CLUSTAL W (1.82) multiple sequence alignment ENST00000224036 --------------------MLLETGLERDRAR---PGAAAVCTLGGTRE ENSMUST00000053167 --------------------MLLEAELDCHRERPGAPGASALCTFSRTPE O42286_Brachydanio_rerio -------------------------------------------------- ENST00000263726 --------------------MMQSATVPAEGAVKGLPEMLGVP----MQQ ENSMUST00000027740 -------------------------------------------------E ENST00000261731 -------------------------------------------------M ENSMUST00000031591 -------------------------------------------------M SINFRUP00000136545 -------------------------------------------------- SINFRUP00000151087 --------------------------------------------GVSPGS O13106_Brachydanio_rerio -------------------------------------------------- ENSMUST00000018842 -------------------------------------------------- ENST00000254457 -------------------------------------------------- ENST00000259471 ---------------------MLDGIKMEEHALRPGPATLGVLLGSDCPH CG10619-RB MVMAEIGGHLAHQLPLHNHNHNQTGLQPSLVMNHHLDLDCHGHDVIKKQR ENST00000224036 IPLCAGCDQHILDRFILKAL-DRHWHSKCLKCSDCHTPLAE--RCFSRGE ENSMUST00000053167 IPMCAGCDQHILDRFILKAL-DRHWHSKCLKCSDCHVPLAE--RCFSRGE O42286_Brachydanio_rerio IPVCAGCNQHIVDRFILKVL-DRHWHSKCLKCSDCQSQLAD--KCFSRGD ENST00000263726 IPQCAGCNQHILDKFILKVL-DRHWHSSCLKCADCQMQLAD--RCFSRAG ENSMUST00000027740 IPQCAGCNQHILDKFILKVL-DRHWHSSCLKCADCQMQLAD--RCFSRAG ENST00000261731 MVHCAGCERPILDRFLLNVL-DRAWHIKCVQCCECKTNLSE--KCFSREG ENSMUST00000031591 MVHCAGCERPILDRFLLNVL-DRAWHIKCVQCCECKTNLSE--KCFSREG SINFRUP00000136545 -------------------------------------------------- SINFRUP00000151087 MLQCTSCEKPILDRFLLKVL-DRPWHVKCVQCCDCKCTLSE--KCFSREG O13106_Brachydanio_rerio MVHCAGCERPILDRFLLSVL-DRAWHAKCVQCCDCKCSLTD--RCFSREG ENSMUST00000018842 MVHCAGCKRPILDRFLLNVL-DRAWHVKCVQCCECKCNLTE--KCFSREG ENST00000254457 MVHCAGCKRPILDRFLLNVL-DRAWHVKCVQCCECKCNLTE--KCFSREG ENST00000259471 PAVCEGCQRPISDRFLMRVN-ESSWHEECLQCAACQQALTT--SCYFRDR CG10619-RB LSHCVGCGGQIHDQYILRVAPDLEWHAACLKCQECRQFLDESCTCFVRDG ENST00000224036 SVYCKDDFFKRFGTKCAACQLGIPPTQVVRRAQDFVYHLHCFACVVCKRQ ENSMUST00000053167 SVYCKDDFFKRFGTKCAACQLGIPPTQVVRRAQDFVYHLHCFACVVCKRQ O42286_Brachydanio_rerio SVYCKDDFFKRFGTKCAACQQGIPPTQVVRRAQDFVYHLHCNACIVCKRQ ENST00000263726 SVYCKEDFFKRFGTKCTACQQGIPPTQVVRKAQDFVYHLHCFACIICNRQ ENSMUST00000027740 SVYCKEDFFKRFGTKCTACQQGIPPTQVVRKAQDFVYHLHCFACIICNRQ ENST00000261731 KLYCKNDFFRRFGTKCAGCAQGISPSDLVRKARSKVFHLNCFTCMVCNKQ ENSMUST00000031591 KLYCKNDFFRRFGTKCAGCAQGISPSDLVRKARSKVFHLNCFTCMVCNKQ SINFRUP00000136545 ---------RRFGTKCAGCLQGISPSDLVRKARSKVFHLNCFTCMVCNKQ SINFRUP00000151087 KLYCKNDFFRRFGTKCDGCAQGILPSDLVRRAKSKVFHLNCFTCMMCNKQ O13106_Brachydanio_rerio RLYCKNDFFRRYGTKCGGCAQGISPSDLVRKARSKVFHLNCFTCIMCNKQ ENSMUST00000018842 KLYCKNDFFRCFGTKCAGCAQGISPSDLVRRARSKVFHLNCFTCMMCNKQ ENST00000254457 KLYCKNDFFRCFGTKCAGCAQGISPSDLVRRARSKVFHLNCFTCMMCNKQ ENST00000259471 KLYCKQDYQQLFAAKCSGCMEKIAPTEFVMRALECVYHLGCFCCCVCERQ CG10619-RB KTYCKRDYVRLFGTKCDKCGNSFSKNDFVMRAKTKIFHIECFRCSACARQ : :.:** * : .:.* :* ::*: * * * :* ENST00000224036 LATGDEFYLMEDSRLVCKADYE---------------------------- ENSMUST00000053167 LATGDEFYLMEDSRLVCKADYE---------------------------- O42286_Brachydanio_rerio LATGDEYYLMEDSRLVCKADYE---------------------------- ENST00000263726 LATGDEFYLMEDGRLVCKEDYE---------------------------- ENSMUST00000027740 LATGDEFYLMEDGRLVCKEDYE---------------------------- ENST00000261731 LSTGEELYVIDENKFVCKDDYL-SSSSLKEGSLNSVSSCTDRSLSPDLQD ENSMUST00000031591 LSTGEELYVIDENKFVCKDDYL-SSSSLKEGSLNSVSSCTDRSLSPDLQD SINFRUP00000136545 LSTGEELYVIDENKFVCKEDFL-SSGATKEANLNSVSSCTDRSLSPDLQD SINFRUP00000151087 LSTGEELYVLDEFKFVCKEDYH-NSS-GKDTILLSVTSCSDPSMSPDSQD O13106_Brachydanio_rerio LSTGEELYILDEYKFVCKEDYL-NNSNGKDTNLLSITTCSDPSLSPESQD ENSMUST00000018842 LSTGEELYIIDENKFVCKEDYLSNSSVAKENSLHSATTGSDPSLSPDSQD ENST00000254457 LSTGEELYIIDENKFVCKEDYLSNSSVAKENSLHSATTGSDPSLSPDSQD ENST00000259471 LRKGDE-FVLKEGQLLCKGDYE------------KEKDLLSSVSPDESDS CG10619-RB LLPGDEFALRDAGALYCKEDHDVLEKSSQSSLTSSSVESNNNISSSNNNN * *:* : . : ** *. ENST00000224036 ---------------------------TAKQRE-AEATAKR--PRTTITA ENSMUST00000053167 ---------------------------TAKQRE-AEATAKR--PRTTITA O42286_Brachydanio_rerio ---------------------------TAKQRE-ADSTAKR--PRTTITA ENST00000263726 ---------------------------TAKQNDDSEAGAKR--PRTTITA ENSMUST00000027740 ---------------------------TAKQNDDSEAGAKR--PRTTITA ENST00000261731 ALQDDPKETDNS--------TSSDKETANNENEEQNSGTKRRGPRTTIKA ENSMUST00000031591 PLQDDPKETDNS--------TSSDKETANNENEEQNSGTKRRGPRTTIKA SINFRUP00000136545 PTQDDIKETDNS--------TSSDKETNNIENEEQNSGTKRRGPRTTIKA SINFRUP00000151087 P-QDDGKDSETG--------HLSDKDACGNENDEQGAVGKRRGPRTTIKA O13106_Brachydanio_rerio P-QDDYKDSESG--------PMSDKETCNNENDEQNLGGKRRGPRTTIKA ENSMUST00000018842 PSQDDAKDSESA--------NVSDKEGGSNENDDQNLGAKRRGPRTTIKA ENST00000254457 PSQDDAKDSESA--------NVSDKEAGSNENDDQNLGAKRRGPRTTIKA ENST00000259471 VKSEDEDGDMKP--------AKGQGSQSKGSGDDGKDPRRPKRPRTILTT CG10619-RB TNLSNNNHSSELGSMSDSGSESGSHKSIRDKRPSGPSDGKPTRVRTVLNE . : ** :. ENST00000224036 KQLETLKSAYNTSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLK ENSMUST00000053167 KQLETLKSAYNTSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLK O42286_Brachydanio_rerio KQLETLKNAYNNSPKPARHVREQLSTETGLDMRVVQVWFQNRRAKEKRLK ENST00000263726 KQLETLKNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLK ENSMUST00000027740 KQLETLKNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLK ENST00000261731 KQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMK ENSMUST00000031591 KQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMK SINFRUP00000136545 KQLETLKAAFVATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMK SINFRUP00000151087 KQLETLKAAFAATPKPTRHIREQLSQETGLNMRVIQVWFQNRRSKERRMK O13106_Brachydanio_rerio KQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMK ENSMUST00000018842 KQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMK ENST00000254457 KQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMK ENST00000259471 QQRRAFKASFEVSSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLA CG10619-RB KQLHTLRTCYNANPRPDALMKEQLVEMTSLSPRVIRVWFQNKRCKDKKKT :* .::: .: ..:* ::* * *.*. **::*****:*.* :: ENST00000224036 KDAGR-QRWGQYFRNMKRSRGGSKSDKDSVQE-GQDSDAEVSFPDEPSLA ENSMUST00000053167 KDAGR-QRWGQYFRNMKRSRGSSKSDKDSIQE-GQDSDAEVSFTDEPSMA O42286_Brachydanio_rerio KDAGR-QRWGQYFRNMKRSRGTSKSDKDSTQEDGMDSDAEVSFTDEAAMS ENST00000263726 KDAGR-HRWGQFYKSVKRSRGSSKQEKESSAEDCGVSDSELSFREDQILS ENSMUST00000027740 KDAGR-HRWGQFYKSVKRSRGGSKQEKESSAEDCGVSDSELSFREDQILS ENST00000261731 QLSALGARRHAFFRSPRRMRPLG----GRLDESEMLGSTPYTYYGDYQGD ENSMUST00000031591 QLSALGARRHAFFRSPRRMRPLG----GRLDESEMLGSTPYTYYGDYQSD SINFRUP00000136545 QLSALGARRHAFFRGPRRMRALG----GRLEDPDILGPGAYGYYGEYQGD SINFRUP00000151087 QLSTLGSRRHVFFRGQRRMRALG----ERLEPDELA---HFSYYGDYPGD O13106_Brachydanio_rerio QLSALGARRHMFFRSPRRMRALG----DRMEPGELMANGHFSFYGDYQSE ENSMUST00000018842 QLSALGARRHAFFRSPRRMRPLV----DRLEPGELIPNGPFSFYGDYQSE ENST00000254457 QLSALGARRHAFFRSPRRMRPLV----DRLEPGELIPNGPFSFYGDYQSE ENST00000259471 RRHQQQQEQQNSQR-----------------------------LGQEVLS CG10619-RB IQMKLQMQQEKEGRKLGYGAMQG---IPMIASSPVRHDSPLNLQGLDVQT . : ENST00000224036 EMGPANGLYGSLGEPTQALGRPSGALGNFSLEHGGLAGP-EQYRELRPGS ENSMUST00000053167 DMGPANGLYSSLGEPAPALGRPVGGLGSFTLDHGGLTGP-EQYRELRPGS O42286_Brachydanio_rerio DLGHSNGIYSSLSESSPALSRQGGNHPAFPLEHGAIIPSQEPYHDIQASS ENST00000263726 ELGHTNRIYGNVGDVTGGQLMN----GSFSMDGTG-----QSYQDLRDGS ENSMUST00000027740 ELGHTNRIYGNVGDVTGGQLMN----GSFSMDGTG-----QSYQDLRDGS ENST00000261731 YYAPGSNYDFFAHGPPS-QAQSPADSSFLAA-------------SGPGST ENSMUST00000031591 YYAPGGNYDFFAHGPPS-QAQSPADSSFLAA-------------SGPGST SINFRUP00000136545 YYGPGSNYDFFPHGPPSSQAQSPAESPYMLG-------------SGPG-- SINFRUP00000151087 YYGPGGNYEYF-QGPPSSQAQTPADLGYMPT-------------SIPAGT O13106_Brachydanio_rerio YYGPGSNYDYFPQGPPSSQAHTPGDLGFMPS-------------SGPAGT ENSMUST00000018842 YYGPGGNYDFFPQGPPSSQAQTPVDLPFVPS-------------SGPSGT ENST00000254457 YYGPGGNYDFFPQGPPSSQAQTPVDLPFVPS-------------SGPSGT ENST00000259471 SRMEGMMASYTPLAPPQQQIVAMEQSPYGSS--------------DPFQQ CG10619-RB YQPPWKALSDFALHADLDSNGAINTHTPAFQ--------------QLVNQ ENST00000224036 PYGVPPSPAAPQSLPGPQPLLSSLVYP-DTSLGLVP-SGAPGGPPPMRVL ENSMUST00000053167 PYGIPPSPAAPQSLPGPQPLLSSLVYP-DTNLSLVP-SGPPGGPPPMRVL O42286_Brachydanio_rerio PYSLLQSPGPLQPLPRHQPLISSLVYP-ESGLPMVGQSGGQNMTPGVRMM ENST00000263726 PYGIPQSPSSISSLPSHAPLLNGLDYTVDSNLGIIA-HAGQGVSQTLRAM ENSMUST00000027740 PYGIPQSPSSISSLPSHAPLLNGLDYTVDSNLGIIA-HAGQGVSQTLRAM ENST00000261731 PLGALEPPLAGPHAA-DNPRFTDMIS--HPDTPSPEPGLPGTLHPMPGEV ENSMUST00000031591 PLGALEPPLAGPHGA-DNPRFTDMIS--HPDTPSPEPGLPGALHPMPGEV SINFRUP00000136545 ---GMEG--SGHHPS-EDQRFTDMIS--HAETPSPDPGLPGSLQPVPGEA SINFRUP00000151087 PLGVLDHHHQGHHHAGELQCFPDTR--HPADSPSPEPHAPGSGRSISGEM O13106_Brachydanio_rerio PLGNMDPHHGAHHPSNDTQCFSEMISHHPGDSPSPEPSAPASIHSISTDM ENSMUST00000018842 PLGGLDHPLPGHHPSSEAQRFTDILAHPPGDSPSPEPSLPGPLHSMSAEV ENST00000254457 PLGGLEHPLPGHHPSSEAQRFTDILAHPPGDSPSPEPSLPGPLHSMSAEV ENST00000259471 GLTPPQMPGDHMNPYGNDSIFHDIDSDTSLTSLSDCFLGSSDVGSLQARV CG10619-RB MHGYDLNGMPILPPHPHSHPAQGPPHQHPPPPGGPHNHQNQQPNQQPGGS ENST00000224036 AG-NGPSSDLSTGSSGGYPDFPASPASWLDEVDHAQF ENSMUST00000053167 AG-NGPSSDLSTESSSGYPDFPASPASWLDEVDHAQF O42286_Brachydanio_rerio AAGNGPSSDLSTGSSGGYPDFPASPASWLDEVDHAQF ENST00000263726 AG--GPTSDISTGSSVGYPDFPTSPGSWLDEMDHPPF ENSMUST00000027740 AG--GPTSDLSTGSSVGYPDFPTSPASWLDEMDHPPF ENST00000261731 FSGG-PSPPFPMSGTSGYSGPLSHPNPELNEAAVW-- ENSMUST00000031591 FSGG-PSPPFPMSGTSGYSGPLSHPNPELNEAAVW-- SINFRUP00000136545 YGGG-PSPPFSLASNSSYSAPMSHQGQEMGESAAW-- SINFRUP00000151087 CGPGTPYTNV-SLSDNGYTNQLSQPSSEMSEGTVW-- O13106_Brachydanio_rerio CDSTPPFTSLNSLSANGYSNQLS---SEMNEGTVW-- ENSMUST00000018842 FGPSPPFSSLSVNGGASYGNHLSHP-PEMNEAAVW-- ENST00000254457 FGPSPPFSSLSVNGGASYGNHLSHP-PEMNEAAVW-- ENST00000259471 GN---PIDRLYSMQSSYFAS----------------- CG10619-RB SLDSGITSHHHPDSTDSYVTYLESDDSMQGSP----- :