CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000022095 -MSYPQFGYPYSSAPQFLMTTNSLSTCCESGGRTLADSGPAASAQAPVYC ENST00000231357 -MSYPQFGYPYSSAPQFLMATNSLSTCCESGGRTLADSGPAASAQAPVYC SINFRUP00000149632 -------------------------------------------------- ENSMUST00000034185 -MAFSPFGHPYGSTSQFLVSASSSATCCETAPRPVSDVASASTSASTLCC ENST00000302006 -------------------------------------------------- ENSMUST00000022093 -MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASSGRPGTAELG Q8JH33_Brachydanio_rerio -MSFPQLGYPQYLSAS-QAVYGGDRPGVLTPSSRAGSAEIGG-------S Q90YN0_Brachydanio_rerio -MSFPQLGYPQFLNAS-QEVYGAERTGVMPSSPREGSSDNSAN------- Q8JJ47_Brachydanio_rerio ----------------------------MPSSPREGSSDNSAN------- SINFRUP00000149640 -MSFPQLGYPQFLGAS-HEVYGGDR----PASAREGGTEGAVN------- ENSMUST00000057876 -MSFPQLGYQYIRPLYPPERPGAAGGGGGGSSAGGRSGPGAGAS------ CG10571-RA MAAYTQFGYGGFPSASQLLPPSVQTTEDASANVNVNVNEALVMTNAPAMS ENSMUST00000001545 ---------LPVPSARLAGALLVPRVRRVRAGGAAQRGAGAFGVGLRVQP Q90YM9_Brachydanio_rerio --MAYPQGYLYQPSASLA-LYSCPAYSASVISGPRTEELGRSSSGSAFAP ENSMUST00000022095 PVYESRLLATARHELNSAAALGVYGSPYGSSQGYGNYVTYG--------- ENST00000231357 PVYESRLLATARHELNSAAALGVYGGPYGGSQGYGNYVTYG--------- SINFRUP00000149632 -------------------------------------------------- ENSMUST00000034185 TPYDSRLLGSARPELG--AALGIYGAPYAAAQSYPGYLTYG--------- ENST00000302006 -------------------------------------------------- ENSMUST00000022093 AGAGAAAVTSVLG------MYAAA-GPYAGAPNYSAFLPY---------- Q8JH33_Brachydanio_rerio ASAAAAAVSSVLG------MYP-------YAHNYSAFLPYT--------- Q90YN0_Brachydanio_rerio PATAAAAITPMLG------MYAN----PWTVQNYSAFLPYN--------- Q8JJ47_Brachydanio_rerio PATAAAAITPMLG------MYAN----PWTVQNYSAFLPYN--------- SINFRUP00000149640 SPAAAAAVGSMLG------MYGS----PWSPHNYSAFLPYSG-------- ENSMUST00000057876 ELAASGSLSNVLSSVYGAPYAAAA-AAAAAAQGYGAFLPY---------- CG10571-RA PTGGQDCQGSQPSGGAGGDASSGALSPNALSQNSNAATVVGAGGGSSAGG ENSMUST00000001545 PARRPSQRR--------------------RQPASAARCSTR--------- Q90YM9_Brachydanio_rerio YAGSTAFTS--------------------ASPGYNSHLPYS--------- ENSMUST00000022095 -------------------------------------------------- ENST00000231357 -------------------------------------------------- SINFRUP00000149632 -------------------------------------------------- ENSMUST00000034185 -------------------------------------------------- ENST00000302006 -------------------------------------------------- ENSMUST00000022093 -------------------------------------------------- Q8JH33_Brachydanio_rerio -------------------------------------------------- Q90YN0_Brachydanio_rerio -------------------------------------------------- Q8JJ47_Brachydanio_rerio -------------------------------------------------- SINFRUP00000149640 -------------------------------------------------- ENSMUST00000057876 -------------------------------------------------- CG10571-RA GGPADLATGGSLDGNGVGTTPTAGGAGGGGSCCENGRPIMTDPVSGQTVC ENSMUST00000001545 -------------------------------------------------- Q90YM9_Brachydanio_rerio -------------------------------------------------- ENSMUST00000022095 -----------------------------------------SEASAFY-S ENST00000231357 -----------------------------------------SEASAFY-S SINFRUP00000149632 -------------------------------------------------- ENSMUST00000034185 -----------------------------------------PEPPTLCGA ENST00000302006 -----------------------------------------AADLSLFSQ ENSMUST00000022093 -----------------------------------------AADLSLFSQ Q8JH33_Brachydanio_rerio -----------------------------------------SADLALFSQ Q90YN0_Brachydanio_rerio -----------------------------------------SAELALLSQ Q8JJ47_Brachydanio_rerio -----------------------------------------SAELALLSQ SINFRUP00000149640 -----------------------------------------ATDLALISQ ENSMUST00000057876 -----------------------------------------ATELPIFPQ CG10571-RA SCQYDSARLALSSYSRLPAASVGVYGTPYPSTDQNPYQSIGVDSSAFYSP ENSMUST00000001545 --------------------------------------RTAAAAAGFPSY Q90YM9_Brachydanio_rerio --------------------------------------ADAAAAATFTSY ENSMUST00000022095 LN-SFESKDGTGSSHAGLPPTAAAAYYPYEPALSQYPYDRYG--TVDSG- ENST00000231357 LN-SFDSKDGSGSAHGGLAP-AAAAYYPYEPALGQYPYDRYG--TMDSG- SINFRUP00000149632 ----------------------------------------YS--CSDGA- ENSMUST00000034185 LNPQYEFKDAAGSFAP--SLTQPGAYYPYETTLGQYQYDRYGGVELSSA- ENST00000302006 MGSQYELKDNPG---------VHPATFAA---HTAPAYYPYGQFQYGDP- ENSMUST00000022093 MGSQYELKDNPG---------VHPATFAA---HTTPAYYPYGQFQYGDP- Q8JH33_Brachydanio_rerio MGSQYDLKDSPG---------VHPASFAA---HTSPAFYPYGQFQYGDP- Q90YN0_Brachydanio_rerio MGSQYELKDNPG---------AHPPGFAV---HAAPGFYPYGQYQYGDP- Q8JJ47_Brachydanio_rerio MGSQYELKDNPG---------AHPPGFAV---HAAPGFYPYGQYQYGDP- SINFRUP00000149640 MSSQYELKDSPA---------THPASLPV---HAAQGFYPYGQYPYGDP- ENSMUST00000057876 LGAQYELKDSPG---------VQHPATAAAFPHPHPAFYPYGQYQFGDP- CG10571-RA LSNPYGLKDTGAGPEMG--AWTSAGLQPTTGYYSYDPMSAYGGLLVSNSS ENSMUST00000001545 VGSPYDTHTTGMTG----------------AISYHPYGSAAYPYQLNDP- Q90YM9_Brachydanio_rerio VSSPYD-HTTGMAG----------------SIGYHPYAAPLGSYPYGDP- .. ENSMUST00000022095 --------TRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMT ENST00000231357 --------TRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMT SINFRUP00000149632 --------SRRKNATRETTSTLKAWLQEHQKNPYPTKGEKIMLAIITRMT ENSMUST00000034185 --------GRRKNATRESTSALKAWLHEHRKNPYPTKGEKIMLAIITKMT ENST00000302006 --------GRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMT ENSMUST00000022093 --------GRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMT Q8JH33_Brachydanio_rerio --------ARPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMT Q90YN0_Brachydanio_rerio --------ARAKSATRETTSTLKAWLQEHKKNPYPTKGEKIMLAIITKMT Q8JJ47_Brachydanio_rerio --------ARAKSATRETTSTLKAWLQEHKKNPYPTKGEKIMLAIITKMT SINFRUP00000149640 --------SRAKAATRETTSTLKAWLQEHQKNPYPTKGEKIMLAIITRMT ENSMUST00000057876 --------SRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMT CG10571-RA YGASYDLAARRKNATRESTATLKAWLNEHKKNPYPTKGEKIMLAIITKMT ENSMUST00000001545 --------AYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMT Q90YM9_Brachydanio_rerio --------AYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMT * ***::*::*****:**:*****************:** ENSMUST00000022095 LTQVSTWFANARRRLKKENKMTWPPRNKCADEKRPYGEGEEEEAGEE--- ENST00000231357 LTQVSTWFANARRRLKKENKMTWPPRNKCADEKRPYAEGEEEEGGEE--- SINFRUP00000149632 LTQVSTWFANARRRLKKENKVTWSPRACKSSDDR----GCEDDS------ ENSMUST00000034185 LTQVSTWFANARRRLKKENKMTWAPKNKG---------GEERKADSG--- ENST00000302006 LTQVSTWFANARRRLKKENKVTWGARSKDQEDGALFGSDTEGDPEKA--- ENSMUST00000022093 LTQVSTWFANARRRLKKENKVTWGARSKDQEDGALFGSDTEGDPEKA--- Q8JH33_Brachydanio_rerio LTQVSTWFANARRRLKKENKVTWGARSKDDEN--IFGSDNEGDAEKN--- Q90YN0_Brachydanio_rerio LTQVSTWFANARRRLKKENKVTCC-RSAEDRDGRIFDSDNEDDADKN--- Q8JJ47_Brachydanio_rerio LTQVSTWFANARRRLKKENKVTWG-RSAEDRDGRIFDSDNEDDADKN--- SINFRUP00000149640 LTQVSTWFANARRRLKKENKVTWG-RSAEDRDGRIFSSDNEDEHGKNGSD ENSMUST00000057876 LTQVSTWFANARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEE-DE CG10571-RA LTQVSTWFANARRRLKKENKMTWEPKNRTDDDDDALVSDDEKDKEDLEPS ENSMUST00000001545 LTQVSTWFANARRRLKKENKMTWAPRNKSEDEDEDE-GDASRSKEESSDK Q90YM9_Brachydanio_rerio LTQVSTWFANARRRLKKENKMTWTPRNRSEDEEEDENIDLEKNDDDEPNK ********************:* : . . ENSMUST00000022095 --ESREEPLKSAKSEGHAGKDDKELELSDLEDFDPLDAET----SECELK ENST00000231357 --EAREEPLKSSKNAEPVGKEEKELELSDLDDFDPLEAEP----PACELK SINFRUP00000149632 --DDAEKPVGSDKDIPDPPCTD---LQSDLEDFDLLESDG----SDCEPK ENSMUST00000034185 --EDSLGCLNGDTKDATASQEARGLRLSDLEDLEEEEEE-----EEAEEE ENST00000302006 -EDDEEIDLESIDIDKIDEHDGDQS---NEDDE-----------DKAEAP ENSMUST00000022093 -EDDEEIDLESIDIDQIDERDGDQS---NEDEE-----------DKAEAP Q8JH33_Brachydanio_rerio -EDEEEIDLESIDIDKIDDNDGDQS---NEEDE-----------DKRAEL Q90YN0_Brachydanio_rerio -DDEEEIDLETIDMDKAEEPRVDQ----NKEAA-----------NNP--- Q8JJ47_Brachydanio_rerio -DDEEEIDLETIDMDKAEEPRVDQ----NKEAA-----------NNP--- SINFRUP00000149640 DEDEEEIDLETVDIERPEDQRTGEQSTGKEEGE-----------TDPGAE ENSMUST00000057876 EESKRELEMEEEELAGEEEDTGGEGLADDDEDEEIDLENL----DSAAAG CG10571-RA KGSQGSVSLAKDETKEEEDAIDEDQKCLGQANILRAGFGY----PSAGSG ENSMUST00000001545 AQDGTETSAEDEGISLHVDSLTDHSCSAESDGEKLPCRAGDALCESGSEC Q90YM9_Brachydanio_rerio PADKGDS----------TDTEADHKLINPGE---IPCDR----FKDETHS . ENSMUST00000022095 TPFQSLDSGPERIPASSDGPGTGKEASTTLRMPLGTAGGAVMDGDLERAR ENST00000231357 PPFHSLDGGLERVPAAPDGP--VKEASGALRMSLAAGGGAALDEDLERAR SINFRUP00000149632 PQFFPGDDG-----AGKDTP----LSHGHVAEPLHKKDG--------LSP ENSMUST00000034185 AAVSAARRLADFQKSTQPLPAPCAAAQERCLESRECGLG-LPRFSFTEAP ENST00000302006 HAPAAPSALARD-------------QGSPLAAADVLKPQDSPLGLAKEAP ENSMUST00000022093 RARVAPPASARD-------------QSSPLSAAETLKSQDSPLGLVKEVS Q8JH33_Brachydanio_rerio ESLQEKRHASKE-------------PSD---------------------G Q90YN0_Brachydanio_rerio -----HAIENIE-------------TPRILSSPALKNTDSPMSSGNREQN Q8JJ47_Brachydanio_rerio -----HAIENIE-------------TPRILSSPALKNTDSPMSSGNREQN SINFRUP00000149640 KQASEQTQKSSD-------------SSRTLSAEGLRGIEASVS-LNRSP- ENSMUST00000057876 SELTLAGAAHRNGDFGLGPISDCKTSDSDDSSEGLEDRPLSVLSLAPPPP CG10571-RA SGGYPGGGGSSSGHPGGYHP----YHHQHPAYYQAGQQGGMLPFHGENSK ENSMUST00000001545 KDKFEDLEDEEDEEDECERDLAPP--KPVTSSPLTGVEAPLLSPAPEAAP Q90YM9_Brachydanio_rerio KDLDPPLTDSELKEAEERTDLLAEQAKPTTSSPSVLQRGSDLITQEKPSE ENSMUST00000022095 NCLRSTVVVPD--SGAEGGPPACEAKLTFAQAGAPPNLETKPRIWSLAHT ENST00000231357 SCLRSAAAGPEPLPGAEGGPQVCEAKLGFVPAGASAGLEAKPRIWSLAHT SINFRUP00000149632 ECPKLTSVHQQ------NSP--------FYPNPGLQSAEAKPKIWSIAHT ENSMUST00000034185 QSGEADFITAE-----PGGP----TMILHYPSG------HKPRIWSLAHT ENST00000302006 EPGSTRLLSPG-----------------AAAGGLQGAPHGKPKIWSLAET ENSMUST00000022093 EPGSTRLLSPG-----------------AAAVGLQGAPHSKPKIWSLAET Q8JH33_Brachydanio_rerio NNNTTRVLSPG-----------------RQG-GFQVPVSNKPKIWSLAET Q90YN0_Brachydanio_rerio VVKSVGEVSPG-----------------GAV--CQRPGNSKPKIWSLAET Q8JJ47_Brachydanio_rerio VVKSVGEVSPG-----------------GAV--CQRPGNSKPKIWSLAET SINFRUP00000149640 VVK--LDPSTG-----------------RQE--CQRPQQNKPKIWSLAET ENSMUST00000057876 PVARAPASPPSP----------PSSLDPCAPAPAPSSALQKPKIWSLAET CG10571-RA LQTDLGDPKNQ-----------------LGRDCGVPIPATKPKIWSLADT ENSMUST00000001545 RGGSGGKTPLG-----------------SRTSPGAPPPASKPKLWSLAEI Q90YM9_Brachydanio_rerio PGHAASTGNSN-----------------VTSVIHSPPSAPKPKLWSLAEI **::**:*. ENSMUST00000022095 AT----AAAATALS-----------------QTEFPSCMLKRQGPTGVSA ENST00000231357 ATA--AAAAATSLS-----------------QTEFPSCMLKRQGPAAPAA SINFRUP00000149632 AA------SLDGAL-----------------QAEYPPCMLSSTGSSSPAY ENSMUST00000034185 AAASAVESAPSTPP-----------------RAQSPECHMIPRQPSSIRR ENST00000302006 ATSPDGAPKASPPP--------PAGHPGAHGPSAGAPLQHPAFLPSHGLY ENSMUST00000022093 ATSPDGAPKASPPP--------PSSHASAHGPPSGSPLQHPAFLPSHGLY Q8JH33_Brachydanio_rerio ATSPDSAQKPTSP---------------------SVPVSHPAFLPSHGLY Q90YN0_Brachydanio_rerio ATSPDNTQKLSIPS--------TPAG------LRASPSTHPAFLSTNGIY Q8JJ47_Brachydanio_rerio ATSPDNTQKLSIPS--------TPAG------LRASPSTHPAFLSTNGIY SINFRUP00000149640 ATAPDNSHKLPPAA--------HVHH------PALASAGHPALIPGHGIY ENSMUST00000057876 ATSPDNPRRSPPGAGG-----SPPGAAVAPPTLQLSPAAAAAAAAAHRLV CG10571-RA VGCKTPPPAYMGHQSMPLQQQQQQQQQQQQAQHQYPPSEAGRDQQLFNGA ENSMUST00000001545 ATSDLKQPSLGPGCG----------------PPGLPAAAAPASTGAPPGG Q90YM9_Brachydanio_rerio ATSSDRCKGSSRLHR----------------PAGLSQSTVIASVASPTRS . ENSMUST00000022095 TT--PASSPAVTAP-SGALDRHQDSPVTSLRNWVDGVFHDPILRHSTLNQ ENST00000231357 VSSAPATSPSVALPHSGALDRHQDSPVTSLRNWVDGVFHDPILRHSTLNQ SINFRUP00000149632 AS-----NMALTKG-----DGQQESPVSTLREWMDGVFHGPPLQHHKPAE ENSMUST00000034185 LL--------VPRD----SEGEEDSPAAKAFGNSTFTLQGLPLNCAPYPR ENST00000302006 TCHIGKFSNWTNSAFLA--QGSLLNMRSFLGVGAPHAAPHGPHLPAPPPP ENSMUST00000022093 TCHIGKFSNWTNGAFLA--QGSLLNMRSFLGVSAPHAAPHGPHLTAPPPP Q8JH33_Brachydanio_rerio TCQIGKFHNWTNGAFLG--QNSLLNVRSFLGVN-QHNHPAQQQQQQTGPA Q90YN0_Brachydanio_rerio TCQIGKLHNWASAAFLS--ANSLMGVRSLLSQNSNFPNHSPVTNPEKKPS Q8JJ47_Brachydanio_rerio TCQIGKLHNWASAAFLS--ANSLMGVRSLLSQNSNFPNHSPVTNPEKKPS SINFRUP00000149640 TCQIGKLHNWANAAFLN--ANSLLNMRSLLGGAP--PGHLPPHG------ ENSMUST00000057876 SAPLGKFPAWTNRPFPGPPAGPRPHPLSMLGSAPQHLLGLPGAAGHP--- CG10571-RA AAPYLRPHTTAYGGFLGATTQQLHTTNNSIPYSNMPPQQQQPQQQQQQLQ ENSMUST00000001545 SPYSASP---LLGRHLYYTSPFYGNYTNYGNLNAALQGQGLLRYNTAASS Q90YM9_Brachydanio_rerio SPQCPLPNNTVLSRPIYYTSPFYPGYTNYSTFGHLHSSHGTNTSSTAHFN ENSMUST00000022095 A----------WATAKGALLDPGPLGRNLGAGTNVLTTPLACSFPPTVPQ ENST00000231357 A----------WATAKGALLDPGPLGRSLGAGANVLTAPLARAFPPAVPQ SINFRUP00000149632 V----------WKDFASAGMDSRTLGQ----------------------- ENSMUST00000034185 R----------REPEVRFQYPSGAEG------------------------ ENST00000302006 QPPVAIAPGALNGDKASVRSSPTLPERDLVPRPDSPAQQLKSPFQPVRDN ENSMUST00000022093 QPPVQVATGVLHGEKASARSSPALPERDLVTRPDSPPQQLKSPFQPVRDN Q8JH33_Brachydanio_rerio SLQVLSAG---NTDKMPEDLSPKH------IAPETSRNQHRGSSQ--RCP Q90YN0_Brachydanio_rerio S---ASGSPCLDSDNSSDSFSPKHNDQENVQRIESPTLASRSPFPVIHDR Q8JJ47_Brachydanio_rerio S---ASGSPCLDSDNSSDSFSPKHNDQENVQRIESPTLASRSPFPVIHDR SINFRUP00000149640 -------------------------------------------------- ENSMUST00000057876 ----------AAAAAAYARPAEPESGTDRCSALEVEKKLLKTAFQPVPRR CG10571-RA QGGTIHTTGSSSGPIIPLQFHNRHPQQQQQLQQQSQSTASQRAMGFLEAQ ENSMUST00000001545 P----------GETLHAMPKAASDTGKAGSHSLESHYRPPGGGYEPKKDT Q90YM9_Brachydanio_rerio -----------GLSQTVLNRAEALVRESKVRSQTQVDLCKDSPYELKKGM ENSMUST00000022095 DVPPAGASRELLATPKAGGKPFCT-------------------------- ENST00000231357 DAPAAGAARELLALPKAGGKPFCA-------------------------- SINFRUP00000149632 -------------------------------------------------- ENSMUST00000034185 -------------------------------------------------- ENST00000302006 SLAPQEGTPRILAALPSA-------------------------------- ENSMUST00000022093 SLAPQEGTPRILAALPSA-------------------------------- Q8JH33_Brachydanio_rerio PLDQHICTPKRTDGTNNGH------------------------------- Q90YN0_Brachydanio_rerio SHHETSQRALKTIS------------------------------------ Q8JJ47_Brachydanio_rerio SHHETSQRALKTIS------------------------------------ SINFRUP00000149640 -------------------------------------------------- ENSMUST00000057876 PQNHLDAALVLSALSSS--------------------------------- CG10571-RA PDTPPQTPPNMKVLSGALSLLPTATQVPMTATCRSSNAFGFPASGYPMNF ENSMUST00000001545 SEGCAVVGAGVPTYRRAKVSSASRCHNCFGKKSQE--------------- Q90YM9_Brachydanio_rerio SN---I-------------------------------------------- ENSMUST00000022095 -------------------------------------------- ENST00000231357 -------------------------------------------- SINFRUP00000149632 -------------------------------------------- ENSMUST00000034185 -------------------------------------------- ENST00000302006 -------------------------------------------- ENSMUST00000022093 -------------------------------------------- Q8JH33_Brachydanio_rerio -------------------------------------------- Q90YN0_Brachydanio_rerio -------------------------------------------- Q8JJ47_Brachydanio_rerio -------------------------------------------- SINFRUP00000149640 -------------------------------------------- ENSMUST00000057876 -------------------------------------------- CG10571-RA SARLGEYSPRDDYSSGNSSSSSSSSPQLQRNEAMFKPLFKKFTN ENSMUST00000001545 -------------------------------------------- Q90YM9_Brachydanio_rerio --------------------------------------------