CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000036999 ---------------------------------MQKPSGLKPPGRGGKHSSPVGRPSVGS ENST00000223398 --------------------PALTLVHLPSGTAMQKPSGLKPPGRGGKHSSPMGRTSTGS SINFRUP00000136424 ------------------------------------------------------------ SINFRUP00000127816 ---------------------------------------------------------MSA ci0100151707 ---------------------------------------------------------MAE CG5020-RB MSDDTSASGGTSAPFPSPVTADPEPGATASKLPGPIRSNIPTPATSGTGIPQPSKMKAPS : ENSMUST00000036999 ASSSVVASTSGSKEGSPLHKQASGPSSSGAATTVSEK----------PGPKAAEVGDDFL ENST00000223398 ASSSAAVAAS-SKEGSPLHKQSSGPSSSPAAAAAPEK----------PGPKAAEVGDDFL SINFRUP00000136424 ------------IAGAPKPVP---PDKPPGSVASPTQ----------EGS---------- SINFRUP00000127816 AKSTGMKGPSKIAKPSGTTAPKTNPSTAGSKAAAADK----------SASSASGDAQGAG ci0100151707 KQSGLKPPSRIGKPGAILMGTKSIPAQKAPSSTNSNS----------NAAS--------- CG5020-RB SFGSTGSVSKIGRPCCNHTTPKSGPPPREATSMSRESDDNLSSINSAYTDNSSAVLTANT . * . ENSMUST00000036999 GDFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQ ENST00000223398 GDFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQ SINFRUP00000136424 AEFQIGDKVWVNGDKPGYVQFIGSTQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEDGR SINFRUP00000127816 ENFQIGDRVWVNGNKPGYIQFLGETQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEALR ci0100151707 -NFIIGDKVILSGSKVGRIQFLGETEFAPGQWAGIVLEDAVGKNNGSVAGVQYFQCEPMH CG5020-RB EQFIIGQRVWLGGTRPGQIAFIGDTHFAAGEWAGVVLDEPNGKNDGCVSGKRYFQCEPKR :* :*::* :.* : * : ::*.*.**.*:***:**::. ***:*.*.* :**:* : ENSMUST00000036999 GIFTRPSKLTRQPTAEG--SGSDTHSVESLTAQNLSLHSGTATP------PLTGRVIPLR ENST00000223398 GIFTRPSKLTRQPTAEG--SGSDAHSVESLTAQNLSLHSGTATP------PLTSRVIPLR SINFRUP00000136424 GIFTRPSKLSKTAMPEKDMNGTQASPKPAAGATSEPAPSGTTSTGNSQTEAFAAEKAFIR SINFRUP00000127816 GIFTRPSKLS---LTEGEANGNQTAPPSRAASPTPSVGTGASQAAN-AKSALPSTTAAAK ci0100151707 GVFARPSKLVRANNETAGNTTVKPPSTLSKPKSATAVKTAPLTIANLKASTGETPTHERK CG5020-RB GIFSRLTRLTTYPLAGAQTPTSPLAKSSPDRS------------------RTVSPTASIR *:*:* ::* : ENSMUST00000036999 ESVLNSSVKT----------GNESGSNLSDSGSVKRGDKDLHLGDRVLVG---GTKTGVV ENST00000223398 ESVLNSSVKT----------GNESGSNLSDSGSVKRGEKDLRLGDRVLVG---GTKTGVV SINFRUP00000136424 TLSQVSGIKTIAA---LNQMSTESASNLSDPESQKKTKRELRLGERVLVG---GTKAGVV SINFRUP00000127816 KTSSTAPAPPATPPSNLARTNSESVSNLSESGSVKKGERELKIGDRVLVG---GTKAGVV ci0100151707 KKGIRSPASS---------IRSLKFGGLGDASSVRYN-EDIKVGDRVNVG---DAKVGTV CG5020-RB SSMLRSPGIG--------------------------GKNGMAVGDRVIVSSGFGSRPGIL : : . : :*:** *. .:: * : ENSMUST00000036999 RYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVIR-------- ENST00000223398 RYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVIR-------- SINFRUP00000136424 RFLGETDFAKGEWCGVELDEPLGKNDGAVAGSRYFQCMPRYGLFAPVHKVTR-------- SINFRUP00000127816 RFLGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTR-------- ci0100151707 RFVGETEFAKGCWVGIELDSAQGKNDGSVAGNRYFTCEANFGLFALRHKVKK-------- CG5020-RB RYLGETQFAPGNWCGVELDEPSGKNDGTVDDIRYFECKPKYGVFVPIAKVSLSPSSKKTR *::***:** * * *:***.. *****:* . *** * ..:*:*. ** ENSMUST00000036999 ------------------IGFPSTSPAKAKKTKRMAMGV-SALTHSPSS----------- ENST00000223398 ------------------IGFPSTSPAKAKKTKRMAMGV-SALTHSPSS----------- SINFRUP00000136424 ------------------IGFP-TTPTKTKSSQRRSF-----LKRSPSA----------- SINFRUP00000127816 ------------------IGFPSTTPAKAKTTVRKTVATPSGMKRSPSS----------- ci0100151707 ------------------VTGTVAKKTAQSAVK----------KRPTVK----------- CG5020-RB LSRTGSRESLTSIGTMNSIATTATSRMRMNAQQRKSSTPVKPILATPKSQFSMQDLLREK : . :. . : .. ENSMUST00000036999 --------------------------------------------SSISSVSSVASSVGGR ENST00000223398 --------------------------------------------SSISSVSSVASSVGGR SINFRUP00000136424 --------------------------------------------SSMSSLSSANSSFSGK SINFRUP00000127816 --------------------------------------------SSISTMSSVASSVSAK ci0100151707 --------------------------------------------SPGSSASSVSSVTSIP CG5020-RB QQHVEKLMVERDLDREDAQNQALQLQKNINELKARIVELESALDNERKKTEELQCSIDEA . .. .. . . ENSMUST00000036999 PSRSGLLTETSSRYARKISGT---------------------------------TALQEA ENST00000223398 PSRSGLLTETSSRYARKISGT---------------------------------TALQEA SINFRUP00000136424 PSRAGLLAETS-RYARKISGT---------------------------------TALQEA SINFRUP00000127816 PSRTGLLTETSSRYNRKISGT---------------------------------TALQEA ci0100151707 SLRRPSKSEVSSRYKQKTAATG-------------------------------VQALQEA CG5020-RB QFCGDELNAQSQVYKEKIHDLESKITKLVSATPSLQSILPPDLPSDDGALQEEIAKLQEK * * .* *** ENSMUST00000036999 LKEKQQHIEQLLAERDLE----RAEVAKATSHICEVEKEIALLKAQHEQY------VAEA ENST00000223398 LKEKQQHIEQLLAERDLE----RAEVAKATSHICEVEKEIALLKAQHEQY------VAEA SINFRUP00000136424 LKEKQQHIEQLLAERDLE----RGEVAKATSHAGAVQQELVLLRKGRDQD------AVEM SINFRUP00000127816 LKEKQQHIEQLMAERDME----RAEVAKATGYAGEMEVELRLLREEQEQSRGTLFCALKM ci0100151707 LVEKQQHVESLIAERDQE----KSELMEVNLTAAMKQDQLNKLQEAHDQF------VKEK CG5020-RB MTIQQKEVESRIAEQLEEEQRLRENVKYLNEQIATLQSELVSKDEALEKFSLSECGIENL : :*:.:*. :**: * : :: . : :: :: : ENSMUST00000036999 EEKLQRAR-LLVENVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHAR ENST00000223398 EEKLQRAR-LLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLE--------- SINFRUP00000136424 EAKLDQLR-SLVEAADRDKVELLNQLEEEKRKVEDLQFRVEEACITKGDLEV-------- SINFRUP00000127816 EAKMDQLR-TLVEAADKDKVDLLNQLEEER---SAQLIRKNEIHILIYALK--------- ci0100151707 ESQLDQLR-RLVEEADLEKVKLAQDLDEERRKAEDYQFQLEEGQIIKDDMEMKNN-FEKH CG5020-RB RRELELLKEENEKQAQEAQAEFTRKLAEKSVEVLRLSSELQNLKATSDSLESERVNKTDE . ::: : : . :..: ..* *: . :: :: ENSMUST00000036999 IGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEELSLRRGEIEELQHCLLQ- ENST00000223398 --------------------------LTTVAEKSRVLQLEEELTLRRGEIEELQQCLLH- SINFRUP00000136424 ------------------------------------------------------------ SINFRUP00000127816 --------------------------VATVSERSRIMELEKDLSQRTREVSDLKLRLGSQ ci0100151707 VQDLMNQGEVSSQELFTYKQQTEEERKAKEKLKSELESLNESLCLANQEKEDLSMQLEKT CG5020-RB CEILQTEVRMRDEQIRELNQQLDEVTTQLNVQKADSSALDDMLRLQKEGTEEKSTLLEKT : : : : : ENSMUST00000036999 -----------------SGPPPADHPEAAETLRLRERLLSASKEHQRDSTLLQDKYEHML ENST00000223398 -----------------SGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKAL SINFRUP00000136424 ------------------------------------------------------------ SINFRUP00000127816 Q---------------GSEGDAALTTVLEEINSLREQLASQQAKHQEEVAQYKEKLETEE ci0100151707 -----------------ASDVEALQCSLKEERGNVEKLEEKVVEVELVLGGERKKFEDDK CG5020-RB EKELVQSKEQAAKTLNDKEQLEKQISDLKQLAEQEKLVREMTENAINQIQLEKESIEQQL : ENSMUST00000036999 KTYQTEVDKLRAANEKYAQEVADLKAKVQQATTENMGLMDNWK-------------SKLD ENST00000223398 KAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWK-------------SKLD SINFRUP00000136424 ------------------------------------------------------------ SINFRUP00000127816 KSHSDAVAQLQATSVRLSGENEQMQMRLSHAEKENAENIELWR-------------SKLE ci0100151707 LGMQGSINDLKKSLETKNSECDNLQIKVKKTESEKTEVQKSLENLKTDLKKVNSEFSEVK CG5020-RB ALKQNELEDFQKKQSESEVHLQEIKAQNTQKDFELVESGESLKKLQQQLEQKTLGHEKLQ : : : : ENSMUST00000036999 SLASDHQKSLEDLKATLNSGPGAQQKEIGELKALVEGIKMEHQLELGNLQAKHDLETA-- ENST00000223398 SLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETA-- SINFRUP00000136424 ------------------------------------------------------------ SINFRUP00000127816 SAVASHKEAIEDLKVSFSKGAGAQTEELLETKSALERLKLEHTLALEEAGAKREAEAR-- ci0100151707 SKLEEENKELESKNAELVISVADLSEKSHQVSSELDELKSKHETLQLSVQQQKQKETETL CG5020-RB AALEELKKEKETIIKEKEQELQQLQSKSAESESALKVVQVQLEQLQQQAAASGEEGSKTV : : ENSMUST00000036999 ------------------------------------------------------MHGKEK ENST00000223398 ------------------------------------------------------MHVKEK SINFRUP00000136424 ------------------------------------------------------------ SINFRUP00000127816 ------------------------------------------------------VWATEK ci0100151707 SFVEKLLTQLDIENNESCDLPQQFEL--------MTSKCIGLQDECKHLEETYRVCENEK CG5020-RB AKLHDEISQLKSQAEETQSELKSTQSNLEAKSKQLEAANGSLEEEAKKSGHLLEQITKLK ENSMUST00000036999 EGLRQKLQEVQEELAGLQQHWR-------------------------------------- ENST00000223398 EALREKLQEAQEELAGLQRHWR-------------------------------------- SINFRUP00000136424 ------------------------------------------------------------ SINFRUP00000127816 RAMDAQLLSLTEDKERLEDSLR-------------------------------------- ci0100151707 TNVEKQCTELSGNFSNLEIEFEGIKTGLSKERARAEELDSKCQELTEKCEKVNSEKVAVT CG5020-RB SEVGETQAALSSCHTDVESKTKQLEAANAALEKVNKEYAESRAEASDLQDKVKEITDTLH : : ENSMUST00000036999 -----------------------------------EQLEEQASQHRLELQEAQDQCRDAQ ENST00000223398 -----------------------------------AQLEVQASQHRLELQEAQDQRRDAE SINFRUP00000136424 ------------------------------------------------------------ SINFRUP00000127816 -----------------------------------SSVERAEEQHLVEMEDVLGKLHAAE ci0100151707 EELEGSRRSLKEMTAQLSEQTAKAKKLDSKFQELTEKYEKQNSENVVVTEELESSRRSLK CG5020-RB AELQAERSSSSALHTKLSKFSDEIATGHKELTSKADAWSQEMLQKEKELQELRQQLQDSQ ENSMUST00000036999 LRAQELEGLDVEYRG--------------------------QAQAIEFLKEQISLAEKKM ENST00000223398 LRVHELEKLDVEYRG--------------------------QAQAIEFLKEQISLAEKKM SINFRUP00000136424 ------------------------------------------------------------ SINFRUP00000127816 IRVKELEEKETELTR--------------------------QAE---------------- ci0100151707 EMTAELADQTAKAKK--------------------------LDSKFQELTEKYEKQNSEK CG5020-RB DSQTKLKAEGERKEKSFEESIKNLQEEVTKAKTENLELSTGTQTTIKDLQERLEITNAEL : : : ENSMUST00000036999 LDYEMLQRAEAQSRQEAERLREKLLVAENRLQAAESLCSAQHSHVIE------------- ENST00000223398 LDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIE------------- SINFRUP00000136424 ------------------------------------------------------------ SINFRUP00000127816 ------------------------------------------------------------ ci0100151707 LVVTEELESSRRSLKEMTAELADVKLQKELLSTNAEDIDAKTMQVKAXXL---------- CG5020-RB QHKEKMASEDAQKIADLKTLVEAIQVANANISATNAELSTVLEVLQAEKSETNHIFELFE : : : : ENSMUST00000036999 ------SSDLSEETIRMKETVEGLQDKLNKRDKEVTALTSQMDMLRAQVSALENKCKSGE ENST00000223398 ------SNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGE SINFRUP00000136424 ------------------------------------------------------------ SINFRUP00000127816 -----------------------------DKDRETKEQMAEMVALRSQVGQNKEEMVTLK ci0100151707 ------TSKLEKLETENKNEIESRVKAVEEAEINIRKLQEEKEAMLIQCNDFESELQSTR CG5020-RB MEADMNSERLIEKVTGIKEELKETHLQLDERQKKFEELEEKLKQAQQSEQKLQQESQTSK : : : ENSMUST00000036999 KKIDSLLKEKRRLEAELEAVSRKTHDASGQLVHISQELLRKERSLNELRVLLLEANRHSP ENST00000223398 KKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSP SINFRUP00000136424 ------------------------------------------------------------ SINFRUP00000127816 KQLDSVQSQ--------------------------------------------------- ci0100151707 SKLELTASEYDNLQVEIKKTESEKTEVKKSLENLKTDLEKVNSQFSEAKSMLEDENKELE CG5020-RB EKLTEIQQSLQELQDSVKQKEELVQNLEEKVRESSSIIEAQNTKLNESNVQLENKTSCLK : : : : : : : ENSMUST00000036999 GPERDLSR-------------EVHKAEWR---------------------IKEQKLKDDI ENST00000223398 GPERDLSR-------------EVHKAEWR---------------------IKEQKLKDDI SINFRUP00000136424 ------------------------------------------------------------ SINFRUP00000127816 ------------------------------------------------------------ ci0100151707 SKNAELVF-------------SVADLSEKSHQVSSELDELKSKHETLVASYDESKKNKDE CG5020-RB ETQDQLLESQKKEKQLQEEAAKLSGELQQVQEANGDIKDSLVKVEELVKVLEEKLQAATS : : ENSMUST00000036999 RGLREKLTGLDKEKSLSEQRRYSLIDPASPPELLKLQHQLVSTEDALRDALNQAQQVERL ENST00000223398 RGLREKLTGLDKEKSLSDQRRYSLIDRSSAPELLRLQHQLMSTEDALRDALDQAQQVEKL SINFRUP00000136424 ------------------------------------------------------------ SINFRUP00000127816 ------------------------------------------------------------ ci0100151707 VERKLDQVNQDHLAVLSEMEKLKLEKQNLEASLCEKNQLLQSSSQEQTQVNSRCSEFTSK CG5020-RB QLDAQQATNKELQELLVKSQENEGNLQGESLAVTEKLQQLEQANGELKEALCQKENGLKE : : : ENSMUST00000036999 VEALRGCSDRTQTISNSGSANGIHQPDKAHKQE--------------------------- ENST00000223398 MEAMRSCPDKAQTIGNSGSANGIHQQDKAQKQE--------------------------- SINFRUP00000136424 ------------------------------------------------------------ SINFRUP00000127816 ------------------------------------------------------------ ci0100151707 LEKLETENKKEIESRVKAVEEAEINIRKLQEEKDAIVKQCNDFESELQSTRSK------- CG5020-RB LQGKLDESNTVLESQKKSHNEIQDKLEQAQQKERTLQEETSKLAEQLSQLKQANEELQKS : ENSMUST00000036999 ------------------------------------------------------------ ENST00000223398 ------------------------------------------------------------ SINFRUP00000136424 ------------------------------------------------------------ SINFRUP00000127816 ------------------------------------------------------------ ci0100151707 -------------LELTASECDNLQVEIKKTESEKTEVENSLENLKTDLEKVNSEFSEAK CG5020-RB LQQKQLLLEKGNEFDTQLAEYQKVIDEMDDAASVKSALLEQLQNRVAELETALRQANDAQ ENSMUST00000036999 ------------------------------------------------------------ ENST00000223398 ------------------------------------------------------------ SINFRUP00000136424 ------------------------------------------------------------ SINFRUP00000127816 ------------------------------------------------------------ ci0100151707 LKLEEENAELVISVADLSEKSHQVSSELDELKS------KHETLVASHDESGDAGQVDFL CG5020-RB KTAYLETKELRRQLESLELEKSREVLSLKAQMNGASSRSGKGDEVESLDIETSLAKINFL ENSMUST00000036999 ------------------------------------------------------------ ENST00000223398 ------------------------------------------------------------ SINFRUP00000136424 ------------------------------------------------------------ SINFRUP00000127816 ------------------------------------------------------------ ci0100151707 NKVIIDQQQKIKMLTDKIEELEGMMLDDGAGGEEAEYNGESRKLAPRLFCDICDVFDAHD CG5020-RB NSIIADMQQKNDALKAKVQTLETLPMD--FTKPHAFDALTKRKPAPRLFCDICDEFDQHD ENSMUST00000036999 -------------------------------------------------------- ENST00000223398 -------------------------------------------------------- SINFRUP00000136424 -------------------------------------------------------- SINFRUP00000127816 -------------------------------------------------------- ci0100151707 TEDCPTQSMMEPDPAGAS-------QHYERGEGRAYCEDCEVFGHWTDDCEEQQIF CG5020-RB TEDCPIQGSEDQDYSTPSSESNNNEKERKLPAPRKYCDSCEVFGHDTSECADDETY