CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000003658 -MSVEAYGPSSQTLTFLDTEEAELLGA--DTQGSEFEFTDFTLPSQTQTPPGGPGG---- ENST00000262803 -MSVEAYGPSSQTLTFLDTEEAELLGA--DTQGSEFEFTDFTLPSQTQTPPGGPGGPGGG SINFRUP00000146603 -MSVEAYGPSSQTLTFLDTEETELLGA--DTQGSEYDFTDFTLPSQTQT----------- SINFRUP00000138487 -MSVEAYGPSSQTLTFLDIEETELLGA--DTQGSEYDFTDFTLPSQTQT----------- ci0100137074 --SVDAYGPSSQTLTFLDPDESGVLTAGGDTQASEYDFTDFTIPSQTQTQTQTQHS---- ENST00000224140 ------------------------------------------------------------ CG7504-RA MSSVWYLEHVTTGARLILHNGTNLMGRHSRCRIILGGQYQFVSREHANIIVSEKGVEVES : :: :: : ENSMUST00000003658 -AGGPGGAGAGGAAGQLDAQV-GPEGILQN-----GAVDDSVAKTSQLLAELN--FEEDE ENST00000262803 GAGGPGGAGAGAAAGQLDAQV-GPEGILQN-----GAVDDSVAKTSQLLAELN--FEEDE SINFRUP00000146603 ---------QGHTQSQLDNQLNGPDDGLHN-----GGMDDSVAKASQLLAELN--FEEDE SINFRUP00000138487 -----------QGQSQLENQVNGPDIVLQN-----G--EDAVVKASQLLAELN--FEEDE ci0100137074 ------QSQLDAGDNSQTQDVAGEDEGLVGRDDDLGGLQENIHIATQGVADLR--FEEDD ENST00000224140 ------------------------------------WLNSPNRENFYQLQVRK--FPADY CG7504-RA LNPLNGLFINGGKLGDKINRLAVAEGSTISLGVTGVNLNEITGIHAIFILKKKEPVVEEI : :. : . . : ENSMUST00000003658 -EDTYYTKDLPVHACSYCGIHDPACVVYCNTSKKWFCNGRGNTSGSHIVNHLVRAKCKEV ENST00000262803 -EDTYYTKDLPIHACSYCGIHDPACVVYCNTSKKWFCNGRGNTSGSHIVNHLVRAKCKEV SINFRUP00000146603 -EDTYYTKDLPVHACSYCGIHDPACVVYCNTSKKWFCNGRGNTSGSHIVNHLVRAKCKEV SINFRUP00000138487 -EDAYYTKDLPAHACSYCGIHDPACVVYCNTSKKWFCNGRGNTSGSHIVNHLVRAKSKEV ci0100137074 DEDGFYTRDLPEHACRYCGIHDPNCVVMCNSTQKWFCNGRGNTSGSHIINHLVRAKCKEV ENST00000224140 --IKYWEFAVYLEECELAKQLYPKENDLVFLAPERINEEKKDTERNDIQDLHEYHSGYVH CG7504-RA VLSSDDDDTTPLPAVRCPTGTQPTEFNLKQQIPNFGGKQDPGQEEEVLPSSSNLHLPKLT * : : . . . : . ENSMUST00000003658 TLHKDGPLGETVLECYNCGCRNVFLLGFIPAKADSVVVLLCRQPCASQSSLKDINWDSSQ ENST00000262803 TLHKDGPLGETVLECYNCGCRNVFLLGFIPAKADSVVVLLCRQPCASQSSLKDINWDSSQ SINFRUP00000146603 TLHKDGPLGETVLECYNCGCRNVFLLGFIPAKADSVVVLLCRQPCASQSSLKDINWDSSQ SINFRUP00000138487 TLHKDGPLGETVLECYNCGCRNVFLLGFIPA-----------QPCASQSSLKDINWDSSQ ci0100137074 TVHRDGQLGDSMLECYNCGCRNIFLLGFIPAKADSVVVLLCRQPCANQTSLKDMNWDASQ ENST00000224140 KFRRTSVMRNGKTECYLS------------------------------------------ CG7504-RA EVKQEIVKHTSEEIQNIFGEPSDAILNSVLELNPYLYNKLTNKTANNEITRKKIHDGDCI .:: :: : : ENSMUST00000003658 WQPLIQDRCFLSWLVKIPS--------EQEQLRARQITAQQINKLEELWKENPSATLEDL ENST00000262803 WQPLIQDRCFLSWLVKIPS--------EQEQLRARQITAQQINKLEELWKENPSATLEDL SINFRUP00000146603 WQPLIQDRCFLSWLVKIPS--------EQEQLRARQITAQQINKLEELWKDNPCATLEDL SINFRUP00000138487 WQPLIQDRCFLSWLVKIPS--------EQEQLRARQITAQQINKLEELWKENPCASLEDL ci0100137074 WQPLIQDRCFLSWLVKIPS--------EEEQLRARQITAQQINKLEELWKENVDATIEDL ENST00000224140 ----------IQTQENFPA--------NLNELVNCIVISSLVTTQRKLKAMSLLGSRNQL CG7504-RA ELDTDTDRRSISEAQKAEDPSAEREVDDEEEYDESFAMSQAVIREMKAEMHVSDGEEDFL :. : : :: :. : : . : * ENSMUST00000003658 EKPGVDEEPQHVLLRYEDAYQYQNIFG---PLVKLEADYDKKLKESQTQDNITVRWDLGL ENST00000262803 EKPGVDEEPQHVLLRYEDAYQYQNIFG---PLVKLEADYDKKLKESQTQDNITVRWDLGL SINFRUP00000146603 EKPGVDEEPQHVLLRYEDAYQYQNIFG---PLVKLEADYDKKLKESQTQDNITVRWDLGL SINFRUP00000138487 EKPGVDEEPQHVLLRYEDAYQYQNIFG---PLVKLEADYDKKLKESQTQDNITVRWDLGL ci0100137074 EKPGVDEDPHAVLLRYEDAYQYQNIFG---PLVKLEADYDRRLKESQTQANVTIRWDIGL ENST00000224140 ARAVLNPNP----MDFCTKDLLTTTSE---RIIAYLRDFNEDQKKAIETAYAMVKHSPSV CG7504-RA LTNGMGNLPEGSPSNQAYDDIVYVSDSDDDELYDKVADWSKLLSQKVVPDVIEMSQTYPL :. * : *:.. .: : : ENSMUST00000003658 NKKRIAFFTLPKTDS-------------DMRLMQGDEICLRYKGDLAPLWKGIGHVIKVP ENST00000262803 NKKRIAYFTLPKTDSGNE--DLVIIWLRDMRLMQGDEICLRYKGDLAPLWKGIGHVIKVP SINFRUP00000146603 NKKRIAYFTLPKTDSG-----------AHMRLMQGDEICLRYKGDLAPLWKGIGHVIKVP SINFRUP00000138487 NKKRIAYFTLPKTDS-------------DMRLMQGDEICLRYKGDLAPPWKGIGHVIKVP ci0100137074 NKKRLAHFQLPKTDTATHNRNCVPRLFSDMKLMKGDEISLRHLG---TLWEGKGHVVKVP ENST00000224140 AK---------------------------ICLIHGP--------------PGTGKSKTIV CG7504-RA ENEHKDSDSDLDIGAKKPKRTLRISSSSDEDSADEVIVHQTKQKGRRSKSKSPNDHVVRQ : . : . .. ENSMUST00000003658 DNYGDEIAIELRSSVGAPVEVTHNFQVDFVW-----KSTSFDRMQSALKTFAVDETSVSG ENST00000262803 DNYGDEIAIELRSSVGAPVEVTHNFQVDFVW-----KSTSFDRMQSALKTFAVDETSVSG SINFRUP00000146603 DNYGDEIAIELRTSVGAPVEIPHNYQVDFVW-----KSTSFDRMQSALKTFAVDETSVSG SINFRUP00000138487 DNYGDEIAIELRSSAGAPVEIPHNFQVDFVW-----KSTSFDRMQSALKTFAVDETSVSG ci0100137074 DNSSDEIAIELRSSVGVPLDKTGNFHVDFVW-----KSTSFDRMQSAMKTFAVDEASVST ENST00000224140 G-------------------LLYRLLTENQR-----KGHSDENSNAKIKQNRVLVCAPSN CG7504-RA DPAKKVIKDISPTKSDTTDNVLNFVDVRQTRGPSVIEAPSLPKNRGKLRGVSAEVKVKDK . : . :. * . .. :: . . ENSMUST00000003658 YIYHKLLGHEVEDVVIKCQLPKRFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKT ENST00000262803 YIYHKLLGHEVEDVIIKCQLPKRFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKT SINFRUP00000146603 YIYHKLLGHEVEDVTIKCQLPKRFTANGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKT SINFRUP00000138487 YIYHKLLGHEVEDVVIKCQLPKRFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKT ci0100137074 YIYHRLLGHEAEEQTLKTNLPKRFSAPGLPELNHSQVYAVKTVLQRPLCLIQGPPGTGKT ENST00000224140 AAVDELMKKIILEFKEKCKDKK------NPLGNCGDINLVR-------------LGPEKS CG7504-RA VLDRQRFIDYQAEMNAKWKQKPKDKKKEDEKLKECRREALKKLSEKPKENSHRSTTNKRK . : . : * : : :: : :. ENSMUST00000003658 VTSATIVYHLAR-------QGNGPVLVCAPSNIAVDQLTEKIHQTGLKVVRLCAKSREAI ENST00000262803 VTSATIVYHLAR-------QGNGPVLVCAPSNIAVDQLTEKIHQTGLKVVRLCAKSREAI SINFRUP00000146603 VTSATIVYHLSR-------QGNGPVLVCAPSNIAVDQLTEKIDKTGLKVVRLCAKSREAI SINFRUP00000138487 VTSATIVYHLAR-------QGSGPVLVCAPSNIAVDQLTEKIHQTGLKVVRLCAKSREAI ci0100137074 VTSATIVYHLVKS------CGQRQVLVCAPSNIAVDQLTEKIHRTGLKVVRLCAKSREAI ENST00000224140 INSEVLKFSLDS-------QVNHRMKKELPSHVQAMHKRKEFLDYQLDELSRQR------ CG7504-RA NPTSVPTVQNTNRGGFLTKGVDGPAPKLAKTDNAKPPPKKPVPKQPPAIETFSQQLQAAD : . . :. : . ENSMUST00000003658 DSPVSFLALHNQ---IRNMDSMPELQKLQQLKDETGELSSADEKRYRALKRTAERELLMN ENST00000262803 DSPVSFLALHNQ---IRNMDSMPELQKLQQLKDETGELSSADEKRYRALKRTAERELLMN SINFRUP00000146603 ESPVSFLALHNQ---ISNMDSMPELQKLQQLKDETGELSSADEKRYRALKRTAERELLMN SINFRUP00000138487 DSPVSFLALHNQ---TRNMESMPELQKLQQLKDETGELSSSDEKRYRALRRTAERELLMN ci0100137074 DSNVSFLSLHNQ---VRSMESLPELQKLQQLKDETGELSSNDEKRYRALKRNAERELLQH ENST00000224140 -------ALCRG---GREIQRQELDENISKVSKERQELAS-KIKEVQGRPQKTQSIIILE CG7504-RA KAVLHPQPQCSRPVERKEAELARNQRTCNKVTFAEMELYHQKAEDSKKLQKKLRKVHFND : . . : .. .::. ** . : : :. . : . ENSMUST00000003658 ADVICCTCVGAGDPRLA-------KMQFRSILIDESTQATEPECMVPVVLGAKQLILVGD ENST00000262803 ADVICCTCVGAGDPRLA-------KMQFRSILIDESTQATEPECMVPVVLGAKQLILVGD SINFRUP00000146603 ADVICCTCVGAGDPRLA-------KMQFRSILIDESTQATEPECMVPVVLGAKQLILVGD SINFRUP00000138487 ADVICCTCVGAGDPRLA-------KMQFRSILIDESTQATEPECMVPVVLGAKQLILVGD ci0100137074 ADVICSTCVGAGDPRLV-------RFRFRSILIDESTQATEPECMVPVVLGAQQLILVGD ENST00000224140 SHIICCTLSTSGGLLLESAFRGQGGVPFSCVIVDEAGQSCEIETLTPLIHRCNKLILVGD CG7504-RA DVKVHCIERVKGASSKVQGRKECIKLRLSSYRERREWIRRENKPVNDIRQHSRSILKWAN : . * . : . . * : : : ...:: .: ENSMUST00000003658 HCQ----------------LGPVVMCKKAAKAGLSQSLFERLVVLGIR------------ ENST00000262803 HCQ----------------LGPVVMCKKAAKAGLSQSLFERLVVLGIR------------ SINFRUP00000146603 HCQ----------------LGPVVMCKKAAKAGLSQSLFERLVVLGIR------------ SINFRUP00000138487 HCQ----------------LGPVVMCKKAAKAGLSQSLFERLVVLGIR------------ ci0100137074 HCQ----------------LGPVVMCKKAANAGLAQSLFERLVVLGIR------------ ENST00000224140 PKQ----------------LPPTVISMKAQEYGYDQSMMARFCRLLEENVEHN-----MI CG7504-RA QWLKHGSVDAVAEQDVLMPIPPEFDSFKNYREIFVPLMKLELLSTIERDYKINNKNTFSV : * . . * . : .: . ENSMUST00000003658 ----PIRLQVQYRMHPALSAFPSNIFYEGSLQNGVTAADRVKKGFDFQWPQPDKPMFFYV ENST00000262803 ----PIRLQVQYRMHPALSAFPSNIFYEGSLQNGVTAADRVKKGFDFQWPQPDKPMFFYV SINFRUP00000146603 ----PIRLQVQYRMHPALSAFPSNIFYEGSLQNGVTAGDRIKKGFDFQWPQPEKPMFFYV SINFRUP00000138487 ----PIRLQVQYRMHPALSAFPSNIFYEGSLQNGVTAADRVKKGFDFQWPQPDKPMFFYV ci0100137074 ----PIRLQVQYRMHPALSAFPSNIFYEGSLQNGVTAGERMRKNLSFVWPSPDKPMFFYK ENST00000224140 SRLPILQLTVQYRMHPDICLFPSNYVYNRNLKT-----NRQTEAIRCSSDWPFQPYLVFD CG7504-RA SLINVETQDMCYRLVTRVNSKPFGKFVLYTLYCCGMLKETFANLLELKFVSGNVFDLTFE : **: . : * . . .* : : : : : ENSMUST00000003658 TQGQEEIASSGTSYLNRTEAANVEKITTKLLKAG--AKPDQ----IGIITPYEGQRSYLV ENST00000262803 TQGQEEIASSGTSYLNRTEAANVEKITTKLLKAG--AKPDQ----IGIITPYEGQRSYLV SINFRUP00000146603 TQGQEEIASSGTSYLNRTEAANVEKITTRLLKAG--AKPDQ----IGIITPYEGQRSYLV SINFRUP00000138487 TQGQEEIASSGTSYLNRTEAANVEKITTRLLKAG--AKPDQ----IGIITPYEGQRSYLV ci0100137074 TSGQEEIASSGTSYLNRTEAAVVERITTKFLKSG--IKPEQ----IGIITPYEGQRSYLV ENST00000224140 VGDGSERRDN-DSYINVQEIKLVMEIIKLIKDKRKDVSFRN----IGIITHYKAQKTMIQ CG7504-RA ILKQDISEEKLKNIKQLTARPVVDSLRVELGALSAVHQLRSSPLCRRILKPTQTVNEVSL . .. . : * : : . . *:. : . ENSMUST00000003658 QYMQFSGSLHTKLYQEVEIASVDAFQ---------------------------------- ENST00000262803 QYMQFSGSLHTKLYQEVEIASVDAFQ---------------------------------- SINFRUP00000146603 QYMQFSGSLHTKLYQQVEIASVDAFQ---------------------------------- SINFRUP00000138487 QYMQFSGSLHTKLYQEVEIASVDAFQ---------------------------------- ci0100137074 QYMQYSGSLHSKLYMEVEIASVDAFQ---------------------------------- ENST00000224140 KDLDKEFDRK----GPAEVDTVDAFQ---------------------------------- CG7504-RA PKQPFTFKGCHKLNEHQENIVLHTYQRIIDDLQPSLTLIQGPPGTGKSRVISELCLQTLY . : * :.::* ENSMUST00000003658 ---GREKDFIILSCVRAN---------------------------EHQG-IGFLNDPRRL ENST00000262803 ---GREKDFIILSCVRAN---------------------------EHQG-IGFLNDPRRL SINFRUP00000146603 ---GREKDFIILSCVRAN---------------------------EHQG-IGFLNDPRRL SINFRUP00000138487 ---GREKDFIILSCVRAN---------------------------EHQG-IGFLNDPRRL ci0100137074 ---GREKDFIILSCVRAN---------------------------EHQG-IGFLNDPRRL ENST00000224140 ---GRQKDCVIVTCVRAN---------------------------SIQGSIGFLASLQRL CG7504-RA GNAAKTLDRKILICAHSNTAVDHIVGLLGSVLRVMNRDQFHLLRFGMHEKMSHYSRPFSL .: * *: *.::* : :.. * ENSMUST00000003658 NVALTRARYG---VIIVGNPKALSKQP--LWNHLLSYYKEQKALVEGPLNNLRESLMQFS ENST00000262803 NVALTRARYG---VIIVGNPKALSKQP--LWNHLLNYYKEQKVLVEGPLNNLRESLMQFS SINFRUP00000146603 NVALTRAKYG---VIIVGNPKALSKQP--LWNNLLNNYKEQKVLVEGPLNNLRESLMQFS SINFRUP00000138487 NVALTRARYG---VIIVGNPKALSKQP--LWNHLLNYYKEQKVLVEGPLNNLRESLMQFS ci0100137074 NVALTRARWDSSLCLTTMSVTALCHPR--FYPKFNKLKKTTNLSISFFIQNLLKLLPRIY ENST00000224140 NVTITRAKYS---LFILGHLRTLMENQ--HWNQLIQDAQKRGAIIKTCDKNYRHDAVKIL CG7504-RA EAHFNKAKEQKLQRVSKENAEILKKQHNDLKDEIQQLKEKTNLTSTYLLQQLQQKEKKLQ :. :.:*: . * . .: . : :: . :: ENSMUST00000003658 KPRKLVN-TVNPGARFMTTAMYDARE---------------------------------- ENST00000262803 KPRKLVN-TINPGARFMTTAMYDARE---------------------------------- SINFRUP00000146603 KPRKLVN-TINPGGRFMSTAMYDARE---------------------------------- SINFRUP00000138487 KPRKLVN-TINPGGRFMSTAMYDARE---------------------------------- ci0100137074 RLLSLVNPHKQQGGRYMSNAMWDARE---------------------------------- ENST00000224140 KLKPVLQRSLTHPPTIAPEGSRPQ------------------------------------ CG7504-RA LISNQLSPPLTQREEFEISHMCVTRANIICTTLSSCVKLANYVDFFDICIVDEATQCTEP :. ENSMUST00000003658 -------------------AIIPGSVYDRS----SQGRPSNMYFQTHDQISMISAGP--- ENST00000262803 -------------------AIIPGSVYDRS----SQGRPSSMYFQTHDQIGMISAGP--- SINFRUP00000146603 -------------------ALIPGSAYDRSN---TAGRPSNMYFQTHDQIGMIGAAA--- SINFRUP00000138487 -------------------ALIPGSVYDRS----NNGRTTNMYFQTHDQIGMIGTGP--- ci0100137074 -------------------ALIPGGAYDRASTYNGAVPPRHQYFRTHDQMGMINQTTSIQ ENST00000224140 -------------------GGLPSSKLDSGFAKTSVAASLYHTPSDSKEITLTVTSKDPE CG7504-RA WTLLPMRFGLTHMVLVGDMQQLPAVVLSKKAIDFGLSNSMFDRIQRSLQTQLDKPGSYHL :*. . . : : ENSMUST00000003658 SHVAAMNIPIPFNLVMPPMPPPGYFGQANGPAAG---------------RGTPKTKTGRG ENST00000262803 SHVAAMNIPIPFNLVMPPMPPPGYFGQANGPAAG---------------RGTPKGKTGRG SINFRUP00000146603 SHLAALNIPIPFNLVMPPMPPPSYQGQTNGPAAG---------------RGAMKGKSGRG SINFRUP00000138487 NPITAMNLPIPFNLVMPPIPPPGYLGQINGPASGGG------------SRGGRQRNRGNM ci0100137074 AQQAVASLPVPVNMYMNPTIPPNYF--HNGQAQG---------------RPVAKGGRAPR ENST00000224140 RPPVHDQLQDPRLLKRMGIEVKGGIFLWDPQPSS----------------PQHPGATPPT CG7504-RA MHTKLFKLSTQYRMHPEICRWPNQYFYEDQLINAECTARFASPLIPYCVINLKYTCDSNG .: : . : . ENSMUST00000003658 GRQKNRFGLPGPSQTTLPNSQASQDVASQPFSQGALTQGY---VSMSQPS--QMSQPGLS ENST00000262803 GRQKNRFGLPGPSQTNLPNSQASQDVASQPFSQGALTQGY---ISMSQPS--QMSQPGLS SINFRUP00000146603 GRQRIR-GSGNQGVGHMPNSQISQDGASQSFSQGPLTQGY---ISMSQPS--QMSQPGLS SINFRUP00000138487 GSGGNSGSDRGLHGGHMGVSQASQDLGSQPFSQGPLTQGY---INMSQPS--QMSQPGLS ci0100137074 LSRTNRHPQAGSNPATQ-----SQD-MTQNFSQGALTQGYGTGLSMSQPISQGMSQLGLS ENST00000224140 GEPGFPVVHQDLSHIQQPAAVVAALSSHKPPVRGEPPAASP--EASTCQSKCDDPEEELC CG7504-RA AQNKSISNNEEARFVAKLLTEMDKHMPSKRFSYGLISPYQNQCYALSQVIPSHMNITPQT : * . : ENSMUST00000003658 QPELS-------------------------------------------QDSYLGDEFKSQ ENST00000262803 QPELS-------------------------------------------QDSYLGDEFKSQ SINFRUP00000146603 QPELS-------------------------------------------QDSYLGDEFKSQ SINFRUP00000138487 QPELS-------------------------------------------QDSYLGDEFKSQ ci0100137074 QAELS-------------------------------------------QDSYMAEEFRSQ ENST00000224140 HRREA-------------------------------------------RAFSEGEQEKCG CG7504-RA VDSYQGLEKDVIIISNARTRGCGFLTNYQRLNVALTRPRRCLVICGNFEDLKSVEMWRNL . : : ENSMUST00000003658 IDVALSQDSTYQGERAYQHGGVTGLSQY--------- ENST00000262803 IDVALSQDSTYQGERAYQHGGVTGLSQY--------- SINFRUP00000146603 IDVALSQDSTYQGERAYQHGGVTGLSQY--------- SINFRUP00000138487 IDVALSQDSTYQGERAY-HGGVTGLSQY--------- ci0100137074 VDAALSQDSTYQGERAYTGQGLN-FSQY--------- ENST00000224140 SETHHTRRNSRWDKRTLEQEDSSSKKRKLL------- CG7504-RA LDDARKRKVYFNLDRDDVNDLDRSLIKKMMVNTINLI : .: .* :