CLUSTAL W (1.82) multiple sequence alignment ci0100153637 --------------------------RRQGEPPLVNHTLPFIG-----AALDFGKDPLNY ci0100150360 -----------------------VKYRRAGEPPLVSHWIPFIG-----SALDFGKAPLEY ENSMUST00000018113 -MSWAALLGLLAVLLLLLLLLSRRRARRPGEPPLDLGSIPWLG-----HALEFGRDAASF ENST00000244043 -MAWAALLGLLAALLLLLLLS-RRRTRRPGEPPLDLGSIPWLG-----YALDFGKDAASF SINFRUP00000149280 --------------------------RQDNEPPLDKGALPWLG-----HALEFGRDAAKF ENSMUST00000062474 MTLWCTVLGALLTVVGCLCLSLLLRHRRPWEPPLDKGFVPWLG-----HSMAFRKNMFEF SINFRUP00000147192 ------------------------------------------------------------ ENSMUST00000035625 ------------------------------------------------------------ ci0100138282 ------------------IWLVAKRKQKDGEPPIVPFWIPWLG-----SGLQYQKDPITF ci0100138987 -----------------------KRQQRDGEPNIVPYSIPYLGRAINLYSLPFYKDPVKF ENSMUST00000055172 MGIMELFSPIAIAVLGSCVLFLFSRLKNLLGPPCIQGWIPWIG-----AGLEFGKAPLEF CG4486-RA MALIEICLALVVIGYLIYKWSTATFKTFEERKLYFEKPYPFVG-----NMAAAALQKSSF : ci0100153637 LRNLQSKFGDVFTIKLAGWDTHVFMNPLDVRSLER--AKFLGHQEIIGDFVTRMVGSPHS ci0100150360 LQSLQKRLGDVFTIKLAGWNVHVFMNPHDVPNLER--AKNIDHKNVIGDFVSRMVGDEHM ENSMUST00000018113 LTRMKEKHGDIFTVLVGGRYVTVLLDPHSYDTVVWELRTRLDFHPYAIFLMERIFDLQ-- ENST00000244043 LTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQ-- SINFRUP00000149280 LARMKEKHGDVFTVRVAGQYITVLLDANSFDSVLNDTVS-LDFVKSKNQLLERIFFLK-- ENSMUST00000062474 LKGMRAKHGDVFTVQLGGQYFTFVMDPLSFGPIIKNTEKALDFQSYAKELVLKVFGYQ-- SINFRUP00000147192 -----------LSCAPAGKYMTFIMDPLMY-PNIIKHGRQLDFHSFSDSMAPVVFGYPPV ENSMUST00000035625 ---------------------------------------QLSFQKFSSRLSAKAFSVK-- ci0100138282 LRKQEKKYGPIFTVFMGGSYFTFVTDPFTH-PIIAKESKVLNFRICTIPTIKKVFDFTR- ci0100138987 LKECEEKYGSVFTLFMGGQYFTFVTDPFVQ-HIIVKEKKVLRFRNCLPPVLKHAFDYYP- ENSMUST00000055172 IEKARIKYGPVFTIFAMGNRMTFVSEEEGINVLLK--SEHVDFESAVQSPVYHTAWIP-- CG4486-RA QRQLTEFYERTRQHKLVGFFNMRTPMITLNDPELIKKVCVKDFDHFPNHQPFITSNDRLF . ci0100153637 IHNHEHLAEIFPK--NGKPKNPDQ--VLSPAADVQKKLTHSIEKNLRGSMQLNLLCSSCK ci0100150360 IHNPARHSDAVPKILESTLRSTMH--LMTLCDSCTNVLPKTIKRTLKSEFN----CK--R ENSMUST00000018113 --LPNFNPSEEKARMKPTLM-------HRDLQALTEAMYTNLRTVLLG---DST-EAGSG ENST00000244043 --LPHYSPSDEKARMKLTLL-------HRELQALTEAMYTNLHAVLLG---DAT-EAGSG SINFRUP00000149280 --LPGLQPAAEREWMEQHFH-------GFRLSNLSGTMKANIESLLLS---DVKGGSASG ENSMUST00000062474 --SVDGDHRMIHLASTKHLM-------GQGLEELNQAMLDSLSLVMLGP--KGSSLGASS SINFRUP00000147192 RSWKTPSLHEDIQRAFKLLQ-------GDHLCALTEGMMGNLMMLLRQDHLGRRPGAGPG ENSMUST00000035625 KLLTDDDLNEDVHRAYLLLQ-------GKPLDALLETMIQEVKELFESQLLKIT-----D ci0100138282 ---RGVDVPTMGGLMVKYMQTINLCLKGHWLETLVSKMMGNLQKVLLH---GSYNNT--E ci0100138987 ---TAVDDEMMK-LTHHYFQ-------GKPLGLLVKQMNRNIQKWILD---GNQGDAGDK ENSMUST00000055172 -------------------------------KNVFSALHERLYALMKG-----------K CG4486-RA NDMLSVMRDQRWKHMRNTLTPVFT---AAKMRNMFTLMNESFAECLQHLDSSSKTLPGRK : . : ci0100153637 PVVIKLHEFSKKLIFDITFNLLFG-------SLPDYERASEETERTYDVFKTYFKGSALL ci0100150360 ETKIGLYELCKKLVSDMTLNLFFG-------SIASDEKCNEETKQICEEFFVYFKSSALL ENSMUST00000018113 WQETGLLEFSYNALLSAGYLTLYGVEA-SPRTHESQAQDRVHSADVFHTFRQLDLLLPKL ENST00000244043 WHEMGLLDFSYSFLLRAGYLTLYGIEA-LPRTHESQAQDRVHSADVFHTFRQLDRLLPKL SINFRUP00000149280 WRQDGLFNFCYSLLFRAGYLTLF------------DSADNVT--AIYKEFRKFDKLLSKL ENSMUST00000062474 WCEDGLFHFCYRILFKAGFLSLFG-------YTKDKQQDLDEADELFRKFRRFDFLFPRF SINFRUP00000147192 WKSGDMYEFCSRVMFEATFLTLYG--------IPQEGGRHDGMDELRKDLFQFDGWFPWL ENSMUST00000035625 WNTERIFAFCGSLVFEITFATLYG--------KILAGNKKQIISELRDDFFKFDDMFPYL ci0100138282 WATTGLLHLVETVMCTAGFKSLFG-----EYPASSGVDNNKLHHKIVEDFVKFDKAFPLL ci0100138987 WETVGLLSLVQRVMGSASFVSLY------VISASN----------VFDFLLNFLTVFPSL ENSMUST00000055172 MGTFNTHHFTG-PLTEELHEQLEG----------LGTHGTMDLNDFVRNWSKSKRWLLAL CG4486-RA GFEVDMKVMCNKLSNDIIATTAFGLKVNSYDNPKNEFYEIGQSLVFSRGLQFFKFMLSTL : : ci0100153637 VDR-IPIHLLPETKKARGIFLKMMEELDWSKRENVSKLIDDIVKVNPKL-------EFLK ci0100150360 VDR-IPIHLLPATKKSRGRLFELLSRFDFENRDNVSELIKKVAAVGSS-----------E ENSMUST00000018113 ARGSLSAGDKDHACSVKNRLWKLLSPARLASRADRSSWLESYLRHLEEM------GVSEE ENST00000244043 ARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEM------GVSEE SINFRUP00000149280 VRGSLKKGETHTVNSSRKRLWELLSADWLSRASGSISWQQSYNRFLEKE------GVDME ENSMUST00000062474 VYSLLGPREWVEVSQLQRLFHQRLSVKQNLEKDGISCWLGYMLQFLREQ------GIASS SINFRUP00000147192 VAG-VPIGLLRQAKTSRNKLTRSLLPMRISSWSNRSQFIRRRQELVEKVD-----ALKDV ENSMUST00000035625 VSD-IPIQLLRNEESMQKKIIKCLTSEKVAQMQGQSKIVQERQDLLKRYY-----RHDDP ci0100138282 VQG-RPISSLKGVKESRANMWKFFTMDEIHKREMVYEMVEQYAKKLEED-------QELE ci0100138987 LRG-LPLSLITRSREYRQDLWKSLTKSKVTKRKEIFPIIDEIVTLHEQN-------GENK ENSMUST00000055172 FEKNIGNIKAHGSAGHSGTLLQAILEVVETETRQYS------------------------ CG4486-RA VPKLFSLLKLTIFDSAKVDYFARLVVEAMQYREKHNITRPDMIQLLMEAKNESEDKWTDD : ci0100153637 QRARHLMVVLWAAQANTTPALFWTLFYLIANPDAKRAVLEEYEQLRRQKMKHSSVR---S ci0100150360 EKVRHLLIILWSAQANTLPALFWTLFYILNDKTARIDVLEEFEKHLRKTVPACDVIGTVT ENSMUST00000018113 MQARALVLQLWATQGNMGPTAFWLLLFLLKNPEALAAVRAELKHTVWQAEQPVSQ----- ENST00000244043 MQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQ----- SINFRUP00000149280 MQRRASLLQLWTTQVSAAHRQTRLLR-----------LESDPSTPLWRDLTP-------- ENSMUST00000062474 MQDKFNFMMLWASQGNTGPTCFWVLLFLLKHQDAMKAVREEATRVMGKARLEAKK----- SINFRUP00000147192 DRAAHHFAMLWASVANTIPACFWSMYNLVSHPDALQVVRQQILDELKLSGVQFSTD---- ENSMUST00000035625 EIGAHHLGFLWASLANTIPAMFWAMYYILRHPEAMEALRDEIDSFLQSTGQKKGPG---- ci0100138282 QLKKELYCVNWAAMSNTLLSAFWALYYILKHPEAMEAANVEIQRMLKETSQCVDGK---- ci0100138987 LLPKRLLPVLVASQVNTNPSSFWILYYLLKNSEALAAVKDEMEKVLQERSKNP-GN---- ENSMUST00000055172 --PNYGLVVLWAALANAPPIAFWTLGYILSHPDIHRTVLESISSVFGTAGKDK------- CG4486-RA EIVAQCFIFFFAAFENNSNLICTTTYELLYNPDVQERLYEEIVETKKALNGAP------- :: . :: . ci0100153637 EEKGWPTMKDILQIERKDLDKLVILDGCLRETMR-LTGASMSIRKATRDESIKTSDGKQY ci0100150360 DDLKWPNLSDIQRMRKGDVDKLVLLDSCTKETMR-MTGSSLAARRAHADTTVTLASGQEY ENSMUST00000018113 ----------MTTLPQKILDSMPVLDSVLNETLR-LTAAPFITREVMADLALPMADGREF ENST00000244043 ----------TTTLPQKVLDSTPVLDSVLSESLR-LTAAPFITREVVVDLAMPMADGREF SINFRUP00000149280 -----------THLAPLSLP----ADSILSETLR-LTAAVLISRVVVGDKVLRMASGQQY ENSMUST00000062474 ----------SFTFTPSALKHTPVLDSVMEESLR-LCATPTLLRVVQEDYVLKMASGQEY SINFRUP00000147192 ---------TDVTLSRDLLDKLLYLESSVNESLR-LSSASMNIRVAQEDFSLHLKNERSA ENSMUST00000035625 ---------ISVHFTREQLDSLVCLESTILEVLR-LCSYSSIIREVQEDMNLSLES-KSF ci0100138282 ---------SEINFTRDDMAKMTVLDSIINETLR-LDISSSLLRQALQDYNLKVVSADRS ci0100138987 ---------NFVCFTKEEMETMTTLESAINESLR-LSISGGMLRKAATEYRLEIPDYGQT ENSMUST00000055172 -----------IKVSEDDLKKLLIIKWCILESVR-LRAPGVITRKVVKP-----VKILNH CG4486-RA -------------LTYDAVQKMTYMDMVISESLRKWTLAAATDRLCSKDYTLTDDDGTKL : . : . * :* * : . ci0100153637 SVRRGD-YTAFFAPVTHMDEDIYENPQDFVHDRFLVS-------LKPRSRFTKNGQRVAV ci0100150360 KIRKGD-YTSYFAPVTHQDADIYDKPEEYRHKRFLQHDDKDPSMLKSRTQFSKNGKRISP ENSMUST00000018113 SLRRGDRLLLFPFLSPQKDPEIYTEPEVFKYNRFLNP------DGSEKKDFYKDGKRLKN ENST00000244043 NLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNP------DGSEKKDFYKDGKRLKN SINFRUP00000149280 KLRRGDKAILFPFLSPQMDPEIHLEPQSFKYDRFLNI------DMSMKDTFYKNEGRLKY ENSMUST00000062474 QIRRGDKVALFPYLSVHMDPDIHPEPTAFKYDRFLNP------DGTRKVDFYKSGKKIHH SINFRUP00000147192 NVRKGDIIVLYPQS-LHMDPEVYEDPQTFQFDRYVQ-------DSK--GGFFKGGQRLKY ENSMUST00000035625 SLRKGDFVALFPPL-IHNDPEIFDAPKEFRFDRFIE-------DGKKKSTFFKGGKKLKT ci0100138282 YKIRKGDKLMTLFQLTHYDPEIYEQPDQFKFDRFLNS------DGSPKTDFYKKGKVVKF ci0100138987 YTIRENDMVLVWTQVNQMDPEIFEEPEVFKYDRFLNE------DGSLKTNFYKDGKLVKY ENSMUST00000055172 TVPSGD-LLMLSPFWLHRNPKYFPEPESFKPERWKEA----------------NLDKYIF CG4486-RA FDFKVGDRINIPISGLHLDDRYFPEPRKFDPDRFSEE---------------RKGDMVPY . : : . * : .*: : ci0100153637 SRAIMTFGYGVTRCPGRHIALIEIKLAVLAMLGHFNVQFVDSNTKP----PSFDLTHLGF ci0100150360 STSIMTFGYGAVRCPGRHIALMEIKFLTLVLLRHFDIKLVKNYSRQSEDYPQFDLTHLGF ENSMUST00000018113 --YNMPWGAGHNQCLGKSYAINSIKQFVVLLLTHFDLELGSEDTEVPE----FDLSRYGF ENST00000244043 --YNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPE----FDLSRYGF SINFRUP00000149280 --YTMPWGAGRHACVGKEFAVATIKQFVFFILTHFDLETCDPQAKLPP----VNPSRYGL ENSMUST00000062474 --YSMPWGSGVSKCPGRFFALSEMKTFVLLMIMYFDFKLVDPDIPVPP----IDPRRWGF SINFRUP00000147192 --YLMPFGSGSSMCPGRHFAVNEIKQFLCLMLLYFNLELEPGQTRAT-----VDSSRAGL ENSMUST00000035625 --YVMPFGLGTSKCPGRYFAVNEMKLLLIMLLTYFDLEIID-RKPIG-----LNHSRMFL ci0100138282 --FLQPFGSGVSKCPGRYWAVTELKQLVILLLLYFDFKLINPEQEIK-----MDQIRVAF ci0100138987 --AFQPFGDGSSKCPGRYWAVLELKQLVVNMLLYYDIKLIDS-QEIK-----MDKGRVGL ENSMUST00000055172 LDYFMAFGGGKFQCPGRWFALLEIQLCIILVLYKYECSLLDPLPKQS--------SRHLV CG4486-RA --TYLPFGVGPRNCIGNRYALMQVKGMLFNLLLHYKIEASPRTIKDLWG------SASGF .:* * * *. *: :: :: . . . . ci0100153637 GVMPPDTDIE---------- ci0100150360 GVMPPSRDVDVTLSI----- ENSMUST00000018113 GLMQPEEDVPIRYRARL--- ENST00000244043 GLMQPEHDVPVRYRIRP--- SINFRUP00000149280 GMLQPEGELQVRYRLK---- ENSMUST00000062474 GTSQPSHEVRFLYRLKPVQ- SINFRUP00000147192 GILFPSAKVHFRYRLR---- ENSMUST00000035625 GIQHPDSAVSFRYKAKSWRS ci0100138282 GSLPPNIDPQVQFK------ ci0100138987 GALNPTKDALMSIRRK---- ENSMUST00000055172 GVPQPAGKCRIEYKQRA--- CG4486-RA NFTPRSGFWMHLVPRK---- .