CLUSTAL W (1.82) multiple sequence alignment SINFRUP00000140662 ------------------------------------------------------------ SINFRUP00000137918 ------------------------------------------------------------ ENST00000287777 ------------------------------------------------------------ SINFRUP00000149223 QMKTRPGETLIDCLDSIEDTKGNNGDRGNQDSIFHDFIVSIFLNNVVVFVFRAYETSKMY SINFRUP00000159317 ------------------------------------------------------------ ENST00000284669 ------------------------------------------------------------ ENST00000293303 ------------------------------------------------------------ ENSMUST00000001599 ------------------------------------------------------------ ci0100151301 ------------------------------------------------------------ ENSMUST00000030841 ------------------------------------------------------------ CG9426-RA ------------------------------------------------------------ SINFRUP00000140662 ------------------------------------------------------------ SINFRUP00000137918 ------------------------------------------------------------ ENST00000287777 ------------------------------------------------------------ SINFRUP00000149223 RDLKLRAALIQNRQLRLLPREQVYDKINGVWNLSSDQWSIRIRDSKFGLALVIESSRQSG SINFRUP00000159317 ------------------------------------------------------------ ENST00000284669 ------------------------------------------------------------ ENST00000293303 ------------------------------------------------------------ ENSMUST00000001599 ------------------------------------------------------------ ci0100151301 ------------------------------------------------------------ ENSMUST00000030841 ------------------------------------------------------------ CG9426-RA ------------------------------------------------------------ SINFRUP00000140662 ------------------------------------------------------------ SINFRUP00000137918 ------------------------------------------------------------ ENST00000287777 ------------------------------------------------------------ SINFRUP00000149223 GYVLGFKIDPAEKLQDALKEINSLHKVYSANPIFGVEFEMEEKPKPLEELTVEQPPDDVE SINFRUP00000159317 ------------------------------------------------------------ ENST00000284669 ------------------------------------------------------------ ENST00000293303 ------------------------------------------------------------ ENSMUST00000001599 ------------------------------------------------------------ ci0100151301 ------------------------------------------------------------ ENSMUST00000030841 ---------------------------------------------------------MAT CG9426-RA ------------------MPPLKTYQIHEYNGNTSPNANANQNANQNPTGGGGDGDFFGQ SINFRUP00000140662 ----------------DEPRVYQQTLLQDGLYDLLENDKLVDCVLKIKDKEFPCHRLVLC SINFRUP00000137918 ---------ALTVDPEQQPRMYQQTLLQDGLCDLLETDKFVDCILKIKDEEFPCHRLVLA ENST00000287777 --------MALGLEQAEEQRLYQQTLLQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLA SINFRUP00000149223 IEPDEQTDAFTVSLLKEDLRLFQTTLLQDGLKELLNENKLIDCILKVGERSIPCHRLILA SINFRUP00000159317 --------------IKEELRLFQSTLLQDGLKELLNENKLVDCTLKVGDRSFPCHRLIMA ENST00000284669 --MDSQRE------LAEELRLYQSTLLQDGLKDLLDEKKFIDCTLKAGDKSLPCHRLILS ENST00000293303 --MEMESAAASTRFHQPHMERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILC ENSMUST00000001599 --MEMESTAASTRFHQPHMERKMSAMTCEIFNELRLEGKLCDVVIKVNGFEFNAHKNILC ci0100151301 --MALCLSDSETSMLTSPLLVDSWAST---FNDLRQRGKFCDVVIKVQDVRFPLHRLVLC ENSMUST00000030841 SGVEKSSKKKTEKKLAAREEAKLLAGFMGVMNNMRKQRTLCDVILTVQERKIPAHRVVLA CG9426-RA NLGSGATAASHRTNLPSYCNAQYPFKVLSNLNQLREQSRFCDVEIIAGMATLSAHRAVLS : :: : * : : *: ::. SINFRUP00000140662 ACSSYFRAIFLSDLEESKK--KEIVLEDVEPGVMGLILKYLYT-SKINVTEHNVQDIFAV SINFRUP00000137918 ASSPFFKAMFLSDLEESKK--REIVLRDVEPGVMGMIIRYLYT-SDIDLTEQNVQDIFIV ENST00000287777 ACSPYFRARFLAEPERAG----ELHLEEVSPDVVAQVLHYLYT-SEIALDEASVQDLFAA SINFRUP00000149223 ACSPYFRELFFSVDGKEVN-QREVVLENLDPNIMEVIVNYLYS-ADIDINDNSVQDILAA SINFRUP00000159317 ACSPYFREIFFTEDGKEVENTKEVVLEDVNPAILNMIIKYLYS-AEIDLTDDNVQDIIAL ENST00000284669 ACSPYFREYFLSEIDEAKK--KEVVLDNVDPAILDLIIKYLYS-ASIDLNDGNVQDIFAL ENST00000293303 SCSSYFRALFTSGWNNTEK--KVYNIPGISPDMMKLIIEYAYT-RTVPITPDNVEKLLAA ENSMUST00000001599 SCSSYFRALFTSGWNNTEK--KVYNIPGISPDMMKLIIEYAYT-RTVPITPDNVEKLLAA ci0100151301 ACSDYFRALFDGGWGSGDK--QEIELTGTSPEIMTSLLNYAYTGQVVIITSQNVEELLPA ENSMUST00000030841 AASHFFNLMFTTNMLESKS--FEVELKDAEPDIIEQLVEFAYT-ARISVNSNNVQSLLDA CG9426-RA AASAYFEAMFRPELGLNEVKQKSVVLHTIDGDILHILLDFIYT-GRCEITQSNVQELLAA :.* :*. * : . :: :: : *: : .*:.:: SINFRUP00000140662 ANMYQIPSIFTVCVSFLQKRLSLSNCLAVFRLGLMLDCPRLAISARNYACERFQLISR-D SINFRUP00000137918 ANMYQIPSIFSVCVSYLQEKMVLGNCLAIFRLGLLLDCSRLVLAAKDFICERYQVVSR-D ENST00000287777 AHRFQIPSIFTICVSFLQKRLCLSNCLAVFRLGLLLDCARLAVAARDFICAHFTLVAR-D SINFRUP00000149223 ANRFQIPSVFTVCVNYLQKKLSRSNCLAIYRLALMMNCARLAIAARDYIADRFETMCK-A SINFRUP00000159317 ANRFQIPSVFTVCVNYLQKKLSLGNCMAIFRLGLVLNCPRLAVAARNYIADRFELLHK-D ENST00000284669 ASRFQIPSVFTVCVSYLQKRLAPGNCLAILRLGLLLDCPRLAISAREFVSDRFVQICK-E ENST00000293303 ADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVS ENSMUST00000001599 ADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVS ci0100151301 SDKFLMDYVKQKCCSYLKKQLTPMNCIGIRQYARSFFCPRLVDAANNYILYNFEEVAQKS ENSMUST00000030841 ANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYK-T CG9426-RA ADMLQLNEVVDGCCEFLCRELHASNALGILRFAEAHNCESLAKSALNFVHANFPAVTL-E : : : * .:* .: *.:.: * * * : .: : SINFRUP00000140662 EDFFQLLPSELAAILSNDNLSVETEETVFEALMSWVS----RDTEQREKELPGLLDCVRL SINFRUP00000137918 QDFLQLGPSELALIITSDALNVLQEELVFESLMDWVK----HDEANRVRELPELLHCIRF ENST00000287777 ADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGSGDAEAQAERQRALPTVFESVRC SINFRUP00000149223 EEFLELDPPELFAIIGADALNVEKEEVVFETLMRWVK----KDKEKRLKSLEEAFDCIRF SINFRUP00000159317 DEFLKLAPHELFAVIGGDSLNVEKEELVFEAVMAWVR----HDKE-RIKVLKDAFNCIRF ENST00000284669 EDFMQLSPQELISVISNDSLNVEKEEAVFEAVMKWVR----TDKENRVKNLSEVFDCIRF ENST00000293303 AEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWIS----HDPQNRKQHISILLPKVRL ENSMUST00000001599 AEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWIS----HDPQNRKQHISVLLPKVRL ci0100151301 PEFLNMAFDDVIQLINDDRLNVRLEETVCESVFRWIR----HDKMGRISNLSVMLKGVRL ENSMUST00000030841 DEFLQLDVKRVTHLLSQDTLTVRAEDQVYDAAVRWLK----YDEPNRQPFMVDILAKVRF CG9426-RA DEFLETPQTLLSQLLNSELLRVDSESQVFQAALRWIK----HDVTQRRCYVFDVLSHVRM :*: : :: : * * *. * :: . * * : : :* SINFRUP00000140662 RLVTEDYLKEAVEKHKLIASNPELREKLQLVRDAHTGKMPDVKKSK-SKEGGGAEN---- SINFRUP00000137918 RLIPLDYFKEKVERHQYLRFNQDIKKDLELVREAHKGRLPQPKK-----LGKGETE---- ENST00000287777 RLLPRAFLESRVERHPLVRAQPELLRKVQMVKDAHEGRITTLRKKKKGKDGAGAKEADKG SINFRUP00000149223 RLIPEKYFKEKVEKEDLIKTNQELLKKIKVIKEAATGKLPE--KKK----GQDEEN---- SINFRUP00000159317 RLLPEKYFKDSVETNETIKSNPELQKMIQVVRDAFKGKLPE--KTKK-EGAEGEAE---- ENST00000284669 RLMTEKYFKDHVEKDDIIKSNPDLQKKIKVLKDAFAGKLPEPSKNAA-KTGAGEVNG--- ENST00000293303 ALMHAEYFMNNVKMNDYVKDS-EECKPVIINALKAMYDLN---MNGPS------------ ENSMUST00000001599 ALMHAEYFMNNVKMNDYVKDS-EECKPVIINALKAMYDLN---MNGPS------------ ci0100151301 GLLDPEYFMTKLKGCELVTESMAECRGLIKDAMKVVCDLHGFDSNTVSP----------- ENSMUST00000030841 PLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPED------------------- CG9426-RA ALVPVKVIDKALKDDCRDMSVKIALRSICRDIASKRGQLVPLRVCPR------------- *: : :: . : SINFRUP00000140662 ------DGDKEEEGLLPGILNDSLRFGMFVRD--LILMVNDT-AVAYDPAGNDCFLASLS SINFRUP00000137918 ------EGEEDEEGYLPGILNNNPRFGMFEMD--LILMISDTGTVAYDPVGNECFVVSES ENST00000287777 TSKAKAEEDEEAERILPGILNDTLRFGMFLQD--LIFMISEEGAVAYDPAANECYCASLS SINFRUP00000149223 ----------GEEGMLPGYLNDNRRFGMYAKD--LVLMINDSTAVAYDPEENECFLASIG SINFRUP00000159317 ----------DGESPFPGFLNDSRRHGMFTRR--FMLLINDTAAVAYDVGENECFLAAMS ENST00000284669 --------DVGDEDLLPGYLNDIPRHGMFVKD--LILLVNDTAAVAYDPTENECYLTALA ENST00000293303 -----------NSDFTNPLTRPRLPYAILFAIGGWSGGSPTNAIEAYDARADRWVNVTCE ENSMUST00000001599 -----------NSDFTNPLTRPRLPYAILFAIGGWSGGSPTNAIEAYDARADRWVNVTCE ci0100151301 -----------HGNVFSSLVRPRLPFEILLAIGGWSGGSPTNAIEAYDPRAESWLNASTI ENSMUST00000030841 -----------REELAGGTRPRRKKHDYRIAL---FGGSQPQSCRYFNPKVSITSWTDPF CG9426-RA ----------QLAKKNIYIIGGSHRDTPRTWN---SADCIFETVAKFDIFRREWTETAPM :: . SINFRUP00000140662 --TQIPKNHNSLVTRENQIFAAGGLFYDEQNKEDPLCSYFLQYDPVTADWMAMPPVPSPR SINFRUP00000137918 --TDIPKNHCSLVTGQNQVFVVGGMRYEE-NKDDPFSSYFLQFDPISSEWLGMPSQPNPR ENST00000287777 --NQVPKNHVSLVTKENQVFVAGGLFYNEDNKEDPMSAYFLQFDHLDSEWLGMPPLPSPR SINFRUP00000149223 --DQIPRNHVSLITKENKLHVLGGLFVDEEDKETPLQCYHYQLDALSSDWTALPPMPSSR SINFRUP00000159317 --EQVPRNHVSLVSQRNQLFIIGGLFVDEENKDVPLQCYVYVLDPLASDWVALPPMPSPR ENST00000284669 --EQIPRNHSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSIASEWVGLPPLPSAR ENST00000293303 --EESPRAYHGAAYLKGYVYIIGG------FDSVDYFNSVKRFDPVKKTWHQVAPMHSRR ENSMUST00000001599 --EESPRAYHGAAYLKGYVYIIGG------FDSVDYFNSVKRFDPVKKTWHQVAPMHSRR ci0100151301 PVADIPRAYHGVAFVKGNVYVIGG------FDGVNYFNTVRRFSVANFEWVEEPQMLHKR ENSMUST00000030841 AAPFEKRRDAACVFWDNVVYILGG-------SQLFPIKRMDCYNVVKDSWYSKLGPPTPR CG9426-RA ---EVGRILPGVSALNGKIYVVGG------ERGSQILANGEVYDPQNDVWQPIAPMIVPR : . . :. ** . * * SINFRUP00000140662 FLFGLAEAENSIFVVGGRELK--------------------------------------- SINFRUP00000137918 CLFGLTEAENSIFVVGGKELK--------------------------------------- ENST00000287777 CLFGLGEALNSIYVVGGREIK--------------------------------------- SINFRUP00000149223 CLFAMGECESLIFAVAGKDLQ--------------------------------------- SINFRUP00000159317 CLFSMGESENLLFAVAGKDLQ--------------------------------------- ENST00000284669 CLFGLGEVDDKIYVVAGKDLQ--------------------------------------- ENST00000293303 CYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVY ENSMUST00000001599 CYVSVTVLSNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVY ci0100151301 CYISVTVLDKKIYALGGMDG------TNRYVSTT----------------------RQVY ENSMUST00000030841 DSLAACAAEGKIYTSGGSEVG--------------------------------------- CG9426-RA CEFGLCTMGGNLFAVGGWIGD--------------------------------------- .. ::. .* : : :: : : : SINFRUP00000140662 -----DQEQTLDSVLVYDRQSFKWGESDPSPYPVYGHSTVSHNDVVYVLGGKGD---NKS SINFRUP00000137918 -----EGEQALDSVMIYDRQSFKWGESDPLPYEVYGHGTVSHGGLVYVIGGKSQ---SKK ENST00000287777 -----DGERCLDSVMCYDR---LWG--------------------------------HRH SINFRUP00000149223 -----SNE-SHDTVLCYDTEKMKWNETKKLPLRIHGHCVVSENGLVYSIGGKTD---DNK SINFRUP00000159317 -----TSE-SLDTVMCYDVEKLKWSETKKLPLKIHGHAVVSHKGLVYCIGGKTD---DNK ENST00000284669 -----TEA-SLDSVLCYDPVAAKWNEVKKLPIKVYGHNVISHKGMIYCLGGKTD---DKK ENST00000293303 ICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGG-FD---GAN ENSMUST00000001599 ICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGG-FD---GAN ci0100151301 IAGGFNGQECLFTAEFYDPETSVWTRITPMRSRRSGVSIISFHDMVYAVGG-FD---GVN ENSMUST00000030841 -------NSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGR CG9426-RA --------DIGGSMECYDPEQDLWKLMGSMPQPRFSMGVVSFEGLIYIVGGCTT---TTR : : *: * : : SINFRUP00000140662 CLKKVCAYDAKRFEWKELAPMTTARSLFGAVVHKDKIYVAAGV-TDTGLTDSVEVYDIKS SINFRUP00000137918 CLRRVCVYNPTKFEWKDLAPLKTARSLFGVTVHNDQIYAVTGV-TDSGLTGSVEVYDIAA ENST00000287777 RADQFCRS---------------------VQHHRQQVGTLRGL-PTGA------------ SINFRUP00000149223 TINKMFAYNHKRSEWKEVASMKTPRSMFGAVIHKGKIIVVGGV-SEEGLTASSEAYDFGT SINFRUP00000159317 ALNKMFAYNHKQSEWREMAAMKTPRSMFGAVIHNGKIVVAGGV-NEEGLTASCEAYDFAS ENST00000284669 CTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHKGKIVIAGGV-TEDGLSASVEAFDLTT ENST00000293303 RLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGF-NGFTTTFNVECYDEKT ENSMUST00000001599 RLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGF-NGFTTTFNVECYDEKT ci0100151301 RLRHAEAYCPRTNTWRNIASMNKPRSNFGIEVVDDQLLVVGGY-NGHQTSWDVEAYDDTA ENSMUST00000030841 VLSSCEVYDPATETWTELCSMIEPRKNHGLVFVKDKIFAVGGQ-NGLGGLDNVEYYDIKL CG9426-RA HLPDLISFNPVTKEWNELARMQTARCQMGVAVLDRYLYVVGGSSISQDILSSVERYSFDE : : : * SINFRUP00000140662 NKWSESTVFPQERSSVNLVSLADSLYAVGGFGMMPLEDSDELVPKEMND-----IWRYDE SINFRUP00000137918 DRWSELTEFPQERSSLSLVSTGGFLYALGGFAMMPSETSEEPIPTEMTD-----IWRYDE ENST00000287777 ------------------------------------------------------------ SINFRUP00000149223 NKWAPFTEFPQERSSVNLVSCGGVLYAVGGFAVVENE-NRECAPSEVID-----IWQYEE SINFRUP00000159317 NKYD-------------------------------------------------------- ENST00000284669 NKWDVMTEFPQERSSISLVSLAGSLYAIGGFAMIQLE-SKEFAPTEVND-----IWKYED ENST00000293303 DEWYDAHDMSIYRSALSCCVVPGLAN--VEEYAARRDN---------------------- ENSMUST00000001599 DEWYDAHDMSIYRSALSCCVVPGLAN--VGEYAARRDN---------------------- ci0100151301 NEWYEIKDMHICRSALSCCVMSGVPYDVIKRYCVPRDTNPTSSSPDTQDGATSSINPEDA ENSMUST00000030841 NEWKMVSPMPWRGVTVKCAAVGSVIYVLAGFQGVGRLGHILEYNTETDK------WIANS CG9426-RA DKWTTVCALNVPRAIPAVVAADGLLYVAGGDQPCEVNFYRAQVTINAVEC-------YDP : SINFRUP00000140662 TQKKWTGILREIQYASGATVLGVRLNTLRLTKM------------ SINFRUP00000137918 SERCWTGMLREISYAEGATVLAARLNILRLNKL------------ ENST00000287777 --------------------------------------------- SINFRUP00000149223 DKKQWTGMIREMRYATGASCVSMHLNTARMPKL------------ SINFRUP00000159317 --------------------------------------------- ENST00000284669 DKKEWAGMLKEIRYASGASCLATRLNLFKLSKL------------ ENST00000293303 ----FPGLALRDEVKYSASTSTLPV-------------------- ENSMUST00000001599 ----FTGLALRDEVKYSASTSTLPV-------------------- ci0100151301 VLSERSGITTDDEEDQALHQPEVDLRARNDHDLSDDDEMEEESDL ENSMUST00000030841 KVRAFPVTSCLICVVDTCGANEETLET------------------ CG9426-RA LSDTWKNCPDLPVSRSEAGAVVV---------------------- :