CLUSTAL W (1.82) multiple sequence alignment ENST00000035307 SLRLCPWGTHLAGPTTMRLSSLLALLRPALPLILGLSLGCSLS-LLRVSWIQGEGEDPCV ENSMUST00000047755 ------------------------------------------------------------ ENST00000243776 ------------------------------------------------------------ ENSMUST00000037567 ----------------MRASLLLSVLRPAGPVAVGISLGFTLS-LLSVTWVEEPCGPGPP SINFRUP00000142555 ----------------MRLSSFLAVFRPALPLILGLSLGCSLS-LLMVSWT------QGE SINFRUP00000134223 ----------------MRLSAFVSLLHSVGPVVIGISLGFTLS-LLCVSWTDEACYPHGE ci0100150757 ----------LAKKMVMRRLKFISNVRPFLPVIIGLSLGFSIS-IVRMPILNEDCVFVSE ci0100137046 ------MIPLRVSDIRMGSHRRLVSRRALIGLGIGILLGFNIASYIAIPTPNRTDIEIAV ci0100134973 -------------------MRKRRLVQNTLRLVSGYACGLLLHYFLLSSKPKVCNEIRND ci0100146174 ------------------------------------------------------------ CG12913-RA ------------------------------------------------------------ : : : : : : ENST00000035307 EAVGERGGPQNPDSRAR----------------LDQSDEDFKPRIVPYY-RDPN------ ENSMUST00000047755 ------------------------------------------------------------ ENST00000243776 ------------------------------------------------------------ ENSMUST00000037567 QPGDSELPPRGNTNAARRPNSVQPGSERERPGAGAGTGESWEPRVLPYHPAQPG------ SINFRUP00000142555 ADDGCGDDLGNGRLFLVGRDSQ-------RESRDQAGEEDFQPRIVPYHKD----PN--- SINFRUP00000134223 EGDAVVPGQDGPLRGARKPSSV-------SNSNDMESGEDFEPRIVPYKQVQPSSPK--- ci0100150757 EHIDRKLNSIPG-----------------AKVSVYDSLEDFEPRIITDPELKPKVDVNLE ci0100137046 IARNGAEGLEGMAGGLTEFRVGAARIRRQKGVGSLHIGKGCKHEVIAYESADVKPLSQKR ci0100134973 VLIRG---------------------------GKRNVVERHSSPVLPQSNIYLG------ ci0100146174 ------------------------------------------------------------ CG12913-RA ------------------------------------------------------------ :: ENST00000035307 KPYKK----------------VLRTRYIQTELGSRERLLVAVLTSRATLSTLAVAVN--- ENSMUST00000047755 ------------------------------------------------------------ ENST00000243776 ------------------------------------------------------------ ENSMUST00000037567 QATKK----------------AVRTRYISTELGIRQKLLVAVLTSQATLPTLGVAVN--- SINFRUP00000142555 KPHKK----------------VLRTRYIHTELGIRERLLVGVLTSRATLNTLAVAVN--- SINFRUP00000134223 KVFRQ----------------VLRAKYISTELGIRERLFVGVLTSKNTINTLGVAVN--- ci0100150757 ANKKK----------------IVRTRYISTELGIREKLVSAVITSSDTYLSMAVAMN--- ci0100137046 MQRRNERMQANQNSKSLKEGGALPDGFDLEQERLKRQKELEVFYESDIENDDGDAKNGGG ci0100134973 ----------------------MMSAEKFIDNRVQRALDTWLQKGSWKVEVFADATP--- ci0100146174 ------------------------------------------------------------ CG12913-RA ------------------------------------------------------------ : : ENST00000035307 ------------------------------------RTVAHHFPRLLYFTG--QRGARAP ENSMUST00000047755 ------------------------------------------------------------ ENST00000243776 ------------------------------------------------------------ ENSMUST00000037567 ------------------------------------RTLGHRLEHVVFLTG--ARGRRTP SINFRUP00000142555 ------------------------------------RTVAHHFHRTFFFTG--LRSPKVP SINFRUP00000134223 ------------------------------------RTISHHLDNVIFFTG--TRNRKVP ci0100150757 ------------------------------------KTFSHHMQKVIFFNGESVANDKAP ci0100137046 FEEFQLPRNFEKYVDYESDVNAQNSDSIDGEHNGDVRDSDQMLARNHFLYIGVLTAQKYL ci0100134973 ------------------------------------------------------DSLQVP ci0100146174 ------------------------------------------------------------ CG12913-RA ------------------------------------------------------------ : : ENST00000035307 --AGMQVVSHGDERPAWLMSET-----------------LRHLHTHFGADYDWFFIMQDD ENSMUST00000047755 ------------------------------------------------------------ ENST00000243776 ------------------------------------------------------------ ENSMUST00000037567 --SGMAVVALGEERPIGHLHLA-----------------LRHLLEQHGDDFDWFFLVPDA SINFRUP00000142555 --HGMSVVAHGDDRPVWLMYET-----------------VRHLHQHYASDYDWFLLAQDD SINFRUP00000134223 --HGMLVVSHGDERLIWNMFQN-----------------IKYILDHYIDEYDWFYFVQDD ci0100150757 TAPGMTLVTHPDDNPVRILSLT-----------------LKYLHLKFKSEYDWFFITTDS ci0100137046 ATRGVEEINAEKKDPLPLVNLQSVQDDVYPPQKKSFLLLKRMYDSYLNSGYQWFMRADDD ci0100134973 AGLDFNIVTLRSVDDAAYPPQKK------------CFMMLRHMYDHHIDNYDWFMRVDDD ci0100146174 ------------------------------------------------------------ CG12913-RA ------------------------------------------------------------ . : : ENST00000035307 TYVQAPRLAALAGHLSIN--QDLYLGRA------EEFIG-AGEQARYCHGGFGYLLSRSL ENSMUST00000047755 ------------------------------------------EQARYCHGGFGYLLSRSL ENST00000243776 ----------------------------------------------------------ML ENSMUST00000037567 TYTEAHGLDRLAGHLSLASATHLYLGRP------QDFIGGDTTPGRYCHGGFGVLLSRTL SINFRUP00000142555 TYMQADRLSELVGHLGTG--QDLYMGRA------EEFIGGE-EKARYCHGGYGYLLSRSL SINFRUP00000134223 AYTEADRLKSLVDHLSVD--RELYLGSP------EEFIGGE-MEGKYCYGGFGYILSRTL ci0100150757 TYAQADRVNHIVDHISIN--RRLYLGKP------MSYN-DKLGVVNYCSIKSGFIISRLL ci0100137046 VYINTHKLELFLRRLNSS--EPIYLGQTGLGNAEERGRLSLLHGENYCMGGPGMIFSREV ci0100134973 VYMDFPRLSKLLNTINSS--MPVFFGTPGFG---MDPDDGIEDGMFYLMGGPGMIFSRGL ci0100146174 ----------------------------------------------LLQGGPGMVFSRAL CG12913-RA --------------------------------------------------MHNSLVTKLL : : : : : :. : ENST00000035307 LLRLRPHLDGCRGD--ILSARPDEWLGRCLIDSLG---VGCVSQHQGQQYRSFEL-AKNR ENSMUST00000047755 LLRLRPHLDGCRGD--ILSARPDEWLGRCLIDTLG---IGCVSQHQGQQYRSFEL-AKNR ENST00000243776 LQQLRPHLEGCRND--IVSARPDEWLGRCILDATG---VGCTGDHEGVHYSHLEL-SPG- ENSMUST00000037567 LQQLRPHLESCRND--IVSARPDEWLGRCILDATG---VGCTGDHEGMHYNYLEL-SPG- SINFRUP00000142555 LARLQPHLDTCRND--ILSVRPDEWLGRCIIDYLG---LSCVEVHQGMNYRYFEL-GKNA SINFRUP00000134223 LLRLQPFLENCRND--ILSARPDEWLGRCIIDHTN---TNCVAEFEGLRYHRFEL-GKNS ci0100150757 LLDLAMQLDACSEDGSQASLSPDKWLGRCIKRATSGA-VECVDEEEAIFYHTFNMENSNL ci0100137046 LRRIGPHIRECVHH--LYSWHEDVEISRCVRKFAGVN-CAWSYQMQELFYEHYTLRKGYI ci0100134973 LLELRAHFSHCIQH--MFSPHEDVEIGRCVWKHAKKAKIPIAWETIEFFYQQYDKNTGAV ci0100146174 MRQLGPHLGECLQH--MYTSHEDIEVGRCVQKYTG-IKCTTSWETKKIFFQNYNS-GTYT CG12913-RA LRLLLLFALLTGASIVVLTKCGFDELTTRETQANN------PSESSGFSYTLSER----- : : : : : ENST00000035307 DPEKE---GSSAFLSAFAVHPVSEGTLMYRLHKRFSALELERAYSEIEQLQAQIRNLTVL ENSMUST00000047755 DPEKE---ESPAFLSAFAVHPVPEGTLMYRLHKRFSALELERAYSEIEQLQAQIRNLTVL ENST00000243776 EPVQE---GDPHFRSALTAHPVRDPVHMYQLHKAFARAELERTYQEIQELQWEIQNTSHL ENSMUST00000037567 EPVQE---GDPRFRSALTAHPVRDPVHMYQLHKAFARAELDRTYQEIQELQWEIQNTSRL SINFRUP00000142555 DPQRE---DSLQFRNAFTVHPVSDPNLMYRLHKRFSQIELELTYLHIQQLQTQINNLSEL SINFRUP00000134223 DPSKE---QSDQLTSALTVHPVSDPEQMYRLHRFFTEIELQKTYSEIVRLQAEIMNVSAD ci0100150757 NFEVE---TTPEFEEAVTVSGVNSPQMMFQLHKKYSQLEIDKAYKEIGEIQDEIKSLVPK ci0100137046 DPYEEP--NNPKFRTAMTLHPNKNPAYQVKLHQFMRSQRLKQRMMDIKRLSRDVVNMDGY ci0100134973 TNVVMADTTEQRTAKTVAYHAVKKHDLLYTLHRQVLERRIKKLLNETAKLKREIQAMQTI ci0100146174 NNIKD--ITAKQLDEGKIFHANKDPAYQYRFHTMVLKRKIATILKRIAQAEKDIQIVSLQ CG12913-RA --------EAEIERLKQEVLALRTQILFLQNNRSTAKPSNGSLQLQETTAGPPTAPLGHH : ENST00000035307 T--PEGEAGLSWPVGLPAPFT---PHSRFEVLGWDYFTEQHTFSCADGAPKCPLQ---GA ENSMUST00000047755 T--PEGEAGLSWPVGLPAPFT---PHSRFEVLGWDYFTEQHTFACADGAPKCPLQ---GA ENST00000243776 A--VDGDQAAAWPVGIPAPSR---PASRFEVLRWDYFTEQHAFSCADGSPRCPLR---GA ENSMUST00000037567 A--ADGERASAWPVGIPAPSR---PASRFEVLRWDYFTEQYAFSCADGSPRCPLR---GA SINFRUP00000142555 T--PEGKAGVTWPVGINSPFK---PRTRFEVINWEYFTEEHIYSCVDGSPKCEMR---GA SINFRUP00000134223 A--FEGNWTSQWPVGVNPPFQ---PQSRFEVLKWEYFTEEEIYSCVDGSPKCQLR---GI ci0100150757 L--PEGERELSWPIGINPSFK---PTNRWDIIVWDYFTEDYTLTCPGEVPKCDLT---GV ci0100137046 L--GSGSDIEDFMLGSPLTLNRFMPRQHSEVLHWNFITDHLLYSTPPHQPRRSTP---ND ci0100134973 QNMKEVKIITSYYLAAWLPQNPMIPRGASTIP-AIFWDKYYRHQVDSVIPARGHQ---GK ci0100146174 NG-FSDDAVIPGHVRINKPTLFLQGMNAHAQYRWSTIYNRDHYKADRSQPMKRMD---PT CG12913-RA Y---DCSSYIRKQVGAAEILHGLPLNNEYELIPYNHFTFTRVYPIDLGLGKRVVEKPIGY . . : ENST00000035307 SRADVGDALETALEQLNRRYQPR-LRFQKQRLLNGYRRFDPARGMEYTLDLLLECVTQ-- ENSMUST00000047755 SRADVGDAVDTALEQLNRRYQPR-LRFRKQRLLNGYRRFDPARGMEYTLDLLLEAVTQ-- ENST00000243776 DRADVADVLGTALEELNRRYHPA-LRLQKQQLVNGYRRFDPARGMEYTLDLQLEALTP-- ENSMUST00000037567 DQADVADVLGTALEELNRRYQPA-LQLQKQQLVNGYRRFDPARGMEYTLDLQLEALTP-- SINFRUP00000142555 DRADVDAVLEIAVERLNERYQPQ-LRFTKRRLLNGYRRFDPTRGMEYVLDLALEAYTQ-- SINFRUP00000134223 DRLDVANVIEAAMGELNRKYKPV-LHLKKQQLINGYRRFDPTRGMEYTLDLQVEVVNQ-- ci0100150757 DKLDIQNILQIALDRLNEKYNPQGLILEKRKLINGYRRFDPQRGMEYILDLLLTVIMEN- ci0100137046 WQMTIRSIVMQVMAMMNSNSRVRGRVIDFKQVGYGYRRVNPLYGAEYVLDLLLIYKRYKG ci0100134973 EQPTLLKYLSEIENGILKKSCPH--LSSNPQFTHGYLWVLPQHGAFISVAHKGLVKGEY- ci0100146174 LNHVLVEDTNTFIRVLQTRVNNEFAKLKEVDFINTYFVVNPLHSMDAISLLECKFSTGPG CG12913-RA RRRDLIEAVNKALESLNRNHSAR-IRAKGAGSAAAYASDVIKYTLDDFIEGIYRNEPTTG . : : . * ENST00000035307 ---RGHRRALARRVSLLRPLSRVEILPMPYVTEATRVQLVLPLLVAEAAAAPAFLEAFAA ENSMUST00000047755 ---RGHRRSLARRVSLLRPLSRVEILPMPYVTEATRVQLVLPLLVAEAPAALAFLEAFAA ENST00000243776 ---QGGRRPLTRRVQLLRPLSRVEILPVPYVTEASRLTVLLPLAAAERDLAPGFLEAFAT ENSMUST00000037567 ---QGGRWPLTRRVQLLRPLSRVEILPVPYVTEASRLTVLLPLAAAERDLASGFLEAFAT SINFRUP00000142555 ---KDHSQVIAKRVNLLRPLSAVEIIPMPYVTEATRVQVILPVTAQDQDFVGNFLDMYVM SINFRUP00000134223 ---KGHGRSITKRVHLVRPLSKTEIIPMPYVTEATRVHIIIPLTLQDRGYVDHFLEAFAS ci0100150757 ---ENQEIELSHRVNMLRPLSQVEIIPMPYVTESAKVHIILPLTKQERVYFEAFMDKYAK ci0100137046 ---KKMTIPVRRHAYLQQSFGRTDMYENSPIDKDE-IKRILRGSKSKVQYDTGSFRVFPQ ci0100134973 -----SYCTTHVQVSFAVTLLGEKDHPLVGYFVGEEIPPARKRLHHHSNTMVRYQEPVLP ci0100146174 KPRTTQHVSVHQRHRFTSATFLSEPIELCPTGCVRKDNEPTVLIKRANETPVNFLTALSG CG12913-RA ---TQYELYFQSVKHQASPVRRALVMRPFAPLQTVQLSELSSSVDNSGAPPSHSPPIIHV . ENST00000035307 NVLEPRE-HALLTLLLVYGPREGGRGAP---------------------------DPFLG ENSMUST00000047755 SVLEPRE-HALLTLLLVYGPREG-RGGP---------------------------DPFLG ENST00000243776 AALEPGDAAAALTLLLLYEPRQAQRVAHA--------------------------DVFAP ENSMUST00000037567 AALEPGD-AAALTLLLLYEPRQAQRAAHS--------------------------DVFAP SINFRUP00000142555 NTLDARD-NVLLTFLFIYDPFDAQRVSQA--------------------------DVFAG SINFRUP00000134223 NAFETSE-NAILTFLFIYDPVEAQQVNQN--------------------------DIFAG ci0100150757 VCLNNDE-NVALNIVFVYDPETAQRIHQD--------------------------DIFAE ci0100137046 DAKSQANVETVNIIVPLSGRYDTFRSFMSNLENVSLSRGDPISLM---------AVVFIG ci0100134973 VSFDSSK-DRVLFVIPLHGRYRALELFMERYKRDFLNPLKEGKIANTLSGNVQLVIVLLG ci0100146174 RPENFIRFLNNFENSFLTRGEKVNLIVDG-------------------------ISPNFG CG12913-RA ILPLAGRLHSFRGFLQMFAKLEDRRLELI--------------------------VVYFG : ENST00000035307 VKAAAAELERR------YPGTRLAWLAVRAEAP-------SQVRLMDVVSKKHPV-DTLF ENSMUST00000047755 VKAAAAELERR------YPGARLAWLAVRAEAP-------SQVRLMDVISKKHPV-DTLF ENST00000243776 VKAHVAELERR------FPGARVPWLSVQTAAP-------SPLRLMDLLSKKHPL-DTLF ENSMUST00000037567 VKAHVAELERR------FPGARVPWLSVQTAAP-------SPLRLMDLLSKKHPL-DTLF SINFRUP00000142555 IKAMIGEVEKR------YGDVKIPWISVKTEVP-------SQVKLMDIISKKHPV-DTLF SINFRUP00000134223 VKNQINAYEHK------YPAVKIPWISVKTETP-------SQIKFMDIISKKHPV-DTLF ci0100150757 QKQLLQSYEKDG-----KEGKLIPWVSIKTEVP-------SQLKTMDIVAKKYPT-ESLF ci0100137046 VDSEYKEEGIKTRDLLDSYSKRYPLYDMRQIPINA---KFSRGLALEIGASHFSN-DSLL ci0100134973 ARGDEHDMNRASAYLLHSYQQEFGTSLIRYHIADTGKRQFSRGAGLQLGSLVAGI-NDIV ci0100146174 KNTPLGPDAKFVTENMNRLQNAYPDSKIAVINLEPG-TEFSRGLGLQVAAKSVESRDEII CG12913-RA TSGLEQARSLAG------RSQRTQFLALNETFSR------AKALRLGAEHIQPAEEDVLL : : : : :. ENST00000035307 FLTTVWTRPGPEVLNRCRMNAISGWQAFFPVHFQEFNPALSPQRSPPGPPGAGPDPPSPP ENSMUST00000047755 FLTTVWTRPGSEVLNRCRMNAISGWQAFFPVHFQEFNPALSPQRSPPGVPGA--DPPSP- ENST00000243776 LLAGPDTVLTPDFLNRCRMHAISGWQAFFPMHFQAFHPAVAP---PQG--------PGP- ENSMUST00000037567 LLAGPDTVLTPDFLNRCRMHAISGWQAFFPMHFQAFHPAVAP---PQG--------PGP- SINFRUP00000142555 FLASVWTEVNADFLNRCRMNTISNWQVFFPIHFQEFSPAVMYRDQQ----------PSAA SINFRUP00000134223 FLAHANTEVNSEFLNRCRMNSINNWQVFFPIHFQDYKPEVAYHNQQ----------LPVT ci0100150757 LLTSVAANMNTNFLNRCRMNAIPGWQVFFPIPFSQYNPQIIFQNGQ---------VPEQI ci0100137046 FFCDVDVVFDNEFTRKCRSNTDLGKRVFYPVLFSEFHPRFNGADTSWKFTSDDIDARNVV ci0100134973 FFMDIDMIVTPNLVAQCRRNVKHGKQAWYPIPYSQYDPDRHGARETIR--------QTPL ci0100146174 FFSDVDLVFAPEILDHIRRNTIRHKQVYYPVFFSQYDPDVVYVDMPKP--------QNYF CG12913-RA FMCDVDIMFTTKFLERCRWNAAPGKKVYYPVVFSLYNPHVVYSLQGKPLPSE----EEQL :: .. : * : :.::*: :. : * ENST00000035307 GADPSRGAPIG--GRFDRQASAEGCFYNADYLAAR-------------ARLAGELAGQE- ENSMUST00000047755 GVDPSRGAPVG--GRFDRQASAEGCFYNADYLAAR-------------ARLAGELAGQE- ENST00000243776 ---PELGRDTG---RFDRQAASEACFYNSDYVAAR-------------GRLA--AASEQ- ENSMUST00000037567 ---PELGRDTG---HFDRQAASEACFYNSDYVAAR-------------GRLV--AASEQ- SINFRUP00000142555 SSAFASESLRD--GRFDRHVFDEACFYNADYMTAR-------------TKMA--ADLLD- SINFRUP00000134223 THLLKDA------GHFDRLSFGEACFYNSDYMATR-------------TRMV--ADVQE- ci0100150757 DIKPSNG-------HFDLYSFDEVCFYNSDYMASR-------------TKMAATVSAEDS ci0100137046 KPRENHYELTENTGHWRSYGYGLLCVYQKDFTETGGFDMTIQGWGLEDVDLIDKFLGSK- ci0100134973 TLEEDRG-------FWRDFGYGIACFYNTDFVSSG-------------------GFDLSI ci0100146174 IFSELAG-------FWRHFSYGMVSLYASDFDKTN-------------------GFDLSI CG12913-RA VISRDTG-------FWRDFGYGMTCQYRSNFLKVRG------------------FDEEEI : . * :: : . ENST00000035307 EEEALEGLEVMDVFLRFSGLHLFRAVEPGLVQKFSLRDCSPRLSEELYHRCRLSNLEGLG ENSMUST00000047755 EEEALEGLEVMDVFLRFSGLHLFRAVEPGLVQKFSLRDCSPRLSEELYHRCRLSNLEGLG ENST00000243776 EEELLESLDVYELFLHFSSLHVLRAVEPALLQRYRAQTCSARLSEDLYHRCLQSVLEGLG ENSMUST00000037567 EEELLESLDVYELFLRFSNLHVLRAVEPALLQRYRAQPCSARLSEDLYHRCRQSVLEGLG SINFRUP00000142555 NEELLESMDVYDIFVRYSGLHVFRAVEPALIQKYVRRTCNPRFSEDVYHRCVLSNLQGLG SINFRUP00000134223 NEEILETLDIYDMFVKYSDLHVFRAVEPALHQKYVYQDCNPRLSEDIYHRCIQGNLEGLG ci0100150757 KDDLVDTLEVYDIMIKYSQLHVFRAVEPQLTRRYVHRNCNKRNGQEIFDRCERSNAEGLA ci0100137046 HKKKADALTKDEAAAKTKNMEIMRVSEPSLVHVYHPSHCDPNLMENQLRMCQASRASGIT ci0100134973 EGWGEEDVRLYKAILASG-VDVFRSKQSDLVHIYHTKHCDQRLVGEQARSCHRTKASHYA ci0100146174 HGWGLEDVHLVNAILAAG-LDVFKSTEPGQVHIFHDKTCDSSLSENQRTSCQNSRAAHYA CG12913-RA VGWGGEDVMLYRKYVRSK-IKIIRATDPGIFHRWHTKICSSSLTADQYRACIRSRALNEA : : :.::: :. : : *. : * ENST00000035307 GRAQLAMALFEQEQANST------------------------------------------ ENSMUST00000047755 ARTQLAMALFEQEQANST------------------------------------------ ENST00000243776 SRTQLAMLLFEQEQGNST------------------------------------------ ENSMUST00000037567 SRTQLAMLLFEQEQGNST------------------------------------------ SINFRUP00000142555 SRSHLAMALFEQEQANST------------------------------------------ SINFRUP00000134223 SRSQLAMLLFEQEQGNST------------------------------------------ ci0100150757 SRTQLAMELFPENKEPSKT----------------------------------------- ci0100137046 STYNLNRMWQLLGLNRTASAVADPVSGIVPVLPHDVAKEQLRERGIENFSDRRERALEIE ci0100134973 SQMCLAKTYFQRNNLS-------------------------------------------- ci0100146174 PSTLLYYLWKTPESIETIEEV--------------------------------------- CG12913-RA SHAQLGFLAFRDDIAAANAAKMTS------------------------------------ * ENST00000035307 ------------------ ENSMUST00000047755 ------------------ ENST00000243776 ------------------ ENSMUST00000037567 ------------------ SINFRUP00000142555 ------------------ SINFRUP00000134223 ------------------ ci0100150757 ------------------ ci0100137046 RRTLKLKQNRKFNRNGIR ci0100134973 ------------------ ci0100146174 ------------------ CG12913-RA ------------------