CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000040043 ------------------------------------------------------------ SINFRUP00000134691 YMKRGGKSEGNRQMRPKTFPTSNYSGNSQQMLQEIRNSLRNLSKPSEPPKVDIGGAAKMP ENSMUST00000022531 -------------MRPKTFPATTYSGNSRQRLQEIREGLKQPSKASTQGLLVGPN-SDTS ENST00000279994 -------------MRPKTFPATTYSGNSRQRLQEIREGLKQPSKSSVQGLPAGPN-SDTS SINFRUP00000137140 -------------MRPKTFPAAPYVGNTRQRLQEIKEGLKQPAKLVSQALHGGSSRAEGS CG12072-RA -------------MHPAGEKRGGRPND--KYTAEALESIKQDLTRFEVQNNHRNNQNYTP ENSMUST00000040043 ------------------------------------------------------------ SINFRUP00000134691 PEDPRLQG----------RCSNPKNPYHKALQEIRKSLLPFANEPVTSGPETRKHTSQEP ENSMUST00000022531 LDAKVLGSKDASRQQQ-MRATPKFGPYQKALREIRYSLLPFANESGTS-------AAAEV ENST00000279994 LDAKVLGSKDATRQQQQMRATPKFGPYQKALREIRYSLLPFANESGTS-------AAAEV SINFRUP00000137140 RGADCKSGKDAASRQQQLRPPQKFNNYQNALREIRRSLMPFANESGPSSGSGHPAGAGEV CG12072-RA LRYTATNGRNDALTPDYHHAKQPMEPPPSASPAPDVVIPPPPAIVGQPGAGSISVSGVGV ENSMUST00000040043 ------------------------------------------------VQHSINRKQSWK SINFRUP00000134691 PFIGFDENNIRSIGPDYMGKVSYQDSMREQMVVPNPNTTGLKAPGASHIQQAVLRRPSWK ENSMUST00000022531 NRQMLQELVNAGCDQEMAGRALKQTGSRS----------------IEAALEYISKMGYLD ENST00000279994 NRQMLQELVNAGCDQEMAGRALKQTGSRS----------------IEAALEYISKMGYLD SINFRUP00000137140 NRQMLQELVNAGCDQEMAVRALKQTGSRN----------------IEAALEYISKMGYLD CG12072-RA GVVGVANGRVPKMMTALMPNKLIRKPSIER------------DTASSHYLRCSPALDSGA . ENSMUST00000040043 GSKESLVPQRHGPSLGENVVYRSESPNSQADVGRPLSGSGIA-AFAQAHPSNGQRVNPP- SINFRUP00000134691 GSKESLAP-RHGPLMADAIMYHSDSP------GPPP-------AFPQGHAGANQRVNPP- ENSMUST00000022531 PRNEQIVRVIKQTSPGKGLAPTPVTR------RPSFEGTGEA--LPSYHQLGGANYEG-- ENST00000279994 PRNEQIVRVIKQTSPGKGLMPTPVTR------RPSFEGTGDS--FASYHQLSGTPYEGPS SINFRUP00000137140 PRNELIVRVIKQTSPGKAGIPNSMDH------RPSLEASGEAGAMPPYHQMGAPMYEGP- CG12072-RA GSSRSDSPHSHHTHQPSSRTVGNPGGNGGFSPSPSGFSEVAPPAPPPRNPTACSAATPPP .. : . . . . : ENSMUST00000040043 ----PPPQVRSVTPPPPPRGQTPPPRGTTPPPPSWEPSSQTKRYSGNMEYVISRISPVPP SINFRUP00000134691 ----LPPQVRSVTPPPN--------RSGMPPAPSWD---NPKRYSGNMDYLVPRISPVPQ ENSMUST00000022531 -----PAALEEMPRQYLD-------FLFPGAGAGTHG-AQAHQHPPKGYSTAVEPS-AHF ENST00000279994 FGADGPTALEEMPRPYVD-------YLFPGVGP--HGPGHQHQHPPKGYGASVEAAGAHF SINFRUP00000137140 ---AGYTPDGEISRPYMSSAPVMNYMMPPTSSMEQHGPMMSYNVPGQPLQLQPQPPGGPV CG12072-RA ---PVPPTSQAYVKRRSPALNNRPPAIAPPTQRGNSPVITQNGLKNPQQQLTQQLKSLNL . . ENSMUST00000040043 GAWQEGYPPPPLTTSPMNPPSQAQRAISSVPVGRQPIIMQSTSKFNFTPGRPGVQNGGGQ SINFRUP00000134691 GAWPDGYQS---------AAPQSQRGISPVSVGHQPIIMQSSGGNKFTFPPSWSQSGSAQ ENSMUST00000022531 P--GTHYGRGHLLS---EQPGYGVQRSSSFQNKTPPDA--------YSSM-AKAQGGPP- ENST00000279994 PLQGAHYGRPHLLVPG-EPLGYGVQRSPSFQSKTPPETGG------YASLPTKGQGGPPG SINFRUP00000137140 P--GPHYDYSHARPHMMDPAGYGVKRTASFQNKMAPPPMAPPD--NYVNMQGKGAMGQNV CG12072-RA YPGGGSGAVVEPPPPYLIQGGAGGAAPPPPPPSYTASMQSRQSPTQSQQSDYRKSPSSGI : . .. . . ENSMUST00000040043 SDFIVHQNVPTGSVTRQPPPPYPLTPANGQSPS--ALQTGASAAPPSFANG-NVPQSMMV SINFRUP00000134691 ADYMAGG-------SRQPPPPYPVTQGSRHSPTDQQMQAGGPAASPSYVNGGNIPQSMMV ENSMUST00000022531 ASLTFP-----AHAGLYTASHHKPAATPPGAHPLHVLGTRGPTFTGESS-----AQAVLA ENST00000279994 AGLAFPP----PAAGLYVPHPHHKQAG-PAAHQLHVLGSRSQVFASDSP-----PQSLLT SINFRUP00000137140 PGGGGAGGGGGYPANRYLPPHSHPRQASPTSHQVHLMSRSPGGVAAMGPDFSDIPQGLMT CG12072-RA YSATSAGSPSPITVSLPPAPLAKPQPRVYQARSQQPIIMQSVKSTQVQKPVLQTAVAPQS . . : : . . . ENSMUST00000040043 PNRNSHNMELYNINVPG--LQTAWPQSSSAPAQSSP--SGGHEIPTWQPN----IPVRSN SINFRUP00000134691 PNRNSHNLDSYNVGLQ---LWSQSPLASNQPQSSSCNSTNQDLSPSWQHN----IPVRSS ENSMUST00000022531 PSRNSLNADLYELGST--VPWSAAPLARRDSLQK--QGLEAS-RPHVAFR---AGPSRTN ENST00000279994 PSRNSLNVDLYELGSTSVQQWPAATLARRDSLQK--PGLEAPPRAHVAFRPDCPVPSRTN SINFRUP00000137140 PSRASLNLDIYEHHWAGPPGPEGAPPGRQPQPQGPFRGEVRVPSRTNSFNSRSAGPNGVR CG12072-RA PSSASASNSPVHVLAAP-PSYPQKSAAVVQQQQQAAAAAHQQQHQHQQSKPPTPTTPPLV *. * . . . . . . . . ENSMUST00000040043 SFNN-PLGSRA-SHSANSQPSATTVTAITPAPIQQP--VKSMRVLKPELQTALAPTHPSW SINFRUP00000134691 SFNNHQMSSRP-AHPASSQPSATTVTAITQAPILQP--VKSMRVQKPELHTAVAPTHPPW ENSMUST00000022531 SFNNPQP--------EPSLPAPNTVTAVTAAHILHP--VKSVRVLRPEPQTAVGPSHPAW ENST00000279994 SFNSHQPRPGPPGKAEPSLPAPNTVTAVTAAHILHP--VKSVRVLRPEPQTAVGPSHPAW SINFRUP00000137140 PTLTAPPTAG---KQDPSLGPPNTITAVTSPPIQQP--VKSIRVMRPEPKTAVGPCHPGW CG12072-RA GLNSKPNCLEPPSYAKSMQAKAATVVQQQQQQQQQQQQVQQQQVQQQQQQQQQQLQALRV . . *:. : *:. :* : : : ENSMUST00000040043 MPQPV-------QTVQPTPFSEG------TASSVPVIPPVAEAPSYQGPPPPYPKHLLHQ SINFRUP00000134691 IQQAQ-------PPPLPAPTYQE------PSAPVPQISVVPEVPSYQGPPPPYPKHLLQQ ENSMUST00000022531 VAAPT-------APATESLETKE------GSAGPHPLDVDYGGSERRCPPPPYPKHLLLP ENST00000279994 VPAPAPAPAPAPAPAAEGLDAKEEHALALGGAGAFPLDVEYGGPDRRCPPPPYPKHLLLR SINFRUP00000137140 MAAQT-------QDAGEPLAYMA--------EEPYPIEPAQ---EPRCPPPPYPKNLLMP CG12072-RA LQAQAQR-----ERDQRERDQRE-------RERDQQKLANGNPGRQMLPPPPYQSNNNNN : ***** .: ENSMUST00000040043 N--PSVPPYESVSKPC-----------KDEQPSLPKEDDSEKSAD-----------SGDS SINFRUP00000134691 QAAPCPPTYDPLTNST-----------EEEGGGGAQDRTPETSET-----------STE- ENSMUST00000022531 SKSEQYS--VDLDSLC-------TSVQQSLRGG-TEQDRSDKSH---------KGAKGDK ENST00000279994 SKSEQY----DLDSLC-------AGMEQSLRAGPNEPEGGDKSR---------KSAKGDK SINFRUP00000137140 GPTAEPGGLEAAGAMCGAQDIGNAAVRSTHGSGSGGSGKVEESHQVKEKTKMCKTDKTDK CG12072-RA SEIKPPSCNNNNIQISNSNLATTPPIPPAKYNNNSSNTGANSSGG----SNGSTGTTASS . : * . . ENSMUST00000040043 GDKEKKQITTSPITVRK--NKKDEERR-ES-RIQSYSPQAFKFFMEQHVENVLKSHQQRL SINFRUP00000134691 --RENKQITTSPVPVRR--NKKDEERRGESGRIAVYSPQAFKFFMEQHVENILKNHQQRI ENSMUST00000022531 AGRDKKQIQTSPVPVRK--NSRDEEKR-ES-RIKSYSPYAFKFFMEQHVENVIKTYQQKV ENST00000279994 GGKDKKQIQTSPVPVRK--NSRDEEKR-ES-RIKSYSPYAFKFFMEQHVENVIKTYQQKV SINFRUP00000137140 TVKDKKQIQTSPVPVRK--NGRDEEKR-ES-RIKTYSPFAFKFYMEQHIENVMKTYNQKL CG12072-RA STSCKKIKHASPIPERKKISKEKEEER-KEFRIRQYSPQAFKFFMEQHIENVIKSYRQRT :* :**:. *: . ..**.* :. ** *** ****:****:**::*.:.*: ENSMUST00000040043 HRKKQLENEMMRV------------------LNFLRLD--HLFPWYFKVVGSS------- SINFRUP00000134691 RRRKQLESEMQRVGLSSEAQEQMRMMLCQKESNYIRLKRAKMEKSMFKRIKTLGIGAFGE ENSMUST00000022531 SRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGE ENST00000279994 NRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGE SINFRUP00000137140 NRRLQLEQEMSKAGLSEAEQEQMRKMLNQKESNYNRLRRAKMDKSMFVKIKTLGIGAFGE CG12072-RA YRKNQLEKEMHKVGLPDQTQIEMRKMLNQKESNYIRLKRAKMDKSMFVKLKPIGVGAFGE *: ***.** :. *: ** :: * : . ENSMUST00000040043 -----------------------ILVG-------KCSMDILAEADNEWVVRLYYSFQDKD SINFRUP00000134691 VCLARKEDTG-SLYAMKTLRKKDVLLRNQV-AHVKAERDILAEADNEWVVRLYYSFQDKD ENSMUST00000022531 VCLACKLDTH-ALYAMKTLRKKDVLNRNQV-AHVKAERDILAEADNEWVVKLYYSFQDKD ENST00000279994 VCLACKVDTH-ALYAMKTLRKKDVLNRNQV-AHVKAERDILAEADNEWVVKLYYSFQDKD SINFRUP00000137140 VCLTRKVDTC-ALYAMKTLRKKDVLNRNQASAHVKAERDILAEADNEWVVRLYYSFQDRE CG12072-RA VTLVSKIDTSNHLYAMKTLRKADVLKRNQV-AHVKAERDILAEADNNWVVKLYYSFQDKD :* *.. ********:***:*******:: ENSMUST00000040043 NLYFVMDYIPGGDMMSLLIRMGIFPENLARFYIAELTCAVESVHKMGFIHRDIKPDNILI SINFRUP00000134691 NLYFVMEYIPGGDMMSLLIRLGIFKEELAQFYIAELTCAVESVHKMGFIHRDIKPDNILI ENSMUST00000022531 SLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILI ENST00000279994 SLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILI SINFRUP00000137140 SLYFVMDYIPGGDMMSLLIRMGVFPEILACFYVAELTLAIESVHKMGFIHRDIKPDNILI CG12072-RA NLYFVMDYIPGGDLMSLLIKLGIFEEELARFYIAEVTCAVDSVHKMGFIHRDIKPDNILI .*****:******:*****:: :* * ** **:**:* *::******************* ENSMUST00000040043 DRDGHIKLTDFGLCTGFRWTHDSKYYQ-SGDHPRQDSMDFSNEWGDPSNCRCGDRLKPLE SINFRUP00000134691 DRDGHIKLTDFGLCTGFRWTHDSKYYQ-SGDHVRQDSMDFSKDWEDPANCRCSDRLKPLE ENSMUST00000022531 DLDGHIKLTDFGLCTGFRWTHNSKYYQ-KGNHMRQDSMEPGDLWDDVSNCRCGDRLKTLE ENST00000279994 DLDGHIKLTDFGLCTGFRWTHNSKYYQ-KGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLE SINFRUP00000137140 DLDGHIKLTDFGLCTGFRWTHNSKYYQ-KGSHVRQDSMEPSDFWDDVSNCRCGDRLMTLE CG12072-RA DRDGHIKLTDFGLCTGFRWTHNSKYYQENGNHSRQDSMEP---WEEYSEN--GPKPTVLE * *******************:***** .*.* *****: * : :: . : ** ENSMUST00000040043 RRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTP SINFRUP00000134691 RRKARQHQRCLAHSLVGTPNYIAPEVLLRTG----------------------------- ENSMUST00000022531 QRAQKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTP ENST00000279994 QRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTP SINFRUP00000137140 QRANRQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTP CG12072-RA RRRMRDHQRVLAHSLVGTPNYIAPEVLERSGYTQLCDYWSVGVILYEMLVGQPPFLANSP :* ::*** ***************** *.* : : ::: ::: :: ENSMUST00000040043 LETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAHPFFKTIDF SINFRUP00000134691 ------------------------------------------------------------ ENSMUST00000022531 TETQLKVINWESTLHIPTQVRLSAEARDLITKLCCAADCRLGRDGADDLKAHPFFNTIDF ENST00000279994 TETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLGRNGADDLKAHPFFSAIDF SINFRUP00000137140 TETQIKVINWESTLQVPAQVKLSPEAIDIIGRLCCSAEDRLGANGAGEIKAHPFFSQTDF CG12072-RA LETQQKVINWEKTLHIPPQAELSREATDLIRRLCASADKRLGKS-VDEVKSHDFFKGIDF :: : : : :: : : : :: : ENSMUST00000040043 SSDLRQQSASYIPKITHPTDTSNFDPVDPDK---LWSDGSEEENISDTLNGWYKNGKHPE SINFRUP00000134691 ------------------------------------------------------------ ENSMUST00000022531 SRDIRKQPAPYVPTISHPMDTSNFDPVDEES---PWHEASGESAKAWDTLAS-PSSKHPE ENST00000279994 SSDIRKQPAPYVPTISHPMDTSNFDPVDEES---PWNDASEGSTKAWDTLTS-PNNKHPE SINFRUP00000137140 SSNLRQQPAPYRPKIAHPMDTSNFDPVEEEGGPGAWSDS-GDSTRTLDMLCS-PQGKHPE CG12072-RA A-DMRKQKAPYIPEIKHPTDTSNFDPVDPEK--------LRSNDSTMSSGDDVDQNDRTF : : : : ENSMUST00000040043 HAFYEFTFRRFFDDNGYPYNYPKPIEYEYIHSQGSEQQSDEDDQHTSSDGNNRDLVYV SINFRUP00000134691 ---------------------------------------------------------- ENSMUST00000022531 HAFYEFTFRRFFDDNGYPFRCPKPS----EPAESADPGDADLEGAAEGCQPVYV---- ENST00000279994 HAFYEFTFRRFFDDNGYPFRCPKPSGAEASQAESSDLESSDLVDQTEGCQPVYV---- SINFRUP00000137140 HAFYEFTFRRFFDDNGCPFRYPKP---------------------------------- CG12072-RA HGFFEFTFRRFFDDKQPPD-------------------------MTDDQAPVYV---- : : : :: :: :