CLUSTAL W (1.82) multiple sequence alignment ENST00000300976 ----------MAESGGSSGGAGGGGAFGAGPGPERPNSTADKNGALKCTFSAPSHSTSLL ENSMUST00000045400 ----------MAESGGSSG---------SSQSPERPSSLADRNGALKCTFSAAGHSTGLL ci0100147735 --------------------------------------MATRNGK---VYSSQRYSQLIL ENST00000312063 ----------------ALTLQLVENRLEEGLKPGAPSQLAMSRSGDRTSTFDPSHSDNLL ENSMUST00000061240 MAPKKKTIKKNKAEINEMTIIVEDSPLSKLNALNGLLEGSNSLSCVSSELTDTSYGPNLL ENST00000244722 MAPKKKIVKKNKGDINEMTIIVEDSPLNKLNALNGLLEGGNGLSCISSELTDASYGPNLL CG6224-RA -MGDLPGSGSTAQPRDAAVTGTGGNSTAGGGSSVGSTAVDRPPSPARLSHTSEKHPKVTL ci0100138113 ------------------------------------------------------------ ENST00000325433 -----------------------------------------MIPNGYLMFEDENFIESSV ENST00000248272 -------------------------------------------MAEGSAVSDPQHAARLL : ENST00000300976 QGLATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGG--------------- ENSMUST00000045400 QGLAALRAQGQLLDVVLTVNSEAFHAHKVVLAACSDYF---------------------- ci0100147735 VGFFQLRVHGSLCDVTLTAEGKSFKAHRGLLASASDYFRAMFTSE--------------- ENST00000312063 HGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPLGGGVGGQDGLGA ENSMUST00000061240 EGLSKMRQESFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKND--------------- ENST00000244722 EGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKKD--------------- CG6224-RA TELNMLRRHRELCDVVLNVGGRKIFAHRVILSACSSYFCAMFTGELE------------- ci0100138113 ----------------MEEKHRDVVKLRGVDAKS-------------------------- ENST00000325433 AKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSD------------- ENST00000248272 RALSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPP------------- : : : : . . : : : . : : ENST00000300976 ------------------------------------MREASQDVIELKGVSARGLRHIID ENSMUST00000045400 ------------------------------------------------------------ ci0100147735 ------------------------------------MKESFSEDIELHGVSSTGLEQVLR ENST00000312063 PKDQQQPPQQQPSQQQQPPPQEEPGTPSSSPDDKLLTSPRAINNLVLQGCSSIGLRLVLE ENSMUST00000061240 ---------------------------------------PSTKRVDLNDIAPLGLATVIA ENST00000244722 ---------------------------------------PSIQRVDLNDISPLGLATVIA CG6224-RA --------------------------------------ESRQTEVTIRDIDENAMELLID ci0100138113 ------------------------------------------------------LEKLVD ENST00000325433 --------------------------------------PHGISHVKFDDLNPEAVEVLLN ENST00000248272 ------------------------------------KDDGSTYKIELEGISVMVMREILD : : : :: ENST00000300976 FAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSVETCLNIGQMATTFSLAS ENSMUST00000045400 ---SAEVTLDLDCVQDVLGAAVFLQMLPVVELCEDFLKAAMSVETCLHIGQMATTFSLTS ci0100147735 FIYSGEIVLSLENIHDILAAASHLQVTAIMDFCNEFLISEVTLENCVDIGHIANAYNLEA ENST00000312063 YLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCKIAALHGLEE ENSMUST00000061240 YAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREISVENCMYVVNIAETYSLKN ENST00000244722 YAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMSVENCMYVVNIAETYSLKN CG6224-RA FCYTAHIIVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDPTNCLGIRAFADTHSCRE ci0100138113 FMYTGKIKINTNNVCRLLAVSDFLHMHSIRNICIEYLLTTVSPQNCFTIQALAECYTIPQ ENST00000325433 YAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISYRNFASCMGDSR ENST00000248272 YIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIGIRDFALHYCLHH :..: . : : .: * : : .* ::* : . :* ENST00000300976 LRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQSCAEIDLFRAAVRWLQHDPA ENSMUST00000045400 LRESVDAFTFRHFLQIAAEEDFLRLPLERLVFFLQSNRLQSCAEIDLFRAAVRWLQHDPA ci0100147735 VDHHVNVYMLQNFNLVS---DFNKVPFDRLTFLLSSNTLKGCSELQLFNAAKRWIEGDVD ENST00000312063 TKKLANKYLVEDVLLLN---------FEEMRALLDSLPPPVESELALFQMSVLWLEHDRE ENSMUST00000061240 AKATAQKFIRDNFIEFAESEQFMKLTFEQINELLVDDDLQLPSELVAFQIAMKWLEFDQK ENST00000244722 AKAAAQKFIRDNFLEFAESDQFMKLTFEQINELLIDDDLQLPSEIVAFQIAMKWLEFDQK CG6224-RA LLRIADKFTQHNFQEVMESEEFLLLPVGQLVDIICSDELNVRSEEQVFNAVMSWLKYNVA ci0100138113 LTEKSNKFVVENYQQLVSSDQFRRLSKDDVIRLLQS-TYDAVSPDLVYTAVMNWVKFDSN ENST00000325433 LLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVMLEDNVCLP-SNGKLYTKVINWVQRSIW ENST00000248272 VHYLATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFEAVIRWIAHDTE : . . : : : .: : *: . ENST00000300976 RRPR-ASHVLCHIRFPLMQSSELVDS----VQTLDIMVEDVLCRQYLLEAFNY-----QV ENSMUST00000045400 RRAR-ASLVLRHVRFPLMQPAELVDS----VQTLDVMLDDALCRQYLLEAFSY-----HV ci0100147735 NRMKHAAALMENIRFPLVNPTDLITH----IQTVDFMRTDNACMRLLLEASNY-----QM ENST00000312063 TRMQYAPDLMKRLRFALIPAPELVER----VQSVDFMRTDPVCQKLLLDAMNY-----HL ENSMUST00000061240 -RVKHAADLLSNIRFGTISAQDLVNY----VQTVPRMMQDADCHKLLVDAMNY-----HL ENST00000244722 -RVKYAADLLSNIRFGTISAQDLVNY----VQSVPRMMQDADCHRLLVDAMNY-----HL CG6224-RA ERRQHLAQVLQHVRLPLLSPKFLVGT----VGSDLLVRSDEACRDLVDEAKNY-----LL ci0100138113 --ESYLNEVIKFVDFHTMSPEMLEDV----VSVEPYIKKKKKKRKITTVVFRP-----RE ENST00000325433 ENGDSLEELMEEVQTLYYSADHKLLDGNLLDGQAEVFGSDDDHIQFVQKKPPRENGHKQI ENST00000248272 IRKVHMKDVMSALWVSGLDSSYLREQ----------MLNEPLVREIVKECSNIP-----L :: : . . . ENST00000300976 LPFRQHEMQSPRTAVRSDVPSLVTFGGTPYT----------------------------- ENSMUST00000045400 LPCRQHDMQSPRTAVRSDVASLVAFGGTPYT----------------------------- ci0100147735 VPYMQPILQTPRTSIRSDATHLVTLGGVLRH----------------------------- ENST00000312063 MPFRQHCRQSLASRIRSNKKMLLLVGGLPPG----------------------------- ENSMUST00000061240 LPYHQNTLQSRRTRIRGGCRVLITVGGRPGL----------------------------- ENST00000244722 LPYHQNTLQSRRTRIRGGCRVLVTVGGRPGL----------------------------- CG6224-RA LPQERPLMQGPRTRPRKPTRRGEVLFAVGGW----------------------------- ci0100138113 DKVTFKLFYRAESRSX---KSLISLGG--------------------------------- ENST00000325433 SSSSTGCLSSPNATVQSPKHEWKIVASEKTSNNTYLCLAVLDGIFCVIFLHGRNSPQSSP ENST00000248272 SQPQQGEAMLANFKPRGYSECIVTVGGEERVS---------------------------- . . ENST00000300976 DSDRSVSSKVYQLPEPGARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRS--GEG ENSMUST00000045400 DSDRAVSSKVFQLPEPGARHFRELTEMELGCSHAGVAVLDNFVYVAGGQHLQHRS--GEG ci0100147735 QLDVSKDLRVYDEK---SKRWINLAPMENSRYQHGIAVIGNFLFVVGGQSNYDTK--GKT ENST00000312063 PDRLPSNLVQYYDDE--KKTWKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPN--GKH ENSMUST00000061240 TEKSLSRDILYRDPE---NGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQAKH ENST00000244722 TEKSLSRDILYRDPE---NGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQAKH CG6224-RA CSGDAIASVERFDPQT--NDWKMVAPMSKRRCGVGVAVLNDLLYAVGGHD-------GQS ci0100138113 --KNTLTKVTKFDLET--EQWSQLPDLPVGRDDAAAVVIDDVLYYTAGNLKTDGED-TAT ENST00000325433 TSTPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAGGYN-------REE ENST00000248272 RKPTAAMRCMCPLYDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDE------NKQ :. : . : .* ENST00000300976 AVDACYRYDPHLNRWLR-LQAMQESRIQFQLNVLCGMVYATGGRNRAGS-LASVERYCPR ENSMUST00000045400 AVDACYRYDPQRNRWLR-LRALRESRVQFQLTALGGLLYATGGRNRAGS-LASVERYCPR ci0100147735 AVDTVFRYDPRYNKWIR-VRSLNEKRTFFHLSAIEGKLYAVGGRNAAGE-LSTVECYNPQ ENST00000312063 STNFVSRYDPRFNSWIQ-LPPMQERRASFYACRLDKHLYVIGGRNETGY-LSSVECYNLE ENSMUST00000061240 AVSNFCRYDPRFNTWIH-LGSMNQKRTHFSLSVFNGLLYAVGGRNSEGS-LASLECYVPS ENST00000244722 AVSNFCRYDPRFNTWIH-LASMNQKRTHFSLSVFNGLVYAAGGRNAEGS-LASLECYVPS CG6224-RA YLNSIERYDPQTNQWSCDVAPTTSCRTSVGVAVLDGFLYAVGGQDGVQC-LNHVERYDPK ci0100138113 NIVHRMKLKEKVLKWEK-VASTRVKRWGFGAAVFNGIIFVFGGGDGNNKRLSSGESYVVS ENST00000325433 CLRTVECYNPHTDHWSF-LAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSN ENST00000248272 TLSSGEKYDPDANTWTA-LPPMNEARHNFGIVEIDGMLYILGGEDGEKE-LISMECYDIY . * : . * . : :: ** : * * * ENST00000300976 RNEWGYACSLKRRTWGHAGAASGGRLYISGGYGISVED-KKALHCYDPVADQWEFKAPMS ENSMUST00000045400 RDSWDFACPLKRRTWGHAGAAAAGRLYISGGYGVSAED-KKALQCYDPAADRWEPRAPMR ci0100147735 HNEWVFVEKMQEPHYGHAGTVYNGQMFISG--GITHDSFQKKLLCYNPTTDKWEQRSPMS ENST00000312063 TNEWRYVSSLPQPLAAHAGAVHNGKIYISGK-GVHNGEYVPWLYCYDPVMDVWARKQDMN ENSMUST00000061240 TNQWQPKAPLEVARCCHASAVADGRVIVTG--GYIGSAYSRSVCAYDPALDAWQELPQLS ENST00000244722 TNQWQPKTPLEVARCCHASAVADGRVLVTG--GYIANAYSRSVCAYDPASDSWQELPNLS CG6224-RA ENKWSKVAPMTTRRLGVAVAVLGGFLYAIG--GSDGQCPLNTVERYDPRHNKWVAVSPMS ci0100138113 LNKWIRIKPMRIARSTHSVVAYNGHLYSLG------GKKLCSVERYDPSLNEWEDVAPMQ ENST00000325433 IDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLN ENST00000248272 SKTWTKQPDLTMVRKIGCYAAMKKKIYAMG--GGSYGKLFESVECYDPRTQQWTAICPLK . * : . : * ::* . * : ENST00000300976 EPRVLHAMVGAGGRIYALGG---RMDHVDRCFDVLAVEYYVPETDQWTSVS-----PMRA ENSMUST00000045400 EPRVLHAMLGAAGRIYALGG---RMDHVDRCFDVLAVEYYVPDADQWTSVT-----PMRA ci0100147735 TVRGLHCMTTVRDRLYVIGGN--HFKGTTDYDDVLECEFYTTETDQWCCVA-----PMLT ENST00000312063 TKRAIHTLAVMNDRLYAIGGN--HLKGFS-HLDVMLVECYDPKGDQWNILQT----PILE ENSMUST00000061240 TPRGWHCAVALGDRLYVMGGS--QLGPRGERVDVLTVESFSPAARQWSFVA-----PLPV ENST00000244722 TPRGWHCAVTLSDRVYVMGGS--QLGPRGERVDVLTVECYSPATGQWSYAA-----PLQV CG6224-RA TRRKHLGCAVFNNYIYAVGG-------RDDCMELSSAERYNPLTNTWSPIV-----AMTS ci0100138113 TPRSSFVAVVLNNTIYAIGG-------YDGNQRLKSVEKYNVEDDTWVYVA-----SMNF ENST00000325433 IRRHQSAVCELGGYLYIIGG-------AESWNCLNTVERYNPENNTWTLIA-----PMNV ENST00000248272 ERRFGAVACGVAMELYVFGGVRSREDAQGSEMVTCKSEFYHDEFKRWIYLNDQNLCIPAS * :* .** * : * ENST00000300976 GQSEAGCCLLERKIYIVGGYNWRLNNVTGIVQVYNTDTDEWERDLHFPESFAGI-ACAPV ENSMUST00000045400 GQSEAGCCLLERKIYIVGGYNWRLNNVTGIVQVYNTETDEWERDLHFPESFAGI-ACAAV ci0100147735 GQSDVGIAVYDGKVYVTGGYSWNNRCMVDIVQCYDPEENKWMKTFSLPAALGGIRACTLT ENST00000312063 GRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTWTELEGDVAEPLAGPACVTV ENSMUST00000061240 GVSTAGVSALHGRAYLLGGWNEGEKKYKKCIQCFNPELNEWTEDDELPEATVGVSCCTLA ENST00000244722 GVSTAGVSALHGRAYLVGGWNEGEKKYKKCIQCFSPELNEWTEDDELPEATVGVSCCTLS CG6224-RA RRSGVGLAVVNGQLYAVGGFDG--SAYLKTIEVYDPETNQWRLCGCMNYRRLGGGVGVMR ci0100138113 ERYVHAACVAQNKIYVLGGVDSN-DTFVKLIECYDDQTDKWSVVGETEAELC-------- ENST00000325433 ARRGAGVAVLNGKLFVCGGFDG--SHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVG ENST00000248272 SSFVYGAVPIGASIYVIGDLDTG--TNYDYVREFKRSTGTWHHTKPLLPSDLRRTGCAAL . : *. . : . * ENST00000300976 LLPRAGTRR--------------------------------------------------- ENSMUST00000045400 LLPRSGHGR--------------------------------------------------- ci0100147735 VLPNFANSNAQSSSSSSMPKHEPDPSGDMMLSVDRPAPSARLPRRPQAQADADIGARPLQ ENST00000312063 ILPSCVPYNK-------------------------------------------------- ENSMUST00000061240 MPNSVSRESRASSVSSVPVSI--------------------------------------- ENST00000244722 MPNNVTRESRASSVSSVPVSI--------------------------------------- CG6224-RA APQTENYMWCENSFKQPNS----------------------------------------- ci0100138113 ------------------------------------------------------------ ENST00000325433 NTIYAVGGFDGNEFLNTVEVYNLESNEWSPYTKIFQF----------------------- ENST00000248272 RIANCKLFRLQLQQGLFRIRVHSP------------------------------------ ENST00000300976 -- ENSMUST00000045400 -- ci0100147735 DR ENST00000312063 -- ENSMUST00000061240 -- ENST00000244722 -- CG6224-RA -- ci0100138113 -- ENST00000325433 -- ENST00000248272 --