CLUSTAL W (1.82) multiple sequence alignment ENST00000270904 MPQRGHPSQEGLWALPSLPMAHGPKPETEGLLDLSFLTEEEQEAIAGVLQRDARLRQLEE ENSMUST00000030674 MPQRGHPSQERLWALPSLPMAHGPGSEAEGLLDLSFLTEEEQEAISDVLKRDAHLRQLEE ENSMUST00000032846 ------------------------------MIDLSFLTEEEQDAILKVLQRDAALKRAEE ENST00000316356 ------------------------------MIDLSFLTEEEQEAIMKVLQRDAALKRAEE SINFRUP00000132331 ------------------------------------------------------------ SINFRUP00000153423 ------------------------------------------------------------ CG7343-RA -------MKQVTRLIGPRRMASSKPKEAPSYNAFASASTSSKKSQPASTAPAPLARVHNY ENSMUST00000033608 ---------------------------MSEILDLSFLSEMERDLILGVLQRDEELRKADE ENST00000297875 ------------------------MSKNSEFINLSFLLDHEKEMILGVLKRDEYLKKVED ci0100154549 ------------------------------------------------------------ ENST00000270904 GRVSKLRASVADPGQLKILTGDWFQEARSQRHHNAHFGSDLVRASMRRKKSTRGDQAPGH ENSMUST00000030674 GRVSKLRASLEDPWQLKILTGDWFQEARSQRHHHAHFGSDLVRASIRRKKSPKGDQALGS ENSMUST00000032846 ERVRHLPEKIKDDQQLKNMSGQWFYEAKAKRHRDKIHGADIIRASMRRKKLPAAAEQNKD ENST00000316356 ERVRHLPEKIKDDQQLKNMSGQWFYEAKAKRHRDKIHGADIIRASMRKKRPQIAAEQSKD SINFRUP00000132331 ------------------------------------------------------------ SINFRUP00000153423 ------------------------------------------------------------ CG7343-RA GRVKSQPAGSSLP-SSSAGKIQYAALNRMRKKRSEDEGKKLKRKSKWRQLFGQCWWKKRR ENSMUST00000033608 KRIRRLKNELLEIKRKGAKRGSQHYSDRTCARCQEGLGRLIPKSSTCVGCNHLVCRECRV ENST00000297875 KRIRKLKNELLEAKRRSGK--TQQEASRVCVHCHRNLGLIFDRGDPCQACSLRVCRECRV ci0100154549 ------------------------------------------------------------ ENST00000270904 ----------------------------DREAEAAVKEKEEG-PEPRLTIDEAPQERLR- ENSMUST00000030674 ----------------------------DGEAEAAGENTIEGEPESRVSIEVAAPERNT- ENSMUST00000032846 TAMRAKESWVNNVNKDAVLPPEIA-VVEEPEDDTDPAGPSSSLVDPASSVIDMSQESTRT ENST00000316356 RENGAKESWVNNVNKDAFLPPELAGVVEEPEEDAAPASPSSSVVNPASSVIDMSQENTRK SINFRUP00000132331 ------------------------------------------------------------ SINFRUP00000153423 ------------------------------------------------------------ CG7343-RA RQRSYQDYWSSSREKSKKSHFFCYCCRRRTNGYGYDSEEEDDDIDAKVASYIVEMKQREA ENSMUST00000033608 LESNGSWRCKVCSKEIELKKATGDWFYDQKVNRFDYR--TGSEIIRMSLRQKPAVNKRET ENST00000297875 AGPNGSWKCTVCDKIAQLRIITGEWFFEEKAKRFKQVNVLGTDVVRQSILRRSPGAEEVQ ci0100154549 ------------------------------------------------------------ ENST00000270904 ------ETEASD------PEEASQAQEDPGQ----------------------------- ENSMUST00000030674 ------ETQGPDLFSPYVPSKASEGQEEEPQDQECEL----------------------- ENSMUST00000032846 PAVSLPKQRKNPFNSPKLPEDHSLQQTKPEQSKTGKAGLFQISKEGELSESKEKSSIPDM ENST00000316356 PNVS-PEKRKNPFNSSKLPEGHSSQQTKNEQSKNGRTGLFQTSKEDELSESKEKSTVADT SINFRUP00000132331 ------------------------------------------------------------ SINFRUP00000153423 ------------------------------------------------------------ CG7343-RA AANGQSEILVEETPNPVPQEQVKQLPTQLRSPPIVKRRAWTWDDSLRSNSDRFLETLEDD ENSMUST00000033608 AGQSLLQQTQMGDIWP--GRRIIQEQQQREQSVLFEVPKTRSGKSALEAESESLDSYTAD ENST00000297875 SQEQTRQDAEKSDTSPVAGKKASHDGPKRKGFLLSKFRSATRG-EIITPKTDTGRSYSLD ci0100154549 ------------------------------------------------------------ ENST00000270904 ------------------------------------------------------------ ENSMUST00000030674 ------------------------------------------------------------ ENSMUST00000032846 PRQQLEKPKQTVSTEPENASHTKAPIPKARKLIYKSNDLEKDDNQSFPRQRRDSLNARGA ENST00000316356 SIQKLEKSKQTLPG-LSNGSQIKAPIPKARKMIYKSTDLNKDDNQSFPRQRTDSLKARGA SINFRUP00000132331 ------------------------------------------------------------ SINFRUP00000153423 ------------------------------------------------------------ CG7343-RA LPVSSEEVVAAASG---------------------------------------------- ENSMUST00000033608 SD----------STSRRDSLDKSGLFPEWKKMSAPKSQVEKEIPPG-------------- ENST00000297875 LDGQHFRSLKSPPGSDRGSTGSSDLNDQEPGPRTPKSSRSNGVTPG-------------- ci0100154549 ------------------------------------------------------------ ENST00000270904 ------------------------------------------------------------ ENSMUST00000030674 ------------------------------------------------------------ ENSMUST00000032846 PRGILKRNSSSSSTDSETLRLNYNLDPKSKILSPGLTIHERISEKEFSLEDDSSTSSLEP ENST00000316356 PRGILKRNSSSSSTDSETLRYNHNFEPKSKIVSPGLTIHERISEKEHSLEDNSSPNSLEP SINFRUP00000132331 ------------------------------------------------------------ SINFRUP00000153423 ------------------------------------------------------------ CG7343-RA ------------------------------------------------------------ ENSMUST00000033608 ------------------------------------------------------------ ENST00000297875 ------------------------------------------------------------ ci0100154549 ------------------------------------------------------------ ENST00000270904 ------------------------------------------------------------ ENSMUST00000030674 ------------------------------------------------------------ ENSMUST00000032846 LKHVRFSAVKNELPQSPRPVLGQEVGEFTVLESDQLQNGTEDAGDIEEFQNHPELS-HKT ENST00000316356 LKHVRFSAVKDELPQSPGLIHGREVGEFSVLESDRLKNGMEDAGDTEEFQSDPKPSQYRK SINFRUP00000132331 ------------------------------------------------------------ SINFRUP00000153423 ------------------------------------------------------------ CG7343-RA ------------------------------------------------------------ ENSMUST00000033608 ------------------------------------------------------------ ENST00000297875 ------------------------------------------------------------ ci0100154549 ------------------------------------------------------------ ENST00000270904 ------------------------------------------------------------ ENSMUST00000030674 ------------------------------------------------------------ ENSMUST00000032846 PLSHYQLVSSPSDSGREREQLMSSGSAPRDEIPCHSDILPTGPQCVESSSVINGQQEKSS ENST00000316356 PSLFHQSTSSPYVSKSETHQPMTSGSFPINGLHSHSEVLTARPQSMENSPTINEPKDKSS SINFRUP00000132331 ------------------------------------------------------------ SINFRUP00000153423 ------------------------------------------------------------ CG7343-RA ------------------------------------------------------------ ENSMUST00000033608 ----------------------------------------NQN----------------- ENST00000297875 ----------------------------------------TQSSPAPSTRTVTSVISREY ci0100154549 ------------------------------------------------------------ ENST00000270904 -------------GDQQVCAEEADPELEPASGGEQEPRPQQAQTKAASQILENG--EEAP ENSMUST00000030674 ----------EAPGEGGVQVAEADPELDPEQKAEQESQPTPAQSKATSKILENG--EEAP ENSMUST00000032846 HFTKLPSELSKSPSDELTQCGEPEPSQTADHSFRDHRQGSEEEHSPVLKTLERR--AARK ENST00000316356 ELTRLESVLPRSPADELSHCVEPEPSQVPGGSSRDRQQGSEEEPSPVLKTLERS--AARK SINFRUP00000132331 ------------------------------------------------------------ SINFRUP00000153423 ------------------------------------------------------------ CG7343-RA --GRTSLILHRRTPLHVTFVENEEEQSEREDRQKQERVTVQEEAKVAAEELSRSPVIGQR ENSMUST00000033608 ---------AVCGDEGDMVFKKNTKKVLRP----------SEYTKSVIDLRPEDVAQESG ENST00000297875 GFENSMDLAAIEGTSQELTKSHRRNTSGTPSIAVSGTSLSSDQSRSELDLSESFTEDSED ci0100154549 ------------------------------------------------------------ ENST00000270904 GPDPSLDRMLSSSSSVSSLN---------------------------------------- ENSMUST00000030674 GLGPSLDRMLSSSSSVSSLN---------------------------------------- ENSMUST00000032846 LPSKSLEDIPSDSSNQAKVDNLPEELVRSAEDDQKADQEPDTNECIPGISTVPSLPDNQF ENST00000316356 MPSKSLEDISSDSSNQAKVDNQPEELVRSAEDDEKPDQKPVTNECVPRISTVPTQPDNPF SINFRUP00000132331 ------------------------------------------------------------ SINFRUP00000153423 ------------------------------------------------------------ CG7343-RA QADGSGSPIQSRASSETWPTQSDEDIDRLVAMHQ-------------------------- ENSMUST00000033608 ILGDRSKSVPGLSVDMEEEEEEEEDIDHLVKLHRQ------------------KLARGSM ENST00000297875 TVSIRSKSVPG-ALDKDSLEETEESIDALVSSQLS------------------TNTHR-L ci0100154549 ------------------------------------------------------------ ENST00000270904 -----SSTLS-------------------------------------------------- ENSMUST00000030674 -----SSTLS-------------------------------------------------- ENSMUST00000032846 SHPDKLKRMSKSVPAFLQDEASSCFEPLETDTASESSYQLRRYKKSPSSLTNLSSSSGMT ENST00000316356 SHPDKLKRMSKSVPAFLQDEAS-------------------------------------- SINFRUP00000132331 ----SLLKLS-------------------------------------------------- SINFRUP00000153423 --------IS-------------------------------------------------- CG7343-RA -NRSSLSSLG-------------------------------------------------- ENSMUST00000033608 QSGSSMSTLG-------------------------------------------------- ENST00000297875 ASGLSTTSLN-------------------------------------------------- ci0100154549 ------------------------------------------------------------ : ENST00000270904 ------GSQMSLSGDAEA------VQVRGSVHFALHYEPGAAELRVHVIQCQGLAAA--R ENSMUST00000030674 ------GSLMSLSGEAEAG----TVQVRGSVLFSLRYEPGTSELRVQVIQCQGLAAA--R ENSMUST00000032846 SLSSASGSVMSVYSGDFG-----NLEVKGSVQFALDYVESLKELHVFVAQCKDLAAADVK ENST00000316356 -----FGSVMSVYSGDFG-----NLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVK SINFRUP00000132331 ------GSMMTMYG---G-----DLEVQGNIMFSINYIQKLREFHIFVAQCQDLAAADLK SINFRUP00000153423 ------SSISSIYPADFG-----ELEVQGSIQFAVNYIQKLGEFQVFVVDCRDLAVADVK CG7343-RA ---VRSESMASVYSGAGEGRY-GTVVVKGQVEFAMQYNYKLSALEVHVVRCKDLAAVDAK ENSMUST00000033608 -------SIMSIYSEAGDFGN---ISVTGKIAFSLKFEQKTQTLVIHVKECHQLAYADEA ENST00000297875 -------SMMSVYSETGDYGN---VKVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEK ci0100154549 ----------SVYSGTSAFAQS--IDVTGSVEFGMKYSHKTGSLNINIVGCSDLAAVDD- :: : * *.: : : : : : : * ** ENST00000270904 RRRSDPYVKSYLLPDK--QSKRKTAVKKRNLNPVFNETLRYSVPQAELQGRVLSLSVWHR ENSMUST00000030674 RRRSDPYVKSYLLPDK--QSKRKTSVKKRNLNPIFNETLRHSVQQADLPGRVLSLSVWHR ENSMUST00000032846 KQRSDPYVKTYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIERQFLKTQKLNLSVWHR ENST00000316356 KQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQKLNLSIWHR SINFRUP00000132331 KGRSNPYVKSYLVPDKSNLGKRKTSVKKKTLNPTFNEILRYRVNMEYLRTQTLILSVWHH SINFRUP00000153423 KNRSDPYVKCYLLPDKSKLGKRKTAVKKKTSHPTFNEILRFKTPLELLKSQTLNVSVWHN CG7343-RA RNRSDPYVKVYLLPDKSKAGKRKTKVKKHTLNPIFDETMRFHTPISSLESRTLWLTVWHS ENSMUST00000033608 KKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETFRYEISESLLAQRTLQFSVWHH ENST00000297875 KQRTDAYVKSYLLPDKSRNNKRKTKIRTG-TNPEFNETLKYTISHTQLETRTLQLSVWHY ci0100154549 KKLSNPYVKTYLLPDK--QSKRKTKAKKKTINPVYNETLKYIIPESELSTRTLNVAVWH- : ::.*** **:*** .*:** :* ::* ::. * : * .::** ENST00000270904 ESLGRNIFLGEVEVPLDTWDWG----SEPTWLPLQPRV----PPSPDDLPSRGLLALSLK ENSMUST00000030674 ESLGRNIFLGEVEVPLDTWNWD----SEATWLPLQPRV----PPSPDELPSRGLLSLSLK ENSMUST00000032846 DTFKRNSFLGEVELDLETWDWDSKQNKQLKWYPLKRKT----APVALETENRGEMKLALQ ENST00000316356 DTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKT----APVALEAENRGEMKLALQ SINFRUP00000132331 DTFGRNSFLGEVDVDLFKWDFG---HTRMNYFPLKSRT----SPNLAAASGRGQLKLAIR SINFRUP00000153423 DTFGRNNFLGEVDVDLSGWDFG---NTRINEYVLQARASAQPSPSSRSMDDRGQMRVAVR CG7343-RA DMFGRNDFLGEVSVNLQGRLFD---NPQSQWYLLQERS----EPFDEVATYRGDIVVGLK ENSMUST00000033608 GRFGRNTFLGEAEVHMDSWKLDKK---LDHCLPLHGKISTES--SPGLPAHKGELVVSLK ENST00000297875 DRFGRNSFLGEVEIPFDSWNFENP---TDEWFVLQPKVEFAP--DIGL-QYKGELTVVLR ci0100154549 DKVGVNVFLGEVNLELNFVDFSDPR--QSDVYVLQPKVRLHEVFKYNLYLIYNIIKLLLP . * ****..: : *: : . : : : ENST00000270904 YVPAG-------------------------------SEGAGLPPSGELHFWVKEARDLLP ENSMUST00000030674 YVPAG-------------------------------SEGGGQPQSGELHFWVKEAQSLVP ENSMUST00000032846 YVPEP-------------------------------SPGKKLPTTGEVHIWVKECLDLPL ENST00000316356 YVPEP-------------------------------VPGKKLPTTGEVHIWVKECLDLPL SINFRUP00000132331 YLPQISH-----------------------------SEGVSHFFNGEIHIWVKECRDLPL SINFRUP00000153423 FLPQT------------------------------------------------------- CG7343-RA YIPPENIKSSFFSRGSSITGSSSNLRKFGGSIKSVASKSERTSKGGQLHVLVKEAKHLSP ENSMUST00000033608 YIPASK---LP----------VGGDR----KKSKGGE-------GGELQVWIKEAKNLTA ENST00000297875 YIPPEENLMLPPE-------QLQGNK----TFKKGKKKESPVISGGILEVFIKEAKNLTA ci0100154549 FIQVAFTDFHSN--------TYNGDMSIALRYIQGREK------FGQLEIVVQGVRSLPT :: ENST00000270904 LRA-GSLDTYVQCFVLPDDSQASRQRTRVVRRSLSPVFNHTMVYDGFGPADLRQACAELS ENSMUST00000030674 LRP-GSLDTYIQCSVLPDDSRASRQRTRVVRRSLSPVFNHTMVYDGFGPADLRQACAELS ENSMUST00000032846 LRG-SHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPVFNHTMVYDGFRPEDLMEACVELT ENST00000316356 LRG-SHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELT SINFRUP00000132331 IR--ATINPYVKCFVLPDTSRKSRQKTRVVRRAVDPVFNHTMVYDGIRDIDLTEACVELT SINFRUP00000153423 -------------AVLPDTSRKSRQKTRVVKRTANPMFNHTMVYDGFRTQDLREACVEIT CG7343-RA IKANGTCDAFCKSYLLPDRTRSSKQKTPVVKRTLHPSWNYTFVYEDVSLEELSERALELT ENSMUST00000033608 AKSGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLSPHYNHTFVYNGVRLEDLQHMCLELT ENST00000297875 VKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLELT ci0100154549 AAD--KSNIFVKGYFLPDKARATKQKTPLLQSSSNVQFDHQFVYTKVASDELSQRCVEIT .** : ::::* : : ::: ::: . :: . . *:: ENST00000270904 LWDHGALAN-RQLGGTRLSLGTGSSYGLQVPWMDSTPEEKQLWQALLEQPCEWVDGLLPL ENSMUST00000030674 LWDHGALAS-RQLGGTRLSLGTGSSYGLQVPWMDSTPEEKQLWQTLLERPCEWVDGLLPL ENSMUST00000032846 VWDHYKLTN-QFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWVEATLPL ENST00000316356 VWDHYKLTN-QFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATLPL SINFRUP00000132331 VWDRDKLAT-NLLGGLRLGIGTGTSYGALVDWMDSTPSEVALWERMKSTPNEWVEDVLPL SINFRUP00000153423 VWDHDRLRN-HFLGGLRLGLGTGRSYGVDVVWMDSTPEEADLWQRMLQSDGEWVEDILPL CG7343-RA VWDHDRLASNEFVGGIRFSLGTGRSYGRQVEWMDATGKELSLWQNMLDRPNFWVEGSLVL ENSMUST00000033608 VWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTGEEVSLWQKMRQYPGSWAEGTLQL ENST00000297875 IWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQGEEQRLWQKMANNPGTPFEGVLML ci0100154549 VWKEGLIGPNKLLGAVRLSTGTGQSFGDNVHWMDSTTEEIQLWQKMFDNFGSWSEGTITL :*.. : :*. *:. *:* * * * ***: .* **: : . : : * ENST00000270904 RTNLAPRT---- ENSMUST00000030674 RTNLVPRA---- ENSMUST00000032846 RMLLIAKLSK-- ENST00000316356 RMLLIAKISK-- SINFRUP00000132331 RIL--------- SINFRUP00000153423 RMLMMTK----- CG7343-RA RSSLDGIRANLP ENSMUST00000033608 RSSMVKQKLGV- ENST00000297875 RSSMGKCRL--- ci0100154549 RN---------- * :