CLUSTAL W (1.82) multiple sequence alignment ENST00000298467 ------------------------------------------------------------ ENSMUST00000028190 ------------------------------------------------------------ SINFRUP00000155892 ------------------------------------------------------------ ENST00000282931 -----GKSRICESPGGSAAAAVRRPGAEPP-----------VAQPLRARAWAGRERPEQR SINFRUP00000143023 ------------------------------------------------------------ CG4032-RA MGAQQGKDRGAHSGGGGSGAPVSCIGLSSSPVASVSPHCISSSSGVSSAPLGGGSTLRGS ENST00000298467 -------------------------MGQQPGKVLGDQRRPSLPALHFIKGAGKKESSRHG ENSMUST00000028190 -------------------------MLEICLKLVGCK-------------------SKKG SINFRUP00000155892 -------------------------MLEICLKLVGCK-------------------SKKG ENST00000282931 QEPEAGAEEECDQGSAGAREYARAGMGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRR SINFRUP00000143023 ------------------------------------------------------------ CG4032-RA RIKSSSSGVASGSGSGGGGGGSGSGLSQRSGGHKDARCNPTVGLNIFTEHNEALLQSRPL : ENST00000298467 GPH----------------------------CNVFVEHEALQRPVASDFEPQGLSEAARW ENSMUST00000028190 LSS----------------------------SSSCYLEEALQRPVASDFEPQGLSEAARW SINFRUP00000155892 LSS----------------------------SSSCYLEEALQKP--------DLTEAARW ENST00000282931 DPAGRTTETGFNIFTQHDHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRW SINFRUP00000143023 -------------------------------------PEALHRPFG--LDSAALTEAVRW CG4032-RA PHIPAG-------STAASLLADAAELQQHQQDSGGLGLQGSSLGGGHSSTTSVFESAHRW :. : .* ** ENST00000298467 NSKENLLAG-PSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG ENSMUST00000028190 NSKENLLAG-PSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG SINFRUP00000155892 NSKENLLAG-PSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG ENST00000282931 SSKENLLG--ATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG SINFRUP00000143023 SSKENLLG--AAESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG CG4032-RA TSKENLLAPGPEEDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSG .******. . *.**:******** *.*:* **:.***::*:*.**:.***.*.::..* ENST00000298467 -QGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLR ENSMUST00000028190 -QGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLR SINFRUP00000155892 -QGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLR ENST00000282931 -QGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLR SINFRUP00000143023 -QGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLR CG4032-RA NVGWVPSNYVTPLNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLR *******:**:************:**.******** **************** ***** ENST00000298467 YEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVAD--GLITTLHYPAPKRNKPT ENSMUST00000028190 YEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVAD--GLITTLHYPAPKRNKPT SINFRUP00000155892 YEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVAD--GLITTLHYPAPKRNKPT ENST00000282931 YEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVAD--GLVTTLHYPAPKCNKPT SINFRUP00000143023 YEGRVYHYRINTASDGKVYVTSESRFATLAELVHHHSTVAD--GLVTTLHYPAPKCNKPT CG4032-RA YEGRVYHYRISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPT **********. .***::*: *::* **********. : **:*.* ***** **** ENST00000298467 VYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFL ENSMUST00000028190 IYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFL SINFRUP00000155892 IYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYNLTVAVKTLKEDTMEVEEFL ENST00000282931 VYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFL SINFRUP00000143023 VYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYNLTVAVKTLKEDTMEVEEFL CG4032-RA VFPLSPEPDEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFL :: :** *:**: **** ************** .***:*. ************ :::** ENST00000298467 KEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMA ENSMUST00000028190 KEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMA SINFRUP00000155892 KEA-VMKEIKHPNLVQLLGVCTREPPFYIITEFMTHGNLLDYLRECNREEVNAVVLLYMA ENST00000282931 KEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMA SINFRUP00000143023 KEAAVMKEVKHPNLVQLLGVCTLEPPFYIVTEYMPHGNLLDYLRDCDKEEVNAVVLLYMA CG4032-RA EEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMA :** :***:********:**** ******:**:*.:*****:**...:: : **.***** ENST00000298467 TQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIK ENSMUST00000028190 TQISSAMEYLEKKNFIHRDLAARNCLVGE-KPLKVADFGLSRLMTGDTYT-HAGAKFPIK SINFRUP00000155892 TQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIK ENST00000282931 TQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIK SINFRUP00000143023 TQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIK CG4032-RA TQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIK ***:*.*.***.:*:*************: : :*******:*** .**** ********* ENST00000298467 WTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGC ENSMUST00000028190 WTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGC SINFRUP00000155892 WTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSLVYELLEKDYRMDRPEGC ENST00000282931 WTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGC SINFRUP00000143023 WTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGC CG4032-RA WTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGC *****.****.** ***********************.***: **. *:*.***::* ** ENST00000298467 PEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGV--------- ENSMUST00000028190 PEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKRGT--------- SINFRUP00000155892 PEKVYELMTACWRWNPAERPSFAETHQAFETMFQESSISDEVEKELGKKGK--------- ENST00000282931 PPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAAS--------- SINFRUP00000143023 PPKVYELMRACWQWSPLDRPSFAEIHQAFETMFHDSSISEEVAEELCKTAAGH------- CG4032-RA PPEVYDLMRQCWQWDATDRPTFKSIHHALEHMFQESSITEAVEKQLNANATSASSSAPST * :**:** **:*.. :**:* . *:*:* **::***:: * ::* . ENST00000298467 ---------------------RGAVSTLLQAPELPTK----------------------- ENSMUST00000028190 ---------------------RGGAGSMLQAPELPTK----------------------- SINFRUP00000155892 ---------------------KATFGSIQQAPELPTK----------------------- ENST00000282931 --------------------SSSVVPYLPRLPILPSK----------------------- SINFRUP00000143023 --------------------CGPLHSFCADMPLLPSK----------------------- CG4032-RA SGVATGGGATTTTAASGCASSSSATASLSLTPQMVKKGLPGGQALTPNAHHNDPHQQQAS * : .* ENST00000298467 ----------------TRTSRRAAEHRDTT-----DVPEMPHSKGQGESDPLDHEPAVSP ENSMUST00000028190 ----------------TRTCRRAAEQKDAP-----DTPELLHTKGLGESDALDSEPAVSP SINFRUP00000155892 ----------------TRTLRKNMDTRDG------DSPDPVEPEG----------AVSSP ENST00000282931 ----------------TRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQASS-GSP SINFRUP00000143023 ----------------SRTLHKHTENKENIEGGLDGRPDQATLSHSGTSRHAYLDTNHSP CG4032-RA TPMSETGSTSTKLSTFSSQGKGNVQMRRTTNKQGKQAPAPPKRTSLLSSSRDSTYREEDP : : : : .* ENST00000298467 LLPRKE--RGPPEGGLNEDERLL----------PKDKKTN------------LFSALIKK ENSMUST00000028190 LLPRKE--RGPPDGSLNEDERLL----------PRDRKTN------------LFSALIKK SINFRUP00000155892 MLPRKE--RLLLDTNLNEDDRLL----------PKDKDKTRS----------GLLGLIKK ENST00000282931 ALPRKQ--RDKSPSSLLEDAKET-C-------FTRDRKGG------------FFSSFMKK SINFRUP00000143023 ALPRKQQPRDKSPGSLLEDAQDMGT-------FIRDRKTG------------FFSSFIKK CG4032-RA ANARCNFIDDLSTNGLARDINSLTQRYDSETDPAADPDTDATGDSLEQSLSQVIAAPVTN .* : .* .* . * . : . :.: ENST00000298467 K------------KKTAPTPPKRSSSFR-----------EMDGQPERR-------GAGEE ENSMUST00000028190 K------------KKMAPTPPKRSSSFR-----------EMDGQPDRR-------GASED SINFRUP00000155892 K------------KKNAPTPPKRSSSFR-----------EMDAHHDRR-------GLIPD ENST00000282931 R--------------NAPTPPKRSSSFR-----------EMENQPHKKYELTGNFSSVAS SINFRUP00000143023 KSSSSSSSPSSQLQQNLPTPPKRSSSFR-----------EMETQPHKKYEPTAEFNAPPP CG4032-RA KMQHSLHSGGGG-GGIGPRSSQQHSSFKRPTGTPVMGNRGLETRQSKRSQLHSQAPGPGP : * ..:: ***: :: : :: ENST00000298467 --------------------------------------------------EGRDISNGAL ENSMUST00000028190 --------------------------------------------------DSRELCNGPP SINFRUP00000155892 P-------------------------------------------------RDGDCFNNGI ENST00000282931 L-------------------------------------------------QHAD---GFS SINFRUP00000143023 L-------------------------------------------------PQSDSLGGFS CG4032-RA PSTQPHHGNNGVVTSAHPITVGALDVMNVKQVVNRYGTLPKGARIGAYLDSLEDSSEAAP : ENST00000298467 AFTPLDTADPAKSPKPSNGAG-----------------VPNGALRES-GGSGFRSPHL-W ENSMUST00000028190 ALT-SDAAEPTKSPKASNGAG-----------------VPNGAFREP-GNSGFRSPHM-W SINFRUP00000155892 TLPINDLSPGLDSTKLLVTN-------------------NNGAVGITNGAPAFPGPLFPW ENST00000282931 FTPAQQEANLVP--PKCYGGSFA---------QRNLCNDDGGGGGGSGTAGGGWSGITGF SINFRUP00000143023 ASPSHSHGEPAQGQSRCCGAAFG---------QK----PSGGGLSSQVTSGSSWGGLAGF CG4032-RA ALPATAPSLPPANGHATPPAARLNPKASPIPPQQMIRSNSSGGVTMQNNAAASLNKLQRH . . .*. . . ENST00000298467 KKSS--TLT---SSRLATG--EEEGGGSSS----KRFLRSCSASCVPHGAKD-------- ENSMUST00000028190 KKSS--TLT---GSRLAAA--EEESGMSSS----KRFLRSCSASCMPHGARD-------- SINFRUP00000155892 KKGA--PAVPGPGGKAATTPPNEEESMSNS----KRFLWS---SSMPVGSDG-------- ENST00000282931 FTPR--LIKKTLGLRAGKPTASDDTS--------KPFPRSNSTSSMSSGLPE-------- SINFRUP00000143023 FTPR--LIKKTLGLRTGKTTSSEDGGSIAAGL--KPFPRSNSTSSMSAGLLD-------- CG4032-RA RTTTEGTMMTFSSFRAGGSSSSPKRSASGVASGVQPALANLEFPPPPLDLPPPPEEFEGG . . : . . . . : . . . . ENST00000298467 ---------------TEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRS- ENSMUST00000028190 ---------------TEWRSVTLPRDLPSAGKQFDSSTFGGHKSEKPALPRKRTSESRS- SINFRUP00000155892 ---------------TEWKSVTLPRDLG--QRHFDSGTFGG----KPALPRKRNGEQKG- ENST00000282931 ---------------QDRMAMTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKS- SINFRUP00000143023 ---------------LERMALTLPRNRS-AKSPLERTASTTSQPENGATRPSECLLRRM- CG4032-RA PPPPPPAPESAVQAIQQHLHAQLPNNGNISNGNGTNNNDSSHNDVSNIAPSVEEASSRFG : **.: . : ENST00000298467 -----------------------------DQVTRG-TVTPPPRLVKKNEEAADEVFKDIM ENSMUST00000028190 -----------------------------EQVAKS-TAMPPPRLVKKNEEAAEEGFKDTE SINFRUP00000155892 -----------------------------EHTRRMGTLTPPPRLNTSPDLSSATLAKDTD ENST00000282931 -----------------------------EESAAPSRERPKAKLLPRGATALPLRTPSGD SINFRUP00000143023 -----------------------------DEGTAQIRERPKAKLLPRG-TSVGARAPGVG CG4032-RA VSLRKREPSTDSCSSLGSPPEDLKEKLITEIKAAGKDTAPASHLANGSGIAVVDPVSLLV : * .:* : ENST00000298467 ESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSA--------------------- ENSMUST00000028190 -SSPGSSPPSLTPKLLRRQVTASPSSGLSHKEEATKGSAS-------------------- SINFRUP00000155892 -PSPGSSPQALTPKAVRRPEVPGLDS---------------------------------- ENST00000282931 LAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPED--------------------- SINFRUP00000143023 GEVGESDSS-------SRVKGPRDENGGGLDRQQSWPSP--------------------- CG4032-RA TELAESMNLPKPPPQQQQKLTNGNSTGSGFKAQLKKVEPKKMSAPMPKAEPANTIIDFKA . . ENST00000298467 -------LGTPAAAEPVTPTSKAGSGA------------------PGGTSKGPAEESRVR ENSMUST00000028190 ------GMGTPATAEPAPPSNKVG------------------------LSKASSEEMRVR SINFRUP00000155892 -------LKTSALHAELLKANVFP------------------------ALGAAAEESRAR ENST00000282931 -------GEQPGWPSPAKAAPVLPT---------------------THNHKVPVLISPTL SINFRUP00000143023 -------SKTSTLSASSTAAGAM-----------------------THNHKVPVLISPTQ CG4032-RA HLRRVDKEKEPATPAPAPATVAVANNANCNTTGTLNRKEDGSKKFSQAMQKTEIKIDVTN . : . ENST00000298467 RHKHSSESP--GRDKGKL--------SRLKPAPPPPPAASAG-KAGGKPSQSPSQEAAGE ENSMUST00000028190 RHKHSSESP--GRDKGRL--------AKLKPAPPPPPACTG--KAG-KPAQSPSQEAG-E SINFRUP00000155892 RQKHAADSAS-VRERGKL--------QKPKPAPPPPPTSTKTSKVSRSPTQEPPSPSPTT ENST00000282931 KHTPADVQLIGTDSQGNK--------FKLLSEHQVTSSGDKDRPRRVKPKCAPPPPPVMR SINFRUP00000143023 KHSPADVHLVGLDSQGNR--------FKLLSDQQ----ADRDRPRLVKPKCAPPPPPNVR CG4032-RA SNVEADAGAAGEGDLGKRRSTGSINSLKKLWEQQPPAPDYATSTILQQQPSVVNGGGTPN : : . *. : . ENST00000298467 AVLGAKTKATSL-VDAVNSDAAKPSQPGEGLKKPVLPATPKPQS-AKPSGTPISPAPVPS ENSMUST00000028190 AGGPTKTKCTSLAMDAVNTDPTKAGPPGEGLRKPVPPSVPKPQSTAKPPGTPTSPVSTPS SINFRUP00000155892 SDIRAKLPSVSEPHHTTTASDQTRSPLSEGSKKLPLGSASKPQPLKTSSSSTSVSASLSS ENST00000282931 LLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAVPISGKAGRPVMPPPQVPLPTS SINFRUP00000143023 SLQQS--YSGDGEEQLAGVPSEVNGDTLKSNR---SGRTSGGVTMGRPSVPPPQVPPASS CG4032-RA AQLSPKYGMKSGAINTVGTLPAKLGNKQPPAAPPPPPPNCTTSNSSTTSISTSSRDCTSR . . . . .. . ENST00000298467 TLP--------SASSALAGDQPSSTA---------------------------FIPLIST ENSMUST00000028190 TAP--------APSPLAGDQQPSSAA---------------------------FIPLIST SINFRUP00000155892 QSLGG-----FSSSLTSPGDQSSPTA---------------------------FIPLVNT ENST00000282931 S-----------ISPAKMANG-----------------------------------TAGT SINFRUP00000143023 SSLSSSCSASTNTIPAKMANGAATTA---------------------------SSHTAAS CG4032-RA QQASSTIKTSHSTQLFTDDEEQSHTEGLGSGGQGSADMTQSLYEQKPQIQQKPAVPHKPT : : ENST00000298467 RVSLRKT--RQPPE---RIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKN- ENSMUST00000028190 RVSLRKT--RQPPE---RIASGTITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKN- SINFRUP00000155892 RRSLRKTAPRQASE---RTPNSAVTRDMVLEGTELLRAAICRNSEQTGSHSAVLEAGKN- ENST00000282931 KVALRKT--KQAAE---KISADKISKEALLECADLLSSALTEPVPN----SQLVDTGHQ- SINFRUP00000143023 KVALRRT--RQQAE---RVPLERISREALLECAKYLSSALHASSESPAS-SQVLDAGHQ- CG4032-RA KLTIYATPIAKLTEPASSASSTQISRESILELVGLLEGSLKHPVNAIAGSQWLQLSDKLN : :: * : .* . ::: :*: . * :: . : :.: ENST00000298467 -LYTFCVSYVDS-IQQMRNKFAFREAINKLENNLRELQICPATAGS--GPAATQDFSKLL ENSMUST00000028190 -LYTFCVSYVDS-IQQMRNKFAFREAINKLESNLRELQICPATASS--GPAATQDFSKLL SINFRUP00000155892 -LSKYCMSYVDS-IQQMRNKFAFREAINKLESSLRELQICPTATG---GANAQQDFSKLL ENST00000282931 -LLDYCSGYVDC-IPQTRNKFAFREAVSKLELSLQELQVSSAAAG---VPGTNPVLNNLL SINFRUP00000143023 -LLDYCSGYVDC-IPQMRNKFAFREAVGKLELSLQELRASSSGGGGLSGVGPNTVLDNLH CG4032-RA ILHNSCVIFAENGAMPPHSKFQFRELVTRVEAQSQHLRSAGSKNVQ----DNERLVAEVG * * :.: :.** *** : ::* . :.*: . : . :: ENST00000298467 SSVKEISDIVQR ENSMUST00000028190 SSVKEISDIVRR SINFRUP00000155892 SSVKEISDIVQR ENST00000282931 SCVQEISDVVQR SINFRUP00000143023 SCIKEISDVVQR CG4032-RA QSLRQISNALNR ..:::**: :.*