CLUSTAL W (1.82) multiple sequence alignment ENST00000322038 -------------------------------------------------- ENSMUST00000060303 --------------YVPEEELKAAEIDEEHAEDGGLSLDIQESEFACN-- Q8QGQ9_Brachydanio_rerio -------------------------------------------------- SINFRUP00000154262 -----------------DELKAATQDEEEHLQDDGLSLDGQDNEFLCNEE ENST00000240587 -------------------------------------------------- ENSMUST00000059274 LPSSSLFSPVIMAAYVSDELKAAALVEDDVEPEEQAADGEPSAKYMCPEK ENST00000317743 --------AGYAQEEQLKEEEEIKEEEEEEDSGSVAQLQGGNDTGTDEEL CG12630-RA ------------------------------MLHEAVMLEIYRQALSASEL ENST00000322038 -------------------------------------------------- ENSMUST00000060303 -EETEIKEAQSYQNSPVSTATNQDAGYGSPFSEGSDQLAHFKSSSSREEK Q8QGQ9_Brachydanio_rerio -------------------------------------------------- SINFRUP00000154262 EEDADGGQPTSYRDSPLSNGTNHDAGYGSPLSDASDRLPDFKSNSSREGQ ENST00000240587 -------------------------------------------------- ENSMUST00000059274 ELSKACP---SYQNSPAAEFSSHEMDSESHISETSDRMADFESSSIKNEE ENST00000317743 ETGPEQKGCFSYQNSPGSHLSNQDAENESLLSDASDQVSDIKSVCGRDAS CG12630-RA TSPRCQSRDSNTSAGAGAGMADVRCPSNESHCSANDRLTPAATPTLTPTE ENST00000322038 -------------------------------------------------- ENSMUST00000060303 EESQC-----PDSVSYPQDSLAQIKAVYANLFSESCWSSLALDLKKSNSA Q8QGQ9_Brachydanio_rerio -------------------------------------------------- SINFRUP00000154262 DREGAALPFRPNNGLSFQDSLAQMKAVYANLLSDASWSSITMDIMKSNSV ENST00000240587 -------------------------------------------------- ENSMUST00000059274 ETKEVQVPLEDTIVS---DSLEQMKAVYNNFLSNSYWSNLNLNLHQPSSE ENST00000317743 DKKAHTHVRLPNEAHN---CMDKMTAVYANILSDSYWSGLGLGFKLSNSE CG12630-RA ATISPNSVGLPLTATLPPAAAVALLPPQS--------------------- ENST00000322038 -------------------------------------------------- ENSMUST00000060303 TSNNDASQKESSTPTPTPPTSTASTACTTATTAITSCSTSTSHSSTTSNS Q8QGQ9_Brachydanio_rerio -------------------------------------------------- SINFRUP00000154262 G---------------------------------------------ASNG ENST00000240587 -------------------------------------------------- ENSMUST00000059274 NNG----------------------------------GSSSSSSSSSSSC ENST00000317743 RRN----------------------------------------CDTRNGS CG12630-RA -------------------------------------------------- ENST00000322038 -------------------------------------------------- ENSMUST00000060303 SSSGYDWHQAALAKTLQQTSSYGLLPEPSLFSTVQLYRQNNKLYGSVFTG Q8QGQ9_Brachydanio_rerio -------------------------------------------------- SINFRUP00000154262 GGVAYDWHQAALAKTLQQTP-YHLLPEPSLFSTVQLYRQNNKLYGSVFTG ENST00000240587 -----------------------MLPEPSLFSTVQLYRQSSKLYGSIFTG ENSMUST00000059274 GSGSFDWHQSAMAKTLQQVSQNRMLPEPSLFSTVQLYRQSSKLYGSIFTG ENST00000317743 NKSDFDWHQDALSKSLQQNLPSRSVSKPSLFSSVQLYRQSSKMCGTVFTG CG12630-RA ------AAMAAYLAAAQQNHLLLTNPLAAAASLVQHATQQAVVEGEVESP ENST00000322038 -------------------------------------------------- ENSMUST00000060303 ASKFRCKDCSAAYDTLVELTVHMNETGHYRDDNRDKDSEKTKRWSKPRKR Q8QGQ9_Brachydanio_rerio ----------------------MNETGHYRDDNKDKEEDRGKKWSKPRKR SINFRUP00000154262 ASKFRCKDCSAAYDTLVGLTVHMNETGHYRDDNKEKEEEQGKRWSKPRKR ENST00000240587 ASKFRCKDCSAAYDTLVELTVHMNETGHYRDDNHETDNNNPKRWSKPRKR ENSMUST00000059274 ASKFRCKDCSAAYDTLVELTVHMNETGHYRDDNHETDNNNPKRWSKPRKR ENST00000317743 ASRFRCRQCSAAYDTLVELTVHMNETGHYQDDNRKKDKLRPTSYSKPRKR CG12630-RA ALDFSRKRPKSHGDDDQEEDQEQDQEQEQEQEPDHDVQCDNGPLDLSVST ENST00000322038 -------------------------------------------------- ENSMUST00000060303 SLMEMEGKEDAQKVLKCMYCGHSFESLQDLSVHMIKTKHYQKVPLKEPVP Q8QGQ9_Brachydanio_rerio SLMEMEGKEDAQKVLKCMYCGHSFESLQDLSVHMIKTKHYQKVPLKEPMP SINFRUP00000154262 SLMEMEG-EDAQKVLKCMYCGHSFESLQDLSVHMIKTKHYQKVPLKEPVP ENST00000240587 SLLEMEGKEDAQKVLKCMYCGHSFESLQDLSVHMIKTKHYQKVPLKEPVT ENSMUST00000059274 SLLEMEGKEDAQKVLKCMYCGHSFESLQDLSVHMIKTKHYQKVPLKEPVT ENST00000317743 AFQDMDK-EDAQKVLKCMFCGDSFDSLQDLSVHMIKTKHYQKVPLKEPVP CG12630-RA GKRQESVSPPARKIPRSISA--DYKSPLPPGSWMPPINPYLAAVAAKTGG : : : ENST00000322038 ---------------------------------MAAEVALSESAKDQK-A ENSMUST00000060303 AIT-KLVP-STKKRALQD-LASPCSPE---PTGVATEVALSESAKDQK-T Q8QGQ9_Brachydanio_rerio ALASKLVP-STKKRVFQD-LMSPCSPDSISS-TPGIPLAETAPTKDPK-I SINFRUP00000154262 ALATKLVPSSAKKRALQDAVVSPCSPDSVHTGGVGGSVSLGDIGKDAKSA ENST00000240587 PVAAKIIPATRKKASLELELPS--SPD---STGGTPKATISDTNDALQKN ENSMUST00000059274 PVAAKIIPAARKKPSLELELPS--SPD---STGGTPKATLSDASDALQKN ENST00000317743 TISSKMVTPAKKR---VFDVNRPCSPD-------STTGSFADSFSSQK-N CG12630-RA LGYSKLAPSEASKALEKMTEMSRLETS--------PTAARSLGATSSVGA : : : ENST00000322038 ANPYVTPNNRYGYQNGASYTWQFEARK--AQILKCMECGSSHDTLQQLTA ENSMUST00000060303 ANPYVTPNNRYGYQNGASYTWQFEARK--AQILKCMECGSSHDTLQQLTA Q8QGQ9_Brachydanio_rerio SNPYVTANNRYGYQNGASYTWQFEARK--AQILKCMECGSSHDTLQQLTA SINFRUP00000154262 ANPYVTPNNRYGYQNGASYTWQFEARK--AQILKCMECGSSHDTLQQLTA ENST00000240587 SNPYITPNNRYGHQNGASYAWHFEARK--SQILKCMECGSSHDTLQELTA ENSMUST00000059274 SNPYITPNNRYGHQNGASYAWHFEARK--SQILKCMECGSSHDTLQELTA ENST00000317743 ANLQLSSNNRYGYQNGASYTWQFEACK--SQILKCMECGSSHDTLQQLTT CG12630-RA GVPAGASSNSGGRHSAWQSHWLNKGADTAKDVFKCVWCKQSFSTLANLTA . :..* * :.. . * :. . :::**: * .*..** :**: ENST00000322038 HMMVTGHFLKVTTSASKKGKQLVLDPV-------VEEKIQSIPLPPTTHT ENSMUST00000060303 HMMVTGHFLKVTTSASKKGKQLVLDPV-------VEEKIQSIPLPPTTHT Q8QGQ9_Brachydanio_rerio HMMVTGHFLKVTNSASKKGKQLVFDPV-------VEEKIQSIPLPPTT-T SINFRUP00000154262 HMMVTGHFLKVTNSASKKGKQLVFDPV-------LEEKIQSIPLPPTT-T ENST00000240587 HMMVTGHFIKVTNSAMKKGKPIVETPVTPTITTLLDEKVQSVPLAATT-- ENSMUST00000059274 HMMVTGHFIKVTNSAMKKGKPIMETPVTPTITTLLDEKVQSVPLAATT-- ENST00000317743 HMMVTGHFLKVTSSASKKGKQLVLDPL-------AVEKMQSLSEAPNSDS CG12630-RA HMKETQHCGVQIPSPLPTGG--VGTPS--------APPPTRLATSASNSA ** * * *. .* :: * :. .... ENST00000322038 RLPASS-IKKQPDSPAGSTTSEEKKEPEKEKPP----VAGDAEKIKEESE ENSMUST00000060303 RLPASS-IKKQPDSPAGSVASEEKKLRRRRKRRKPHRQLGMQRKIKEETE Q8QGQ9_Brachydanio_rerio RLPAPA-IKSQPDSPIHPSIMDDRKEL-EEEKFE----EPEEKKIKQEKE SINFRUP00000154262 RLPVPASVKSQPVSPALSSGSEDRREAGEEEKSES--GEPLEKKIKEEKE ENST00000240587 -FTSPS---NTPASISPKLNVEVKKEVDKEKAVT-------DEKPK-QKD ENSMUST00000059274 -FTSPS---NTPASVSPKLAVEIKKEVDKEKAVP-------DEKPK-ERE ENST00000317743 LAPKPS---SNSASDCTASTTELKKESKKERPEE----TSKDEKVVKSED CG12630-RA CSSSSS----STSSSSNSSKSELNMLIKETMPLPRKLVRGQDVWLGKGAE . .: : . * : . . : ENST00000322038 DSLEKFEP---STLYPYLREEDLDDSPKGGLDILKSLENTVSTAISKAQN ENSMUST00000060303 DATEKFEP---TALYQYLREEDLDDSPKGGVDILKSLENTVSTAISKAQN Q8QGQ9_Brachydanio_rerio DPSERVEKSEKLSHYKYLREEDLEESPKGGLDILKSLENTVSSAISKAQT SINFRUP00000154262 EPGEKSE--TDATSYKYLREEDLEETPKEGLDILKSLENTVSSAISKAQT ENST00000240587 KPGEEEEKCDISSKYHYLTENDLEESPKGGLDILKSLENTVTSAINKAQN ENSMUST00000059274 KPSEEEEKYDISSKYHYLTENDLEESPKGGLDILKSLENTVTSAINKAQN ENST00000317743 YEDPLQKPLDPTIKYQYLREEDLEDGSKGGGDILKSLENTVTTAINKAQN CG12630-RA QTRQILKCMWCGQSFRSLAEMTSHMQETQHYTNIISQEQIISWKSGDERE : : * * . . : * *: :: .. : ENST00000322038 GAPSWGGYPSIHAAYQLPGTVKPLP----AAVQSVQVQPSYAGGV-KSLS ENSMUST00000060303 GAPSWGGYPSIHAAYQLPGTVKPLQ----SAVQSVQIQPSYASSV-KSLS Q8QGQ9_Brachydanio_rerio GTPTWGGYPSIHAAYQLQGSVKSS----IPAIQSVQIQPTFNASS-LKSL SINFRUP00000154262 GTPTWGGYSSIHAAYQLQGSIKNSATALPPMVQSVQMQPVFNSG--LRGL ENST00000240587 GTPSWGGYPSIHAAYQLPNMMKLSLG---SSGKSTPLKPMFGNSE-IVSP ENSMUST00000059274 GTPSWGGYPSIHAAYQLPNMMKLSLG---SSGKSTPLKPMFGNSE-IVSP ENST00000317743 GAPSWSAYPSIHAAYQLSEGTKPPLP---MGSQVLQIRPNLTNKLRPIAP CG12630-RA RPTNTGVPSTSTAAPSSPSCTAPSVS---AVLTCKVCDQAFGSLKELSTH ... . .: ** . ENST00000322038 SAEHNALLHSPGSLTPP-PHKSNVSAMEELVEKVTGKVNIKKEERPPEKE ENSMUST00000060303 STEHNALLHSPGSLTPP-PHKSNVSAMEELVEKVTGKVSIKKEERPTEKE Q8QGQ9_Brachydanio_rerio TSDSSTLIHSPSSPSPPPNHKSNVLAMEELVEKVTGKIPS-KKDRDEKLT SINFRUP00000154262 VNDPNSVIQSPQSPSSPTPLRSNVSAMEELVEKVTGKASAVKKEKEEKMV ENST00000240587 TKN-QTLVSPPSSQTSP-MPKTNFHAMEELVKKVTEKVAKVEEKMKEPDG ENSMUST00000059274 TKT-QTLVSPPSSQTSP-MPKTNFHAMEELVKKVTEKVAKVEEKMKEPEG ENST00000317743 KWKVMPLVSMPTHLAPYTQVKKESEDKDEAVKECG------KESPHEEAS CG12630-RA MAQKSHYKESPAPSASPPAAGTGNPKRGRQNRNEKRKKSLPVRKLLELER * :. . . .: .. ENST00000322038 ------KSSLAKAASPIAKENKDFPKTEEVSGKPQKKG-----------P ENSMUST00000060303 ------KSSPVKAISPVAKENKDLPKTEETGSKPQKKG-----------S Q8QGQ9_Brachydanio_rerio --ERNSKHLTAELPSPVLKERKDLPK-PDDLTKPTKNG----TVDKDLEH SINFRUP00000154262 TAERCRLPSLVKSPSPALREQRELLASPNDLSVGKHKSGLRSSSPGSVDS ENST00000240587 ----KLSPPKRATPSPCSSEVGEPIKMEASSDGGFRSQ--------ENSP ENSMUST00000059274 ----KLSPPKRATPSPCSSEQSEPIKMEASSDGSFKSQ--------ENSP ENST00000317743 --------SFSHSEGDSFRKSETPPEAKKTELGPLKEE-----------E CG12630-RA ----SGSNSSLDSALKPLRDFAAATKITCEKCGSKIET--------ALFV . . ENST00000322038 EAETGKAKKEGPLD---VHTPNGTEPLKAKVTNGCNNLGIIMDHSPEPSF ENSMUST00000060303 DSETGKAKKESTLD---AHTPNGTEPLKAKVTNGCGHLGIITDHSPEPSF Q8QGQ9_Brachydanio_rerio TPVREGEYKESHAD---NPIKNGTDALKTQVSNGCGNLGIITDHSPEQPL SINFRUP00000154262 EVICKKEPKESLVDGHSNNSKNSSEPCQSPVMNGN-SLGIITDHSPESPF ENST00000240587 SPPRDGCKDGSPLA---EPVENGKELVKPLASSLSGSTAIITDHPPEQPF ENSMUST00000059274 SPPRDACKEASPSA---EPVENGKELVKPLSGGLSGSTAIITDHPPEQPF ENST00000317743 KLMKEGSEKEKPQP--------------LEPTSALSNGCALANHAPALPC CG12630-RA EHIRKCLGESIPIP--PRRSNAGVDRLPSPSLGLGAEKPPSVLNALEQLI . . :. ENST00000322038 INPLSALQSIMNTHLGKVSKPV------SPSLDPLAMLYKISNSMLDKP- ENSMUST00000060303 INPLSALQSIMNTHLGKVSKPV------SPSLDPLAMLYKISNSMLDKP- Q8QGQ9_Brachydanio_rerio VNPLSALQSIMNTHLGKASKTV------SPLLDPLAMXYKISNNMMEKPM SINFRUP00000154262 ISPLSALQSIMNTHLGKASKPV------SPAADPLSMLYKISNSMMEKPS ENST00000240587 VNPLSALQSVMNIHLGKAAKPS------LPALDPMSMLFKMSNSLAEKAA ENSMUST00000059274 VNPLSALQSVMNIHLGKAAKPS------LPALDPMSMLFKMSNSLAEKAA ENST00000317743 INPLSALQSVLNNHLGKATEPLRSPSCSSPSSSTISMFHKSNLNVMDKP- CG12630-RA EKSFESRTSRTMTHGGYSEAGTP-----LGASILKRLGIEDSSDYTKPLM ..:.: * * * : : . . . ENST00000322038 --VYPATPVKQADAIDRYY-YENSDQPIDLTKSKN--------------- ENSMUST00000060303 --VYPTTPAKQADAIDRYY-YENSDQPIDLTKSKN--------------- Q8QGQ9_Brachydanio_rerio --YNP-AQVKQVEPINRYYENDD-DQPMDLTKSKSGIGPTNNCTSTIISN SINFRUP00000154262 --FTPTPQGKPAEPINHYQLYENNDQPIDLSKNKS---NSSSGGRALLTN ENST00000240587 VATPPPLQSKKADHLDRYFYHVNNDQPIDLTKGKSDKGCSLGSVLLSPTS ENSMUST00000059274 VATPPPLQAKKAEHLDRYFYHVNNDQPIDLTKGKSDKGCSLGSGLLSPTS ENST00000317743 ---VLSPASTRSASVSRRYLFENSDQPIDLTKSKS--------------- CG12630-RA DAQAMHLLRSSFASRDRSASESSSASRVESSYTPDRQQATPHKSPDTPAP . .: . . :: : . ENST00000322038 -------KPLVSSVADSVA-----SPLRESALMDISDMVKNLTGRLTPKS ENSMUST00000060303 -------KPLVSGVADAVS-----SPLRESALMDISDMVKNLTGRLTPKS Q8QGQ9_Brachydanio_rerio SSITNSTRPILSTLAEQVS-----SPLRENALMDISDMVKNLTGRLTPKS SINFRUP00000154262 SSLN-GNKPLVS-LPDPVS-----SPLRENALMDISDMVKNLTGRLTPKS ENST00000240587 TAPATSSSTVTTAKTSAVVSFMSNSPLRENALSDISDMLKNLTESHTSKS ENSMUST00000059274 TSPATSSSTVTTAKTSAVVSFMSNSPLRENALSDISDMLKNLTESHTSKS ENST00000317743 -------KKAESSQAQSCM-----SPPQKHALSDIADMVKVLPKATTPKP CG12630-RA PPPPPPTIKAEPLEAEPLVG-CDREGCSPRQQIQVKKEFSMEACRESPRS . .. . :: . .. . :.:. ENST00000322038 STPSTVS-EKSDADGSSFEEALDELSPVHKRKGRQSNWNPQHLLILQAQF ENSMUST00000060303 STPSTVS-EKSDADGSSFEEALDELSPVHKRKGRQSNWNPQHLLILQAQF Q8QGQ9_Brachydanio_rerio STPSSIS-EKSDADGCAFEDGLEDLSPIQKRKGRQSNWNPQHLLILQAQF SINFRUP00000154262 STPSSIS-EKSDADGSTFEDALEDLSPVQKRKGRQSNWNPQHLLILQAQF ENST00000240587 STPSSIS-EKSDIDGATLEEA-EESTPAQKRKGRQSNWNPQHLLILQAQF ENSMUST00000059274 STPSSIS-EKSDIDGATLEEA-EESTPAQKRKGRQSNWNPQHLLILQAQF ENST00000317743 ASSSRVPPMKLEMDVRRFEDVSSEVSTLHKRKGRQSNWNPQHLLILQAQF CG12630-RA VSKSPAPQTERSPPDNGSLLALNSMFDQLSGVENSGNNNSGHCFNNNNSC : * . : . .. . ...* *. * : : . ENST00000322038 ASSLRETTEGKYIMSDLGPQERVHISKFTGLSMTTISHWLANVKYQLRRT ENSMUST00000060303 ASSLRETAEGKYIMSDLGPQERVHISKFTGLSMTTISHWLANVKYQLRRT Q8QGQ9_Brachydanio_rerio ASSLRETPDGKYIITDLGPQERVHICKFTGLSMTTISHWLANVKYQLRRT SINFRUP00000154262 ASSLRETSEGRYAMTDLGPQERVHICKFTGLSMTTISHWLANVKYQLRRT ENST00000240587 AASLRQTSEGKYIMSDLSPQERMHISRFTGLSMTTISHWLANVKYQLRRT ENSMUST00000059274 AASLRQTSEGKYIMSDLSPQERMHISRFTGLSMTTISHWLANVKYQLRRT ENST00000317743 ASSLFQTSEGKYLLSD-GPQERMQISKFTGLSMTTISHWLANVKYQLRKT CG12630-RA SSVSAQKPK-AHPLAALQKLCETTDPPSTGLRSASSAGSSTASATLPSAN :: :... : :: : . *** :: : : . ENST00000322038 GGTKFLKNLDTGHPVFFCNDCASQFRTASTYISHLETHLGFSLKDLSKLP ENSMUST00000060303 GGTKFLKNLDTGHPVFFCNDCASQFRTASTYVSHLETHLGFSLKDLSKLP Q8QGQ9_Brachydanio_rerio GGTKFLKNIDSGHPLFLCSDCASQFRTPSTYINHLESHLGFSLKDLSKLS SINFRUP00000154262 GGTKFLKNMDSCQPVFLCSDCASQFRTPSSYISHLESHLGFSLKDLSKLS ENST00000240587 GGTKFLKNLDTGHPVFFCNDCASQIRTPSTYISHLESHLGFRLRDLSKLS ENSMUST00000059274 GGTKFLKNLDTGHPVFFCNDCASQIRTPSTYISHLESHLGFRLRDLSKLS ENST00000317743 GGTKFLKNMDKGHPIFYCSDCASQFRTPSTYISHLESHLGFQMKDMTRLS CG12630-RA GNDLVAFSWACNEAVLSASNGGSAGDSSIIKCSYCDTPFASKGAYRHHLS *. . . ..:: ..: .* :. .: :: :. :*. ENST00000322038 LNQIQEQQ-NVSKVLTNKT-----LGPLGATEEDLGSTFQCKLCNRTFAS ENSMUST00000060303 LSQIQEQQSVVSKALTNKT-----LGPLGSSEEDLGSTFQCKLCNRTFAS Q8QGQ9_Brachydanio_rerio IDLIRDQQ-AVTKMITDKT-----FRALDLNEEDSNSIFQCKLCNRTFVS SINFRUP00000154262 AEHLREQQ-AASKVITDKMTFGSPLSALATPEDDTGSVYQCRLCNRTFVS ENST00000240587 TEQINSQI-AQTKSPSEKM-------VTSSPEEDLGTSYQCKLCNRTFAS ENSMUST00000059274 TEQINNQI-AQTKSPSEKL-------VTSSPEEDLGTTYQCKLCNRTFAS ENST00000317743 VDQQSKVEQEISRVSSAQR-----SPETIAAEEDTDSKFKCKLCCRTFVS CG12630-RA KVHFVKDAGEDSPRLKSPA-------VQSPRSMPLASPRRSASRSPATGS . : . . : :. : * ENST00000322038 KHAVKLHLSKTHGKSPEDHLIYVTELEKQ------ ENSMUST00000060303 KHAVKLHLSKTHGKSPEDHLIYVTELEKQ------ Q8QGQ9_Brachydanio_rerio KHAVKLHLSKTHGKSPEDHLIFVTELEKLEKA--- SINFRUP00000154262 KHAIKLHLSKTHGKSPEDHLVFVTALEK------- ENST00000240587 KHAVKLHLSKTHGKSPEDHLLYVSELEKQ------ ENSMUST00000059274 KHAVKLHLSKTHGKSPEDHLLFVSELEKQ------ ENST00000317743 KHAVKLHLSKTHSKSPEHHSQFVTDVDEE------ CG12630-RA QQPPPSPTISPYDESPQSKFLKYTELAKQLSSKNA ::. ..:.:**: : : : :