CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000025468 ------------------------------------------------------------ ENST00000255266 ------------------------------------------------------------ ENSMUST00000031456 ------------------------------------------------------------ ENST00000255622 ------------------------------------------------------------ SINFRUP00000140469 ------------------------------------------------------------ SINFRUP00000148073 ------------------------------------------------------------ ENSMUST00000052791 ------------------------------------------------------------ CG8279-RA MHGPVSRSSSSSNMTDVSSPAGGAASPVEMSTTSSSSAATTSASSSKPLTNGANKTAIST ENSMUST00000025468 ------------------------------------------------------------ ENST00000255266 ------------------------------------------------------------ ENSMUST00000031456 ------------------------------------------------------------ ENST00000255622 ------------------------------------------------------------ SINFRUP00000140469 ------------------------------------------------------------ SINFRUP00000148073 ------------------------------------------------------------ ENSMUST00000052791 ------------------------------------------------------------ CG8279-RA AAGGVTPGAVPGPGSGAIPASSSSGNQVKLEHHHRQSNNNRPAVTNRSSETKLMTPTGSS ENSMUST00000025468 ------------------------------MGEVTAEEVEKFLDSNIGFAKQYYNFHYRG ENST00000255266 ------------------------------MGEVTAEEVEKFLDSNIGFAKQYYNLHYRA ENSMUST00000031456 -------------------------------MSLSEEQVRSFLDGNPTFAHQYFGKKLSP ENST00000255622 -------------------------------MSLSEEQARSFLDQNPDFARQYFGKKLSP SINFRUP00000140469 -------------------------------------SVEKYLENNPQFAKEYFDKKVRA SINFRUP00000148073 -----------------------------------KDTVEKFLDNNPEFAKVYYEKKVKA ENSMUST00000052791 ------------------------------MGEISQEAVERYLEKNPCFAKEYFDKKLRV CG8279-RA SSPSQSPSQTQASIQTQTSQQDRLAKASTTASQQDVDEVARLFEEKPEAFEKWLTERAPP . :: : . : : ENSMUST00000025468 KVISDLLG-AKEAAVDFSN------------------------------------YHDVN ENST00000255266 KLISDLLG-AKEAAVDFSN------------------------------------YHSPS ENSMUST00000031456 ENVAGAC--EDGWLADCGS------------------------------------LRELC ENST00000255622 ENVAAAC--EDGCPPDCDS------------------------------------LRDLC SINFRUP00000140469 EALAAAFS-APLDIKDTAS------------------------------------FKEIN SINFRUP00000148073 DVITAAFN-NQVQVKDPAS------------------------------------YKDLS ENSMUST00000052791 EALGVIFKNSHAGVQTGLS------------------------------------LPEMT CG8279-RA EALSRLQEFIENRKPHKRPSVTSDLFQQWMAASPTVQQKSPRSLSNSSASSLPECRRHLM . : ENSMUST00000025468 SVEESEIIFDLLRDVQ-ENLQAEKCTFNVMKKLCFLLRADRMSLFMYRTRNGIAELATRL ENST00000255266 SMEESEIIFDLLRDFQ-ENLQTEKCIFNVMKKLCFLLQADRMSLFMYRTRNGIAELATRL ENSMUST00000031456 QVEESAALFELVQDMQ-ESVNMERVVFKILRRLCTILHADRCSLFMYRQRNGIAELATRL ENST00000255622 QVEESTALLELVQDMQ-ESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRL SINFRUP00000140469 CVLEAGLIMELVQELQ-KPGNMEQCLHKVLQRVGLIIQADRLSYFQCRGRNGTPELTTCL SINFRUP00000148073 TIQEAEFIFELIKEIQ-SSNPLEKILHKILQRIALLIQADRCSYFGCRARNGTPELSTIL ENSMUST00000052791 QVEESAVCLELLQCMQDEAGSAEQMAHRALQRLAQLLQADCCSMFSCRARNGIPEVASRL CG8279-RA DLDEGELFMELIRDVA-NELDIDVLCHKILVNVGLLTHADRGSLFLAKGTPTNKYLVAKL : *. ::*:: . . : .. : .: : :** * * : : : * ENSMUST00000025468 FNVHKDAVLEDCLVMP-DSEIVFPLDMGVVGHVAHSKKIANVPNTEEDEHFCDFVDNLTE ENST00000255266 FNVHKDAVLEDCLVMP-DQEIVFPLDMGIVGHVAHSKKIANVPNTEEDEHFCDFVDILTE ENSMUST00000031456 FSVQPDSLLEDCLVPP-DSEIVFPLDIGIVGHVAQTKKMINVQDVAECPHFSSFADELTD ENST00000255622 FSVQPDSVLEDCLVPP-DSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTD SINFRUP00000140469 FDVTPTSKFEANLVHP-QTEIVFPLEMGIVGHTAQSKKPQNVPDVSASKKFSDFVDKQTG SINFRUP00000148073 FDVTHNSPLEKNIVNP-NVEIVFPTDMGVVGWTAHSKKPQNIPDVKKESHFSDFVDKQTK ENSMUST00000052791 LNVTPTSKFEDNLVAP-DREVVFPLDIGIVGWVAHVKKALNVSDVKKNSHFSDFMDKQTG CG8279-RA FDVTQKTALKDAVTRASAEEIIIPFGIGIAGMVAQTKQMINIKEAYKDARFNCEIDLKTG :.* : :: :. . *:::* :*:.* .*: *: *: :. :* * * ENSMUST00000025468 YQTKNILASPIMNGK-DVVAIIMAVNKI-DEPHFTKRDEEILLKYLNFVNLIMKVFHLSY ENST00000255266 YKTKNILASPIMNGK-DVVAIIMAVNKV-DGSHFTKRDEEILLKYLNFANLIMKVYHLSY ENSMUST00000031456 YVTKNILSTPIMNGK-DVVAVIMAVNKL-DGPCFTSEDEDVFTKYLNFATLNLKIYHLSY ENST00000255622 YKTKNMLATPIMNGK-DVVAVIMAVNKL-NGPFFTSEDEDVFLKYLNFATLYLKIYHLSY SINFRUP00000140469 YKTKCMLAYPMVVDK-ECIGVVMALNKI-GADAFTAEDDQLFQKYMNFAQVITLQHHTAY SINFRUP00000148073 YTTKCVITAPVMSGK-EPIGVIMALNKQ-GAEDFSKSDQELFNKYVNFAAVVVMQAHTSY ENSMUST00000052791 YVTRNLLAVPIVAGK-EVLAVVMAVNKI-SAPEFSKQDEEVFSKYLSFVAVALRLQHTSY CG8279-RA YKTNAILCMPICNYEGDIIGVAQIINKTNGCMEFDEHDVEIFRRYLTFCGIGIQNAQLFE * *. :: *: : : :.: :** . * * ::: :*:.* : : ENSMUST00000025468 LHNCETRRGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFF ENST00000255266 LHNCETRRGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFF ENSMUST00000031456 LHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFF ENST00000255622 LHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFF SINFRUP00000140469 MFNVESRRSQVLLWSASKVFEELTDIERQFHKALYTVRTYLQCERYSVGLLDMTKEKEFY SINFRUP00000148073 MWDVESRKSQVLLWAASKVFEELTDIERQFHKALYTVRTYIKCERYSVGLLDMTKDKEFF ENSMUST00000052791 LYSVESRRSQILMWSANKVFEELTDVERQFHKALYTIRTYLNCDRYSIGLLDMTKEKEFY CG8279-RA MSVQEYRRNQILLNLARSIFEEQNNLECLVTKIMTEARELLKCERCSVFLVDLDCCEASH : * *:.*:*: . .:*** .::* . * : * ::*:* *: *:*: : . ENSMUST00000025468 DVWPVLMGEAPAYSGPRTPDGRE--------INFYKVIDYILHGKEDIKVIPNPPADHWA ENST00000255266 DVWPVLMGEVPPYSGPRTPDGRE--------INFYKVIDYILHGKEDIKVIPNPPPDHWA ENSMUST00000031456 DVWPVLMGEAQPYSGPRTPDGRE--------IVFYKVIDYILHGKEDIKVIPTPPADHWA ENST00000255622 DVWSVLMGESQPYSGPRTPDGRE--------IVFYKVIDYVLHGKEEIKVIPTPSADHWA SINFRUP00000140469 DEWPIKLGDVEPYKGPKTPDGRE--------VIFYKIIDYLLEGKEEIKVIPGPPADHWA SINFRUP00000148073 DEWAIKLGDQEPYKGPKTPDGRE--------ISFYKIIDYLLEDKEEIKVIPGPPADHWA ENSMUST00000052791 DEWPIKLGEVEPYKGPKTPDGRE--------IIFYKIIDYILHGKEEINVIPSPPADHWT CG8279-RA LEKIIEKPNQPATRAIKSADSFEEKKMRNRFTVLFELGGEYQAANVSRPSVSELSSSTLA : : . . ::.*. * :::: . : . :. ... : ENSMUST00000025468 LVSGLPTYVAQNGLICNIMNAPAEDFFEFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVA ENST00000255266 LVSGLPAYVAQNGLICNIMNAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVA ENSMUST00000031456 LASGLPTYVAESGFICNIMNASADEMFNFQEGPLDDSGWVIKNVLSMPIVNKKEEIVGVA ENST00000255622 LASGLPSYVAESGFICNIMNASADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVA SINFRUP00000140469 LISGLPTYVAENGFICNMMNVAADDFFAFQKEAVDETGFIIKNVLSLPIVNKKEEIVGIA SINFRUP00000148073 LVSGLPSYVAENGMICNMMNAAADDYFTFQKEAVDESGWKIKNVLALPIVNKKEEIVGVA ENSMUST00000052791 LVSGLPTYVAENGFICNMLNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVA CG8279-RA QIAQFVATTGQTVNICDVIEWVRDHNQIRAEDEIDST----QAILCMPIMNAQKKVIGVA : : : ..:. **:::: :. : :*.: :: :*.:**:* ::.::*:* ENSMUST00000025468 TFYNRKDGKPFDDMDETLMESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCD ENST00000255266 TFYNRKDGKPFDEMDETLMESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCD ENSMUST00000031456 TFYNRKDGKPFDDQDEVLMESLTQFLGWSVLNTDTYDKMNKLENRKDIAQDMVLYHVRCD ENST00000255622 TFYNRKDGKPFDEQDEVLMESLTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCD SINFRUP00000140469 TFFNRKDGKPFDEHDEQITEALTQFLGWSVLNCDTYDRLNRMEHRKDIAQEMLMYQTKCT SINFRUP00000148073 TFFNRKDGKPFDENDEQIIESLTQFLGWATLNSDTYDKLNRTEWRKEVAQEMLMYQTKAS ENSMUST00000052791 TFYNRKDGKPFDEHDEHITETLTQFLGWSLLNTDTYERVNKLESRKDIAQEMVMNLTKAT CG8279-RA QLINKANGVPFTDSDASIFEAFAIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATAS : *: :* ** : * : *::: * * . * : *: : ::.: : : . . ENSMUST00000025468 NEEIQKILKTREVYGKEP-WECEEEELAEILQGELPDAESYE---INKFHFSDLPLTELE ENST00000255266 NEEIQKILKTREVYGKEP-WECEEEELAEILQAELPDADKYE---INKFHFSDLPLTELE ENSMUST00000031456 KDEIQEILPTRDRLGKEP-ADCEEDELGKILKEELPGPTKFD---IYEFHFSDLECTELE ENST00000255622 RDEIQLILPTRARLGKEP-ADCDEDELGEILKEELPGPTTFD---IYEFHFSDLECTELD SINFRUP00000140469 SDELQSILNTKEKFDAEP-EDCDQKEMYKLLKSTCPPSDNINGENLYSFAFSDFPVSEFD SINFRUP00000148073 LSDVQTILNTQEKFGSDP-EDCDQKEMYKLLKSNIPDAKTVD---LHEFHFSDFPLSEFE ENSMUST00000052791 PDEISSILKFKEKLNVEVIEECEERQLLAILKEDLPDPRTAD---LYEFCFSDFPITEHE CG8279-RA -----------------------QDQTEKLTQDVIAEAESYN---LYSFTFTDFELVDDD : :: : : : : . . . : : .* *:*: : : ENSMUST00000025468 LVKCGIQMYYELRVVDKFHIPQEALVRFMYSLSKGYRRITYHNWRHGFNVGQTMFSLLVT ENST00000255266 LVKCGIQMYYELKVVDKFHIPQEALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVT ENSMUST00000031456 LVKCGIQMYYELGVVRKFQIPQEVLVRFLFSVSKAYRRITYHNWRHGFNVAQTMFTLLMT ENST00000255622 LVKCGIQMYYELGVVRKFQIPQEVLVRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMT SINFRUP00000140469 LIKAGIRMFFELGVVEKFKVPAETLTRWMYTVRKGYRAITYHNWRHGFNVGHTMFCLLQT SINFRUP00000148073 LIKCGIRCFFELGVVEKFKVQAETLTRWMYTVRKGYRDITYHNWRHGFNVGQTMFTLLLT ENSMUST00000052791 LVKCGLRLFLEINVVEKFKVPVEVLTRWMYTVRKGYRPVTYHNWRHGFNVGQTMFTLLMV CG8279-RA TCRAVLRMFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVKYHNWRHALNVAQTMFAMLKT :. :: : : :* :*:: :.* *:: :: * ** :.******.:**.:*** :* . ENSMUST00000025468 GKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQMK-SQNPLAKLHGSSILERHHLEFGK ENST00000255266 GKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQMK-SQNPLAKLHGSSILERHHLEFGK ENSMUST00000031456 GKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMK-SQNPLAKLHGSSILERHHLEFGK ENST00000255622 GKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMK-SQNPLAKLHGSSILERHHLEFGK SINFRUP00000140469 GKLRKYYSDLDAFAMVAAAFCHDIDHRGTNNLYQTKRSAHPLAKLHGTSIMERHHLEYSK SINFRUP00000148073 GKLKKYYSDLDAFAMVAAGFCHDIDHRGTNNLYQTK-SLSPLAKLHSSSVMERHHLEYSK ENSMUST00000052791 GRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMK-STSPLARLHGTSILERHHLEYSK CG8279-RA GKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTK-TESPLAILYTTSTMEHHHFDQCV *::. : :**: :.::.* :***:******* :* * : *** *: :* :*:**:: ENSMUST00000025468 TLLRDESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESTQE ENST00000255266 TLLRDESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQE ENSMUST00000031456 FLLAEESLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRTMFQKIVDESKNYEDKKS ENST00000255622 FLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRAMFQKIVDESKNYQDKKS SINFRUP00000140469 TLMGEEVLNIFCNLQKRQFEHVQHLFDVCIIATDLALYFK-------------------- SINFRUP00000148073 TLMEDENLNIFQNLQKRQFETVQHLFEVCIIATDLALYFKKRTMFQKLVESMQAMPEEKE ENSMUST00000052791 TLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDTCEQMQSEEE CG8279-RA MILNSEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVENGE------- :: .* **: *. .:.. . : .: .*::****:*** : :: ENSMUST00000025468 WTQYMMLEQTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLQQN ENST00000255266 WTQYMMLEQTRKEIVMAMMMTACDLSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQN ENSMUST00000031456 WVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQ ENST00000255622 WVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQ SINFRUP00000140469 ------------------------------------------------------------ SINFRUP00000148073 RISYVSNNPTRKEIIMAMMMTACDLSAITKPWEVQ------------------------- ENSMUST00000052791 TIKYVTSDPTKKEVIMAMMMTACDLSAITKPWEVQS---------------------QAS CG8279-RA ---FDWQGEEKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQLNTQ :: ::: : : : : :: : : : ENSMUST00000025468 PIPMMDRNKADELPKLQVGFIDFVCTFVYK-----EFSRFHEEITPMLDGITNNRKEWKA ENST00000255266 PIPMMDRNKADELPKLQVGFIDFVCTFVYK-----EFSRFHEEITPMLDGITNNRKEWKA ENSMUST00000031456 PIPMMDRNKAAELPKLQVGFIDFVCTFVYK-----EFSRFHEEILPMFDRLQNNRKEWKA ENST00000255622 PIPMMDRNKAAELPKLQVGFIDFVCTFVYKASGSREFSRFHEEILPMFDRLQNNRKEWKA SINFRUP00000140469 ------------------------------------------------------------ SINFRUP00000148073 ------------------------------------------------------------ ENSMUST00000052791 PTAFPSLSKKDELPKLQVGFIDFVCTFVYK-----EFSRFHGEITPMLNGLQNNRVEWKS CG8279-RA PVAMMDRERKDELPKMQVGFIDVICLPLYR-----VLCDTFPWITPLYEGTLENRRNWQD : : : : :: .: : : : : ENSMUST00000025468 LADEYEAKMKALEEEKQKQQAAKQAASGNQPGGNPTPGGAPASKSCCIQ----------- ENST00000255266 LADEYDAKMKVQEEKKQKQQSAKSAAAGNQPGGNPSPGGATTSKSCCIQ----------- ENSMUST00000031456 LADEYEAKVKALEEEKKKEEDRVAAKKVGTEVCNGGP--APKSSTCCIL----------- ENST00000255622 LADEYEAKVKALEE--KEEEERVAAKKVGTEICNGGP--APKSSTCCIL----------- SINFRUP00000140469 ------------------------------------------------------------ SINFRUP00000148073 ------------------------------------------------------------ ENSMUST00000052791 LAEEYEAKVKVTEEEAGKQEEEASDGKGWLD----------------------------- CG8279-RA LAEKVEMGLTWIDHDTIDKPVEEFAACADEEIKDIEFTVTTLNCNQQSQHGSEDSHTPEH : : ENSMUST00000025468 ------------------------------------------------------------ ENST00000255266 ------------------------------------------------------------ ENSMUST00000031456 ------------------------------------------------------------ ENST00000255622 ------------------------------------------------------------ SINFRUP00000140469 ------------------------------------------------------------ SINFRUP00000148073 ------------------------------------------------------------ ENSMUST00000052791 ------------------------------------------------------------ CG8279-RA QRSGSRLSMKKTGALGKAVRSKLSKTLYNSMDGSKPKTSLKLLESHVSEDMDDKSPTSPS ENSMUST00000025468 -------------------------------------- ENST00000255266 -------------------------------------- ENSMUST00000031456 -------------------------------------- ENST00000255622 -------------------------------------- SINFRUP00000140469 -------------------------------------- SINFRUP00000148073 -------------------------------------- ENSMUST00000052791 -------------------------------------- CG8279-RA QPQASGSMGRMSASSSTSSAGGQMVDKSKKRSKLCALL