CLUSTAL W (1.82) multiple sequence alignment ENST00000310773 ------------------------------------------------------------ SINFRUP00000131248 ------------------------------------------------------------ SINFRUP00000160771 --------------------------------------EVWGYQLCLWKIVLVGVGAVCS ENST00000264733 ------------------MGHFEKGQHALLNEGEENEMEIFGYRTQGCRKSLCLAGSIFS ENSMUST00000039090 ------------------------------------------------------------ SINFRUP00000130506 ------------------------------------------------------------ ENST00000290531 ---MSADSSPLVGSTPTGYGTLTIGTSIDPLSSSVSSVRLSGYCGSPWRVIGYHVVVWMM CG6230-RA MTEAAGATNPGGAAGDAESYGKEMALQSGRPKEPTKLDDLVQYVSLHVRIPTPLTGVVLP : ENST00000310773 ------------------------------------------------------------ SINFRUP00000131248 ------------------------------------------------------------ SINFRUP00000160771 GGLLLLLLYWLPEWGVKGTCTPTSLKEAHTLLLRTTDEFRQWF--------------RAR ENST00000264733 FGILPLVFYWRPAWHVWAHCVPCSLQEADTVLLRTTDEFQIYS--------------WKK ENSMUST00000039090 ------------------------------------------------------------ SINFRUP00000130506 ------------------------------------------------------------ ENST00000290531 AGIPLLLFRWKPLWGVRLRLRPCNLAHAETLVIEIRDKEDSSW--------------QLF CG6230-RA FVPLYLSAFYLWINVTGGQENDTTNNDVITADNQTTTDNITTWNDVGFIGVLAIAFLHIL : ENST00000310773 ------------------------------------------------------------ SINFRUP00000131248 ------------------------------------------------------------ SINFRUP00000160771 LRVIS------------------------------------------------------- ENST00000264733 VIWIY------------------------------------------------------- ENSMUST00000039090 ------------------------------------------------------------ SINFRUP00000130506 ------------------------------------------------------------ ENST00000290531 TVQVQTEAIGEGSLEPSPQSQAEDGRSQAAVGAVPEGAWKDTAQLHKSEEAKRVLRYYLF CG6230-RA TLLFCYWSVHVLAFLTCRRVKLPGANVLAKVVPTPNNGNSKIVPIRSSKLEDGSTQYYFV . ENST00000310773 ------------------------------------------------------------ SINFRUP00000131248 ------------------------------------------------------------ SINFRUP00000160771 ----------------------------APGKTPFENVDPQLVAQLPNRDGSIQEHGRKS ENST00000264733 ----------------------------LSALNSAFGLTPDHPLMTDEEYIINRAIRKPD ENSMUST00000039090 ------------------------------------------------------------ SINFRUP00000130506 -------------------------------------------RKCIYGPNLIDVPVKSC ENST00000290531 QGQRYIWIETQQAFYQVSLLDHGRSCDDVHRSRHGLSLQDQMVRKAIYGPNVISIPVKSY CG6230-RA FQKTKYVWNEDRKTFRAVEFPVNGLLSTYSSSRGLETEEDIKRATQTYGNNEMEMVVPEF ENST00000310773 ------------------------------------------------------------ SINFRUP00000131248 -------VLNPFYIFQLFSVILWSADEYYYYAVAIVIMSVISIATSLYTIKKVGKHL--L SINFRUP00000160771 GERQPVQVLNPFYIFQFFSVILWSAEDYYYYASAIVFMSVISIATSLYTIKKQYVMLRDM ENST00000264733 LKVRCIKVQKIRYVWNYLEGQFQKIGSLEDWLSSAKIHQKFGSGLTREEQEIRRLICGPN ENSMUST00000039090 -----------------------------------------------QDLESRLLVPG-- SINFRUP00000130506 ASLLFEEVLNPFYIFQLCSITLWIIDNYYIYAACILVISVLSICISLYQIRKQSITLHKM ENST00000290531 PQLLVDEALNPYYGFQAFSIALWLADHYYWYALCIFLISSISICLSLYKTRKQSQTLRDM CG6230-RA HELFIERATAPFFVFQVFSVGLWCMDDYWYYSLFTLFMLIAFECTIVKQQLRNMSEIRKM : . ENST00000310773 ----------IS---------------EIEEIFSTDLVPGDVMVIP--LNGTIMPCDAVL SINFRUP00000131248 IFDVYILLCCLA---------------EIEEILSTDLVPGDLMVIP--SNGTIMPCDAVL SINFRUP00000160771 VAAHSVLRVSVCRGNQ-----------EMEQAMSTELVPGDVIAIP--ANGMVMPCDAVL ENST00000264733 TIDVEVTPIWKLLIKEVLNPFYIFQLFSVCLWFSEDYKEYAFAIII--MSIISISLTVYD ENSMUST00000039090 ----------------------------------------DLLILT--GSRVQMPCDAIL SINFRUP00000130506 AHYVTNVTVLRQS--------------REEHVSSVDLVPGDCLIIP--QEGLVLPCDVAV ENST00000290531 VKLSMRVCVCRPGG-------------EEEWVDSSELVPGDCLVLP--QEGGLMPCDAAL CG6230-RA GNKPYLIYAFRQN--------------KWRHLGSDELLPGDLVSITRSQNDNIVPCDLVI : . :. ENST00000310773 INGTCIVNESMLT--------------------------GESVPVTKTNLPNPSVDVKG- SINFRUP00000131248 VSGTCIVNESMLT--------------------------GESVPVTKTNLPNPFHGDGGD SINFRUP00000160771 LQGTCIVNESMLT--------------------------GESVPVTKTSLPS-----AGE ENST00000264733 LREQSVKLHHLVESHNSITVSVCGRKAILPHKTRCLFSVGESIPVTKTPLPK----MDSS ENSMUST00000039090 IDGSCVVDEGMLT--------------------------GESIPVTKTPLSQ----TASS SINFRUP00000130506 LAGECLVNESMLT--------------------------GESVPVLKTPLPA-------- ENST00000290531 VAGECMVNESSLT--------------------------GESIPVLKTALPE-------- CG6230-RA LRGSCIVDESMLT--------------------------GESVPLMKESLES-----LDN : .: . : ***:*: * * ENST00000310773 IGDELYNPETHKRHTLFCGTTVIQTR-------FYTGELVKAIVVRTGFSTSKGQLVRSI SINFRUP00000131248 EADCPYNTEEHKRHTLFCGTNVIQTR-------FYTGELVKAVVVRTGFSTAKGQLVRSI SINFRUP00000160771 EGAQSYDKEEHKRHTLFCGTLVIQTR-------FYSGELVKAVVVRTGFSTEKGQLVRSI ENST00000264733 VPWKTQSEADYKRHVLFCGTEVIQAK-------AACSGTVRAVVLQTGFNTAKGDLVRSI ENSMUST00000039090 VPWKMQSEADPRRHVLFCGTEVIQAK-------AAGSGAVRAVVLQTGFNTAKGDLVRSI SINFRUP00000130506 -GEETYSAESERRHTLYCGTHLIQAKG-----GGPGGHGAIAVVTNTGFFTAKGSLVSSI ENST00000290531 -GLGPYCAETHRRHTLFCGTLILQAR-------AYVGPHVLAVVTRTGFCTAKGGLVSSI CG6230-RA LDVEMDAEGDGKLFVLFGGTKVVQHTAPTKESLRAPDGGCIGYVIRTGFNTSQGKLLRTI : ..*: ** ::* . . * .*** * :* *: :* ENST00000310773 LYPKPTDFKLYRDAYLFLLCLVAVAGIGFIYTIINSILN-EVQVGVIIIESLDIITITVP SINFRUP00000131248 LYPKPTDFKLYHDAYIFLFCLVGVAAIGFIYSIALSIIH-EVPAKTIIIESLDIVTITVP SINFRUP00000160771 LHPKPTDFKLYRDAYLFLLCLVGVAAIGFIYTIVLSIMS-KVPAQTIIIESLDIITITVP ENST00000264733 LYPKPVNFQLYRDAIRFLLCLVGTATIGMIYTLCVYVLS-GEPPEEVVRKALDVITIAVP ENSMUST00000039090 LYPKPMNFKLYRDAIRFLLCLVGTATIGMVYTLCVYVLS-GEPPEEVVRKALDVITIAVP SINFRUP00000130506 MYPQPINFRFYQDAAKFLLILGCLAFLGTIYSFVALYRS-RATLKELIIRSLDVVTIVVP ENST00000290531 LHPRPINFKFYKHSMKFVAALSVLALLGTIYSIFILYRN-RVPLNEIVIRALDLVTVVVP CG6230-RA LFGANRATENNVETFAFIAFLMVFAVAAASYVWVKGSEDPERNRYKLFLECTLILTSIIP :. . .: *: * * . * :. .. ::* :* ENST00000310773 PALPAAMTAGIVYAQRRLKKIGIFCISPQRINICGQLNLVCFDKTGTLTEDGLDLWGIQR SINFRUP00000131248 PALPAAMTAGIVYAQRRLKNLRIFCISPQRINICGQINLVCFDKTGTLTEDGLDLWGVQR SINFRUP00000160771 PALPAAMTVGIVYAQRRLKRVGIFCISPQRINMCGQLNLVCFDKTGTLTEDGLDLWGVHR ENST00000264733 PALPAALTTGIIYAQRRLKKRGIFCISPQRINVCGQLNLVCFDKTGTLTRDGLDLWGVVS ENSMUST00000039090 PALPAALTTGIIYAQRRLKKKGIFCISPQRINVCGQLNLVCFDKTGTLTRGGLDPWGVVP SINFRUP00000130506 PALPAAITTGTIYAQNRLKNKGIFCISPPRINVSGKLSIFCFDKTGTLTEEGLDVWGVME ENST00000290531 PALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQLVCFDKTGTLTEDGLDVMGVVP CG6230-RA PDLPIELTLAVNTSLIQLTKLFVFCTEPFRIPFAGKVQICCFDKTGTLTTDNLMVEGIAG * ** :* : :* . :** * ** . *::.: ********* .* *: ENST00000310773 VENARFLSPEENVCNEMLVKSQFVACMATCHSLTKIEGVLSGDPLDLKMFEAIGWILEEA SINFRUP00000131248 VDNGSFFLSEENAYKENLVKSQFVACMATCHSLTKIDGQLSGDPLDLKMFEATGWILEEA SINFRUP00000160771 AASGSFSPPEFDVTGENLVNSTFVACMASCHSLTKIEGELSGDPLDLKMFNATGWVLEEP ENST00000264733 CDRNGFQEVHSFASGQALPWGPLCAAMASCHSLILLDGTIQGDPLDLKMFEATTWEMAFS ENSMUST00000039090 CDQNGFQAVHSFASGKALPQGPLCAAMASCHSLILLDGTIQGDPLDLKMFEATKWVPPRE SINFRUP00000130506 GGPAGFSEMVP--DPKLLPHGHMLSGLACCHTVTLFKDQPLGDPLELKMIESTGWSG--- ENST00000290531 LKGQAFLPLVP--EPRRLPVGPLLRALATCHALSRLQDTPVGDPMDLKMVESTGWVLEEE CG6230-RA LAPN------GACVPIEKAEGNTVQVLACCHSLALLDDGLVGDPLEKATLAAVDWTLTKM : . :* **:: :.. ***:: . : * ENST00000310773 TEEETALHNRIMPTVVRPPKQLLP-ESTPAGNQEMELFELPATYEIGIVRQFPFSSALQR SINFRUP00000131248 TEEETSLHNRIMPTVVRPPKQLLPPEPVTSPEQDMS------TYEIGIVRQFPFSSTLQR SINFRUP00000160771 TEEETSLHNPIMPTVVRPPKNSSP-EANQKHSLDQN-----MTGEIGIVRQFPFSSALQR ENST00000264733 GDDFHIKGVPAHAMVVKPCRTAS----------QVP------VEGIAILHQFPFSSALQR ENSMUST00000039090 TATMALILLSATVPPVLPAALTIGNVLLPLMSLQSP------VDSITILRQFPFSSGLQR SINFRUP00000130506 -------------------------------------------KAVAIVQRFPFSSALQR ENST00000290531 PAADSAFGTQVLAVMRPPLWEPQL------QAMEEP------PVPVSVLHRFPFSSALQR CG6230-RA DSVIPKRPQ---------------------------------FKPLKIIQRYHFSSALKR : ::::: *** *:* ENST00000310773 MSVVARVLG----DRKMDAYMKGAPEAIAGLCKPETVPVDFQNVLEDFTKQGFRVIALAH SINFRUP00000131248 MSVVARLLG----EKCMDAYMKGAPEVVASLCKKETVPENFAEVLEGYTKQGFRVIALAH SINFRUP00000160771 MSVVVRKLG----EKHMDAYLKGAPEVIASLCKQHTVPQSFSETLESYTRQGFRVIALAH ENST00000264733 MTVIVQEMG----GDRL-AFMKGAPERVASFCQPETVPTSFVSELQIYTTQGFRVIALAY ENSMUST00000039090 MSVIAQLAG----DLHLHVYMKGAPEMVARFCRSETVPKNFSQELRNYTVQGFRVIALAH SINFRUP00000130506 MSVVTTTPQ----GCSAFAYIKGSPEMVASLCQEDTVPPQFSSQLQMFSSEGLRVLALAY ENST00000290531 MSVVVAWPG----ATQPEAYVKGSPELVAGLCNPETVPTDFAQMLQSYTAAGYRVVALAS CG6230-RA MSVLAGHLIPYSNEVKHIGAVKGAPEVIQKMLR--EVPADYEKVYLEYARRGARVLALGI *:*:. :**:** : : . ** .: . :: * **:**. ENST00000310773 RKLESKLTWHKVQNISRDAIENNMDFMGLIIMQNKLKQETPAVLEDLHKANIRTVMVTGD SINFRUP00000131248 RRLESKLTWHKVQNVNRDHLEAKMDFLGLIIMQNKLKAETAGVLHDLHKARIRTVMVTGD SINFRUP00000160771 RQLESKLSWHRIQTLSRDVIETNMEFLGLIIMQNKIKEETAGVLYQLRQANIRTLMVTGD ENST00000264733 K--KLENDHH-ATTLTRETVESDLIFLGLLILENRLKEETKPVLEELISARIRTVMITGD ENSMUST00000039090 KTLKMERLSD-MDHLAREKVESELAFLGLLIMENRLKKETRPVLKELSEARIRTVMVTGD SINFRUP00000130506 KPLDRTDNLKTIE---RRELEKDMLFLGLLMMKNMVKPQSKEVINILREAQLRCIMVTGK ENST00000290531 KPLPTVPSLEAAQQLTRDTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGD CG6230-RA KDLGTLGAQR-VREMKREEVECDLTFAGFLIISCPMKPDSKSVIKELIQSSHKVVMITGD : : : * :* .: : *:::: :* :: *: * : : :*:**. ENST00000310773 SMLTAVSVARDCGMILPQDKVIIAEALPPKDGKVAKINWHYADSL---TQCSHPSAIDPE SINFRUP00000131248 NMLTAISVARDCGMIPPQDTVIIADALPPHNGQTAKITWRYADKP---ALTTRLGEVN-- SINFRUP00000160771 NMLTAISVARDCGMVQTHERVIIVDAVPPRDFQPASITWRYTEN---------------- ENST00000264733 NLQTAITVARKSGMVSESQKVILIEANETTGSSSASISWTLVEE------KKHIMYGNQD ENSMUST00000039090 NLQTAITVAKNSEMIPVGSQVVIVEANEPGDLVPASVTWQLVGTQEPGSGKKVSRCSKTS SINFRUP00000130506 SKENLFTLL--------------------------------------------------- ENST00000290531 NLQTAVTVARGCGMVAPQEHLIIVHATHPERGQPASLEFLPMESP--------------- CG6230-RA SPLTACHVARELRFTR----KKLIILTPPEEDRKNNWSWVSIDGD-------------QS . . : : : ENST00000310773 AIPVKLVHDSLEDLQMTRYHFAMNGKSFSVILEHFQDLVPKLMLHGTVFARMAPDQKTQL SINFRUP00000131248 -ISLEDVCHEDALKRKERYHFAMNGKSFAVIAEHFPDMLHKLMLHGTVFARMAPDQKTQL SINFRUP00000160771 ------------------------------------------------------------ ENST00000264733 NYINIRDEVSDKGREGS-YHFALTGKSFHVISQHFSSLLPKILINGTIFARMSPGQKSSL ENSMUST00000039090 GWVWVGGTQPSSVPAGKGYHFAMSGKSYQVLFHHFYSMLPQILVNGTIFARMSPGQKSSL SINFRUP00000130506 ------------------------------------------------------------ ENST00000290531 ----------------------------------TAVNGVKVLVQGTVFARMAPEQKTEL CG6230-RA YELDTKPGSKKLSHLLATHDLCITGEGLQYLQQNQPQYMRQLLPQITVCARFAPKQKELV ENST00000310773 IEALQNVDYFVGMCGDGANDCGALKRAHGGISLSE------------------------- SINFRUP00000131248 IEILQDVDYYVGMCGDGANDCGALKRAHGGISLSE------------------------- SINFRUP00000160771 ------------------------------------------------------------ ENST00000264733 VEEFQKLDYFVGMCGDGANDCGALKMAHVGISLSE------------------------- ENSMUST00000039090 VEEFQKLNYYVGMCGDGANDCGALKMAHAGISLSE------------------------- SINFRUP00000130506 ---LHRCSYRVGMCGDGANDCGALRAADVGVSLSE------------------------- ENST00000290531 VCELQKLQYCVGMCGDGANDCGALKAADVGISLSQ------------------------- CG6230-RA ITQLKQLGYCTLMCGDGTNDVGALKHANVGVSLLTSAPVKRKRTEEEQQQAAANAAAIAA ENST00000310773 ----------------------------------------------LEASVASPFTSKTP SINFRUP00000131248 ----------------------------------------------LEASVASPFTSKTP SINFRUP00000160771 ------------------------------------------------------------ ENST00000264733 ----------------------------------------------QEASVASPFTSKTP ENSMUST00000039090 ----------------------------------------------QEASVASPFTSKTA SINFRUP00000130506 ----------------------------------------------AEASVASPFTSKSE ENST00000290531 ----------------------------------------------AEASVVSPFTSSMA CG6230-RA QAQANANQQLTTRERALRRRQEHLNQTQARLQNALRDMEEQTMVKLGDASIAAPFTSKSS ENST00000310773 SISCVPNLIREGRAALITSFYLLSCELALFSIVTYSLDHFIISIL------------ISN SINFRUP00000131248 NISCVPSLIREGRAALITSFCVFK-FMALYSIIQYISVTLLYSILSNLGDFQFLFIDIAI SINFRUP00000160771 ------------------------------------------------------------ ENST00000264733 NIECVPHLIKEGRAALVTSFCMFK-YMALYSMIQETNSLSNYQFLFQ---------DLAI ENSMUST00000039090 NIECVPHLIREGRAALVSS----------------------------------------- SINFRUP00000130506 NISCVPMLISEGRCSLITSFSLFR-YMALYSLCQFSSVLILYTLKTNLGDLQFLFVDICL ENST00000290531 SIECVPMVIREGRCSLDTSFSVFK-YMALYSLTQFISVLILYTINTNLGDLQFLAIDLVI CG6230-RA SIMCVNHIIKQGRCTLVTTLQMFK-ILALNALIQAYCQSVLYIDGIKFSDTQATMQGIFI ENST00000310773 MLVLFFSDFHNCAFYSLV------------------------------------------ SINFRUP00000131248 ILLIVFTMSLNAAWKELVSCRPPSGLISAPLLLSVITQILICLGFQIFTFLLVKQQPCVC SINFRUP00000160771 ------------------------------------------------------------ ENST00000264733 TTLIGVTMNLNGAYPKLVPFRPAGRLISPPLLLSVIFNILLSLAMHIAGFILVQRQPWYS ENSMUST00000039090 ------------------------------------------------------------ SINFRUP00000130506 MTSLALLMGRGGPSQELHACRPPASLLALPVLGSIFLHTCMIAAGQLAALFTTMSQEWYI ENST00000290531 TTTVAVLMSRTGPALVLGRVRPPGALLSVPVLSSLLLQMVLVTGVQLGGYFLTLAQPWFV CG6230-RA AACFLFITR-AKPLKTLSKVAPLPNIFNFYTISTILSQFAVHFGTLYYLTSQANILAPPR ENST00000310773 ------------------------------------------------------------ SINFRUP00000131248 NQSSYINKSDLNDTEADDHN------------IQNFENTSIFYVSCFQYLIVAIVFSKGK SINFRUP00000160771 ------------------------------------------------------------ ENST00000264733 VEIHSACTVQNESISELTMSPTAPEKMESNSTFTSFENTTVWFLGTINCITVALVFSKGK ENSMUST00000039090 ------------------------------------------------------------ SINFRUP00000130506 PLNSTTKIGQEN--------------------LPNMENSSVFVLSGFQFIIMAVVVTKGY ENST00000290531 PLN-RTVAAPDN--------------------LPNYENTVVFSLSSFQYLILAAAVSKGA CG6230-RA EGKVKLYIDMDAEEKTKYDP--------------NIVSSTVYIICLSLQVATIAVNYKGY ENST00000310773 ------------------------------------------------------------ SINFRUP00000131248 PFRQPSYKN--------------------------------------------------- SINFRUP00000160771 ------------------------------------------------------------ ENST00000264733 PFRQPTYTNYIFVLVLIIQLGVCLFILFADIPELYRRLDLLCTPVLWRASIVIMLSLNFI ENSMUST00000039090 ------------------------------------------------------------ SINFRUP00000130506 PHKKPLYYNR---------------------------MFLCLVLLLFAVMTWLVIYPGEF ENST00000290531 PFRRPLYTNERARPVPPRLP-----APPPAQAGLQEALQAAGTRAGRAALAAAARRPPEV CG6230-RA PFMESLRSNRMLMYAIGASAALVILLSTGLAPELTEFFEIIDFPTDFRKTLLGVLVLDIV ENST00000310773 ------------------------------------------------------------ SINFRUP00000131248 ------------------------------------------------------------ SINFRUP00000160771 ------------------------------------------------------------ ENST00000264733 VSLVAEEAVIENRALWMMIKRCFGYQSKSQYRIWQRDLANDPSWPPLNQTSHSDMPECGR ENSMUST00000039090 ------------------------------------------------------------ SINFRUP00000130506 LTETLKLYNFPDVQFKFLLVALAALN-------FFLCFVIE------------------- ENST00000290531 VQAHGHPRHWNSLPLSHQLDPSPATPPPPPPTSLRLATVYTPPPRPPPPWGSVDYCPLPW CG6230-RA GAFLLDRICSFLFGETRRKSKVLNC----------------------------------- ENST00000310773 ------------------ SINFRUP00000131248 ------------------ SINFRUP00000160771 ------------------ ENST00000264733 GVSYSNPVFESNEEQL-- ENSMUST00000039090 ------------------ SINFRUP00000130506 ------------------ ENST00000290531 TIPRRGGSPQLPSVLLSV CG6230-RA ------------------