CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000025477 -------------------------------------------------- ENST00000238498 ILCLDRTVTLFQSHLSCRRRRRWQPRWKRAGEPEPAAGDARRCALLRHAA SINFRUP00000160743 -------------------------------------------------- SINFRUP00000162731 -------------------------------------------------- ENST00000231461 -------------------------------------------------- ENSMUST00000043336 -------------------------------------------------- Q8QH83_Brachydanio_rerio -------------------------------------------------- ENSMUST00000013990 -------------------------------------------------- ENST00000319914 -------------------------------------------------- ENSMUST00000028154 -------------------------------------------------- ENST00000291839 -------------------------------------------------- SINFRUP00000158540 -------------------------------------------------- ENSMUST00000044278 -------------------------------------------------- ENST00000235717 -------------------------------------------------- ENSMUST00000028153 -------------------------------------------------- CG4871-RB -------------------------------------------------- ENSMUST00000023429 -------------------------------------------------- ENSMUST00000025477 -------------------------------------------------- ENST00000238498 AQPLHLPARHRAPRAPAYGVPLLSGAPASPNPRPRWPPPTPARVPLLRHT SINFRUP00000160743 -------------------------------------------------- SINFRUP00000162731 -------------------------------------------------- ENST00000231461 -------------------------------------------------- ENSMUST00000043336 -------------------------------------------------- Q8QH83_Brachydanio_rerio -------------------------------------------------- ENSMUST00000013990 -------------------------------------------------- ENST00000319914 -------------------------------------------------- ENSMUST00000028154 -------------------------------------------------- ENST00000291839 -------------------------------------------------- SINFRUP00000158540 -------------------------------------------------- ENSMUST00000044278 -------------------------------------------------- ENST00000235717 -------------------------------------------------- ENSMUST00000028153 -------------------------------------------------- CG4871-RB ---------------------------------------MRQVTRASSGQ ENSMUST00000023429 -------------------------------------------------- ENSMUST00000025477 --------------------------------------MRNCKMARVASV ENST00000238498 RARSHTHTHTHTHIYTPASCWPLNGPISPVSLNPAQPGMRNCKMARVASV SINFRUP00000160743 -------------------------------------------------- SINFRUP00000162731 -------------------------------------------------- ENST00000231461 -------------------------------------------MRSIRKR ENSMUST00000043336 -------------------------------------------MRSIRKR Q8QH83_Brachydanio_rerio --------------------------------------------MSFEFR ENSMUST00000013990 ----------------------------------------------MRRK ENST00000319914 -------------------------------------------MVTLRKR ENSMUST00000028154 -------------------------------------------------- ENST00000291839 -------------------------------------------------- SINFRUP00000158540 -------------------------------------------------- ENSMUST00000044278 -------------------------------------------------- ENST00000235717 -------------------------------------------------- ENSMUST00000028153 -------------------------------------------------- CG4871-RB SQALLSCLIIAVCAALIIQSGHIQGVKAQPGREPGEVNSRQPGNGAYENS ENSMUST00000023429 -------------------------------------------------- ENSMUST00000025477 LGLVMLSVALLILSLISYVSLKKENIFTTPKYASPGAPRMYMFHAGFRSQ ENST00000238498 LGLVMLSVALLILSLISYVSLKKENIFTTPKYASPGAPRMYMFHAGFRSQ SINFRUP00000160743 ------SNLLLLFLLCS-------------------------------SQ SINFRUP00000162731 -------VALIR-----------------------------------RSQ ENST00000231461 WTICTISLLLIFYKT--------------KEIARTEEHQETQLIGDGELS ENSMUST00000043336 WTICTISLLLIFYKT--------------KEIARTEEHQETQLIGDGELC Q8QH83_Brachydanio_rerio ILMFGIGTALVIFVIIADISE------VEEEIANIEDSRKFHLKSVALQS ENSMUST00000013990 TLKYLTFFLLFIFLT-----------------SFVLNYSNTGVPSAWFPK ENST00000319914 TLKVLTFLVLFIFLT-----------------SFFLNYSHTMVATTWFPK ENSMUST00000028154 --------------------------------MACSR------------- ENST00000291839 ---------------------------GARTPALGSRRHVRGLGGRGGPG SINFRUP00000158540 -------------------------------------------------- ENSMUST00000044278 -------------------------------------------------- ENST00000235717 -------------------------------------------------- ENSMUST00000028153 -------------------------------------------------- CG4871-RB TGTERRLRKVIWKCIPTGNGTTGHRVPRSVFHVRWNPNEKFIVESRENPA ENSMUST00000023429 ---------------------------------MKGYLVAIFLSSIFLYY :. ENSMUST00000025477 FALKFLDQS--------------FVPITNSLTHELQEKPSKWTFNRTAFL ENST00000238498 FALKFLDPS--------------FVPITNSLTQELQEKPSKWTFNRTAFL SINFRUP00000160743 LAMKYLDPV--------------FTPLTSSLSEDLQN-ASKWSFNSSAFA SINFRUP00000162731 LAVNSLNPS--------------FIPLTNALNEELHGKPSKWKFNKTAFY ENST00000231461 LSRSLVNSS---------DKIIRKAGSSIFQHNVEG-----WKINSSLVL ENSMUST00000043336 LSRSLVNSS---------DKIIRKAGSTIFQHSVQG-----WKINSSLVL Q8QH83_Brachydanio_rerio NRSSDLNAAPTSLVTYRKSKVSSLASPSDIKRKTSNSSSSEWTFNRTLSN ENSMUST00000013990 QMLLELSEN--------------FRRFIKSQPCTCRHCISQDKVSYWFDQ ENST00000319914 QMVLELSEN--------------LKRLIKHRPCTCTHCIGQRKLSAWFDE ENSMUST00000028154 -PPSQCDPTT-------------LPPGPPAGRWPLPFSRRRREMSSNKEQ ENST00000291839 APRRRCEPTS-------------LPPGPPAGRRHLPLSRRRREMSSNKEQ SINFRUP00000158540 ------------------------------------------ERQGQQSH ENSMUST00000044278 -------------------------------------------------- ENST00000235717 --MKTLMRHG-------------LAVCLALTTMCTSLLLVYSSLGGQKER ENSMUST00000028153 ---------------------------------------GRLLLLTLCIL CG4871-RB INSSKLAPHPR--------LKVSKNTKLTLSPKLYLCHDKHSELCHNKTQ ENSMUST00000023429 VLYCILWGTNG-------------YWFPAEEMRTRNNVNNCFKKPAFANL ENSMUST00000025477 HQRQEILQHVDVIKNFSLTKSSVRIGQLMHYDYSSHKYVFSISNNFRSLL ENST00000238498 HQRQEILQHVDVIKNFSLTKNSVRIGQLMHYDYSSHKYVFSISNNFRSLL SINFRUP00000160743 QLKNEISQYIDVPRNFTLTRDSVRIGQLMHYDYSSHKYVFSIGENFRSLL SINFRUP00000162731 KQRKDILGFIDIPNNFSLTKDRVRVGQLMHFDYSSHKYVFSISNNFKSLL ENST00000231461 EIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLD-RRRTLNISHDLHSLL ENSMUST00000043336 EIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLD-RRRTLNISHNLHSLL Q8QH83_Brachydanio_rerio LIRKNILKFLDAERDISILKSTFKPGDVIHYIFD-RQSTTNISENLYHLL ENSMUST00000013990 RFNKTMQPLLTVHN-ALMEEDTYRWWLRLQRERKPNNLSDTVKELFRLVP ENST00000319914 RFNQTMQPLLTAQN-ALLEDDTYRWWLRLQREKKPNNLNDTIKELFRVVP ENSMUST00000028154 RSAVFVILFALITILILYSSNSANEVFH--YGSLRGRTRRPVNLKKWSFS ENST00000291839 RSAVFVILFALITILILYSSNSANEVFH--YGSLRGRSRRPVNLKKWSIT SINFRUP00000158540 RMVILVAAFILMTLLIFCGSNNVIEEVYSNFHVAVNNAAGATNLKKWPWK ENSMUST00000044278 -------------------------------------------------- ENST00000235717 PPQQQQQQQQQQQQASATGSSQPAAESS--------TQQRPGVPAGPRPL ENSMUST00000028153 TFSAVCVFLCCWACLPLCLATCLDRHLP--------AAPRSTVPGPLHFS CG4871-RB QFRQRIVRAFEKAMVESVNESQANHYNVDYKPVFGDSFEEQYYPSTCLVM ENSMUST00000023429 LRFPQLYPFLCRADFIKVAAMSGTNNFPLPYGIKTFETYFSSALSKLQSC ENSMUST00000025477 PDVSPIMNKR------------------------YNVCAVVGNSGILTGS ENST00000238498 PDVSPIMNKH------------------------YNICAVVGNSGILTGS SINFRUP00000160743 PETSPILQKH------------------------YNVCAVVGNSGILTGS SINFRUP00000162731 PDTSPIHNKH------------------------YSLCSVVGNSGILTGS ENST00000231461 PEVSPMKNRR------------------------FKTCAVVGNSGILLDS ENSMUST00000043336 PEVSPMKNRR------------------------FKTCAVVGNSGILLDS Q8QH83_Brachydanio_rerio PTVSPMKNQH------------------------YRKCAIVGNSGILLNS ENSMUST00000013990 GNVDPMLNKRLVG---------------------CRRCAVVGNSGNLKDS ENST00000319914 GNVDPMLEKRSVG---------------------CRRCAVVGNSGNLRES ENSMUST00000028154 SAYFPILGNKTLP-------------------SRCNQCVIITSSSHLLGT ENST00000291839 DGYVPILGNKTLP-------------------SRCHQCVIVSSSSHLLGT SINFRUP00000158540 GGYVPVHGNKNMS-------------------LRCHHCALVTSSSHVLGT ENSMUST00000044278 ----------PLK-------------------MHCKDCALVTSSGHLLRS ENST00000235717 DGYLGVADHKPLK-------------------MHCRDCALVTSSGHLLHS ENSMUST00000028153 -GYSSVPDGKPLIR------------------ELCHSCAVVSSSGQMLGS CG4871-RB EAGVRVLRRKDAPFNKLPFGRLFPRQKLFRNVKDIKTCAIVSSAGSLAGS ENSMUST00000023429 DLFDEFDRVP------------------------CKRCVVVGNGGVLKNK . * :: ... : . ENSMUST00000025477 QCGQEIDKSDFVFRCNFAPTEAFHKDVGRKTNLTTFNPSILEKYYNNLLT ENST00000238498 QCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNPSILEKYYNNLLT SINFRUP00000160743 RCGQQIDRFDFVFRCNFAPTEIFKKDVGRRTNMTTFNPSILEKYYNNLLT SINFRUP00000162731 HCGDNIDQADFVFRCNFAPTEVYSKDVGRKTNMTTFNPSILERYYNNLLT ENST00000231461 ECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRN ENSMUST00000043336 GCGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRN Q8QH83_Brachydanio_rerio SCGREIDSHDFVIRCNLAPVEEYAADVGLRTSLVTMNPSVVQRAFQDLNS ENSMUST00000013990 SYGPEIDSHDFVLRMNKAPTVGFEADVGSRTTHHLVYPESFRELGENVN- ENST00000319914 SYGPEIDSHDFVLRMNKAPTAGFEADVGTKTTHHLVYPESFRELGDNVS- ENSMUST00000028154 KLGPEIERAECTIRMNDAPTSGYSADVGNKTTFRVVAHSSVFRVLRKPQ- ENST00000291839 KLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQ- SINFRUP00000158540 GAGAEIDRTECVIRMNDAPTLGFEADVGNHTSLRVIAHSSVFRVARKMP- ENSMUST00000044278 QQGPHIDQTECVIRMNDAPTRGYGLDVGNRTSLRVIAHSSIQRILRNRH- ENST00000235717 RQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVIAHSSIQRILRNRH- ENSMUST00000028153 GLGAQIDGAECVLRMNQAPTVGFEEDVGQRSTLRVISHTSVPLLLRNYS- CG4871-RB KLGRFIDTHDIVMRFNHAPTQGHEVDVGSKTTIRVVNSQVVTKPEFDFT- ENSMUST00000023429 TLGATIDSYDVIIRMNNGPVLGHEEEVGTRTTFRLFYPESVFSDSSHYDP * *: : :* * .*. . :** :: . . ENSMUST00000025477 IQDRNNFFLSLKKLDGAILWIPAFF------FHTSATVTRTLVDFFVEHR ENST00000238498 IQDRNNFFLSLKKLDGAILWIPAFF------FHTSATVTRTLVDFFVEHR SINFRUP00000160743 VQDRNNFFLSLKKLDTTILWIPAFF------FHTSATVTRTLVDFFVEHR SINFRUP00000162731 IQDRNNFFLNLKKLGGAILWIPAFF------LHTSATVTRTLVDFFVEHK ENST00000231461 ESDREKFVHRLSMLNDSVLWIPAFM------VKGGEKHVEWVNALILKNK ENSMUST00000043336 ESDREKFVHRLSMLNDSVLWIPAFM------VKGGEKHVEWVNALILKNK Q8QH83_Brachydanio_rerio EEWVQRFVQRPQSLSGSVLWIPAFM------AKGGEERVEWAIRLILLHT ENSMUST00000013990 -------MVLVPFKTTDLQWVISAT------TTGTITHTYVPVPPKIKVK ENST00000319914 -------MILVPFKTIDLEWVVSAI------TTGTISHTYIPVPAKIRVK ENSMUST00000028154 -----EFVNRTP-ETVFIFWGPPNK------MQKPQ-GSLLRVIQRAGLM ENST00000291839 -----EFVNRTP-ETVFIFWGPPSK------MQKPQ-GSLVRVIQRAGLV SINFRUP00000158540 -----EFLHRAVGNPVIIFWGPPNK------IGKEANGSLYRLIQRV-MA ENSMUST00000044278 -----DLLNVSQ-GTVFIFWGPSSY------MRRDGKGQAYNNLQLLSQV ENST00000235717 -----DLLNVSQ-GTVFIFWGPSSY------MRRDGKGQVYNNLHLLSQV ENSMUST00000028153 -----HYFQHAR-DTLYVVWGQGRH------MDRVLGGRTYRTLLQLTRM CG4871-RB -------RAPIFRNVTIAAWDPGKYNGTLEDWLTSADYDLFSNYELYRRR ENSMUST00000023429 N----TTAVLVVFKPQDLRWLVEILLG-----KKINTQGFWKTPALKLIY * ENSMUST00000025477 GQLKVQLAWPGN-IMQHVNRYWKN----KHLSPKRLSTGILMYTLASAIC ENST00000238498 GQLKVQLAWPGN-IMQHVNRYWKN----KHLSPKRLSTGILMYTLASAIC SINFRUP00000160743 GQLKVRLAWPGN-IMQYINNYWKT----KQLSPKRLSTGILMYTLASSMC SINFRUP00000162731 GQLKVELAWPGN-IMHDVNKYWKT----KNLSPKRLSTGILMYTLASAMC ENST00000231461 --LKVRTAYPSLRLIHAVRGYWLT----NKVPIKRPSTGLLMYTLATRFC ENSMUST00000043336 --LQVRTAYPSLRLIHAVRGYWLT----NKVPIKRPSTGLLMYTLATRFC Q8QH83_Brachydanio_rerio --VNVRTAFPSLRLLHAVRGYWLT----NHVQIKRPTTGLLMYTMATRFC ENSMUST00000013990 ---QEKILIYHPAFIKYVFDNWLQ----GHG--RYPSTGILSIIFSIHIC ENST00000319914 ---QDKILIYHPAFIKYVFDNWLQ----GHG--RYPSTGILSVIFSMHVC ENSMUST00000028154 FPNMEAYAVSPARMQQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELC ENST00000291839 FPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELC SINFRUP00000158540 YSKLSCFTITATKMRRFDNLFHTETGRDRQKSHSWLSTGWFTMVIAIEIC ENSMUST00000044278 LPRLKAFMITRHRMLQFDELFKQETGKDRKISNTWLSTGWFTMTIALELC ENST00000235717 LPRLKAFMITRHKMLQFDELFKQETGKDRKISNTWLSTGWFTMTIALELC ENSMUST00000028153 YPGLQVYTFTERMMAYCDQIFQDETGKNRRQSGSFLSTGWFTMILALELC CG4871-RB YPKSRAFLIDPHSVWRLWQSLQMFAG-NRPISKNPPSSGFIGLALLLPHC ENSMUST00000023429 KQYQIRILDPYITSEAAFQMLRFPRVFPKDQKPKHPTTGIIAITMAFHIC ::* : : * ENSMUST00000025477 EEIHLYGFWPFGFDPN--TREDLPYHYYDKKG------------------ ENST00000238498 EEIHLYGFWPFGFDPN--TREDLPYHYYDKKG------------------ SINFRUP00000160743 DQIHLYGFWPFGWDPN--TGKELPYHYYDKKG------------------ SINFRUP00000162731 DEIHLYGFWPFGWDPN--TGKELPYHYYDKKG------------------ ENST00000231461 DEIHLYGFWPFPKDL---NGKAVKYHYYDDLK------------------ ENSMUST00000043336 DEIHLYGFWPFPKDL---NGKAVKYHYYDDLK------------------ Q8QH83_Brachydanio_rerio DEIHLYGFWPFAHDP---DGKPVKYHYYDTLT------------------ ENSMUST00000013990 DEVDLYGFG------A--DSKGNWHHYWENNP------------------ ENST00000319914 DEVDLYGFG------A--DSKGNWHHYWENNP------------------ ENSMUST00000028154 DHVHVYGMVPPDYCSG-PACSACHTTTMNPRGRTSVSPTSRTSTAVRAIT ENST00000291839 DHVHVYGMVPPNYCSQRPRLQRMPYHYYEPKG---------PDECVTYIQ SINFRUP00000158540 DNIKVYGMVPPSHCGKQTGAKKVPYHYYKPRG---------PDECVTYTQ ENSMUST00000044278 DRIDVYGMVPPDFCRD-PKHPSVPYHYYEPSG---------PDECTMYLS ENST00000235717 DRINVYGMVPPDFCRD-PNHPSVPYHYYEPFG---------PDECTMYLS ENSMUST00000028153 EEIVVYGMVSDSYCSE-KSPRSVPYHYFEKGR---------LDECQMYRL CG4871-RB PQVDFVEYVPSTRLNG-------RCHYYSKEMN----------------- ENSMUST00000023429 SEVHLAGFKYNFYSPN------SPLHYYGNAT------------------ .: . ENSMUST00000025477 TKFTTKWQES---------------------HQLPAEF------------ ENST00000238498 TKFTTKWQES---------------------HQLPAEF------------ SINFRUP00000160743 TKFTTKWQES---------------------HQLPTEF------------ SINFRUP00000162731 TKFTTKWQET---------------------HQLPTEF------------ ENST00000231461 YRYFSNASP----------------------HRMPLEF------------ ENSMUST00000043336 YRYFSNASP----------------------HRMPLEF------------ Q8QH83_Brachydanio_rerio YHYTSSASP----------------------HTMPLEF------------ ENSMUST00000013990 SAGAFRKTGV---------------------HDGDFEY------------ ENST00000319914 SAGAFRKTGV---------------------HDADFES------------ ENSMUST00000028154 TASSPRRGSSRPGPNSTVSPSPTPPGPSYPVHRSRTDTNEVALAQPFNHG ENST00000291839 NEHS-RKGN---------------------HHRFITEK------------ SINFRUP00000158540 HESS-RRGN---------------------HHRFITEK------------ ENSMUST00000044278 HERG-RKGS---------------------HHRFITEK------------ ENST00000235717 HERG-RKGS---------------------HHRFITEK------------ ENSMUST00000028153 HEQAPRSAH-----------------------RFITEK------------ CG4871-RB --SACTFGS---------------------WHPLAAEK------------ ENSMUST00000023429 -MSLMKQNAY---------------------HNLTAEQ------------ : ENSMUST00000025477 ---------------------QLLYRMHGEGLTKLTLSHCA--------- ENST00000238498 ---------------------QLLYRMHGEGLTKLTLSHCA--------- SINFRUP00000160743 ---------------------KLLYKMHREGLLKLSLSHCA--------- SINFRUP00000162731 ---------------------KLLYKLHREGVIRLSLTHC---------- ENST00000231461 ---------------------KTLNVLHNRGALKLTTGKCVKQ------- ENSMUST00000043336 ---------------------KTLNVLHNRGALKLTTGKCMKQ------- Q8QH83_Brachydanio_rerio ---------------------RTLSALHRQGALRLHTGPCKPPT------ ENSMUST00000013990 ---------------------NITTTLAAINKIRIFKGR----------- ENST00000319914 ---------------------NVTATLASINKIRIFKGR----------- ENSMUST00000028154 HLPASSGWLEYFPANQIRALMRVFFSSQSGLGLSLGQSGIWNSVWFNRVS ENST00000291839 ---------------------RVFSSWAQLYGITFSHP-SWT-------- SINFRUP00000158540 ---------------------QVFARWAKHYNITFVHP-TW--------- ENSMUST00000044278 ---------------------RVFKNWARTFNIHFFQP-DWKPESPAVNH ENST00000235717 ---------------------RVFKNWARTFNIHFFQP-DWKPESLAINH ENSMUST00000028153 ---------------------AVFSRWAKKRPIVFAHP-SWRAK------ CG4871-RB -------------------LMALDMNMAEDDDMSVFQFGILRIRRPDKLL ENSMUST00000023429 ----------------------LFLNDIIKKKMVINLT------------ . ENSMUST00000025477 --------- ENST00000238498 --------- SINFRUP00000160743 --------- SINFRUP00000162731 --------- ENST00000231461 --------- ENSMUST00000043336 --------- Q8QH83_Brachydanio_rerio --------- ENSMUST00000013990 --------- ENST00000319914 --------- ENSMUST00000028154 GGLSRLVRV ENST00000291839 --------- SINFRUP00000158540 --------- ENSMUST00000044278 AEGKPVF-- ENST00000235717 PENKPVF-- ENSMUST00000028153 --------- CG4871-RB CGFNFFGY- ENSMUST00000023429 ---------