVMLDYYRQSRVTRSGSLKG SINFRUP00000151872 LNVAQDELISFSEELANLYNHVCMCNN---------ETPNRVMLDYYKQGKAIIKKGQEG ci0100137969 --HSAEELSVVSEELSQLYHHACLAAG---------DTPQRVVLDSIRKEVTVRT----- ci0100134183 LELENSELHKQVEDLKPEMEQLKMVAEESLLLKKKLEDSDAVILQHKEDNLSIKEKMSQL CG3493-RA LLAKEKELKASGNKLNKIKKQHEQHQAKSSDQSARLEALQSELADRLSHSRQVESEKEEL : .** :.* .: : : : : . ENSMUST00000003544 PDDPRGLLSPRLSRRGVSSPVESRTS---------------SEPVSKENTETSKEPSPTK ENST00000281474 PDDPRGLLSPRLARRGVSSPVETRTS---------------SEPVAKESTEASKEPSPTK SINFRUP00000140623 CDDPRALLSPRLARRLAAVSAACSTEPPRSPMDFPFRDCHHADTPANTADSSSCHSSPTR SINFRUP00000151872 KEHQSSLL---LSNGMLETEVKNSQS---------------------ANTSTTLAPAPEQ ci0100137969 --IISIFIKMLCFIDLVCTDKENILP--------------------KENTSDYSSDTVTT ci0100134183 QGKLQKSDSQCGAMGEEISSLKEENE---------------KLVAGKSSASNSVAELQKE CG3493-RA QARVTGILEEIGTMQAQMQQVQDSHSELERE--------KRKLESRIESLQQEQVDSSAQ . ENSMUST00000003544 TPTISP-VITAPPSSPVLDTS--DIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQR ENST00000281474 TPTISP-VITAPPSSPVLDTS--DIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQR SINFRUP00000140623 NLTGSPGQAISPCPSPVPSEAGGDLRKEPMNIYNMNAIIRDQIKHLQRAVDRSLQLSRQR SINFRUP00000151872 -------------------------RPEPMNIYNLVAIIRDQIRHLQQAVDRTTDLSRQR ci0100137969 -------------------------TTVLSTMRDQLKCLRGSIEKLATNKETSCTVTLAP ci0100134183 LNEYKSQMGEQATAHSAEIQELNCQIETLTRGASLTQDEKTEMDQLKRVAEESLLLKKKL CG3493-RA DERTSAKLEEIQSENTKLAERNCLLEEQTNHLESQLQAKQDEIGKIQAKLQQVLDEHSKL . : .: :: : ENSMUST00000003544 AAARELAPMID-----------KDKEALMEEILKLKSLLSTKR-------EQIATLR--- ENST00000281474 AAARELAPMID-----------KDKEALMEEILKLKSLLSTKR-------EQIATLR--- SINFRUP00000140623 AAARELAPMFD-----------KDKELCMEEILKLKSLLSTKR-------EQIATLR--- SINFRUP00000151872 LANMELSSVAD-----------KDKEACMEEILKLKSLLSTKR-------EQIATLR--- ci0100137969 LPGQTSLAESQ-----------EQVRLLEEEVLRLRSLLSSKR-------EQIATLR--- ci0100134183 EDSDAVILQQK-----------EDNLSIKEEMSQLQGKLQESESWCGAMGEEISSLKEEN CG3493-RA QNAQELMDHDHRTLQDKCDAYEKDKLLTKHTLDCLQSASEELHRVKANLDRELKEQDQQL . :: . : *:. . . .:: ENSMUST00000003544 AVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFS---------- ENST00000281474 AVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFS---------- SINFRUP00000140623 LVLKANKQ---------------------------------------------------- SINFRUP00000151872 AVLKANKQTAEVALANLKSKYDSEKAMVTETMMKLRNELKALKEDAATFS---------- ci0100137969 TVLKANKHTAEVAISNLKSKYQHEKLFVSETMLKLRGELKALKEDAVTFA---------- ci0100134183 EKLVAGKSSASNSVAELQKELNEYKSQMEEQATAHSAEIQELNCQIETLTRGASLTQDEK CG3493-RA SELRERQREQEQQLKDQAERCAKLKAQNSESETQLQATISNLREQLDAYKQT-------- * : : : : ENSMUST00000003544 ------------SLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLN------------- ENST00000281474 ------------SLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLN------------- SINFRUP00000140623 ------------------------------------------------------------ SINFRUP00000151872 ------------SLRAMFATRCDEYVTQLDDMQRQLAVAEDEKKTLN------------- ci0100137969 ------------QLRMMFAARCDEYVAQLDAMQRHLASAEEEKRTLN------------- ci0100134183 TEMDQLKRVAEESLHENLQKSGDEFQAGMTDLKQQLSLVEKKKSELENKKETLKHDYESY CG3493-RA ----------EQGIQEKLQATNSSYTTQIATLEARWSAANSDVERLHEAN-----DALQL : : : : : ENSMUST00000003544 -----TLLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKLGKSKIGSPKI----------- ENST00000281474 -----TLLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKLGKSKIGSPKVSGEASVTVPTI SINFRUP00000140623 ------------------------------------------------------------ SINFRUP00000151872 -----SLLRMAIQQKLALTQRLEDLEFDHKQARRSSAAAA-------------------- ci0100137969 -----TLLRKTITQKLAITQRLEDLEFDREQQTR-------------------------- ci0100134183 KVRVHSVLKQQKSKDTQPPAKQDTTEINNLKLTMEQIKMKLHESQNILASREGELDLLQG CG3493-RA EMEQLKIKHGQEREEVKESIAQKNRQVVELQEAMATRDRQLQEKIEASEKLAKFDEILIE : . ENSMUST00000003544 ----------------VSS------------------------------LLPPYRHSAHN ENST00000281474 DTYLLHSQGPQTPNIRVSSGTQRKRQFSPSLCDQSRPRTSGASYLQNLLRVPPDPTSTES SINFRUP00000140623 ------------------------------------------------------------ SINFRUP00000151872 ------------------------------------------------------------ ci0100137969 ------------------------------------------------------------ ci0100134183 DYDRLLRQQQESSDSAVEREGRWKSRVKSLQQELASVRKQYADALQNISDREDSVSAASQ CG3493-RA NEYLNKHTKQLEAELAESAELKEKLKSLQCELYVLQEKAEQHAVQMAEKETQSATATAEV ENSMUST00000003544 ------------------------------------------------------------ ENST00000281474 FLLKGPPSMSEFIQGHRLSKEKRLTVAPP------------------------------- SINFRUP00000140623 ------------------------------------------------------------ SINFRUP00000151872 ------------------------------------------------------------ ci0100137969 ------------------------------------------------------------ ci0100134183 LEMQRMKEDHEKVVSLIKEDVAHLERELQKARSDAKRKAEDKIESHPSMMSSVDYRSVAR CG3493-RA SELKKAIEEQAVELTRQKEHASFVTEQSDAVQKDLLQAQQQLHDKQIELAMSRDEQALLQ ENSMUST00000003544 ------------------------------------------------------------ ENST00000281474 ------------------------------------------------------------ SINFRUP00000140623 ------------------------------------------------------------ SINFRUP00000151872 ------------------------------------------------------------ ci0100137969 ------------------------------------------------------------ ci0100134183 EDGEGEENPDRSSVVSFEQILKTP----------NQIKSVTVLSDTVSLSSEVQLKQLES CG3493-RA AEADGLRQEVICLKEHLSPSTDSDSLRSLNERLQRELEDLKHKSAGAESNMQQEIEELQA ENSMUST00000003544 ------------------------------------------------------------ ENST00000281474 ------------------------------------------------------------ SINFRUP00000140623 ------------------------------------------------------------ SINFRUP00000151872 ------------------------------------------------------------ ci0100137969 ------------------------------------------------------------ ci0100134183 RFEAQSKQLEHLSEVASENEATTARLIDQNQVLKDEIRRLEKNQERQASVSNLEYLKNVI CG3493-RA NNQQMAERINELETLRAGIQAQQLLASMAPKNVQEAAAAGEKAELESKLKEIMNEVQDVT ENSMUST00000003544 ------------------------------------------------------------ ENST00000281474 ------------------------------------------------------------ SINFRUP00000140623 ------------------------------------------------------------ SINFRUP00000151872 ------------------------------------------------------------ ci0100137969 ------------------------------------------------------------ ci0100134183 YKFATLPPCDEKQHLLPVLDTMLKLTAEEKLTLQTIALGDNTVTESQEASGWGSYLQRWS CG3493-RA NRNLFLEQKCENFLILEQSNERLKLQNAKLSRQLDETLVSMQHSEAVPANTEFEYLRNIM ENSMUST00000003544 ---------------------------------------------- ENST00000281474 ---------------------------------------------- SINFRUP00000140623 ---------------------------------------------- SINFRUP00000151872 ---------------------------------------------- ci0100137969 ---------------------------------------------- ci0100134183 GMQ------------------------------------------- CG3493-RA FQYLTGNTNNETLVKVISAVLKFSPQQAQVALEKEHQRRSLLNKLI