CLUSTAL W (1.82) multiple sequence alignment ENST00000294888 RGSPPPPGSPSTPHPASLAAPPAPGNRLARSPPSLLSAYPGGAAAGSGSPSSSSASSSLF ENST00000294247 ------------------------------------------------------------ SINFRUP00000146277 ------------------------------------------------------------ ci0100151427 ------------------------------------------------------------ CG30132-RB ------------------------------------------------------------ ENST00000294888 PPPGPLVAPPRGLREPLAPALCSRPHPFPVAPRGPHHSPAGETPARPRCPHKMSARTPLP ENST00000294247 ------------------------------------------------------------ SINFRUP00000146277 ------------------------------------------------------------ ci0100151427 ------------------------------------------------------------ CG30132-RB ------------------------------------------------------------ ENST00000294888 TVNERDTENHTSVDGYTEPHIQPTKSSSRQNIPRCRNSITSATDEQPHIGNYRLQKTIGK ENST00000294247 -------------------------------MIRGRNSATSA-DEQPHIGNYRLLKTIGK SINFRUP00000146277 ------------------------------------------------------------ ci0100151427 ---------MSRSATEDRGGSGDGLRSHRNPSNHMQRSRMATGDDQPHIGQYRILKTIGK CG30132-RB ----------------------MQMRSS---------APMRWRATEEHIGKYKLIKTIGK : : : ENST00000294888 GNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIG-------- ENST00000294247 GNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIET SINFRUP00000146277 ------------------------------------------------------------ ci0100151427 GNFAKVKLARHVLTGREVAIKIIDKKQLNTSSLQKLFREVRIMKHLDHPNIVKLYEVIEN CG30132-RB GNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIET : : : : : : :: : : :: : :: : : : :: ENST00000294888 --------------EVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENL ENST00000294247 EKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQVVSAVQYCHQKFIVHRDLKAENL SINFRUP00000146277 ------------------------------------QILSAVQYCHQKHIVHRDLKAENL ci0100151427 SKQLLLVMEYANGGEVFDYLVAHGRMKEKEARAKFRQIVSSVQYLHSKNIVHRDLKAENL CG30132-RB EKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENL : ::: :: :: : : *::*:*** *.* *:********* ENST00000294888 LLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILY ENST00000294247 LLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILY SINFRUP00000146277 LLDADMNIKIADFGFSNEFSVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILY ci0100151427 LLDADMNIKIADFGFSNEFTPGHKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILY CG30132-RB LLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILY ***.::*************: * ************************************* ENST00000294888 TLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGSLEQIMKD ENST00000294247 TLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKD SINFRUP00000146277 TLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPGKRGTLEQIMKD ci0100151427 TLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCEHLLRKFLVLNPTKRGTLTSVMQD CG30132-RB TLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGD ***********..*:**********************:**:::*:*** **.:* :* * ENST00000294888 RWMNVGHEEEELKPYTEPDPDFNDTKRIDIMVTMGFARDEINDALINQKYDEVMATYILL ENST00000294247 RWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLL SINFRUP00000146277 RWINTGSEEEELKPFIQPDLDIRDQARIDLMVVMGYCKDDIADSLSKMKYDDITATYLLL ci0100151427 KWMNIGHEDEPLKPYVDAPFQENDEGRLQSMIDMGYNKEEVENSIRTRAYDDSFATYLLL CG30132-RB KWMNMGFEEDELKPYIEPKADLADPKRIEALVAMGYNRSEIEASLSQVRYDDVFATYLLL :*:* * *:: ***: :. : * * : :: **: :.:: :: *:: ***:** ENST00000294888 GRKPPEFEGGESLSSGNLCQRSRPSSDLNNSTLQSPAHLKVQRSISANQKQRRFSDHAG- ENST00000294247 GYKSSELEG------DTITLKPRPSADLTNSSAPSPSH-KVQRSVSANPKQRRFSDQAAG SINFRUP00000146277 GHKVAEVRD----------------RQHSNNSLSNFSHHRGSASSTTSSKQRRYSEQAAC ci0100151427 GTKPSELSDPSAS----RSSSALSLKQVGQPSPSNQQTRKVHRSVSANQKPRRVSTENSK CG30132-RB GRKSTDP-ESDGS----RSGSSLSLRNISGNDAGANAGSASVQSPTHRGVHRSISASSTK * * .: : * : * * ENST00000294888 PSIPPAV------------SYT-KRPQA-----NSVESEQKEEWDKDVARKLGSTTVGSK ENST00000294247 PAIPTSN------------SYS-KKTQS-----NNAENKRPEE-DRESGRKASST----- SINFRUP00000146277 PSSAALP------------SRGGQASVQ-----AEVKREVGGQSKKSDTAETGSPLLGNA ci0100151427 KSFNNLRYRICFSIFSDHRSEGGLAAGSFSFEQNLVRVNFTRSMPRDKMRIVRNYLENQR CG30132-RB PSR---------------RASSGVGP------TNAAATVAAATGAVGAVNPSNNY--NAA : : : :: : . : : . . ENST00000294888 SEMTASPLVGPERKKSSTIPSNN-VYSGGSMARRNTYVCER-------TTDRYVALQNGK ENST00000294247 AKVPASPLPGLERKKTTPTPSTNSVLSTSTNRSRNSPLLER-------ASLGQASIQNGK SINFRUP00000146277 TNPNMADVLGRRRVLATPTSASS------SMSRRNTYVCTER-----GAADQHAPLQNGK ci0100151427 ASVSTASSYASAQAKQALLASTAANPNKAEIPS-NQRPETAKTWKNNDMTRRNTYVCTDR CG30132-RB GSAADRASVGSNFKRQNTIDSATIKENTARLAAQNQRPASAT---QKMLTTADTTLNSPA . . : * : . : . ENST00000294888 DSSLTEMSVSSISSAGSSVASAVPSARPR-HQKSMSTSGHPIKVT-LPTIKDGSEAYRPG ENST00000294247 DS----LTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPR SINFRUP00000146277 DS----------------SSATTPPQRS-------------------------------- ci0100151427 KGD-KAALVQVDELYIFLPLGAISCCSPQEETSVRPRHHKTQSSTAVPPIPTVVNSEEPE CG30132-RB KP---RTATKYDPTNGNRTVSGTSGIIPRRSTTLYEKTSSTEKTNVIPAETNLFD----- . . . . : ENST00000294888 ---TTQRVPAASPSAHSIST--ATPDRTRFPRGSSSRSTFHGEQLRERR---SVAYNGPP ENST00000294247 QVTAPQRVPVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTP SINFRUP00000146277 ---------AGGSSTHSVSGGAAPSERPRFPRGTASRSTFHGGQLRERR---SATYNGPP ci0100151427 -----HRPTIAPGARSSIHARHSQTSATPFPRNARERRTYHGPQTQERTR-RTATYNGPP CG30132-RB ------RLRMASAVKSSRH----------FPRNVPSRSTFHSGQTRARNN-TALEYSG-- . . ***. .* *:*. * : *. ENST00000294888 ASP------------------SHETGAFAHARRGTSTGIISKITSKFVR-RSTS------ ENST00000294247 ASP------------------SGHS----QGRRGASGSIFSKFTSKFVR-RNLSFRFARR SINFRUP00000146277 ASPSL----------------SHDTTPLSQSRSRGSTNLFSKLTSRLTRSHNVS------ ci0100151427 PPTSPSVSECMPGAMASGRDSNTTSRGGPSGSREGASGFLSKLSSKFNRSTSRG------ CG30132-RB -----------------------TSGASGDSSHPGRMSFFSKLSSRFSKRPT-------- : : : : . .::**::*:: : . ENST00000294888 --GEPKERD------------------KEEGKDSKPRSLRFTWSMKTTSSMDPNDMMREI ENST00000294247 NLNEPESKDRVETLRPHVVGSGGNDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREI SINFRUP00000146277 --GDQKEEP--------------GSPAVPPLKESKPRSLRFTWSMKTTSSMEPQDMMREI ci0100151427 --------------------------VPEAEKDSKPRSLRFTWSMKTTSAMEPKEMMKEI CG30132-RB ----------------------------IADEAAKPRVLRFTWSMKTTSPLMPDQIMQKI . :*** ***********.: *.::*::* ENST00000294888 RKVLDANNCDYEQKERFLLFCVHGDARQDSLVQWEMEVCKLPRLSLNGVRFKRISGTSIA ENST00000294247 RKVLDANSCQSELHEKYMLLCMHGTPGHEDFVQWEMEVCKLPRLSLNGVRFKRISGTSMA SINFRUP00000146277 RKVLDTNNCDYEQRERFLLLCVHGDGHADNLVQWEMEVCKLPRLSLNGVRFKRISGTSIA ci0100151427 RKVLDANSCDYEQREKYLLFCVNGHGHADNLVQWEMEVCKLPRLSLNGVRFKRISGTSIA CG30132-RB REVLDQNNCDYEQRERFVLWCVHGDPNTDSLVQWEIEVCKLPRLSLNGVRFKRISGTSIG *:*** *.*: * :*:::* *::* :.:****:**********************:. ENST00000294888 FKNIASKIANELKL ENST00000294247 FKNIASKIANELKL SINFRUP00000146277 FKNIASKIANELRL ci0100151427 FKNIASKIANELKL CG30132-RB FKNIASRIAFDLKL ******:** :*:*