CLUSTAL W (1.82) multiple sequence alignment ENST00000276212 -------------------------------------------------- SINFRUP00000135869 -------------------------------------------------- SINFRUP00000152480 -------------------------------------------------- SINFRUP00000138304 -------------------------------------------------- ENST00000262862 --------------------------------MARFGLPALLCTLAVLSA ENSMUST00000033450 --------------------------------MARLGLLALLCTLAALSA Q90Z52_Brachydanio_rerio --------------------------------MKMIVVFTVCMSVVVLAS ENST00000264039 ------------------------------MELRARGWWLLCAAAALVAC ENSMUST00000045970 ------------------------------MELRTRGWWLLCAAAALVVC CG4974-RA MAARSVRLAQLLLFTLLCGFVGLSAAKHLDLDGIHHHQHHLHSATTHHRR ci0100146542 ---------------------------------MVSIHQLFVVFIGISVT ENST00000276212 -------------------------------------------------- SINFRUP00000135869 -------------------------------------------------- SINFRUP00000152480 -------------------------------------------------- SINFRUP00000138304 ---------------------------------PGESLRVCVHPGPSCCT ENST00000262862 ALLAAELKSKSCSEVRRLYVSKGFNKNDAPLHEINGDHLKICPQGSTCCS ENSMUST00000033450 SLLAAELKSKSCSEVRRLYVSKGFNKNDAPLYEINGDHLKICPQDYTCCS Q90Z52_Brachydanio_rerio --AQADQKSKNCNEVRTAYSSKGFNVNDVPNKGVQGAHLKVCPQGFSCCT ENST00000264039 ARGDPASKSRSCGEVRQIYGAKGFSLSDVPQAEISGEHLRICPQGYTCCT ENSMUST00000045970 ARGDPASKSRSCSEVRQIYGAKGFSLSDVPQAEISGEHLRICPQGYTCCT CG4974-RA RLQRDSRAKDAVGGSTHQCDAVKSYFESIDIKSSGTYSEKGAICGGNCCN ci0100146542 VVTRGSSPPQRCHQVLEFYRQQNFN----ETLDVEVVNGKVCRE-PSCCT ENST00000276212 ---------------------------------------AFEIVVRHAKN SINFRUP00000135869 -------------------------VFALLIILSLLLTEAFDLVLRHGRN SINFRUP00000152480 -------------------------LHSLLSVSLPLFPDMFQYLLSFSQG SINFRUP00000138304 SKMEDSYMAAVRSETQQKMRSYSFELKYLIAGHTKAYQETFDSLVSFTSN ENST00000262862 QEMEEKYSLQSKDDFKSVVSEQCNHLQAVFASRYKKFDEFFKELLENAEK ENSMUST00000033450 QEMEEKYSLQSKDDFKTVVSEQCNHLQAIFASRYKKFDEFFKELLENAEK Q90Z52_Brachydanio_rerio LEMEEKLSQLSRVDLKVPVHQLSSNLQSTFTQRHRHFDQFFRELLDNAEK ENST00000264039 SEMEENLANRSHAELETALRDSSRVLQAMLATQLRSFDDHFQHLLNDSER ENSMUST00000045970 SEMEENLANHSRMELESALHDSSRALQATLATQLHGIDDHFQRLLNDSER CG4974-RA NATELELRDKAAGMFEQLLHHHTSSLRGVLETNAKQFQSHVLELAQISEN ci0100146542 GKMERNLRLKVEEDLKAGVLRGGEQVGGELKAKHDNLDKFFIELIDQSKS . : ENST00000276212 YTNAMFKNNYPSLTPQAFEFVGEFFTDVSLYILGSD-------------- SINFRUP00000135869 ATLTLLKSEFPGLGTGAQSSVGQLFMDMSLYILGSD-------------- SINFRUP00000152480 HLSSLLEGTYTPMSRHALPHVNQLFSSLSLYLRGAN-------------- SINFRUP00000138304 LTSSLFDTAYSALASDCRPLVFQLFSSIKRHLSGDP-------------- ENST00000262862 SLNDMFVKTYGHLYMQNSELFKDLFVELKRYYVVGN-------------- ENSMUST00000033450 SLNDMFVKTYGHLYMQNSELFKDLFVELKRYYVAGN-------------- Q90Z52_Brachydanio_rerio SLNHMFVRTYGLMYVKNKELFEGFFSDLRRYYSHGSS------------- ENST00000264039 TLQATFPGAFGELYTQNARAFRDLYSELRLYYRGAN-------------- ENSMUST00000045970 TLQEAFPGAFGDLYTQNTRAFRDLYAELRLYYRGAN-------------- CG4974-RA MTHSLFSKVYTRMVPSSRMMIHQLYTEIMNHLIYTSNYTNSNGQLGRRGI ci0100146542 QLDILFYETYGSLYIDNSEIFSFFFKELEEYYRGGP-------------- : : : . :: .: : ENST00000276212 ---IN-VDDMVNELFDSLFPVIYTQLMNPGLPDSAL--------DINECL SINFRUP00000135869 ---SS-VDHMVSVLYGRLFLLTYRRLLGASVPSAS-----------EECV SINFRUP00000152480 ---VS-VEASVHQFFNNLFPLTYTRLINPGIQGGTMS-------DMGDCL SINFRUP00000138304 ---VSSLDNAVHRFYDDLFPLVYQRLLNPGMGHPSPQPSSFHSGTHKHCL ENST00000262862 ----VNLEEMLNDFWARLLERMFRLVNSQYHFTDEY----------LECV ENSMUST00000033450 ----VNLEEMLNDFWARLLERMFRLVNSQYHFTDEY----------LECV Q90Z52_Brachydanio_rerio ---EVNLDDMLAEFWSELLERMFRLVNVQYEFSDSY----------MECV ENST00000264039 ----LHLEETLAEFWARLLERLFKQLHPQLLLPDDY----------LDCL ENSMUST00000045970 ----LHLEETLAEFWARLLERLFKQLHPQ-LLPDDY----------LDCL CG4974-RA GSVQSNLEEAVRHFFVQLFPVAYHQMVHLSKNNLGDLH-----EDYVNCL ci0100146542 ----LMVEEISENFFTSLMLKVFQLLNKSYLLDDEY----------MACI :: :: *: : : *: ENST00000276212 RGARRDLKVFGNFPKLIMTQVSKSLQVTRIFLQALNLGIEVINTTDHLK- SINFRUP00000135869 RGAWKDSAAFGPYPKLVTTRLSRSLLATRVFLQALNLGIEVVNTTNHLR- SINFRUP00000152480 RMIRQDVNPFGPHPAVMAQELSGALGVGRQLGLALEEGLEVMNATEHVS- SINFRUP00000138304 RTMRQEVGPFGPHPRLLLSSLSRVLGVGRALSQLLKLAGEVVNATERLT- ENST00000262862 SKYTEQLKPFGDVPRKLKLQVTRAFVAARTFAQGLAVAGDVVSKVSVVN- ENSMUST00000033450 SKYTEQLKPFGDVPRKLKLQVTRAFVAARTFAQGLAVARDVVSKVSVVN- Q90Z52_Brachydanio_rerio SRHTDQLKPFGDVPRKLRLQLTRSFIAVRAFTRGLTLMPDVVRKVSTVS- ENST00000264039 GKQAEALRPFGEAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQVP- ENSMUST00000045970 GKQAEALRPFGDAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQVP- CG4974-RA QHNFDEMHPFGDIPQQVQSNLGKSVHMSNVFMNALLQAAEVLSEADALYG ci0100146542 GENVGRIRPFTDIPDRLSMQLQQAFVASRAFVRGLETGSDVIKKLSKIS- * * : . . : * :*: : ENST00000276212 --FSKDCGRMLTRMWYCSYCQG-----LMMVKPCGGYCNVVMQGCMAGVV SINFRUP00000135869 --PSRDCSRALLRLWYCPHCQG-----ILGQPACRGFCHTVMHGCLGGVA SINFRUP00000152480 --LSKECVRGLVKMVYCSHCRG-----LTLIKPCVGYCLNVMRGCLASVS SINFRUP00000138304 --LSRECGRGLVRMQYCSHCRG-----LTLIRPCTGLCVNIMRGCL---- ENST00000262862 --PTAQCTHALLKMIYCSHCRG-----LVTVKPCYNYCSNIMRGCLANQG ENSMUST00000033450 --PTAQCTHALLKMIYCSHCRG-----LVTVKPCYNYCSNIMRGCLANQG Q90Z52_Brachydanio_rerio --ASPSCVRASMKMLYCPYCSG-----QVALKPCKNYCLNVMRGCLANQA ENST00000264039 --LGPECSRAVMKLVYCAHCLG-----VPGARPCPDYCRNVLKGCLANQA ENSMUST00000045970 --LAPECSRAIMKLVYCAHCRG-----VPGARPCPDYCRNVLKGCLANQA CG4974-RA EQLTDTCKLHLLKMHYCPNCNGHHSSSRSETKLCYGYCKNVMRGCSAEYA ci0100146542 --LSDECSSSLMRMKYCGRCGG------TMAPECDGFCLNVVRGCLCSLQ * :: ** * * * . * :::** ENST00000276212 -EIDKYWREYILSLE-ELVNGMYRIYDMENVLLGLFSTIHDSIQYVQKNA SINFRUP00000135869 -EVQPHWKSYIDGLG-KLAGSMRGEQDMEAVVLLLPSMIKLALKHAVNAR SINFRUP00000152480 -ELDQPWRRYTSLLE-QLTHATAGHHSLELALLGVRGHVNEALLYAQLHG SINFRUP00000138304 -------------------------------------------------- ENST00000262862 -DLDFEWNNFIDAML-MVAERLEGPFNIESVMDPIDVKISDAIMNMQDNS ENSMUST00000033450 -DLDFEWNNFIDAML-MVAERLEGPFNIESVMDPIDVKISDAIMNMQDNS Q90Z52_Brachydanio_rerio -DLDTEWNNFLDSML-GLAERLEGPFNFESVVDPIDVKISDAIMNMQENS ENST00000264039 -DLDAEWRNLLDSMV-LITDKFWGTSGVESVIGSVHTWLAEAINALQDNR ENSMUST00000045970 -DLDAEWRNLLDSMV-LITDKFWGPSGAESVIGGVHVWLAEAINALQDNK CG4974-RA GLLDSPWSGVVDSLNNLVTTHILSDTGIINVIKHLQTYFSEAIMAAMHNG ci0100146542 -QVGGVWKKYIDTMD-SLLEKLSGSFNIEIVLGSIDVQISEAIMTFQEHK : : : : : . : ENST00000276212 GKLTTTIGKLCAHSQQRQYRSAYYPEDLFIDKKVLKVAHVEHEETLSSRR SINFRUP00000135869 TRLTALVS------------------------LTLK-------------- SINFRUP00000152480 PLITATV------------------------------------------- SINFRUP00000138304 -------------------------------------------------- ENST00000262862 VQVSQKVFQGCGPPKPLPAGRISRSISESAFSARFRPHHPEERPTTAAGT ENSMUST00000033450 VQVSQKVFQGCGPPKPLPAGRISRSISESAFSARFRPYHPEQRPTTAAGT Q90Z52_Brachydanio_rerio MQVSQKVFQGCGQPKLSMGFRSRRSAKDSGFPGRFRPYSPEARPTTAAGT ENST00000264039 DTLTAKVIQGCGNPKVNPQGPGPEEKR------RRGKLAPRERPPSGT-- ENSMUST00000045970 DTLTAKVIQACGNPKVNPHGSGPEEKR------RRGKLALQEKPSTGT-- CG4974-RA PELEKKVKKTCGTPSLTPYSSGEPDAR-----------PPPHKNNVKWAT ci0100146542 VAITKTVFGICGKPKSNPN------------------------------- : : ENST00000276212 RELIQKLKSFISFYSALPGYICSHSPVAENDTLCWNGQELVERYSQKAAR SINFRUP00000135869 -------------------------------------------------- SINFRUP00000152480 -------------------------------------------------- SINFRUP00000138304 -------------------------------------------------- ENST00000262862 SLDRLVTDVKEKLKQAKKFWSSLPSNVCNDERMAAGNGNEDDCWNGKGKS ENSMUST00000033450 SLDRLVTDVKEKLKQAKKFWSSLPSTVCNDERMAAGNENEDDCWNGKGKS Q90Z52_Brachydanio_rerio TLDRLLTDVKKKLKHAKKFWSTLPDTVCVGERIAPS----DDCWNGTAKS ENST00000264039 -LEKLVSEAKAQLRDVQDFWISLPGTLCS-EKMALSTASDDRCWNGMARG ENSMUST00000045970 -LEKLVSEAKAQLRDIQDFWISLPGTLCS-EKMAMSPASDDRCWNGISKG CG4974-RA DPDPGMVLFLSTIDKSKEFYTTIVDNFCDEQQHSRD---DHSCWSGDRFG ci0100146542 -------------ATLPTLTMSYPQPHGAEESYPVHYPSLYPGYQGPSSF : ENST00000276212 NGMKNQFNLHELKMKGPEPVVSQIIDKLKHINQLLRTMSMPKGRVLDKNL SINFRUP00000135869 -------------------------------------------------- SINFRUP00000152480 -------------------------------------------------- SINFRUP00000138304 -------------------------------------------------- ENST00000262862 RYLFAVTGNGLANQGNNPEVQVDTSKPDILILRQIMALRVMTSKMKNAYN ENSMUST00000033450 RYLFAVTGNGLANQGNNPEVQVDTSKPDILILRQIMALRVMTSKMKNAYN Q90Z52_Brachydanio_rerio RYESVVMSSGLANQVSNPDVEVDITKPDMVIRRQIAVLKEMTSWLKAAYT ENST00000264039 RYLPEVMGDGLANQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLRSAYN ENSMUST00000045970 RYLPEVMGDGLANQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLRGAYG CG4974-RA DYTQLLINPGTDSQRYNPEVPFNAKAQTGKLNELVDKLFKIRKSIGAAAP ci0100146542 EDLAGYGADPDNWIGDSPLSRKSRSTKKNRKRRGRKRSRDISMDQRGMLR ENST00000276212 DEEGFESGDCGDDEDECIGGSG--------DGMIKVKNQLRFLAELAYDL SINFRUP00000135869 -------------------------------------------------- SINFRUP00000152480 -------------------------------------------------- SINFRUP00000138304 -------------------------------------------------- ENST00000262862 GNDVDFFDISDESSGEGSGSGC--------EYQQCPSEFD-YNATDHAGK ENSMUST00000033450 GNDVDFFDISDESSGEGSGSGC--------EYQQCPSEFE-YNATDHSGK Q90Z52_Brachydanio_rerio GNDIS-FTSDDAGSGEESGSGC--------DSPSCEGDGDIYFSTPAPGK ENST00000264039 GNDVDFQDASDDGSGSGSGDGC--------LDDLCSRKVSRKSSSSRTPL ENSMUST00000045970 GNDVDFQDASDDGSGSGSGGGC--------PDDTCGRRVSKKSSSSRTPL CG4974-RA SNSIQATHDIQNDMGEGSGGGEGQIGDDEEEYGGAHGSGDGSGDGPHTPI ci0100146542 PSSRYVEDK----------------------------------------- ENST00000276212 DVDDAPGNSQQATPKDNEISTFHNLGNVHSPLKLLTSMAISVVCFFFLVH SINFRUP00000135869 -------------------------------------------------- SINFRUP00000152480 -------------------------------------------------- SINFRUP00000138304 -------------------------------------------------- ENST00000262862 S-------ANEKADSAG-VRPGAQAYLLTVFCILFLVMQR-EWR------ ENSMUST00000033450 S-------ANEKADSAGGAHAEAKPYLLAALCILFLAVQG-EWR------ Q90Z52_Brachydanio_rerio PRILK-TQEVEQASSGTRLAPCSLALALASLLLTLLTLQT-R-------- ENST00000264039 THALPGLSEQEGQKTSAASCPQPPTFLLPLLLFLALTVARPRWR------ ENSMUST00000045970 THALPGLSEQEGQKTSAATCPEPHSFFLLFLVTLVLAAARPRWR------ CG4974-RA EESEGTTTNEVESRDSGKTSGSNPLEGTATWMLLTLVTMLFSSCS----- ci0100146542 -------------------------------------------------- ::::