CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000025544 -------------------------------------------------- ENST00000265284 -------------------------------------------------- ENSMUST00000058172 -------------------------------------------------- ENST00000251737 -------------------------------------------------- ENST00000267900 RARRSPGKAAGRCPPSPRRTKPAPAARPRRPPTTLPPAPRLFVSTWGGRP ENSMUST00000034820 -------------------------------------------------- SINFRUP00000149795 -------------------------------------------------- Q98TH2_Brachydanio_rerio -------------------------------------------------- SINFRUP00000165042 -------------------------------------------------- CG8384-RB -------------------------------------------------- : ::: ENSMUST00000025544 -------------------------------------------------- ENST00000265284 -------------------------------------------------- ENSMUST00000058172 -------------------------------------------------- ENST00000251737 -------------------------------------------------- ENST00000267900 TLGFRCENELGGPGASSRFPGRPPLGLGSPLPRTSPARALGASTLSESRP ENSMUST00000034820 -------------------------------------------------- SINFRUP00000149795 -------------------------------------------------- Q98TH2_Brachydanio_rerio -------------------------------------------------- SINFRUP00000165042 -------------------------------------------------- CG8384-RB -------------------------------------------------- : : : : : : : : : ENSMUST00000025544 ---MYPQTRHPAPHQPA-QPFKFTISESCDRIKEEFQFLQAQYHSLKLEC ENST00000265284 ---------------------------NVLWVEYRNAQAETVFHKLKAVA ENSMUST00000058172 ---MFPQSRHPTPHQAAGQPFKFTIPESLDRIKEEFQFLQAQYHSLKLEC ENST00000251737 -------------------------------------------------- ENST00000267900 LPAMYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEY ENSMUST00000034820 ----CPCG-LQAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEY SINFRUP00000149795 ------------PHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEY Q98TH2_Brachydanio_rerio ---MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEY SINFRUP00000165042 --------------------------------------------SLKVEY CG8384-RB -MYPSPVRHPAAGGPPPQGPIKFTIADTLERIKEEFNFLQAQYHSIKLEC : : : : : : ENSMUST00000025544 EKLASEKTEMQRHYVMYYEMSYG--LNIEMHKQAEIVKRLNAICAQVIPF ENST00000265284 TLNGAVLPIACAHFVS------------LCHILAEIVKRLNAICAQVIPF ENSMUST00000058172 EKLASEKTEMQRHYVMYYEMSYG--LNIEMHKQTEIAKRLNTICAQVIPF ENST00000251737 -------------------------------------------------- ENST00000267900 DKLANEKTEMQRHYVMYYEMSYG-LNIEMHKQT-EIAKRLNTILAQIMPF ENSMUST00000034820 DKLANEKTEMQRHYVMYYEMSYG-LNIEMHKQT-EIAKRLNTILAQIMPF SINFRUP00000149795 DKLANEKTEMQRHYVMVENIIIESDNGSIAKLVGALLWQPILITCVVVIV Q98TH2_Brachydanio_rerio DKLANEKTEMQRHYVMYYEMSYG-LNIEMHKQT-EIAKRLNAILAQIMPF SINFRUP00000165042 DKLANEKTEMQRHYVMDY-----------------VSKPVCVSVCVKLML CG8384-RB EKLSNEKTEMQRHYVMYYEMSYG--LNVEMHKQTEIAKRLNTLINQLLPF : : : : . ENSMUST00000025544 LSQEHQQQVVQAVERAKQVTMAELNAIIGQ----------QQLQAQHLSH ENST00000265284 LSQEHQQQVVQAVERAKQVTMAELNAIIG-----------QQLQAQHLSH ENSMUST00000058172 LSQEHQQQVAQAVERAKQVTMAELNAIIGQ----------QQLQAQHLSH ENST00000251737 -------------------------------------------------- ENST00000267900 LSQEHQQQVAQAVERAKQVTMTELNAIIG----------QQQLQAQHLSH ENSMUST00000034820 LSQEHQQQVAQAVERAKQVTMTELNAIIG----------QQQLQAQHLSH SINFRUP00000149795 VECQHQQQVAQAVERAKQVTMTELNAIIGVRGLPNLPLTQQQLQAQHLSH Q98TH2_Brachydanio_rerio LSQEHQQQVAQAVERAKQVTMTELNAIIGVRGLPNLPLTQQQLQAQHLSH SINFRUP00000165042 YLCQHQQQVAQAVERAKQVTMTELNAIIG----------QQQLQAQHLSH CG8384-RB LQADHQQQVLQAVERAKQVTMQELNLIIG-----------QQIHAQQVPG : : : : : :: : : ENSMUST00000025544 G-HGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQSHLPIKDEKK ENST00000265284 G-HGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQSHLPIKDEKK ENSMUST00000058172 G-HGPPVPLTPHPSGLQPPGIPPLGGSASLLALSSALSGQSHLAIKDDKK ENST00000251737 --------------------------------MTRSTTMQSTTEVRG--- ENST00000267900 ATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALGALGSQAHLTVKDEKN ENSMUST00000034820 ATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALGALGSQAHLAVKDEKN SINFRUP00000149795 AAHGPPVQLPPHPSGLQPPGIPPVTGSGSGLLALGALGSQAHLPVKDEKN Q98TH2_Brachydanio_rerio AAHGPPVQLPPHPSGLQPPGIPPVTGSGSGLLALGALGSQAHLPVKDEKN SINFRUP00000165042 AAHGPPVQLPPHPSGLQPPGLPPVTGAGSGLLALGALGSQAHLPVKDEKN CG8384-RB GPPQPMGALNPFGALGATMGLP---HGPQGLLNKPPEHHRPDIKPTGLEG : : : : . :. . ENSMUST00000025544 HHDNDHQRERALRS-------SSSVSPSASFRGS-EKHRNSTDYSSESKK ENST00000265284 HHDNDHQRDRDSIK-------SSSVSPSASFRGA-EKHRNSADYSSESKK ENSMUST00000058172 HHDAERHRDREPGT-------SNSLLVPDSLRGT-DKRRNGPEFSSDIKK ENST00000251737 ------------RA-------SNSLLVPDSLRGT-DKRRNGPEFSNDIKK ENST00000267900 HHELDHRERESSA--------NNSVSPSESLRAS-EKHRGSADYSMEAKK ENSMUST00000034820 HHELDHR-GSSSS--------NNSVSPSESLRAS-EKHRGSADYSMEAKK SINFRUP00000149795 HHDLEHR-VWSLQ--------NNSISPSESLHTSSEKHRSSSDYSLDSKK Q98TH2_Brachydanio_rerio HHDLEHRERESST--------NNSVSPSDSLRAS-EKHRGSSEYSLDPKK SINFRUP00000165042 HHDLEHRGNWRLMRFLAFVWQNNSVSPSDSLRAASEKHRGSSDYNHDPKK CG8384-RB PAAAEER-------------LRNSVSPADREKYR---TRSPLDIENDSKR .*: . : *. : . : *: ENSMUST00000025544 QKTEEKEIAARYDSDGEKSDDNLVVDVSNE-DPSSPRGSPAHSPREN--- ENST00000265284 QKTEEKEIAARYDSDGEKSDDNLVVDVSNE-DPSSPRGSPAHSPREN--- ENSMUST00000058172 RKVDDKD---NYDSDGDKSDDNLVVDVSNE-DPSSPHASPTHSPREN--- ENST00000251737 RKVDDKDSS-HYDSDGDKSDDNLVVDVSNE-DPSSPRASPAHSPREN--- ENST00000267900 RKAEEKDSLSRYDSDGDKSDD-LVVDVSNE-DPATPRVSPAHSPPEN--- ENSMUST00000034820 RKAEEKDSLSRYDSDGDKSDD-LVVDVSNE-DPATPRVSPAHSPPEN--- SINFRUP00000149795 RKVEEKDSMSRYDSDGEKSDD-LVVDVSNE-DPATPRASPAHSPPEN--- Q98TH2_Brachydanio_rerio RRVEEKDNMSRYDSDGDKSDD-LVVDVSNE-DPATPRVSPSHSPPEN--- SINFRUP00000165042 RKVDDKDSMSRYDSDGDKSDD-LVVDVSNE-DPATPRVSPAHSPPEN--- CG8384-RB RKDEKLQ-----EDEGEKSDQDLVVDVANEMESHSPRPNGEHVSMEVRDR :: :. : :.:*:***: *****:** :. :*: . * . * ENSMUST00000025544 -GLDKTRLLKKD----APISPASVASSSSTPSSKSKELSLNEKSTTPVSK ENST00000265284 -GLDKTRLLKKD----APISPASIASSSSTPSSKSKELSLNEKSTTPVSK ENSMUST00000058172 -GIDKNRLLKKD----ASGSPASTASSGSSSSLKSKEVSLHEKANTPVLK ENST00000251737 -GIDKNRLLKKD----ASSSPASTASSASSTSLKSKEMSLHEKASTPVLK ENST00000267900 -GLDKARSLKKD----APTSPASVASSSSTPSSKTKDLGHNDKSSTPGLK ENSMUST00000034820 -GLDKARGLKKD----APTSPASVASSSSTPSSKTKDLGHNDKSSTPGLK SINFRUP00000149795 -GIDKTRPPKKD----TPNSPASVASSGSTPSSKAKELGHNDKSSTPGLK Q98TH2_Brachydanio_rerio -GLDKARALKKD----APNSPASVASSGSTPSSKAKDHPHNDKSSTPGLK SINFRUP00000165042 -GLDKSRVLKKDV---APNSPASVASSGSTPSSKAKDHAHNDKSSTPSLK CG8384-RB ESLNGERLEKPSSSGIKQERPPSRSGSSSSRSTPSLKTKDMEKPGTPGAK .:: * * . *.* :.*.*: * : . :*. ** * ENSMUST00000025544 SNTPTPRTDAPTPGSNSTPGLRPV-PGKPPGVDPLA-----SSLRTPMAV ENST00000265284 SNTPTPRTDAPTPGSNSTPGLRPV-PGKPPGVDPLA-----SSLRTPMAV ENSMUST00000058172 SSTPTPRSDMPTPGTSATPGLRPG-LGKPPAMEPLVN-QAAAGLRTPLAV ENST00000251737 SSTPTPRSDMPTPGTSATPGLRPG-LGKPPAIDPLVN-QAAAGLRTPLAV ENST00000267900 SNTPTPRNDAPTPGTSTTPGLRSMP---------------ASALRTPISI ENSMUST00000034820 SNTPTPRNDAPTPGTSTTPGLRSMPGKPP-GMDPIG--IMASALRTPITL SINFRUP00000149795 SNTPTPRNDAPTPGTSSTPGLRPI-LGKPPGMEALA----APALRTPLSI Q98TH2_Brachydanio_rerio SNTPTPRNDAPTPGTSNTPGLRPH-PGKPPGMEALT----APALRTPLSI SINFRUP00000165042 SNTPTPRNEAPTPGTSTTPGLRPLTMGKPPGMEALISPAAAPALRTPLSI CG8384-RB ARTPTPNAAAPAPGVNPKQ----------------------------MMP : ****. *:** . . : : : ENSMUST00000025544 PCPYPTPFGIVPHAGMNGELTSPGAAYAGLHNISPQMS-AAAAAAAAAAA ENST00000265284 PCPYPTPFGIVPHAGMNGELTSPGAAYAGLHNISPQMS-AAAAAAAAAAA ENSMUST00000058172 PGPYPAPFGMVPHAGMNGELTSPGAAYAGLHSMSPQMSAAAAAAAAAVVA ENST00000251737 PGPYPAPFGMVPHAGMNGELTSPGAAYASLHNMSPQMS--AAAAAAAVVA ENST00000267900 TSSYAAPFAMMSHHEMNGSLTSP-GAYAGLHNIPPQMSA---AAAAAAAA ENSMUST00000034820 TSSYPAPFAMMSHHEMNGSLTSP-SAYAGLHNIPSQMSA---AAAAAAAA SINFRUP00000149795 AGSYPTPFAMMGHHEMNGGLTSP-GVYAGLH-ISPQMS------AAAAAA Q98TH2_Brachydanio_rerio APPYGTPFMMGHHPEMNGSLTSP-GVYPGLH-ISPQMS------AAAAAA SINFRUP00000165042 AG-YASPFAMMGHHEMNGSLTSP-SVYPGL--ISPQMS------AAAAAA CG8384-RB QGPPPAGYPGAPYQRPADPYQRP----------------------PSDPA : : : . * : : : .: * ENSMUST00000025544 YGRSPVV--------GFDPHHHMRVPAIPPNLTGIPGGKPAYSFHVSADG ENST00000265284 YGRSPVV--------GFDPHHHMRVPAIPPNLTGIPGGKPAYSFHVSADG ENSMUST00000058172 YGRSPMV--------GFDPPPHMRVPSIPPNLAGIPGGKPAYSFHVTADG ENST00000251737 YGRSPMV--------GFDPPPHMRVPTIPPNLAGIPGGKPAYSFHVTADG ENST00000267900 YGRSPMVSFG---AVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSADG ENSMUST00000034820 YGRSPMVSFG---AVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSADG SINFRUP00000149795 YGRSPM---------GFDPHTHMRAPGLPASLTSISGGKPAYSFHVSADG Q98TH2_Brachydanio_rerio YGRTHMP--------GFDPHPHMRAPVLPASLTSIPGGKPAYSFHVSADG SINFRUP00000165042 YGRSPIVSYLRGCRAGFDPHPHMRAPGLPASLTSIPGGKPAYSFHVSADG CG8384-RB YGRPPPMP--------YDPHAHVRTNGIP-HPSALTGGKPAYSFHMNGEG ***. :** :*. :* :.:.*********:..:* ENSMUST00000025544 QMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGK ENST00000265284 QMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGK ENSMUST00000058172 QMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGK ENST00000251737 QMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGK ENST00000267900 QMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGK ENSMUST00000034820 QMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGK SINFRUP00000149795 QMQPVPFPPDALIGPRIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGK Q98TH2_Brachydanio_rerio QMQPVPFPPDALIGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGK SINFRUP00000165042 QMQPVPFPPDALIGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGK CG8384-RB SLQPVPFPPDALVGVGIPRHARQINTLSHGEVVCAVTISNPTKYVYTGGK .:****** *** * ***********.**************::****** ENSMUST00000025544 GCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCRLLPDGRTLIVGGEASTL ENST00000265284 GCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCRLLPDGRTLIVGGEASTL ENSMUST00000058172 GCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTL ENST00000251737 GCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTL ENST00000267900 GCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTL ENSMUST00000034820 GCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLNCG------ SINFRUP00000149795 GCVKIWDISQPGSKSPVSQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTL Q98TH2_Brachydanio_rerio GCVKIWDISQPGSKSPVSQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTL SINFRUP00000165042 GCVKIWDISQPGSKSPVSQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTL CG8384-RB GCVKVWDISQPGNKNPVSQLDCLQRDNYIRSVKLLPDGRTLIVGGEASNL ****:****:**.*.*:******:******* :***** ** * : ENSMUST00000025544 SIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLH ENST00000265284 SIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLH ENSMUST00000058172 SIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLH ENST00000251737 SIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLH ENST00000267900 TIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLH ENSMUST00000034820 -------CTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLH SINFRUP00000149795 TIWDLASQTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLH Q98TH2_Brachydanio_rerio TIWDLASQTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLH SINFRUP00000165042 TIWDLASQTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLH CG8384-RB SIWDLASPTPRIKAELTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLH : : **********:************:****************** ENSMUST00000025544 NQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQH ENST00000265284 NQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQH ENSMUST00000058172 NQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQH ENST00000251737 NQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQH ENST00000267900 NQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQH ENSMUST00000034820 NQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQH SINFRUP00000149795 NQTLVR-------------------------------------------- Q98TH2_Brachydanio_rerio NQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQH SINFRUP00000165042 NQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQH CG8384-RB NEILVRQFQGHTDGASCIDISPDGSRLWTGGLDNTVRSWDLREGRQLQQH *: *** : : : : : : : : ENSMUST00000025544 DFTSQIFSLGYCPTGEWLAVGMENSNVEVLHVTKPDKYQLHLHESCVLSL ENST00000265284 DFTSQIFSLGYCPTGEWLAVGMENSNVEVLHVTKPDKYQLHLHESCVLSL ENSMUST00000058172 DFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSL ENST00000251737 DFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSL ENST00000267900 DFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSL ENSMUST00000034820 DFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSL SINFRUP00000149795 -------------------------------------------------- Q98TH2_Brachydanio_rerio DFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSL SINFRUP00000165042 DFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSL CG8384-RB DFSSQIFSLGYCPTGDWLAVGMENSHVEVLHASKPDKYQLHLHESCVLSL : :: : : : : : :: : : :: : ENSMUST00000025544 KFAHCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYI ENST00000265284 KFAHCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYI ENSMUST00000058172 KFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYI ENST00000251737 KFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYI ENST00000267900 KFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYI ENSMUST00000034820 KFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYI SINFRUP00000149795 -------------------------------------------------- Q98TH2_Brachydanio_rerio KFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYI SINFRUP00000165042 KFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYI CG8384-RB RFAACGKWFVSTGKDNLLNAWRTPYGASIFQSKETSSVLSCDISTDDKYI : :: :: :: :: : : ENSMUST00000025544 VTGSGDKKATVYEVIY ENST00000265284 VTGSGDKKATVYEVIY ENSMUST00000058172 VTGSGDKKATVYEVIY ENST00000251737 VTGSGDKKATVYEVIY ENST00000267900 VTGSGDKKATVYEVIY ENSMUST00000034820 VTGSGDKKATVYEVIY SINFRUP00000149795 ---------------- Q98TH2_Brachydanio_rerio VTGSGDKKATVYEVIY SINFRUP00000165042 VTGSGDKKATVYEVIY CG8384-RB VTGSGDKKATVYEVIY : : ::