CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000035020 MQLGEQLLVSSVNLPGAHFYSLESARGGGGGGGGGGGGGGGSVSLLPGAA ENST00000295743 MQLGEQLLVSSVNLPGAHFYPLESARGGSGGSAG----------HLPSAA SINFRUP00000140844 -------------------------------------------------- Q98TU2_Brachydanio_rerio MQLESILPGASVNLP-KTFYNLSSSSESTNNSPG---------------- SINFRUP00000153340 --MQVESCVSPASDLSKKFMNVGSGFEGSDGPEL---------------- Q9DDU4_Brachydanio_rerio -------------------------------------------------- ENSMUST00000048934 --MQLEHCLSPSIMLSKKFLNVSSSYPHSGGSEL---------------- SINFRUP00000139368 -------------------------------------------------- ENST00000177694 -------------------------------------------------- ENSMUST00000001484 -------------------------------------------------- ENST00000321616 -------------------------------------------------- CG6634-RA -------------------------------------------------- : : : : : : ENSMUST00000035020 PSPQRLDLDKASKKFPGSLPCQAGSAEPAGAGAGAPAAMLSDADAGDTFG ENST00000295743 PSPQKLDLDKASKKFSGSLSCEAVSGEPAAASAGAPAAMLSDTDAGDAFA SINFRUP00000140844 -------------------------------------------------- Q98TU2_Brachydanio_rerio ---------------STQIDFQDMDRTDSEQSSGAKKFLMDDADSESFTG SINFRUP00000153340 ---------------PLEDHPIICASDNLERSSPLKKNSREMTNQSEADN Q9DDU4_Brachydanio_rerio -------------------------------------------------- ENSMUST00000048934 ---------------VLHDHPIISTTDNLERSSPLKKITRGMTNQSDTDN SINFRUP00000139368 -------------------------------------------------- ENST00000177694 ------------------------------MGIVEPGCGDMLTGTEPMPG ENSMUST00000001484 ------------------------------MGIVEPGCGDMLTGTEPMP- ENST00000321616 -------------------------------------------------- CG6634-RA --------------MLVGSHPYLCNGVPAAPAAPNASGQTTTTASKSAAG : : : ENSMUST00000035020 STSAVAKPGPPDGRKGSPCAE--EELP--------SAATAAATARYSMS- ENST00000295743 SAAAVAKPGPPDGRKGSPCGE--EELPSAAAAAAAAAAAAAATARYSMDS SINFRUP00000140844 ----------PDARKGSPMLG-EDDLT--------------SGRRYTIDD Q98TU2_Brachydanio_rerio TKAAAAATAAPDARKSSPVIGADDELS--------------STRRYNIDD SINFRUP00000153340 FPDSKDASGDVQRGKLSPDLHGVSDIR------------------HNFDG Q9DDU4_Brachydanio_rerio -------------------------------------------------- ENSMUST00000048934 FPDSKDSPGDVQRSKLSPVLDGVSELR------------------HSFDG SINFRUP00000139368 ---------------YP--------------------------------- ENST00000177694 SDEGRAPGADPQHRYFYPEPG--------------------------AQD ENSMUST00000001484 SDEGRGPGADQQHRFFYPEPG--------------------------AQD ENST00000321616 -------------------------------------------------- CG6634-RA SATDFSIAAIMAREDASSRESSIRSAS------------------PISVE ENSMUST00000035020 LSSERYYLPSPGPQGSELAAPCSLFQYPAAAGAAHGPVYPASNGARYPYG ENST00000295743 LSSERYYLQSPGPQGSELAAPCSLFPYQAAAGAPHGPVYPAPNGARYPYG SINFRUP00000140844 LGSDRYFISSSQAS-SDMASPCSLFPYAGQTGSVYTGSSASRYPASLHYG Q98TU2_Brachydanio_rerio LGTDRYFISSSQPS-SDVANPCSLFPYGGQTGSVYSGSNGSRYSSSLHYG SINFRUP00000153340 SAGERCIFSPSTQPHSVSAAPSAMFPYPSQHGPAHPAFSIGSPSRYMAHH Q9DDU4_Brachydanio_rerio -------------------------------------------------- ENSMUST00000048934 SAADRYLLSQSSQPQSAATAPSAMFPYPSQHGPAHPAFSIGSPSRYMAHH SINFRUP00000139368 -------------------------------------------------- ENST00000177694 ADERRGGGSLGSPYPGGALVPAPPSRFLGAYAYPPRPQAAGFPGAGESFP ENSMUST00000001484 PTDRRAGSSLGTPYSGGALVPAAPGRFLGSFAYPPRAQVAGFPGPGEFFP ENST00000321616 -------------------------------------------------- CG6634-RA DEVDVDVVDCSDAEEPPTKARRLNHHQHHQHHQHHHNNNNNNNNNNVAHK ENSMUST00000035020 SMLPPGGFPAAVCPPARAQFGPAAGSGSGAGSSGGGAGGPGAYPYGQG-S ENST00000295743 SMLPPGGFPAAVCPPGRAQFGPGAGAGSGAGGSSGGGGGPGTYQYSQG-A SINFRUP00000140844 SVLPPTGFTSSTVCTGRSQFSS------------------GGYQFSQGPG Q98TU2_Brachydanio_rerio SVLPPAGFSS-AVCASRSQFG-------------------GGYQFGQGPG SINFRUP00000153340 PVISNGAYNSLLTNTSPQGYPA------------------AGYPYAQQYG Q9DDU4_Brachydanio_rerio -------------------------------------------------- ENSMUST00000048934 PVITNGAYNSLLSNSSPQGYPT------------------AGYPYPQQYG SINFRUP00000139368 ----------------------------------------AGFQHGYQRS ENST00000177694 PPADAEGYQPG-----------------------------EGYAAPDPRA ENSMUST00000001484 PPAGAEGYPPV-----------------------------DGYPAPDPRA ENST00000321616 -------------------------------------------------- CG6634-RA SRNSGGAVAQTASAESQLNTSS--------------TSSQGRCSTPPQSP ENSMUST00000035020 PLYGPYAGTSAAGSCGGLGGLGVPGSG--FRAHVYLCNRPLWLKFHRHQT ENST00000295743 PLYGPYPGAAAAGSCGGLGGLGVPGSG--FRAHVYLCNRPLWLKFHRHQT SINFRUP00000140844 CLYPSYPGTGTG-----IGSMSLPGSAAGARAQVYLCNRPLWLKFHRHQT Q98TU2_Brachydanio_rerio CLYPSYPGPGSS-----LSSMPIPGSGSAARAQVYLCNRPLWLKFHRHQT SINFRUP00000153340 HTYQGGAFYQFS---------TAQAGLVPGKAQVYLCNRALWLKFHRHQT Q9DDU4_Brachydanio_rerio -------------------------------------------------- ENSMUST00000048934 HSYQGAPFYQFS---------STQPGLVPGKAQVYLCNRPLWLKFHRHQT SINFRUP00000139368 PLYP------------------LPGLQVCGKTQALLNNFPLWAKFHKFQT ENST00000177694 GLYPGPREDYALP----------AGLEVSGKLRVALNNHLLWSKFNQHQT ENSMUST00000001484 GLYPGPREDYALP----------AGLEVSGKLRVALSNHLLWSKFNQHQT ENST00000321616 -------------------------------------------------- CG6634-RA GTEDSEERLTPEPVQKAPKIVGSCNCDDLKPVQCHLETKELWDRFHDLGT : : : : ENSMUST00000035020 EMIITKQGRRMFPFLSFNING----LNPTAHYNVFVEVVLADPNHWRFQG ENST00000295743 EMIITKQGRRMFPFLSFNING----LNPTAHYNVFVEVVLADPNHWRFQG SINFRUP00000140844 EMIITKQGRRMFPFLSFNITG----LNLTAHYNVFVEVVLADPNHWRFQG Q98TU2_Brachydanio_rerio EMIITKQGRRMFPFLSFNITG----LNLTAHYNVFVEIVLADPNHWRFQG SINFRUP00000153340 EMIITKQGRRMFPFLSFNISG----LDPTAHYNIFVDVILADPNHWRFQG Q9DDU4_Brachydanio_rerio -------------------SG----LDPTAHYNIFVDVILADPNHWRFQG ENSMUST00000048934 EMIITKQGRRMFPFLSFNISG----LDPTAHYNIFVDVILADPNHWRFQG SINFRUP00000139368 EMIITKQGRRMFPFLSFNISV----LDPSVHYNVYVDVVLADQHHWRYQG ENST00000177694 EMIITKQGRRMFPFLSFTVAG----LEPTSHYRMFVDVVLVDQHHWRYQS ENSMUST00000001484 EMIITKQGRRMFPFLSFTVAG----LEPTSHYRMFVDVVLVDQHHWRYQS ENST00000321616 ----------MFPVLKISVTG----LDPNAMYSLLLDFVPTDSHRWKYVN CG6634-RA EMIITKTGRRMFPTVRVSFSGPLRQIQPADRYAVLMDIIPMDSKRYRYAY ::: :: : . . :: * : ::.: * ::::: ENSMUST00000035020 G--KWVTCGKADNNMQG---------------NKMYVHPESPNTGSHWMR ENST00000295743 G--KWVTCGKADNNMQG---------------NKMYVHPESPNTGSHWMR SINFRUP00000140844 G--KWVTCGKADNNMQG---------------NKMYVHPESPNTGAHWMR Q98TU2_Brachydanio_rerio G--KWVTCGKADNNMQG---------------NKVYVHPESPNTGAHWMR SINFRUP00000153340 G--KWVPCGKADTNVIG---------------NRVYMHPDSPNTGAHWMR Q9DDU4_Brachydanio_rerio G--KWVPCGKADTNVTG---------------NRVYMHPDSPNTGAHWMR ENSMUST00000048934 G--KWVPCGKADTNVQGKSFQLTRFLDTYL-GNRVYMHPDSPNTGAHWMR SINFRUP00000139368 G--KWVQCGKAEGNMPGKDVSFSLLPVVVLSGNRMYMHPDSPNTGAHWMR ENST00000177694 G--KWVQCGKAEGSMPG---------------NRLYVHPDSPNTGAHWMR ENSMUST00000001484 G--KWVQCGKAEGSMPG---------------NRLYVHPDSPNTGAHWMR ENST00000321616 G--EWVPAGKPEVSSHS----------------CVYIHPDSPNFGAHWMK CG6634-RA HRSAWLVAGKADPAPPA----------------RLYAHPDSPFSCEALRK *: .**.: . :* **:** : ENSMUST00000035020 QEISFGKLKLTNNKGANNNNTQMIVLQSLHKYQPRLHIVEVTEDGVEDLN ENST00000295743 QEISFGKLKLTNNKGANNNNTQMIVLQSLHKYQPRLHIVEVTEDGVEDLN SINFRUP00000140844 QEISFSKLKLTNNKGANNNNTQMIVLQSLHKYQPRLHIVEVTEDGVEDMS Q98TU2_Brachydanio_rerio QEISFGKLKLTNNKGANNNNTQMIVLQSLHKYQPRLHIVEVTEDGVEDMS SINFRUP00000153340 QEISFGKLKLTNNKGASNNTGQMVVLQSLHKYQPRLHVVEVNEDGTEDTS Q9DDU4_Brachydanio_rerio QEISFGKLKLTNNKGATNNTGQMVVLQSLHKYQPRLHVVQVNEDGTEDTS ENSMUST00000048934 QEISFGKLKLTNNKGASNNNGQMVVLQSLHKYQPRLHVVEVNEDGTEDTS SINFRUP00000139368 QEVSFSKLKLTNNKGSTNNSAQMIVLQSLHKYQPRLHIVEVKEDGSEEPF ENST00000177694 QEVSFGKLKLTNNKGASNNVTQMIVLQSLHKYQPRLHIVEVNDGEPEAAC ENSMUST00000001484 QEVSFGKLKLTNNKGASNNVTQMIVLQSLHKYQPRLHIVEVNDGEPEAAC ENST00000321616 APISFSKVKLTN-KLNGGGQ---IMLNSLHKYEPQVHIVRVGSAHRMVTN CG6634-RA QVISFEKVKLTNNEMDKNGQ---IVLNSMHRYQPRIHLVRLSHGQSIPSN :** *:**** : .. :::*:*:*:*:*::*:*.: ENSMUST00000035020 ----EPSKTQTFTFSETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDS ENST00000295743 ----EPSKTQTFTFSETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDS SINFRUP00000140844 ----NDARTQTFTFPENQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDS Q98TU2_Brachydanio_rerio ----SEAKTQTFTFPENQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDS SINFRUP00000153340 ----QPGRVQTFTFTETQFVAVTAYQNTDITQLKIDHNPFAKGFRDNYDT Q9DDU4_Brachydanio_rerio ----QPGRVQTFTFPETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDT ENSMUST00000048934 ----QPGRVQTFTFPETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDT SINFRUP00000139368 ----LSSKAQTFIFPETQFIAVTAYQNADITQLKIDHNPFAKGFRDNYDT ENST00000177694 ----NASNTHIFTFQETQFIAVTAYQNAEITQLKIDNNPFAKGFRENFES ENSMUST00000001484 ----SASNTHVFTFQETQFIAVTAYQNAEITQLKIDNNPFAKGFRENFES ENST00000321616 -----------CSFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAK-- CG6634-RA PKELQDLDHKTYVFPETVFTAVTAYQNQLITKLKIDSNPFAKGFRDSSRL * *. * ******* ** ***. *****.* : ENSMUST00000035020 -------------------SHQIVPGGRYGVQN--FFPEPFVNTLPQA-R ENST00000295743 -------------------SHQIVPGGRYGVQS--FFPEPFVNTLPQA-R SINFRUP00000140844 MYTAPESDRLTPSPTDSPRSTQIVPGARYSMQP--FFQDQFVNNLPQN-R Q98TU2_Brachydanio_rerio MYTAPESDRLTPSPTDSPRSHQIVPGARYAMQP--FFQDQFVNNLPQNHR SINFRUP00000153340 VYTGCDIDRLTPSPGDSP-RSQIVPGARYAMPSS-FLQDQFVSTYAKS-R Q9DDU4_Brachydanio_rerio VYTGCDIDRLTPSPGDSP-RSQIMPSARYAMTGS-FLQDQFVSSYAKS-R ENSMUST00000048934 IYTGCDMDRLTPSPNDSP-RSQIVPGARYAMAGS-FLQDQFVSNYAKA-R SINFRUP00000139368 LYAPADSDRLTPSPTD---SQQLLPGSCY--PQG-YLSEAYMSPLPQT-R ENST00000177694 MYTSVDT------------SIPSPPGPNCQFLGGDHYSPLLPNQYPVPSR ENSMUST00000001484 MYASVDT------------SVPSPPGPNCQLLGGDPFSPLLSNQYPVPSR ENST00000321616 -----------------------------ERNHLRDVPEAISESQHVT-- CG6634-RA TDFDRDP-------------MEALLLEQQLRSPLRLFPDPLMQQFAAQGD . ENSMUST00000035020 YYNGE---------RTVPQTNGLLSPQQSE--EVANPPQRWLVTPVQQPV ENST00000295743 YYNGE---------RTVPQTNGLLSPQQSE--EVANPPQRWLVTPVQQPG SINFRUP00000140844 FYTSE---------RAVPQTNSLLSPQSED-AGAAASAQRWFVPPVQQPG Q98TU2_Brachydanio_rerio FYGSE---------RAVPQTNGLLSPQSEDSAAGSASAQRWFVGPVQQSG SINFRUP00000153340 FHPGMGTGPG--TERSVPLGNSLLSPQQSEEPTVDTPPQRWFVTPANNRL Q9DDU4_Brachydanio_rerio FHPGVGGAPG--TDRSVPLSNSLLSPQQTEETTVASP-QRWFVTPANNRL ENSMUST00000048934 FHPGAGAGPGPGTDRSVPHTNGLLSPQQAEDPGAPSP-QRWFVTPANNRL SINFRUP00000139368 FYSRE------------PIA---VGAQHKDTSSSPGPHSRWYLPPQQGVT ENST00000177694 FYPDL-------------------PGQAKD----VVPQAYWLGAPRDH-- ENSMUST00000001484 FYPDL-------------------PGQPKD----MISQPYWLGTPREH-- ENST00000321616 YSHLN------------------LIESSSNNLQVFSGPDSWTSLSST--- CG6634-RA PSSMA------------------LFEKARQHLQMFGGNSPYAQLMMP--- : :: . : : ENSMUST00000035020 TN-KLDIGS---YESEYTSSTLLPY---GIKSLPLQTS----HALGYYPD ENST00000295743 TN-KLDISS---YESEYTSSTLLPY---GIKSLPLQTS----HALGYYPD SINFRUP00000140844 SN-KLDLS----YENDYSTSSLLSY---SIKPLSLPTS----HALSYYPD Q98TU2_Brachydanio_rerio ATTKLDLS----YDSEYSASSLLPY---GIKPLPLQSP----HALGYYPD SINFRUP00000153340 DFAASAYD---AADFAGNAATLLSYAAAGVKALPLSTAGCSNRPLGYYAD Q9DDU4_Brachydanio_rerio DFAASAYDAAAAADFAGNAATLLSYAAAGVKALPLPGAGCSNRPLGYYGE ENSMUST00000048934 DFAASAYDT--ATDFAGNAATLLSYAAAGVKALPLQAAGCTGRPLGYYAD SINFRUP00000139368 PN-RLDFTS--PYDSDFSGNGFYKP-------FPLQTS--AHHALNYYPD ENST00000177694 -----------SYEAEFRAVSMKPA------FLPSAPG----PTMSYYRG ENSMUST00000001484 -----------SYEAEFRAVSMKPT------LLPSAPG----PTVPYYRG ENST00000321616 ------------PHASILSVPHTNG--------PINPGP----------- CG6634-RA ------------QMYQAAAAAAGPP--------PPPPGLG---------- : :. : ENSMUST00000035020 P------------------------TFPAMAG-WGGRGAYQRKMAAGLPW ENST00000295743 P------------------------TFPAMAG-WGGRGSYQRKMAAGLPW SINFRUP00000140844 T------------------------AFASMAAGWGARGSYQRKMTTALPW Q98TU2_Brachydanio_rerio S------------------------AFASMAAGWSSRSSYQRKMTTGLPW SINFRUP00000153340 PSGWGGRTPPQYCGVN--------SKSGSVFSCWP-SNSIGGR-AGTSYL Q9DDU4_Brachydanio_rerio P-GVGHRTPPQYC-----------SKSSSVLSCWP-SNSVGSRTTASSYL ENSMUST00000048934 PSGWGARSPPQYCG----------AKSGSVLPCWPNSAAAAARMAGANPY SINFRUP00000139368 HPFASTSMSVSGVTTAGWTTSRPTPQYLSHAAKPNPNLGWFRPISSSSSS ENST00000177694 Q------------------------EVLAPGAGWPVAPQYPPKMGPASWF ENSMUST00000001484 Q------------------------DVLAPGAGWPVAPQYPPKMSPAGWF ENST00000321616 -------------------------------SPYPCLWTISNGAGGPSGP CG6634-RA -------------------------AFHMFQQQWPQLTAGFLASANQQAA ENSMUST00000035020 TS---RMSPPVFPEDQLAK--EKVKEEIS---------SSWIETPPSIKS ENST00000295743 TS---RTSPTVFSEDQLSK--EKVKEEIG---------SSWIETPPSIKS SINFRUP00000140844 SP---RPSPPAFPEDQLGIPKDKMPEE---SAPPAS---TWIETSQSLKS Q98TU2_Brachydanio_rerio SP---RPSPPAYTDDLLSS-KDKLQDENSTAAPTAASTGPWMEAPPVLKS SINFRUP00000153340 A---EEGDSIPAERSPIG-GSEENKGKDVAS------ESNWIKTPSSIKS Q9DDU4_Brachydanio_rerio VPGLEDGDPIAPERSPLG-GADESKPKDLS-------ESSWIETPSSIKS ENSMUST00000048934 LG--EEAEGLAAERSPLAPAAEDAKPKDLS-------DSSWIETPSSIKS SINFRUP00000139368 SSSTSPGHPRLHPPPLLEPLQSVLPQDKPKDSVDPVGEDPWLEP-TSVKS ENST00000177694 RP-----MRTLPMEPGPGGSEGRGPEDQG---------PPLVWTEIAPIR ENSMUST00000001484 RP-----MRTLPMDPGLGSSEEQGS-------------SPSLWPEVTSLQ ENST00000321616 GP---EVHASTPGAFLLGNPAVTSPPSVL---------STQAPTSAGVEV CG6634-RA AA---QAAAQAQAQAQAAAAAMAANRTPP---------PPPTASTPSSTS . ENSMUST00000035020 LDSSDSGVYNSAC---KRKRLSPSTPSNGNSPPIKCEDINTEEYSKDTSK ENST00000295743 LDSNDSGVYTSAC---KRRRLSPSNSSNENSPSIKCEDINAEEYSKDTSK SINFRUP00000140844 VDSTDSGVYSMVC---KRRRMSPGGSSTENSPTIKCEDLTTEEY-KDNPK Q98TU2_Brachydanio_rerio VDSGDTSGYSMAC---KRRRVSPGGSSTDASPTIKCEDLSSEEYNKESHK SINFRUP00000153340 IDSSDSGIFEQAK---RRRISPTPTPVSETMSPLKSELLSPRECEKNCTK Q9DDU4_Brachydanio_rerio IDSSDSGIFEQAK---RRRISPSATPVSETSSPLKSEMLTPRECEKNCSK ENSMUST00000048934 IDSSDSGIYEQAK---RRRISPADTPVSESSSPLKSEVLAQRDCEKNCAK SINFRUP00000139368 AASTDSGLFEGGMGEHKKRRVSPYTSSTENSPPPR----SSETCEKDSNS ENST00000177694 PESSDSGLGEGDS---KRRRVSPYPSSGDSSSPAG----APSPFDKEAE- ENSMUST00000001484 PEPSDSGLGEGDT---KRRRISPYPSSGDSSSPAG----APSPFDKETE- ENST00000321616 LGEPSLTSIAVST----WTAVASHPFAGWGGPGAGGHHSPSSLDG----- CG6634-RA SGSPSPD-MRPRQ----YQRFSPYQLPGGQGPPSSAAGSPPAVNASRSPA . .. . ENSMUST00000035020 GMGAYYAFYTSP ENST00000295743 GMGGYYAFYTTP SINFRUP00000140844 GMG-YYAFYTSP Q98TU2_Brachydanio_rerio AMG-YYAFYTSP SINFRUP00000153340 DIN-YYNFYTHS Q9DDU4_Brachydanio_rerio DIG-YYKFYPHS ENSMUST00000048934 DIGGYYGFYSHS SINFRUP00000139368 DAD-YYGYYTH- ENST00000177694 --GQFYNYFPN- ENSMUST00000001484 --GQFYNYFPN- ENST00000321616 ------------ CG6634-RA H-----------