CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000033765 ----------------MILVSTTSAVPGALSSPSSPSNSSQEELLDDRDP ENST00000247312 ----------------MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDP SINFRUP00000161883 -----------------------------------------------RDL SINFRUP00000156712 -------------------------------------------------- SINFRUP00000149294 ---------MGELLREQSACLLNVSWNNPNVSHG---NDTVNPLK--RNE SINFRUP00000127611 ---------METVANESDFWLCNTSCRDPGVANETVLSNQTNPLK--RNE ENSMUST00000053306 ---------MEGTPAANWSIELDLGSGVPPGAEG---NLTAGPPR--RNE ENST00000316793 ---------MEGALAANWSAEAANASAAPPGAEG---NRTAGPPR--RNE SINFRUP00000141525 ---------------------------------LN--SNGSDPFA--RNE Q8JHD6_Haplochromis_burtoni -------------------------MGTSGNGTDQ--HNGSDPFA--RNE Q9PUG3_Platichthys_flesus -------------------------MEKPGNITLH--PNGSDPFG--RNE SINFRUP00000161762 ----------------------------------------TDPFG--RNE ENSMUST00000020323 MSFPRGSHDLPAGNSSPWWPLTTEGANSSREAAGL--GEGGSPPGDVRNE ENST00000299178 MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEAL--GEGNGPPRDVRNE ENSMUST00000027690 ------------MDSEPSWTATP----SPGGTLFV--PNTTTPWLG-RDE ci0100139176 -----------------------------MTSSIPLLAMHRVRNGTALQR CG6111-RA ----------------------------------------MKCDHTLFFA ENSMUST00000033765 LLVRAELALLSTIFVAVALSNGLVLGALIRRGRRGRWAPMHVFISHLCLA ENST00000247312 LLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLA SINFRUP00000161883 NLARAEIAVLSLVLALTTLGNSFVLWVLLR--RRKYNAPMHVFMVNLCVA SINFRUP00000156712 ----------------LNLG---VLLVLWK--RRKQLSRMRVFVFHLCVA SINFRUP00000149294 DVAKVEVAVLVLVLLLALTGNLCVLWATHA--TKHSQSRMYFFMKHLSIA SINFRUP00000127611 EVAKVEVTVLALVLFLALAGNLCVLLAIHT--TKHSQSRMYYFMKHLSIA ENSMUST00000053306 ALARVEVAVLCLILFLALSGNACVLLALRT--TRHKHSRLFFFMKHLSIA ENST00000316793 ALARVEVAVLCLILLLALSGNACVLLALRT--TRQKHSRLFFFMKHLSIA SINFRUP00000141525 EVAQIEIMVLSITFVVAVIGNVSVLLAMHN--TKKKISRMHLFIKHLSLA Q8JHD6_Haplochromis_burtoni EVAQIEIMVLSITFVVAVIGNVSVLLAMYN--TKKKMSRMHLFIKHLSLA Q9PUG3_Platichthys_flesus EVAQIEIMVLSITFVVAVIGNVSVLLAMYN--TKKKMSRMHLFIKHLSLA SINFRUP00000161762 EVAKIEIGVLSLTFVAAVLGNVSVLLATH-----RKPSRVHLFMKHLSLA ENSMUST00000020323 ELAKLEVTVLAVIFVVAVLGNSSVLLALHR--TPRKTSRMHLFIRHLSLA ENST00000299178 ELAKLEIAVLAVTFAVAVLGNSSVLLALHR--TPRKTSRMHLFIRHLSLA ENSMUST00000027690 ELAKVEIGILATVLVLATGGNLAVLLILGL--QGHKRSRMHLFVLHLALT ci0100139176 QIRITELYIIATVFILGLIGNSCVLVALWQ--RYSKHTRMHILIFHLAVA CG6111-RA LFQTEQFAVLWILFTVIVLGNSAVLFVMFIN--KNRKSRMNYFIKQLALA . . :: : . ** : : :: :*.:: ENSMUST00000033765 DLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQMVGMYASSYMILAMT ENST00000247312 DLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMT SINFRUP00000161883 DLVVAFFQVLPQLIWDITERFRGPDLLCRSVKYLQIVGMFASSYMIVAMT SINFRUP00000156712 DLVVTFFQVCPQLMWDVTDRFVGPDVLCRLVKYLQVVGMFASTYMIVAMT SINFRUP00000149294 DLVVALFQVFPQLIWDITFRFYGSDVLCRLVKYLQVVSMFASTYMLVLMS SINFRUP00000127611 DLVVAIFQVLPQLIWDITFRFYGPDILCRLVKYLQVVGMFASTYMLVLMS ENSMUST00000053306 DLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMS ENST00000316793 DLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMS SINFRUP00000141525 DLVVAFFQVLPQLCWEITFRFYGSDFLCRIVKHLQVMGMFASTYMMVMMT Q8JHD6_Haplochromis_burtoni DLVVAFFQVLPQLCWEITFRFYGPDFLCRIVKHLQVMGMFASTYMMVMMT Q9PUG3_Platichthys_flesus DLVVAFFQVLPQLCWEITYRFFGPDFLCRIVKHLQVTGMFASTYMMVMMT SINFRUP00000161762 DLVVAFFQVLPQLCWEVTFRFYGPDFLCRIVKHLQVLGMFASAYMMVMMT ENSMUST00000020323 DLAVAFFQVLPQLCWDITYRFRGPDWLCRVVKHLQVFAMFASSYMLVVMT ENST00000299178 DLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQVFGMFASAYMLVVMT ENSMUST00000027690 DLGVALFQVLPQLLWDITYRFQGSDLLCRAVKYLQVLSMFASTYMLLAMT ci0100139176 DLIVVLFEMLPEWIIRFGFGFFASDAMCKFVKYMQILGMYGSTYVLLCAA CG6111-RA DLCVGLLNVLTDIIWRITISWRAGNLACKAIRFSQVCVTYSSTYVLVAMS ** * .::: .: : . : *: ::. *: :.*:*::: : ENSMUST00000033765 LDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRD-- ENST00000247312 LDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQRN-- SINFRUP00000161883 VDRHHAICCPLQAYRGGAVSRWNTPVMVAWGLALVLSLPQVFIFSRSE-- SINFRUP00000156712 IDRYQAICKPMVTFQK-RRARCNGPVCAAWCVSLVGSLPQIFIFSRVE-- SINFRUP00000149294 VDRCLAICQPLRLVDR--KKDR-LYVFASWMLSLIFSTPQAFIFSLKEVG SINFRUP00000127611 VDRCLAICQPLRSLHR--RKDR-FYVIFSWGLSLVFSVPQMFIFSLREVG ENSMUST00000053306 LDRCLAICQPLRSLRR--RTDR-LAVLATWLGCLVASVPQVHIFSLREVA ENST00000316793 LDRCLAICQPLRSLRR--RTDR-LAVLATWLGCLVASAPQVHIFSLREVA SINFRUP00000141525 LDRYIAICHPLKTLQQSSQRSY-IMIISTWMCSLALSTPQYFIFSLSE-- Q8JHD6_Haplochromis_burtoni LDRYIAICHPLKTLQQSTRRSY-IMIISTWICSLVLSCSQYFIFSLSE-- Q9PUG3_Platichthys_flesus LDRYIAICHPLKTLQQPTQRSY-IMIVSTWMCSLVFSTPQYFIFSLSE-- SINFRUP00000161762 LDRYIAICHPLQTLQRPAQRAY-VMIGGTWAGSLALSAPQYFIFSLSE-- ENSMUST00000020323 ADRYIAVCHPLKTLQQPARRSR-LMIAASWGLSFVLSIPQYFIFSVIEFE ENST00000299178 ADRYIAVCHPLKTLQQPARRSR-LMIAAAWVLSFVLSTPQYFVFSMIE-- ENSMUST00000027690 LDRYLAVCHPLRSLQQPSQSTY-PLIAAPWLLAAILSLPQVFIFSLRE-- ci0100139176 FDRYRAIRYPMQSFQLTAKRVH-TSVLIAWGVSAFLSTPQLFLFEKPE-- CG6111-RA IDRYDAITHPMNFSKSWKRARH--LVAGAWLISALFSLPILVLYEEKL-- ** *: *: : .* . * . :: . ENSMUST00000033765 VGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREI ENST00000247312 VEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREI SINFRUP00000161883 VAPG--EYECWGHFAEPWGLKAYVTWMTVAVFLLPALIITICQVILA--L SINFRUP00000156712 VAPG--VYDCWAQFIKPWGLRTYVTWTTLVIFVLPILTVTVCQVRICRTV SINFRUP00000149294 ----SGVYDCWGDFVQPWGTKAYITWMSLSIYIIPVAILCVCYGLICFKI SINFRUP00000127611 SAG-SGVYDCWGDFVKPWGAKAYITWISLTIYIIPVAILSVCYGLISFKI ENSMUST00000053306 ----DGVFDCWAVFIQPWGPKAYVTWITLAVYIVPVIVLAACYGLISFKI ENST00000316793 ----DGVFDCWAVFIQPWGPKAYITWITLAVYIVPVIVLAACYGLISFKI SINFRUP00000141525 IEKGSEVYDCWAHFIEPWGAKAYITWITVGIFLVPVTMLMMCYGFICHSI Q8JHD6_Haplochromis_burtoni IQNGSGVYDCWARFIEPWGARAYITWITVGIFLVPVVLLMMCYGFICHSI Q9PUG3_Platichthys_flesus VKNGSTVKDCWAHFIEPWGARAYITWITGGIFLVPVVILVMCYGFICHTI SINFRUP00000161762 VSPGSAVYDCWGHFVEPWGLRAYITWMTAGIFVVPVAALVFCYGFICRTI ENSMUST00000020323 VNNGTKAQDCWATFIPPWGTRAYVTWMTSGVFVVPVIILGTCYGFICYHI ENST00000299178 VNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNI ENSMUST00000027690 VIQGSGVLDCWADFYFSWGPRAYITWTTMAIFVLPVVVLTACYGLICHEI ci0100139176 ----TRNMCRMKRFPSAAFDQAYTTWYFFVIMFIPTCFLIYLYGMIAVLI CG6111-RA ---IQGHPQCWIELGSPIAWQVYMSLVSATLFAIPALIISACYAIIVKTI : . :.* : : * : : : ENSMUST00000033765 HASLVPGPSERAGRRRRGHR-------------TGSPSEGAHVSAAMAKT ENST00000247312 HASLVPGPSERPGGRRRGRR-------------TGSPGEGAHVSAAVAKT SINFRUP00000161883 LDTPSPRGSPRCSIDYAPPH-------------SPSIPP-PSITKAMSKT SINFRUP00000156712 NLNFHMKTHHNGEVVSRPP--------------SSRASNVAGVSKARVKT SINFRUP00000149294 WKNFNVKTSRDRFLALTAGPSKC-------AHPLSRVSSVRLISKAKIRT SINFRUP00000127611 WQNFRLKTRREHCVSMTPRTAK--------DNTLTRVSSVKLISKAKITT ENSMUST00000053306 WQNLRLKTAAAAAAAEGSDAAGG-----AGRAALARVSSVKLISKAKIRT ENST00000316793 WQNLRLKTAAAAAAEAPEGAAAGD----GGRVALARVSSVKLISKAKIRT SINFRUP00000141525 WKNIKFK-KRKGTTGAATKN--------GLIGKNS-VSSITTISRAKLRT Q8JHD6_Haplochromis_burtoni WKNIKYK-KRKTTAGAASRN--------GLIGKNS-VSSVTTISRAKLRT Q9PUG3_Platichthys_flesus WKNIKYK-KRKTIPGAASKN--------GLIGKNS-VSSVTTISRAKLRT SINFRUP00000161762 WKNLKCKTQRKSVEAVAEATGA------GILGPCS-VSSVSTLSRAKLRT ENSMUST00000020323 WRNVRGKTASRQSKGGKGSGEAAGPFHKGLLVTPC-VSSVKSISRAKIRT ENST00000299178 WCNVRGKTASRQSKGAEQAG---VAFQKGFLLAPC-VSSVKSISRAKIRT ENSMUST00000027690 YKNLKVKTQAGREERRGWPKSSSSAAAAATRGLPSRVSSISTISRAKIRT ci0100139176 MRNLKQKNKAGSSTSPVRQGGIFSS---TTGNFAPRASSTAGISRAKIKT CG6111-RA WAKGSIFVPTERAGFGAAPAR--------------RASSRGIIPRAKVKT . :. * * ENSMUST00000033765 VRMTLVIVIVYVLCWAPFFLVQLWAAWDPEAPLERP--------PFVLLM ENST00000247312 VRMTLVIVVVYVLCWAPFFLVQLWAAWDPEAPLEG--------------- SINFRUP00000161883 VRMTLVIVLVYTICWSPFFIVQLWAAWDPNSPDQGV--------AFTILM SINFRUP00000156712 LKMTVVIVVAYVICWAPFFTVQLWSVWDDEAPTHS--------------- SINFRUP00000149294 VKMTFVVVLAYVVCWTPFFSVQLWSAWDPAAPRED--------MAFIIAM SINFRUP00000127611 VKMTFVIVVAYIVCWTPFFSVQMWSAW--ATP-------------FIISM ENSMUST00000053306 VKMTFIIVLAFIVCWTPFFFVQMWSVWDVNAPKEA--------SAFIIAM ENST00000316793 VKMTFIIVLAFIVCWTPFFFVQMWSVWDANAPKEA--------SAFIIVM SINFRUP00000141525 VKMTFVIVLAYIVCWAPFFTVQMWSVWDENFQWAD-----SENTAVTLSA Q8JHD6_Haplochromis_burtoni VKMTFVIVLAYIVCWAPFFIVQMWSVWDENFQWDD-----SENTAVSLSA Q9PUG3_Platichthys_flesus VKMTFVIVLAYIICWAPFFTVQMWSVWDENFQYAD-----SENTAVTISA SINFRUP00000161762 VKMTFVIVLAYVLCWAPFFTVQMWSVWDHTFSWDD-----SESTAVTLSA ENSMUST00000020323 VKMTFVIVSAYILCWTPFFIVQMWSVWDTNFVWTD-----SENPSTTITA ENST00000299178 VKMTFVIVTAYIVCWAPFFIIQMWSVWDPMSVWTE-----SENPTITITA ENSMUST00000027690 VKMTFVIVLAYIACWAPFFSVQMWSVWDENAPNEGEYVGYSTNVAFTISM ci0100139176 VQMTLVIVITYVVLWTPFFTVQMLAAWGAINEDHI---------AASCIK CG6111-RA VKMTLTIVFVFIICWSPYIIFDLLQVFGQIPHSQTN------IAIATFIQ ::**. :* .: *:*:: .:: .: ENSMUST00000033765 LLASLNSCTNPWIYASFSSSVSSELRSL-----LCCAQRHTTHSLGPQDE ENST00000247312 ------GCSRG--------------------------------------- SINFRUP00000161883 LLASLNSCTNPWIYTAFSSSVSRELQNL-----LHCRPGPGRR--GSLPD SINFRUP00000156712 -------KTNMLACSTFS-------------------------------- SINFRUP00000149294 LLASLNSCCNPWIYMFFAGHLFQDLRRG-----FSCCCKR--DATASSCS SINFRUP00000127611 LLASLNSCCNPWIYMFFAGHLFQDLRQT-----FLCCSPRYLKSPQSQCE ENSMUST00000053306 LLASLNSCCNPWIYMLFTGHLFHELVQR-----FLCCSARYLKGSRP--- ENST00000316793 LLASLNSCCNPWIYMLFTGHLFHELVQR-----FLCCSASYLKGRRL--- SINFRUP00000141525 LLASLNSCCNPWIYMIFSGHLLQDFVHC-----LPCCVKMNTDFKKEDSD Q8JHD6_Haplochromis_burtoni LLASLNSCCNPWIYMIFSGHLLQDFVQC-----FSCCRKINTDFKKEDSD Q9PUG3_Platichthys_flesus LLASLNSCCNPWIYMIFSGHLLQDFMNC-----FAWCRRANADFKKEDSD SINFRUP00000161762 LLASLNSCCNPWIYMLFGGRLLSDCAGS-----LPCCSRLGRRFTRRHSD ENSMUST00000020323 LLASLNSCCNPWIYMFFSGHLLQDCVQS-----FPCCQSIAQKFAKDDSD ENST00000299178 LLGSLNSCCNPWIYMFFSGHLLQDCVQS-----FPCCQNMKEKFNKEDTD ENSMUST00000027690 LLGNLSSCCNPWIYMGFNSHLLPRSLSH-----RACCRGSKPRVHRQLSN ci0100139176 LLASLNSCTNPWIYMAFSGNLLGDIKRF-----ILCQKKKKSSFTNKSRQ CG6111-RA SLAPLNSAANPLIYCLFSSQVFRTLSRFPPFKWFTCCCKSYRNNSQQNRC : : . : : ENSMUST00000033765 SCATASSSLMKDTPS----------------------------------- ENST00000247312 -------------------------------------------------- SINFRUP00000161883 DSTTTHTSTTKDS------------------------------------- SINFRUP00000156712 -------------------------------------------------- SINFRUP00000149294 CNQRCRHKRNSSTCVMKN-TSSQRSLT------------HTCST------ SINFRUP00000127611 REYDSSHKSVSSNFAIKS-TSSQRSVT------------QTSTT------ ENSMUST00000053306 GETSISKKSNSSTFVLSRRSSSQRSCS------------QPSSA------ ENST00000316793 GETSASKKSNSSSFVLSHRSSSQRSCS------------QPSTA------ SINFRUP00000141525 S--SLRRTTLLSKMTNRSPTASSGNWRELD------NSPKSSNE---VE- Q8JHD6_Haplochromis_burtoni S--SLRRTTLLTKMTNRSPTARTFFSRNPDAFKGCCASPQCCRTPFPVKV Q9PUG3_Platichthys_flesus S--SIRRTTLLTKMTNRSPTGSTGNWRDLD------NSPKTSIQ---ME- SINFRUP00000161762 C--SLRGTTLLSRLQG--P------------------------------- ENSMUST00000020323 S--MSRRQTSYS--NNRSPTNSTGTWK---------DSPKSSKSIRFIPV ENST00000299178 S--MSRRQTFYS--NNRSPTNSTGMWK---------DSPKSSKSIKFIPV ENSMUST00000027690 SSLASRRTTLLTHTCGPSTLRLSLNLS-------LHAKPKPAGSLKDLEQ ci0100139176 GDTGKKTRNYSAFDPTTKETDMTATTNMELSVAKPKARNANNKKKYQTSE CG6111-RA HTVGRRLHNSCDSMRTLTTSLTVSRRSTNKTNARVVICERPTKVVTVPAM ENSMUST00000033765 ---------------- ENST00000247312 ---------------- SINFRUP00000161883 ---------------- SINFRUP00000156712 ---------------- SINFRUP00000149294 ---------------- SINFRUP00000127611 ---------------- ENSMUST00000053306 ---------------- ENST00000316793 ---------------- SINFRUP00000141525 ---------------- Q8JHD6_Haplochromis_burtoni FTKIKPI--------- Q9PUG3_Platichthys_flesus ---------------- SINFRUP00000161762 ---------------- ENSMUST00000020323 ST-------------- ENST00000299178 ST-------------- ENSMUST00000027690 VDGEATMETSIS---- ci0100139176 LSDIASSGLMENESEN CG6111-RA SERRGVSLKGNTDIL-