CLUSTAL W (1.82) multiple sequence alignment


ENSMUST00000003461      -MFHLRTCAAKLRPLTASQTVKTFSQNKP----AAIRTFQQIRCYSAPVAAEPFLSGTSS
ENST00000309514         -MFHLRTCAAKLRPLTASQTVKTFSQNRP----AAARTFQQIRCYSAPVAAEPFLSGTSS
SINFRUP00000153892      -MHRLRTCAARLRPLTAAQAAQTVGQQRPVTFTGGTRTFQPLRSYTTPVASEPFLNGTSS
SINFRUP00000145347      ------------------------------------------------------------
ENSMUST00000022480      -MSQLRLLPFRLGPRATKLLATRAIPVFS----------GCRRSSGPPTTIPRSRSGVSS
ENST00000265903         -MSQLRLLPSRLGVQAARLLAAHDVPVFG----------WRSRSSGPPATFPSSKGGGGS
SINFRUP00000148054      ------------------------------------------------------------
CG11661-RC              MHRAHTAFSLALSPMAHKNFATWLLKSSSSQQMAKVTAAAAVRTYN-SAAAEPFANGSTA
                                                                                    

ENSMUST00000003461      NYVEEMYCAWLENPKSVHKSWDIFFRNTNAGAPPGTAYQSPLSLSRSSLATMAHAQSLVE
ENST00000309514         NYVEEMYCAWLENPKSVHKSWDIFFRNTNAGAPPGTAYQSPLPLSRGSLAAVAHAQSLVE
SINFRUP00000153892      NYVEEMYYAWLENPKSVHKSWDVFFRNANAGAPPGAAYQSPLGLS-----AAPQLSSLVG
SINFRUP00000145347      ------------------------------------------------------------
ENSMUST00000022480      SYVEEMYFAWLENPQSVHKSWDSFFQRASKEASVGPAQPQ-------LPAVLQESRTSVS
ENST00000265903         SYMEEMYFAWLENPQSVHKSWDSFFREASEEAFSGSAQPR-------PPSVVHESRSAVS
SINFRUP00000148054      ------------------------------------------------------------
CG11661-RC              SYVEEMYNAWLRDPTSVHTSWDAYFRSNSYVSPPNLAPVQAN----TLPLTAFNFGGAVA
                                                                                    

ENSMUST00000003461      AQPNVDKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSSVPADIISSTDKLGFY
ENST00000309514         AQPNVDKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSSVPADIISSTDKLGFY
SINFRUP00000153892      AQPNVEKLVEDHLAVQSLIRAYQIRGHQVAQLDPLGIMDADLDSCVPTDIITSSDKLGFY
SINFRUP00000145347      ------------------------------------------------------------
ENSMUST00000022480      SCTKTSKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSFVPSDLITTIDKLAFY
ENST00000265903         SRTKTSKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSFVPSDLITTIDKLAFY
SINFRUP00000148054      -----------------LLLSPQIRGHQVAQLDPLGILEADLDSFVPSDLITSIDKLGYY
CG11661-RC              GAAPDSKTIDDHLAVQAIIRSYQIRGHNIAHLDPLEINTPELPGNSSTKSIYAN-----F
                                                                                    

ENSMUST00000003461      GLHESDLDKVFHLPTTTFIGGQEPALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWIR
ENST00000309514         GLDESDLDKVFHLPTTTFIGGQESALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWIR
SINFRUP00000153892      GLDESDLDKVFRLPTTTFIGGSESVLPLKEIIRRLEMSYCQHIGVEFMFINDLEQCQWIR
SINFRUP00000145347      ---------------------------------------------EFMFINDVQQCHWIR
ENSMUST00000022480      DLQEADLDKEFRLPTTTFIGGPENTLSLREIIRRLESTYCQHIGLEFMFINDVEQCQWIR
ENST00000265903         DLQEADLDKEFQLPTTTFIGGSENTLSLREIIRRLENTYCQHIGLEFMFINDVEQCQWIR
SINFRUP00000148054      DLKESDLDRSFQLPSTTFIGGEDSTLPLREIIRRLETAYCGHIGVEFMFINNVDQCQWIR
CG11661-RC              SFGEQDMDRQFKLPSTTFIGGDEASLPLKEILNRLENVYCNKIGVEFMFINSLEQCNWIR
                                                                     ******.::**:***

ENSMUST00000003461      QKFETPGIMQFTNEEKRTLLARLVRSTRFEEFLQRKWSSEKRFGLEGCEVLIPALKTIID
ENST00000309514         QKFETPGIMQFTNEEKRTLLARLVRSTRFEEFLQRKWSSEKRFGLEGCEVLIPALKTIID
SINFRUP00000153892      QKFETPGIMQFTLEEKRTLLARMIRSTRFEEFLQKKWSAEKRFGLEGCESLIPALKTIID
SINFRUP00000145347      EKFETPGIMKFSLEEKRTLXGRVIRSTRFEEFLQKKWSSEKRFGLEGCESLIPALKTIID
ENSMUST00000022480      QKFETPGVMQFSVEEKRTLLARLVRSMRFEDFLARKWSSEKRFGLEGCEVMIPALKTIID
ENST00000265903         QKFETPGVMQFSSEEKRTLLARLVRSMRFEDFLARKWSSEKRFGLEGCEVMIPALKTIID
SINFRUP00000148054      QKIETPGIMRLTDVDKRTLLARLIRSTRFEDFLARKWSSEKRFGLEGCEVLIPALKTIID
CG11661-RC              KRFETPGVLNFSPEEKRLILARLTRATGFEAFLAKKYSSEKRFGLEGCEIMIPALKEIID
                        :::****::.::  :** : .*: *:  ** ** :*:*:********** :***** ***

ENSMUST00000003461      MSSANGVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAADEGSGDMKYHLGMYH
ENST00000309514         KSSENGVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAADEGSGDVKYHLGMYH
SINFRUP00000153892      KSSEKGVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAADEGPGDVKYHLGMYH
SINFRUP00000145347      ISSQSGVESIIMGMPHRGRLNVLANVIRKELDQIFCQVDSKLEAADEGSGDVKYHLGMYH
ENSMUST00000022480      KSSEMGIENVILGMPHRGRLNVLANVIRKDLEQIFCQFDPKLEAADEGSGDVKYHLGMYH
ENST00000265903         KSSEMGIENVILGMPHRGRLNVLANVIRKDLEQIFCQFDPKLEAADEGSGDVKYHLGMYH
SINFRUP00000148054      ESSTAGVDSVIMGMPHRGRLNVLANVIRKDLDQIFCQFDPKLEAADEGSGDVKYHLGMYH
CG11661-RC              VSTELGVESVIMGMPHRGRLNTLANVCRKPLNQIFTQFAG-LEAADDGSGDVKYHLGTYI
                         *:  *:: :*:*********.**** ** *:*** *.   *****:*.**:***** * 

ENSMUST00000003461      RRINRVTDRNITLSLVANPSHLEAADPVVMGKTKAEQFYCGDTEGKKVMSILLHGDAAFA
ENST00000309514         RRINRVTDRNITLSLVANPSHLEAADPVVMGKTKAEQFYCGDTEGKKVMSILLHGDAAFA
SINFRUP00000153892      RRINRVTDRNITLSLVANPSHLEAADPVVQGKTKAEQFYCGDNDGKRVMSILLHGDAAFA
SINFRUP00000145347      RWLNRVSNKYITMSLMANPSHLEAVDPVVQGKTKAEQFYSGDAEGKRVMSILLHGDAAFA
ENSMUST00000022480      ERINRVTNRNITLSLVANPSHLEAVDPVVQGKTKAEQFYRGDAQGRKVMSILVHGDAAFA
ENST00000265903         ERINRVTNRNITLSLVANPSHLEAVDPVVQGKTKAEQFYRGDAQGKKVMSILVHGDAAFA
SINFRUP00000148054      ERINRKTDKNIMLSLMANPSHLEAVDPVVQGKTKAEQFYRGDSEGKKVMSILIHGDAAFA
CG11661-RC              ERLNRVTNKNIRLAVVANPSHLEAVDPVVQGKTRAEQFYRGDQEGKKVMSILIHGDAAFC
                        . :** ::: * ::::********.**** ***:***** ** :*::*****:******.

ENSMUST00000003461      GQGIVYETFHLSDLPSYTTHGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHV
ENST00000309514         GQGIVYETFHLSDLPSYTTHGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHV
SINFRUP00000153892      GQGIVYETFHLSDLPSYTTHGTVHVVVNNQIGFTTDPRVARSSPYPTDVARVVNAPIFHV
SINFRUP00000145347      GQGIVYETFHLSDLPSYTTHGTIHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHV
ENSMUST00000022480      GQGVVYETFHLSDLPSYTTNGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHV
ENST00000265903         GQGVVYETFHLSDLPSYTTNGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHV
SINFRUP00000148054      GQGVVYETFHLSELPSYSTHGTIHVVVNNQIGFTTDPRVARSSPYPTDVARVVNAPIFHV
CG11661-RC              GQGVVYETMHLSDLPDYTTHGTIHVVANNQIGFTTDPRFSRSSPYCTDVARVVNAPIFHV
                        ***:****:***:**.*:*:**:***.***********.:***** **************

ENSMUST00000003461      NSDDPEAVMYVCKVAAEWRNTFHKDVVVDLVCYRRNGHNEMDEPMFTQPLMYKQIRKQKP
ENST00000309514         NSDDPEAVMYVCKVAAEWRSTFHKDVVVDLVCYRRNGHNEMDEPMFTQPLMYKQIRKQKP
SINFRUP00000153892      NADDPEAVIYVCKVAAEWRNTFHKDVVVDLVCYRRMGHNEMDEPMFTQPLMYKQIKKQKP
SINFRUP00000145347      NADDPEAVMYVCKVAAEWRNTFHKDVVVDLVCYRRNGHNEMDEPMFTQPLMYKKIKKQKG
ENSMUST00000022480      NADDPEAVIYVCSVAAEWRNTFNKDVVVDLVCYRRRGHNEMDEPMFTQPLMYKQIHKQVP
ENST00000265903         NADDPEAVIYVCSVAAEWRNTFNKDVVVDLVCYRRRGHNEMDEPMFTQPLMYKQIHRQVP
SINFRUP00000148054      NADDPEAVVYVCQIAAEWRSTFNKDVVIDLVSYRRFGHNEMDEPMFTQPLMYKVIRRQEH
CG11661-RC              NADDPEAVMHVCKVAAEWRATFHKDCVIDLVGYRRNGHNEIDEPMFTQPLMYQKIRKHKN
                        *:******::**.:***** **:** *:*** *** ****:***********: *:::  

ENSMUST00000003461      VLQKYAELLVSQGVVNQPEYEEEISKYDKICEEAFTRSKDEKILHIKHWLDSPWPGFFTL
ENST00000309514         VLQKYAELLVSQGVVNQPEYEEEISKYDKICEEAFARSKDEKILHIKHWLDSPWPGFFTL
SINFRUP00000153892      VLQKYAEKLIAEGAVSRQEYEEEIAKYDKICEEAYARSKDEKILHIKHWLDSPWPGFFTL
SINFRUP00000145347      VLKIYVEKLIAEGVITLQEYQEEVAKYDKICEDAYSRSKDEKILHIKHWLDSPWPDFFTL
ENSMUST00000022480      VLKKYADKLIAEGTVTLQEFEEEIAKYDRICEEAYGRSKDKKILHIKHWLDSPWPGFFNV
ENST00000265903         VLKKYADKLIAEGTVTLQEFEEEIAKYDRICEEAYGRSKDKKILHIKHWLDSPWPGFFNV
SINFRUP00000148054      VLKKYSDRLIAERVVTLQEYEEEVAKYDKICEEAYASSKDEKILHIRHWLDSPWPDFFTA
CG11661-RC              CLDLYADKLIAEGTVTAEEVKSVAAKYENICEEAFALAKTETHVKYKDWLDSPWSGFFEG
                         *. * : *::: .:.  * :.  :**:.***:*:  :* :. :: :.******..**  

ENSMUST00000003461      DGQPRSMTCPSTGLEEDVLFHIGKVASSVP--VENFTIHGGLSRILKTRRELVTNRTVDW
ENST00000309514         DGQPRSMSCPSTGLTEDILTHIGNVASSVP--VENFTIHGGLSRILKTRGEMVKNRTVDW
SINFRUP00000153892      EGQPKSMSCPSTGLTEENLTHIGQVASSVP--VEDFTIHGGLSRILKARAEMVRNRVVDW
SINFRUP00000145347      DGQPKTMSCNSTGIPEEQLCHIGSIASSVP--LKDFTIHGGLTRILKSRANMVSQRVCDW
ENSMUST00000022480      DGEPKSMTCPTTGIPEEMLTHIGSVASSVP--LEDFKIHTGLSRILRGRADMTKKRTVDW
ENST00000265903         DGEPKSMTCPATGIPEDMLTHIGSVASSVP--LEDFKIHTGLSRILRGRADMTKNRTVDW
SINFRUP00000148054      DGEPKTMSYIPTGLDEEILQHIGKEASSVP--LEDFNIHPGVSRILRGRADLVKKRQVDW
CG11661-RC              KD---PLKVAPTGVKEETLIHIGNRFSSPPPNAAEFVIHKGLLRVLAARKAMVDEKVADW
                        ..   .:.  .**: *: * ***.  ** *    :* ** *: *:*  *  :. ::  **

ENSMUST00000003461      ALAEYMAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHDQNVDKRTCIPMNHLWPNQAPY
ENST00000309514         ALAEYMAFGSLLKEGIHIRLSGQDVERGTFSHRHHVLHDQNVDKRTCIPMNHLWPNQAPY
SINFRUP00000153892      ALGEYMAFGSLLKEGTHIRLSGQDVERGTFSHRHHVLHDQNVDKRICIPMNHLAPDQAPY
SINFRUP00000145347      ALGEYMAFGSLLQDGIHVRLSGQDVERGTFSHRHHVLHDQNVDKRICIPMNHISTSQAPY
ENSMUST00000022480      ALAEYMAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHDQEVDRRTCVPMNHLWPDQAPY
ENST00000265903         ALAEYMAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHDQEVDRRTCVPMNHLWPDQAPY
SINFRUP00000148054      ALGEYMAFGSLLKDGIHVRLSGQDVERGTFSHRHHVLHDQEVDKRICVPMNHLWSNQAPY
CG11661-RC              ALGEAMAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHHQLVDKATYNSLQHMYPDQAPY
                        **.* *******::* *:********************.* **:    .::*: ..****

ENSMUST00000003461      TVCNSSLSEYGVLGFELGFAMASPNALVLWEAQFGDFNNMAQCIIDQFICPGQAKWVRQN
ENST00000309514         TVCNSSLSEYGVLGFELGFAMASPNALVLWEAQFGDFHNTAQCIIDQFICPGQAKWVRQN
SINFRUP00000153892      TVCNSSLSEYGVLGFELGFAMASPNALILWEAQFGDFHNTAQCIIDQFICPGQAKWVRQN
SINFRUP00000145347      TVCNSSLSEYGVLGFELGFAMASPNALVLWEAQFGDFHNTAQCIIDQFISPGQAKWVRQN
ENSMUST00000022480      TVCNSSLSEYGVLGFELGYAMASPNALVLWEAQFGDFHNTAQCIIDQFISTGQAKWVRHN
ENST00000265903         TVCNSSLSEYGVLGFELGYAMASPNALVLWEAQFGDFHNTAQCIIDQFISTGQAKWVRHN
SINFRUP00000148054      TVCNSSLSEYGVLGFELGFAMASPNALILWEAQFGDFHNTAQCIIDQFISSGQAKWVRNN
CG11661-RC              SVSNSSLSEYAVLGFEHGYSMTNPNALVLWEAQFGDFSNTAQSIIDQFISSGQSKWVRQS
                        :*.*******.***** *::*:.****:********* * **.******..**:****:.

ENSMUST00000003461      GIVLLLPHGMEGMGPEHSSARPERFLQMCNDDPDVLPDLQEENFDINQLYDCNWIVVNCS
ENST00000309514         GIVLLLPHGMEGMGPEHSSARPERFLQMCNDDPDVLPDLKEANFDINQLYDCNWVVVNCS
SINFRUP00000153892      GIVLLLPHGMEGMGPEHSSARPERFLQMCNDDPDVMPVIS-DDFTVRQLYDCNWIVVNCS
SINFRUP00000145347      GIVLLLPHGMEGMGPEHSSARPERFLQMCNDDPDASPIVT-EDFAVHQLFDCNWIVVNCS
ENSMUST00000022480      GIVLLLPHGMEGMGPEHSSARPERFLQMSNDDSDAYPVFT-EDFEVSQLYDCNWIVVNCS
ENST00000265903         GIVLLLPHGMEGMGPEHSSARPERFLQMSNDDSDAYPAFT-KDFEVSQLYDCNWIVVNCS
SINFRUP00000148054      GIVLLLPHGMEGMGPEHSSARPERFLQMSNDDPDHFPEFS-GDFEVEQLYDCNWIVVNCS
CG11661-RC              GLVMLLPHGMEGMGPEHSSCRVERFLQMSSDDPDYFPPES-DEFGVRQLHDINWIVANCS
                        *:*:***************.* ******..**.*  *     :* : **.* **:*.***

ENSMUST00000003461      TPGNFFHVLRRQILLPFRKPLIVFTPKSLLRHPEARTSFDEMLPGTHFQRVIPENGPAAQ
ENST00000309514         TPGNFFHVLRRQILLPFRKPLIIFTPKSLLRHPEARSSFDEMLPGTHFQRVIPEDGPAAQ
SINFRUP00000153892      NPANYFHVLRRQILLPFR-PLIIFTPKSLLRHPEARSSFDDMLPGTHFQSLIPEDGTAAQ
SINFRUP00000145347      TPANYFHVLRRQILLPFRKPLIVFTPKSLLRHPEAKSSFDDMLPGTHFKRIIPDDGPTTV
ENSMUST00000022480      TPASYFHVLRRQILLPFRKPLIVFTPKSLLRHPDAKSSFDQMVSGTSFQRLIPEDGPAAH
ENST00000265903         TPANYFHVLRRQILLPFRKPLIIFTPKSLLRHPEAKSSFDQMVSGTSFQRVIPEDGAAAR
SINFRUP00000148054      TPANYCHVLRRQVLLPFRKPLVVFTPKSLLRHPDARSSFDELTTGTKFKRLIPDDGPAAQ
CG11661-RC              TPANYYHILRRQIALPFRKPLILCTPKSLLRHPEAKSPFSEMSEGSEFQRIIPDNGPAGQ
                        .*..: *:****: **** **:: *********:*::.*.::  *: *: :**::*.:  

ENSMUST00000003461      DPHKVKRLLFCTGKVYYDLTRERKARNMEEEVAITRIEQLSPFPFDLLLKEAQKYPNAEL
ENST00000309514         NPENVKRLLFCTGKVYYDLTRERKARDMVGQVAITRIEQLSPFPFDLLLKEVQKYPNAEL
SINFRUP00000153892      HPEEVKRLIFCN-KVFYELIKERKTRGMDASVAISRIEQLSPFPFDQVKAEVDRFPKADL
SINFRUP00000145347      DPQKVKRVVFCTGKVYYELIRERKNRGMDDAVAVVRIEQLSPFPFDLVKAEIDQYINADL
ENSMUST00000022480      SPEQVQRLIFCTGKVYYDLVKERSSQGLEQQVAITRLEQISPFPFDLIMREAEKYSGAEL
ENST00000265903         APEQVQRLIFCTGKVYYDLVKERSSQDLEEKVAITRLEQISPFPFDLIKQEAEKYPGAEL
SINFRUP00000148054      DPARVKRVIFCSGKVYYDLAKERKQQNLEREVAIIRLEQISPFPFDLVRTEAEMYAEAEL
CG11661-RC              NPSNVKKVVFCSGRVYYDLTKTRREKQLEGEIAIVRVEQISPFPFDLVKEQANLYKNAEL
                         * .*::::**. :*:*:* : *  : :   :*: *:**:****** :  : : :  *:*

ENSMUST00000003461      AWCQEEHKNQGYYDYVKPRLRTTIDRAKPVWYAGRDPAAAPATGNKKTHLTELQRFLDTA
ENST00000309514         AWCQEEHKNQGYYDYVKPRLRTTISRAKPVWYAGRDPAAAPATGNKKTHLTELQRLLDTA
SINFRUP00000153892      VWCQEEHKNQGYYDYVKPRIRTTIQRAKPVWYAGRDPAAAPATGNKNTH-----------
SINFRUP00000145347      VWCQEEHKNQGYYDYVKPRISNTTQHRRPVWYVGREPAAAPATGNKHTHLVELQHFLDTA
ENSMUST00000022480      VWCQEEHKNMGYYDYISPRFMTLLGHSRPIWYVGRDPAAAPATGNKNAHLVSLRRFLDTA
ENST00000265903         AWCQEEHKNMGYYDYISPRFMTILRRARPIWYVGRDPAAAPATGNRNTHLVSLKKFLDTA
SINFRUP00000148054      VWCQEEHKNMGYYDYVRPRFLTVLANRKPIWYVGREPAAAPATGNKFTH-----------
CG11661-RC              VWAQEEHKNQGSWTYVQPRFLTALNHSRDVSYVGRACGASTATGSKAQHIRELNALLNDA
                        .*.****** * : *: **: .   . : : *.**  .*:.***.:  *:  :  ::   

ENSMUST00000003461      FDLDAFKKFS-
ENST00000309514         FDLDVFKNFS-
SINFRUP00000153892      -----------
SINFRUP00000145347      FDLEAF-----
ENSMUST00000022480      FNLKAFEGKTF
ENST00000265903         FNLQAFEGKTF
SINFRUP00000148054      -----------
CG11661-RC              IST--------
                        :    :