CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000034225 ------------------------------------------------------------ ENSMUST00000038061 ------------------------------------------------------------ SINFRUP00000143191 ------------------------------------------------------------ ENSMUST00000052983 ----------------------------GRKKALVSRE-----PRRKAGGLSQNGSPSGA ENST00000318601 EKSGGPGTREREREKREERQSAWGRKERGREGWVRRRERSAANPRRRAWSPSQNSSPSRS CG6827-RA --------------------------------------------------------MRPP ENSMUST00000034225 ------MNMGSVAGAVLKMLLLLSTQNWNRVEAGNSYDCDEPLVSALPQASFSSSSELSS ENSMUST00000038061 ----------------LLLLLLLSVQTLPLVAAGDPHNCDAPLASSLPQLSFSSSSQLSS SINFRUP00000143191 ------------------------------------------------------------ ENSMUST00000052983 TRLTPSVG--QLRMMSLRLFSILLATVVSGAWGWGYYGCNEELVGPLYARSLGASSYYGL ENST00000318601 RSQGGGCRDRQPCMMHLRLFCILLA-AVSGAEGWGYYGCDEELVGPLYARSLGASSYYSL CG6827-RA RSNTKAAFSSLQFGLLCLLLLVNNGIKSVQADAFTDYFSDYDCNQPLMERAVLTATSSLT :: : : . ENSMUST00000034225 SHGPGFARLNRRDGAGGWSPLVSNKYQWLQIDLGERMEVTSVATQGGYGSSNWVTSYLLM ENSMUST00000038061 SHGPGFARLNRRDGAGGWTPLVSNKYQWLQIDLGERMEVTAVATQGGYGSSDWVTSYLLM SINFRUP00000143191 ------------------------------------------------------------ ENSMUST00000052983 FTTARFARLH---GISGWSPRIGDPNPWLQIDLMKKHRIRAVATQGAFNSWDWVTRYMLL ENST00000318601 LTAPRFARLH---GISGWSPRIGDPNPWLQIDLMKKHRIRAVATQGSFNSWDWVTRYMLL CG6827-RA ERGPDKARLN---GNAAWTPVENTYNHFLTLDLGDPRMVRKIATMGRMHTDEFVTEYIVQ : : : : : : : :: ENSMUST00000034225 FSDSGRNWKQYRQEDS-IWGFSGNANADSVVYYRLQPSIKARFLRFIPLEWNPKGRIGMR ENSMUST00000038061 FSDGGRNWKQYHQEES-ISGFPGNTNADSVVQYSLQPSFHTRFLRFLPLTWNPKGRIGMR SINFRUP00000143191 --------------------FPGNSNADSVVLHKLQHAVIARYIRIVPLDWNPSGRIGLR ENSMUST00000052983 YGDRVDSWTPFYQKGH-NATFFGNVNDSAVVRHDLHYHFTARYIRIVPLAWNPRGKIGLR ENST00000318601 YGDRVDSWTPFYQRGH-NSTFFGNVNESAVVRHDLHFHFTARYIRIVPLAWNPRGKIGLR CG6827-RA YSDDGEFWRSYVNPTSEPQMFKGNSDGNSIHYNVFEVPIIAQWVRINPTRWHDR--ISMR * ** : .:: :. . ::::*: * *: *.:* ENSMUST00000034225 IEVFGCAYRSVVIDLDGKSSLLYRFDQNSLSPIRDIISLKFKTMESDGILLHRAGPAGDH ENSMUST00000038061 IEVYGCSYKSEVVYFDGQSSLLYKFDNGAFFPLREVISLKFKAMQNSGIIFHGKGQHGTH SINFRUP00000143191 LETYGCPYASDVVGFDGSSSLLYSLSPWWKPATTDSISLKFKTLRNSGVLLHMEGQSENS ENSMUST00000052983 LGIYGCPYTSSILYFDGDDAISYRFQRGASQSLWDVFAFSFKTEEKDGLLLHTEGSQGDY ENST00000318601 LGLYGCPYKADILYFDGDDAISYRFPRGVSRSLWDVFAFSFKTEEKDGLLLHAEGAQGDY CG6827-RA VELYGCDYISENLYFNGTGLVRYDLRREPITSTKESIRFRFKTAFANGVMMYSRGTQGDY : :** * : : ::* . : * : . : : : **: .*:::: * ENSMUST00000034225 ITLELRRGKLFLLINSGDARLTSSSTLINLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEH ENSMUST00000038061 IVLELNKGKLVGYLNSGDGNLPPVNSIMNFTLGSLLDDRHWHSVLIELHNMHMNFTLDKY SINFRUP00000143191 LSLQLHGGKLLLLLQKGEP--ASPDGRYQVSLGSLLDDQYWHHVTMERRGARLDLTVDNS ENSMUST00000052983 VTLELQGAHLLLHMSLGSSPIQPRPGHTTVSLGGVLNDLSWHYVRVDRYGRDANFTLDGY ENST00000318601 VTLELEGAHLLLHMSLGSSPIQPRPGHTTVSAGGVLNDQHWHYVRVDRFGRDVNFTLDGY CG6827-RA YALQLKDNKMVLNLDLGSR------VMTSLSVGSLLDDNVWHDVVISRNQRDIIFSVDRV *:*. ::. :. *. .: *.:*:* ** * :. :::* ENSMUST00000034225 RRHFHAQGEFNYLDLDYEVCFGGISAP-AKSVSLPYKHFHGCLENLFYNGVDVIGLVKEH ENSMUST00000038061 MHHVHVNKETSYLDLNFEISFGEILMPGGRFLTFPHKNFHGCLENIYYNGVNIIKLAKKH SINFRUP00000143191 AVWVQMPHTYTRWDHD-QMSVGATHAFGSQWSAGSYGGFNGCLENLSYNGMNLIDLAKRK ENSMUST00000052983 AHHFVLNGDFERLNLENEIFIGGLVGAARKNLAYRHN-FRGCIENVIYNRINIAEMAVMR ENST00000318601 VQRFILNGDFERLNLDTEMFIGGLVGAARKNLAYRHN-FRGCIENVIFNRVNIADLAVRR CG6827-RA IVRGRIQGEFTRLNLNRELYLGG--VPNVQEGLIVQQNFSGCLENIYFNSTNFIRVMKDS : : :: .* : * **:**: :* :. : ENSMUST00000034225 SPQ----IITMGNASFSCSQPQSMPLTFLSPRSYLVLPASTKEEAI--SASFQFRTWNKA ENSMUST00000038061 ESQ----ILIKGNVSFTCPQPQTIPVTFLSSGSYLALPSSLREDKM--SLAFQLRTWNKA SINFRUP00000143191 VPQ----VTVKGNVTFSCAEPVFVAVTFNGPKSFLSLPGPTESHLIGTSIRLQFRTWNEA ENSMUST00000052983 HSR----ITFEGNVAFRCLDPVPHPINFGGPHNFVQVPGFPRRGRL--AVSFRFRTWDLT ENST00000318601 HSR----ITFEGKVAFRCLDPVPHPINFGGPHNFVQVPGFPRRGRL--AVSFRFRTWDLT CG6827-RA TELGEGYLFTRVNTIYACPSPPIYPVTFTTRSSFVRLKGYENSQRLN--VSFYFRTYEET : :. : * .* .:.* .:: : . . : : :**:: : ENSMUST00000034225 GLLLFSELQLVSGSLLLLLSDGKLKLTLYQPGKSPSDIT-AGAGLGDGQWHSVSLSAKRN ENSMUST00000038061 GHVFFSQVGHGSGSLVLFLKNGKLILNLSEPGQPLQSIT-TGAVLNDGLWHSVSVSAKGS SINFRUP00000143191 GLLLTFNLPMHSGAVWLYLSNARLHLLVHKAGRARLELS-AGSALNDGQWHSVALNSRKG ENSMUST00000052983 GLLLFSHLGDGLGHVELMLSEGQVNVSIAQTGRKKLQFA-AGYRLNDGFWHEVNFVAQEN ENST00000318601 GLLLFSRLGDGLGHVELTLSEGQVNVSIAQSGRKKLQFA-AGYRLNDGFWHEVNFVAQEN CG6827-RA GVMLHHDFYSG-GYLKVFLEFGKVKIDLKVKDKARIILDNYDDQFNDGKWHSFVISIEKN * :: . * : : *. .:: : : .: : . :.** **.. . . . ENSMUST00000034225 HLSVVVDGHISPASPWLGPEQVNSGGVFYFGGCPDKGFGSKCKSPLGGFQGCMRLISIN- ENSMUST00000038061 YLSLLVDGDTAQT---LMSVEIHLGDTYYFGGCPNNSSSFGCEHSFGGFQGCLRLISVG- SINFRUP00000143191 RLTVTADEDEGGYAHARPPFLIVTGSQLFFGGCPVEGNLQECENPFSRFQGCMRLLAVD- ENSMUST00000052983 HAVISIDDVEGAEVRVSYPLLIRTGTSYFFGGCPKPASRWGCHSNQTAFHGCMELLKVD- ENST00000318601 HAVISIDDVEGAEVRVSYPLLIRTGTSYFFGGCPKPASRWDCHSNQTAFHGCMELLKVD- CG6827-RA RLILNIDQ---RPMTTTKSMQVATGAQYYIAGGKDK----------NGFVGCMRLISVDG : * . : * ::.* * **:.*: :. ENSMUST00000034225 NKMVDLIAVQQGALGNFSDLQIDSCGISDRCLPNSCEHGGECSQSWSTFHCNCTNTGYTG ENSMUST00000038061 DKVVDPIAVQQGVLGSFSDLQIDSCGIIDRCLPSYCEHGSRCTQSWDTFSCDCEGTGYTG SINFRUP00000143191 RQSVDLIKVQQRLMGNYSDLQTDTCGIIDRCSRSRCEHGGHCSQSWSNFHCNCTNTGYSG ENSMUST00000052983 GQLVNLTLVEFRKLGYFAEVLFDTCGITDRCSPNMCEHDGRCYQSWDDFICYCELTGYKG ENST00000318601 GQLVNLTLVEGRRLGFYAEVLFDTCGITDRCSPNMCEHDGRCYQSWDDFICYCELTGYKG CG6827-RA NYKLPQDWVKGEEVCCGDDVVVDACQMIDRCNPNPCQHKGLCHQNSREFFCDCGHTGYAG : *: : :: *:* : *** . *:* . * *. * * * *** * ENSMUST00000034225 ATCHSSVYEQSCEAYKHQGNASG--FYYIDSDGSGPLQPFLLYCNMT--ETAWTVMQHNG ENSMUST00000038061 TTCHSSIYEQSCEAHRHRGSPSG--LYYIDVDGSGPLAPFLVYCNMTA-DTAWTVVQHGG SINFRUP00000143191 ATCHSSIYEQSCEAYKHRGRNSG--YYFIDMDGSGPIRPQLLYCNMTE-DKTWTVVEHNN ENSMUST00000052983 VTCHEPLYKESCEAYRLSGKYSG--NYTIDPDGSGPLKPFVVYCDIRE-NRAWTVVRHDR ENST00000318601 ETCHTPLYKESCEAYRLSGKTSG--NFTIDPDGSGPLKPFVVYCDIRE-NRAWTVVRHDR CG6827-RA AVCHTSNNPLSCLALKNVQHVQQRVNLNLDVDGSGPLEPFPVTCEFYSDGRVITTLSHSQ .** . ** * : . : :* *****: * : *:: . *.: *. ENSMUST00000034225 SDLMRVRNTHSENAHTGVFEYT-ASMEQLQAAINRAEHCQQELVYYCKKSRLVNQQDGS- ENSMUST00000038061 PDVVTVRGGPEGHMHSATFSYA-ANAAQLHAVVNVAEHCEQQVDLQCRTSGPSDTGDGT- SINFRUP00000143191 TEPTKVRPQPGTNQLAVHFEYA-SEAEQLAAIISQSEHCEQELIYHCRRSRIFNSPDGP- ENSMUST00000052983 LWTTRVTGSSMDRPFLGAIQYWNASWEEVSALANASQHCEQWIEFSCYNSRLLNTAGGY- ENST00000318601 LWTTRVTGSSMERPFLGAIQYWNASWEEVSALANASQHCEQWIEFSCYNSRLLNTAGGY- CG6827-RA EHTTTVDGFQEPGSFEQSIMYD-ANQLQIEALLNRSHSCWQRLSYSCRSSRLFNSPSEAG * : * :. :: * . :. * * : * * : . ENSMUST00000034225 ---PRSWWVGRTN--ETQTYWGGSLPVHQKCTCGLEGNCIDAQYHCNCDADLNEWTNDTG ENSMUST00000038061 ---SLSWWVGRSN--ETYTYWGGSLPNPQKCTCGFEGNCIDSQYHCNCDADRNEWTSDTI SINFRUP00000143191 ---PFSWWVGGPNGGQVQTYWGGAPQGSRQCSCGLQQNCVDPKHQCNCDADRNEWASDSG ENSMUST00000052983 ---PYSFWIGRNE--EQHFYWGGSQPGIQRCACGLDQSCVDPALHCNCDADQPQWRTDKG ENST00000318601 ---PYSFWIGRNE--EQHFYWGGSQPGIQRCACGLDRSCVDPALYCNCDADQPQWRTDKG CG6827-RA NFRPFSWWISRHN--QPMDYWAGALPGSRKCECGILGKCHDPTKWCNCDSNSLEWMEDGG : . *:*:. : : **.*: ::* **: .* *. ****:: :* * ENSMUST00000034225 FLSYKEHLPVTKIVITDTGRPHSE--AAYKLGPLLCRGDRPFWNAASFNTEASYLHFPTF ENSMUST00000038061 VLSHKEHLPVTEMVVTDTGRPYSE--AAYTLGPLLCQGDKSFWNSASFNTEASYLHFPTF SINFRUP00000143191 FLTHKETLPVRSLVLGDVHRPGSE--SIYRLGPLQCHGDKNIWNAAFFDKETSYLHFPTF ENSMUST00000052983 LLTFVDHLPVTQVVVGDTNRSNSE--AQFFLRPLRCYGDRNSWNTISFHTGAA-LRFPPI ENST00000318601 LLTFVDHLPVTQVVIGDTNRSTSE--AQFFLRPLRCYGDRNSWNTISFHTGAA-LRFPPI CG6827-RA DIREKEYLPVRAVKFGDTGTPLDEKMGRYTLGPLRCEGDDLFSNVVTFRIADASINLPPF : : *** : . *. . .* :. : * ** * ** * * : :.:*.: ENSMUST00000034225 HGELSADVSFFFKTTALSGVFLENLG------ITDFIRIELRSPTTVTFSFDVGNGPFEL ENSMUST00000038061 RGELTADVHFLFKTTISSGVFMENLG------ITDFIRIELRAPTEVTFSFDVGNGPCEL SINFRUP00000143191 HGELSADISFLFKTTSFSGVFLENLG------IKDFIRIELSSPLEVLFSFDVGNGPFEV ENSMUST00000052983 RANHSLDVSFYFRTSAPSGVFLENMGGPFCRWRRPYVRVELNTSRDVVFAFDIGNGDENL ENST00000318601 RANHSLDVSFYFRTSAPSGVFLENMGGPYCQWRRPYVRVELNTSRDVVFAFDVGNGDENL CG6827-RA DMGHSGDIYLEFRTTQENSVIFHATG------PTDYIKLSLNGGNKLQFQYQAGSGPLGV : *: : *:*: ..*::. * ::::.* : * :: *.* : ENSMUST00000034225 SVHSP-THFNDNQWHHVRVERNMKEASLRVDELPPKIQAAPTDGHVLLQLNSQLFVGGTA ENSMUST00000038061 TIQSP-TPFNDNRWHHVRAERNVKGASLQVDQLPQKTQSTPADGHVRLQLNSQLFIGGTA SINFRUP00000143191 RAKSS-VPLNDNRWHRVRAERNIKEALLRLDELPAATQEAPSDGHIHLQLNSQLFIGGTA ENSMUST00000052983 TVHSDDFEFNDDEWHLVRAEINVKQARLRVDHRPWVLRPMPLQTYIWLVYDQPLYVGSAE ENST00000318601 TVHSDDFEFNDDEWHLVRAEINVKQARLRVDHRPWVLRPMPLQTYIWMEYDQPLYVGSAE CG6827-RA NVGTS-YHLNDNNWHTVSVERNRKEARLVVDGSIKAEVREPPGPVRALHLTSDLVIGATT : :**:.** * .* * * * * :* * : . * :*.: ENSMUST00000034225 TRQRGFLGCIRSLQLNGMALDLEERAT-VTPGVQPGCRGHCGSYGKLCRHGGKCREKPSG ENSMUST00000038061 SRQKGFLGCIRSLQVNGMALDLEERAV-MTPGVEPGCSGHCSSYGHLCRNGGMCQEKHRG SINFRUP00000143191 SRQKGFRGCIRSLQLNGVTLDLEARAK-VTPGVQAGCPGYCSSYGALCQNWGRCVEGTRS ENSMUST00000052983 LKRRPFVGCLRAMRLNGVTLNLEGRAN-ASEGTFPNCTGHCTHPRFPCFHGGRCVERYSY ENST00000318601 LKRRPFVGCLRAMRLNGVTLNLEGRAN-ASEGTSPNCTGHCAHPRLPCFHGGRCVERYSY CG6827-RA EYRDGYVGCIRALLLNGKMVDLKEYSKRGLYGISTGCVGRCESN--PCLNNGTCIERYDG : : **:*:: :** ::*: : * ..* * * * : * * * ENSMUST00000034225 FFCDCSSSAYAGPFCSKEISAYFGSGSSVIYNFQENYSLSK------------------- ENSMUST00000038061 IACDCAFSAYDGPLCSYEISAYFETGSSVTYNFQEYSTLSA------------------- SINFRUP00000143191 FSCDCGPSAYSGAFC--------------------------------------------- ENSMUST00000052983 YTCDCDLTAFDGPYCNHDIGGFFETGTWMRYNLQSALRSAAREFSHMLSRPVPGYEPGYV ENST00000318601 YTCDCDLTAFDGPYCNHDIGGFFEPGTWMRYNLQSALRSAAREFSHMLSRPVPGYEPGYI CG6827-RA YSCDCRWSAFKGPICADEIGVNLRSSSIIRYEFEGSFRSTIA------------------ *** :*: *. * : : : : ENSMUST00000034225 ---NSSFHAASFHGD---------------------MKLSREMIKFSFRTTRAPSLLLHM ENSMUST00000038061 ---NTSYLASSLHGD---------------------VILSRETITLSFRTTQTPCLLLYV SINFRUP00000143191 ------------------------------------------------------------ ENSMUST00000052983 PGYDTPGYVPGYHGPGYRLPEYPRPGRPVPGYRGPVYNVTGEEVSFSFSTNSAPAVLLYV ENST00000318601 PGYDTPGYVPGYHGPGYRLPDYPRPGRPVPGYRGPVYNVTGEEVSFSFSTSSAPAVLLYV CG6827-RA -----------------------------------------ENIRVGFTTTIPKGFLLGF : . : .:: . ENSMUST00000034225 SS-FYKEYLSIIIAKNGSLQIRYKLNKYHEPDVISFDLKSMADGQLHHIKINREEGMVFV ENSMUST00000038061 TS-FYEEYLSIILANNGSLQVRYKLDRHRNADAFNFDLRNLADGHFHQLTINREEAVVSV SINFRUP00000143191 ------------------------------------------------------------ ENSMUST00000052983 SS-FVRDYMAVLIKEDGTLQLRYQLG--TSPYVYQLTTRPVTDGQPHSVNITRVYRNLFI ENST00000318601 SS-FVRDYMAVLIKDDGTLQLRYQLG--TSPYVYQLTTRPVTDGQPHSINITRVYRNLFI CG6827-RA SSNLTGEYLTIQISNSGHLRCVFDFGFERQEIIFPKKHFGLGQYHDMHFMRKNGGSTVVL : : : : : : : . : : ENSMUST00000034225 EIDEN--TRRQTYLSS--GTEFSAVKSLVLGRMLEYSDVDQETALAAAHGFTGCLSAVQF ENSMUST00000038061 EVNQS--TKRQVILSS--GTEFNAVKSLVLGKVLEPLDADPETQQAAAQGFTGCLSSVRF SINFRUP00000143191 ------------------------------------------------------------ ENSMUST00000052983 QVDYFPLTEQKFSLLV--DSQLDSPKALYLGRVMETGVIDPEIQRYNTPGFSGCLSGVRF ENST00000318601 QVDYFPLTEQKFSLLV--DSQLDSPKALYLGRVMETGVIDPEIQRYNTPGFSGCLSGVRF CG6827-RA KVDNYEPVEYNFDIKASADAQFNNIQYMYIG-----------KNESMTDGFVGCVSRVQF : : : : : : : : : ENSMUST00000034225 SHIAPLKAALQPGPPAPVTVTGHVTESSCVA--PSGTDATSRERTHSFADHSGTMDDREP ENSMUST00000038061 GLEVPLKAALNQNR-ARVTIQGSVAAAAHCAEGPGSAERKLSPGPSMDAGHSGSAEDRQP SINFRUP00000143191 ------------------------------------------------------------ ENSMUST00000052983 NNVAPLKTHFRTPRPMTAELAEAMRVQGELSESNCGAMPRLVSEVPPELDP-WYLPPDFP ENST00000318601 NNVAPLKTHFRTPRPMTAELAEALRVQGELSESNCGAMPRLVSEVPPELDP-WYLPPDFP CG6827-RA DDIYPLKLMFQQNPPKNVKSLG-----TQLTEDFCGVEPVTHPPIEIETRPPPLVDEEKL : : ENSMUST00000034225 LTHAIKSDSAVIGGLIAVVIFILL-CVSAIAVRIYQQKRLYKRNEAKRSENVDSAEAVLK ENSMUST00000038061 LPNTDRSDPGVIGGITAVVIFILL-CVSAIAIRVHQQRRLHQKNESTVSKTEEC------ SINFRUP00000143191 ------------------------------------------------------------ ENSMUST00000052983 YYHDDGWIAILLGFLVAFLLLGLVGMLVLFYLQNHRYKGSYHTNEPKATHDSHPGGKAPL ENST00000318601 YYHDEGWVAILLGFLVAFLLLGLVGMLVLFYLQNHRYKGSYHTNEPKAAHEYHPGSKPPL CG6827-RA RKAYNEVDSVLLACLLVILFLLLILMFFLIGRYLHRHKGDYLTHEDQGADGADDPDDAVL :: : .::: :: . : ENSMUST00000034225 SELHIQNAVGENQKEYFF-------------------------------- ENSMUST00000038061 -------------------------------------------------- SINFRUP00000143191 -------------------------------------------------- ENSMUST00000052983 PPSGPAQAPAPTPAPTQLPTPAPAPAPAPASGPGPRDQNLPQILEESRSE ENST00000318601 PTSGPAQVPTPTAAPNQAPASAPAPAPTPAPAPGPRDQNLPQILEESRSE CG6827-RA HSTTGHQVRKRTEIFI----------------------------------