CLUSTAL W (1.82) multiple sequence alignment ENST00000326793 MKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFM ENSMUST00000057622 ------------------------------------------------------------ SINFRUP00000147090 ------------------------------------------------------------ ENSMUST00000052754 --MTVEFEECIKDSPRFRATIDEVETDVVEIEAKLDKLVKLCSGMIEAGKAYVTTNRLFV SINFRUP00000131400 ------------------------------------------------------------ ENST00000158762 MTVKLDFEECLKDSPRFRASIELVEAEVSELETRLEKLLKLGTGLLESGRHYLAASRAFV ENSMUST00000001631 MTVKLDFEECLKDSPRFRASIELVETEVSELETRLEKLLKLGSCLLESGQHYLAAGRAFV ci0100149748 --ISLEFEECIKDSPKFRDLVHQSEVDVVDLESQIDRMVKHCSVMVDSGKVYNNACKGFI CG6742-RA MRATIEFEECLKDSPRFRQFVSKEESDIEHLEQRLEKIIKLCNVAVDSGKEYVKNQSAFA ENST00000326793 NGIRDLAQYSSNDAVVETSLTKFSDSLQEMINFHTI-------LFDQTQRSIKAQLQNFV ENSMUST00000057622 ------------------------------------------------------------ SINFRUP00000147090 ------------------------------------------------------------ ENSMUST00000052754 SGVRDLSQQCQGDTVISECLQRFGDSLQEMVNYHTVSPMGHVGFPLLSENMPCISRALPR SINFRUP00000131400 -------------------------------------------FSVR------------- ENST00000158762 VGICDLARLGPPEPMMAECLEKFTVSLNHKLD-------SHAELLDATQHTLQQQIQTLV ENSMUST00000001631 VGICDLARLGPPEPMMAECLEKFTVSLNHKLD-------SHAELLDATQHTLQQQIQTLV ci0100149748 GSVNDVGYASTDDAFVQGTLKRFTSTMSELSS-------FHTMLFDQAQRSVRTQLNNFL CG6742-RA MSLWDLQQHFLDNKNAHNALGKLIHCFQEMNK-------FHTILLDQASRTVLKNLSVFV ENST00000326793 KEDLRKFKDAKKQFEKVSEEKENALVKNAQVQRNKQHEVEEATNILTATRKCFRHIALDY ENSMUST00000057622 ------------------------------------------------------------ SINFRUP00000147090 ---------------------------------NKQHEVEEATSILTATRKCFRHIVLDY ENSMUST00000052754 QEDVRKFKETKKQFDKVREDMELSLVRNAQAPRHRPHEVEEATGALTVTRKCFRHLALDY SINFRUP00000131400 --DVRKFKETKKNFDKVREDMEIAQVKNAQAPRNKPHEVEEAAGALRITRRCFRHLALDY ENST00000158762 KEGLRGFREARRDFWRGAESLEAALTHNAEVPRRRAQEAEEAGAALRTARAGYRGRALDY ENSMUST00000001631 KEGLRGFREARRDFWRGAENLEAALTHNAEVPRRRVQEAEEAGTALRTARAGYRSRALDY ci0100149748 REEVKPTKDLKKTFDKVSDDYLSSLNKHAAANKLKPNEVEDTNSVLTSSRNCFRSVAMDY CG6742-RA KDDINQVKDYKGHFLKVSEGYDNALIKNAQASKNRPQEMQEAANILSASKSCFQHTALDY : : ENST00000326793 VLQINVLQSKRRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAK ENSMUST00000057622 --------------------------------------------------LDRLVVDAAK SINFRUP00000147090 VLQINVLQSKRRSEILKSMLSFMYAHLTFFHQGYDLFSELQPLMKLLGGQLDQLVVDAAK ENSMUST00000052754 VLQINVLQAKKKFEILDSMLSFMHAQYSFFQQGYSLLHQLDPYMKKLAAELDQLVIDSAV SINFRUP00000131400 VLQINVLQTKKKFEILDAVLSFMHAQHALFQQGFSLLDDVHPYMKQLAAALDQLVIDSAV ENST00000158762 ALQINVIEDKRKFDIMEFVLRLVEAQATHFQQGHEELSRLSQYRKELGAQLHQLVLNSAR ENSMUST00000001631 ALQVNVIEDKRKFDIMEFVLRLVEAQATYFQQGHEELNRLAQYRKELGTQLHNLVLNSAR ci0100149748 VYQINMLHKKKKFQSVDKILSYMHALFTFFHQGYDLLKDLEPYMKSVSGQLEEMCK---- CG6742-RA VNYITLAQARKVPSILSTLLDYYQACVTYYHQGFDLCNDFDEFFKNISEDLNALRGDYQQ : : : :: . : *. : ENST00000326793 EKREMEQKHSTIQQK----DFSSDDSKLEYNVDAANGIVMEGYLFKRASNAFKTWNRRWF ENSMUST00000057622 EKREMEQKHSTIQQK----DFSSDDSKLEYNVDAANGIVMEGYLFKRASNAFKTWNRRWF SINFRUP00000147090 EKRDMEQKHSTIQQK----DFSNDDTRLEYNVDTDNGIAMEGYLFKRASNAFKTWNRRWF ENSMUST00000052754 EKREMERKHAAIQQR----DFSYDEPKVEFDVDAPSGVVMEGYLFKRASNAFKTWNRRWF SINFRUP00000131400 EKREMERKHATVQQRTLLQDFSCEETKVEFNVDAPNGVVMEGYLFKRASNAFKTWNRRWF ENST00000158762 EKRDMEQRHVLLKQK----ELGGEEPEPSLR-EGPGGLVMEGHLFKRASNAFKTWSRRWF ENSMUST00000001631 QKRDMEQRHVLLKQK----ELGGEEPEPSLK-EGPSGLVMEGHLFKRASNAFKTWSRRWF ci0100149748 -RHEESRKSMIVEQE---RHQSMTGDSGMYMTCVNNAIVIEGHLFKRASNAFKTWNRRWF CG6742-RA LEKAMQNRHMSVNRY-------CDSN------TNSTSNKIEGYLFKKKSKGFKTWCRRWF .: ..: ::: . :**:***: *:.**** **** ENST00000326793 SIQNNQLVYQKKFK----------------------------DNPTVVVEDLRLCTVKHC ENSMUST00000057622 SIQNNQLVYQKKFK----------------------------DSPTVVVEDLRLCTVKHC SINFRUP00000147090 SIQNNQLVYRKKFK----------------------------DTPTVVVEDLRLCTVKHC ENSMUST00000052754 SIQNSQLVYQKKLK----------------------------DALTVVVDDLRLCSVKPC SINFRUP00000131400 SIQNSQLVYQKRLKAGSSQSSAELLTSAAFTEKVEKVFVRQQDSLTVVVEDLRLCSVKPF ENST00000158762 TIQSNQLVYQKKYK----------------------------DPVTVVVDDLRLCTVKLC ENSMUST00000001631 TIQNNQLVYQKKYK----------------------------DPVTVVVDDLRLCTVKLC ci0100149748 TIKDNKLFYQKKKD-----------------------------DLTVVVDDIRLCTVRLT CG6742-RA YLSDNQLVYRKRSN---------------------------EDSFSVMEEDLRICSVRPV :...:*.*:*: . :*: :*:*:*:*: ENST00000326793 EDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKAVQTSIATAYR----EKGD--ESEKLD ENSMUST00000057622 EDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKAVQTSIATAYR----EKGD--ESEKLD SINFRUP00000147090 EDIERRFCFEVVSPTKSCILQADSEKLRQAWIKAVQNSIATAFR----DKGE--EGEKLD ENSMUST00000052754 EDIERRFCFEVVSPTKSCMLQADSEKLRQAWVQAVQASIASAYR----ESPDSCYSERLD SINFRUP00000131400 EDIERRFCFEVVSPFKSCMLQAESEKLRQAWIQAVQASIASAYR----ESPDAFYTEHLD ENST00000158762 PDSERRFCFEVVSTSKSCLLQADSERLLQLWVSAVQSSIASAFSQARLDDSPRGPGQGSG ENSMUST00000001631 PDSERRFCFEVVSTSKSCFLQADSERLLQLWVSAVQSSIASAFSQAHLENSPRGPGQVSG ci0100149748 EETERRFCFEVVLPGKSFLLQAESDDARTAWIKAIQSSIGAAFK-------DTMEETNSQ CG6742-RA NEGDRRFCFEVISPTKSHILQADSADMLSLWISALQHSIGAAIQ------------HDST : :*******: . ** :***:* *:.*:* **.:* ENST00000326793 KKSSPSTGSLDSGNESKEKLLKGE-SALQRVQCIPGNASCCDCGLADPRWASINLGITLC ENSMUST00000057622 KKSSPSTGSLDSGNESKEKLLKGE-SALQRVQCIPGNTSCCDCGLADPRWASINLGITLC SINFRUP00000147090 RKSSTSTGSLDSGGEPKERSLKGE-SALQKVLAIPGNACCCDCGQPDPRWASINLGITLC ENSMUST00000052754 RTASPSTSSIDSTTDSRERGVKGE-SVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLC SINFRUP00000131400 RAASPSTSSIDSASEPRERGVRGD-AILQRIQALPGNGQCCDCGQADPRWASINLGVLLC ENST00000158762 HLAIGSAATLGSGGMARGREPGGVGHVVAQVQSVDGNAQCCDCREPAPEWASINLGVTLC ENSMUST00000001631 YHAPGSAATLACGGAARGRESGGVGQVAAQVQSVDGNAQCCDCREPAPEWASINLGVTLC ci0100149748 TTLNKKETKSGENTNPTSFLEEGANNVMSKIYQVPGNKTCADCGKAEPRWASISLGITLC CG6742-RA HHSRPQSTNAPNNSLPAKRR-----IHWEEFLKIPGNAYCCDCRSPEPRWASINLGITLC . . . .. : ** * ** . *.****.**: ** ENST00000326793 IECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCELGNDVINRVYEANV-EKMGIKK-PQ ENSMUST00000057622 IECSGIHR---------------------------------------------------- SINFRUP00000147090 IQCSGIHR---------------------------------------------------- ENSMUST00000052754 IECSGIHRSLGVHCSKVRSLTLDSWEPELLKLMCELGNSTVNQIYEAQC-EGPGVRKPTA SINFRUP00000131400 IECSGIHR---------------------------------------------------- ENST00000158762 IQCSGIHRSLGVHFSKVRSLTLDSWEPELVKLMCELGNVIINQIYEARV-EAMAVKKPGP ENSMUST00000001631 IQCSGIHRSLGVHFSKVRSLTLDSWEPELVKLMCELGNVIINQIYEARV-EAMAVKKPGP ci0100149748 IECSGCHRSLGVHISKVRSLTLDQWEPEVVKVMLKLGNSRVNEIYTANA-TSDDQIK--P CG6742-RA IECSGVHRSLGVHYSKVRSLTLDAWESENVKVMMELGNEVVNRIYEARIGDDCGLKKPTE *:*** ** ENST00000326793 PGQRQEKEAYIRAKYVERKFVDKYS----ISLSPPEQQKKFVSKSSEEKRLSISKFGPGD ENSMUST00000057622 ----QEKEAYIRAKYVERKFVDKYS----ALLSPSEQEKRIISKSCEDQRLS-------- SINFRUP00000147090 --------------SLGVHFSKVRS----LTLDTWEPELLKV------------------ ENSMUST00000052754 SSSRQDKEAWIKDKYVEKKFLRKLT----SAP-AREPPRRWRAQKCQRPHSSPHAPTTRR SINFRUP00000131400 ------------------------------------------------------------ ENST00000158762 SCSRQEKEAWIHAKYVEKKFLTKLP----EIRGRRGGRGRPRG----------------- ENSMUST00000001631 SCSRQEKEAWIHAKYVEKKFLTKLP----EIRGRRGGRGPPRG----------------- ci0100149748 GSSNDSRLAFIQAKYVDRKFAMPLP----KALGPQPAYHGATGRRLTRWTVSKRKRTRPS CG6742-RA QCEIGVREAWIKAKYVERRFVCGMPKPQELLASETAEVLSIDSGGVVEDGESGGSGIAKR : : ENST00000326793 QVRASAQSSVRSNDSGIQQSSDDGRE-------SLPSTVSANSLYEPEGERQDSSMFLDS ENSMUST00000057622 HARASVHTPVAAVTS-----DEARRE-------SLFCPDELDSLFS----YFDTSSKLRS SINFRUP00000147090 ------------------------------------------------------------ ENSMUST00000052754 KVRLEPVLPSVAALSSEGAESEESSS-------EVDGEAEAWSLADVRELHPGLLAHQAA SINFRUP00000131400 ------------------------------------------------------------ ENST00000158762 QPPVPPKPSIRPRPGSLRSKPEPPSE-------DLGSLHPGALLFRASGHPPSLPTMAD- ENSMUST00000001631 HPPVPPKPPIRPHSGIVRSKSECPSD-------DMGSLHPGALLFQAAGHPPSLPTMAD- ci0100149748 PNRSPNRPRSPKVSFVCCSCPAQHIENYRIEHSTLFVTNELKNIFSYFDGSKSVAAVVVM CG6742-RA ATLSLGGTRKWAVKKLRRRQKQRSIPKTLSDDPSIYNTAKTGDELEDDDDDESINIPSMS ENST00000326793 KHLN----------------------------------------------------PGLQ ENSMUST00000057622 ------------------------------------------------------------ SINFRUP00000147090 ------------------------------------------------------------ ENSMUST00000052754 RTR--------------------------------------------------------- SINFRUP00000131400 ------------------------------------------------------------ ENST00000158762 ------------------------------------------------------------ ENSMUST00000001631 ------------------------------------------------------------ ci0100149748 LLLCSCSLSPLTLTLFLFCWLHVACQINIFLHNHHCMFVDGKEYEETEICKLENLHPDLL CG6742-RA LSISRDDLLVIGDDLALDRLETPG-----ILGSDQESTDGESDAESPEELPFSQLDANQL ENST00000326793 LYRASYEKNLPKMAEALAHGADVNWANSEENKATPLIQAVLGGSLVTCEFLLQNGANVNQ ENSMUST00000057622 ------------------------------------------------------------ SINFRUP00000147090 ------------------------------------------------------------ ENSMUST00000052754 --------DLPALAAALAHGAEVNWADAADEGKTPLVQAVLGGSLIVCEFLLQNGADVNQ SINFRUP00000131400 ------------------------------------------------------------ ENST00000158762 ---------------ALAHGADVNWVNGGQDNATPLIQATAANSLLACEFLLQNGANVNQ ENSMUST00000001631 ---------------ALAHGADVNWVNVGQGNATPLIRATAANSLLACEFLLQNGANVNQ ci0100149748 LYRATEAANLPVMLLAKCNKAKVNWMNDADEGKTALMQAAIVGSVPACEFMLANGAKIET CG6742-RA LYMASVVHNLPVMCMAFALGADKMWKNPQDRQRSFLHQAVISGSVMACEFLLLNGAAIDA ENST00000326793 RDVQGRGPLHHATVLGHTGQVCLFLKRGANQHATDEEGKDPLSIAVEAANADIVTLLRLA ENSMUST00000057622 ------------------------------------------------------------ SINFRUP00000147090 ------------------------------------------------------------ ENSMUST00000052754 RDSLGRAPLHHATLLGRTGQVCLFLKRGADQHALDQEQQDPLTIAVQAANADIVTLLRLA SINFRUP00000131400 ------------------------------------------------------------ ENST00000158762 ADSAGRGPLHHATILGHTGLACLFLKRGADLGARDSEGRDPLTIAMETANADIVTLLRLA ENSMUST00000001631 ADSAGRGPLHHATILGHTGLACLFLKRGADLGARDTEGRDPLTIAMETTNADIVTLLRLA ci0100149748 FDWKKRTALHYAALHNHTSVACQLLKRRMDLNAVDEDGKSALDIAVDEANADIVTLIRLK CG6742-RA VDEMGYSALHISTAKGHIAQVYLLLKHKAAYDLSSSDGKKALDIAVDQENADIVTLLRLT ENST00000326793 RMNEEMRESEGLYGQPGDETYQDIFRDFSQMASNNPEKLNRFQQDSQKF---------- ENSMUST00000057622 ----------------------------------------------------------- SINFRUP00000147090 ----------------------------------------------------------- ENSMUST00000052754 RMAEEMREAEAPPGQPG------------------------------------------ SINFRUP00000131400 ----------------------------------------------------------- ENST00000158762 ----KMREAEAAQGQAGDETYLDIFRDFSLMASDDPEKLSRRSHDLHTL---------- ENSMUST00000001631 ----KMREAEAAQGQAGDETYLDIFRDFSLMASDDPEKLSRRSHDLHTL---------- ci0100149748 KMSDEMKE--------------------------------------------------- CG6742-RA QLNDEIGPNDEYNGE--DETYKNVMKDFSKLPASQTRVLRQRHDSNTLESQRSSLTNSD