CLUSTAL W (1.82) multiple sequence alignment SINFRUP00000158609 -------------------------------------------RLIEKRQ SINFRUP00000141634 -----------------------------------------VHRVLEKKQ ENSMUST00000020102 ----MPFKAFDTFKEKILKPGKEGVKNAVGDSLGI------LQRKIDGTN ENST00000323346 ----MPFKAFDTFKEKILKPGKEGVKNAVGDSLGI------LQRKIDGTT SINFRUP00000143039 -------------------------------------------------- SINFRUP00000132369 -------------------------------------------RRLEKKQ SINFRUP00000165121 -------------------------------------------------- Q8JFT2_Brachydanio_rerio ----------METPREPAGFSKEGLKQLAGKTLGH------VYRVIEKRQ ENSMUST00000032710 ---------MESVKQRILAPGKEGIKNFAGKSLGQ------IYRVLEKKQ ENSMUST00000003509 -----------------MEFRQEEFRKLAGRALGR------LHRLLEKRQ CG9887-RA MKGLTAFKEKATGVFGGLKPNMEKFEISQSYHGGHGGYEEMEGGDREGRG SINFRUP00000158609 PNGETIELSAEGRP---ELVEEKELP-------VVDCTCFGLPR------ SINFRUP00000141634 ENGETIELSAEGRP---ETVEEKELP-------VVDCTCFGLPR------ ENSMUST00000020102 EEEDAIELNEEGRP---VQTSRAHRP-------VCDCSCCGIPKRYICDC ENST00000323346 EEEDNIELNEEGRP---VQTSRPSPP-------LCDCHCCGLPK------ SINFRUP00000143039 -----IELTEDGRP---VTSAPRPAP-------LVDCSCGGLPK------ SINFRUP00000132369 QTGEAIELTEDGRP---KADQERRAP-------LCDCTCFGLPR------ SINFRUP00000165121 -------------------------------------------------- Q8JFT2_Brachydanio_rerio KPGENIELTEDGRP---AQINERKAP-------LCDCTCFGLPR------ ENSMUST00000032710 DNRETIELTEDGKP---LEVPEKKAP-------LCDCTCFGLPR------ ENSMUST00000003509 EGAETLELSADGRP---VTTHTRDPP-------VVDCTCFGLPR------ CG9887-RA PGGGHAYDDDDDRPDSPASFEEIERPPLRKIDKYCKAECPCMPA------ : SINFRUP00000158609 -------RYIIAILSGLGFCISFGIRCNLGVAIVSMVNDHTVYKGNK-EV SINFRUP00000141634 -------RYIIAILSGIGFCISFGIRCNLGVAIVSMVNSHTIFRDNK-EI ENSMUST00000020102 SCCGIPKRYIIAVMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGK-PE ENST00000323346 -------RYIIAIMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGK-PE SINFRUP00000143039 -------RYIIAILSGLGFCISFGIRCNLGVAIVEMVNNNTVYINGT-PV SINFRUP00000132369 -------RYIIAMLSGIGFCISFGIRCNLGVAIVSMVNNSTIHQNGKIII SINFRUP00000165121 -------------------------------------------------- Q8JFT2_Brachydanio_rerio -------RYIIAIMSGLGFCISFGIRCNLGVAIK---------------- ENSMUST00000032710 -------RYIIAIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGK-VI ENSMUST00000003509 -------RYIIAIMSGLGFCISFGIRCNLGVAIVSMVNNSTTHRGGHVVV CG9887-RA -------RYTIATMACVGFMIAFGMRCNMSAAKLKGEHNGTVF------- : : : : : : : : SINFRUP00000158609 LV------------------------AAQFTWDPETVGMIHGSFFWGYIV SINFRUP00000141634 VV------------------------KAQFDWDPETVGMIHGSFFWGYIV ENSMUST00000020102 IQ------------------------TAQFNWDPETVGLIHGSFFWGYIV ENST00000323346 IQ------------------------TAQFNWDPETVGLIHGSFFWGYIM SINFRUP00000143039 LQ------------------------KAEFDWDPETVGLIHGSFFWGYIV SINFRUP00000132369 KE------------------------KAKFNWDPETVGMIHGSFFWGYIV SINFRUP00000165121 -------------------------------------------------- Q8JFT2_Brachydanio_rerio ---------------------------AKFNWDPETVGLIHGSFFWGYIV ENSMUST00000032710 KE------------------------KAKFNWDPETVGMIHGSFFWGYII ENSMUST00000003509 QTPYRSVHKQEAVTPTLGDIQGGDTEKAQFNWDPETVGLIHGSFFWGYIV CG9887-RA -----------------------------MNWTVAVESHVDSSFFWGYLV : : :: :: SINFRUP00000158609 TQIPGGFICQKFAANRVFGFAIVATSTLNMLIPSAARCHYS-CVILVRIC SINFRUP00000141634 TQIPGGFICQKFAANKVFGFAIVATSCLNMFIPTAARMHFG-CVIIVRLL ENSMUST00000020102 TQIPGGFISNKFAASRVFGAAIFLTSTLNMFIPSAARVHYG-CVMGVRIL ENST00000323346 TQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYG-CVMCVRIL SINFRUP00000143039 TQIPGGFISNKLFANRVFGAAIFLTSLLNMFIPSAARVHYG-CVMFVRIL SINFRUP00000132369 TQIPGGYISSRLAANRVFGAAILLTSTLNMFIPSAARAHYG-CVIFVRIL SINFRUP00000165121 -------------------------------------------------- Q8JFT2_Brachydanio_rerio TQIPGGYISSRLAANRVFGAAILLTSTLNMFIPSAARGHYG-CVIFVRIL ENSMUST00000032710 TQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYG-CVIFVRIL ENSMUST00000003509 TQIPGGFICQKFAANRVFGFAIVATSTLNMLIPSAARVHYG-CVIFVRIL CG9887-RA TQIPGGFIASKFPANKIFGLSIVSSATLHLFVPFAMTLMHGHVVICVRVL : : : :: :. : ::: :: : : SINFRUP00000158609 QGLVEGVSYPACHGIWAKWAPPLERSRLATTAFCGSYAGAVVAMPLAGIL SINFRUP00000141634 QGLVEG-SYPACHGIWAKWAPPLERSRLATTAFCG--------------- ENSMUST00000020102 QGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVL ENST00000323346 QGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVL SINFRUP00000143039 QGLVEGVTYPACHGMWAKWAPPLERSRLATTSFCGSYAGAVIAMPLAGVL SINFRUP00000132369 QGLVEGVTYPACHGIWSKWAPPLERSRLATISFCGSYAGAVIAMPLAGIL SINFRUP00000165121 ---VQGVTYPACHGIWSKWAPPLERSRLATISFCGSYAGAVIAMPLAGIL Q8JFT2_Brachydanio_rerio QGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGIL ENSMUST00000032710 QGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGIL ENSMUST00000003509 QGLVEGVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVL CG9887-RA QGLFEGVTYPACHGIWRFWAPPMERSRLATLAFSGSYAGVVVGLPLSGLL :.:*::******:* ****:******* :*.* :: : : :: SINFRUP00000158609 VQYTGWPSVFYVYGSFGIFWYMFWILVSYESPAAHPTITPEERKYIEDAI SINFRUP00000141634 --------------TFGIMWYCFWLLVSYESPAAHPTITEEERKYIEESI ENSMUST00000020102 VQYIGWASVFYIYGMFGIIWYMFWLLQAYECPAAHPTISNAERTYIETSI ENST00000323346 VQYIGWSSVFYIYGMFGIIWYMFWLLQAYECPAAHPTISNEEKTYIETSI SINFRUP00000143039 VQYIGWSSVFYVYGVFGIIWYVSWLLLAYGSPAEHPTITEEERTYIETAI SINFRUP00000132369 VQYTGWSSVFYVYGCFGIIWYVFWVLTSYNSPAEHPTITDEERRYIEESI SINFRUP00000165121 VQYSGWSSVFYVYGCVGIFWYMFWVLVSYESPAEHPTISDEERCYIEESI Q8JFT2_Brachydanio_rerio VQYTGWSSVFYVYGCFGIFWYMFWILVSYESPAEHPTITAEERCYIEESI ENSMUST00000032710 VQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEERRYIEESI ENSMUST00000003509 VQYSGWSSVFYVYGSFGIFWYLFWLLVSYESPALHPSISEEERKYIEDAI CG9887-RA ADAVGYQAPFYAYGVFGIIWYMFWIWLCFENPRKHPAISIPELKYIEKSL : .*:.** *: .: * **:*: * *** :: SINFRUP00000158609 GESAG----------------------------------------FLN-- SINFRUP00000141634 GDSAQHSITVETRSSPALLVILMPADCPGPPPPMTVSGMWHQLINFNNTQ ENSMUST00000020102 GEGAN--------------------------------------------- ENST00000323346 GEGAN--------------------------------------------- SINFRUP00000143039 GEKVHQ-------------------------------------------- SINFRUP00000132369 GESAQL-------------------------------------------- SINFRUP00000165121 GESAKL-------------------------------------------- Q8JFT2_Brachydanio_rerio GESAKL-------------------------------------------- ENSMUST00000032710 GESANL-------------------------------------------- ENSMUST00000003509 GESAKL-------------------------------------------- CG9887-RA GESAHP-------------------------------------------- *: . : SINFRUP00000158609 ---PLQKFKTPWRHFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVF SINFRUP00000141634 DTFLLQKFNTPWRAFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVF ENSMUST00000020102 -LASLSKFNTPWRRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVF ENST00000323346 -VVSLSKFSTPWKRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVF SINFRUP00000143039 -ISATEKFKTPWGHFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVF SINFRUP00000132369 -MGAMEKFKTPWRKFFSSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVF SINFRUP00000165121 -CGPSEKFKTPWKKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVF Q8JFT2_Brachydanio_rerio -LGPAD-------------------------------------------- ENSMUST00000032710 -LGAMEKFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVF ENSMUST00000003509 -MNPVTKFNTPWRRFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEE-- CG9887-RA --TMPSLKTTPWREMMRSMPVYAIIVANFCRSWNFYLLVLFQSSFLKHKF :: : : ::: : : :::: : : SINFRUP00000158609 GFEISKVGIVSALPHLVMTIIVPVGGQLADYMRTHNIMSTTNVRKLMNCG SINFRUP00000141634 GFEISKVGLVSALPHLVMTIIVPIGGQIADYLRSNHIMTTTNVRKMMNCG ENSMUST00000020102 GFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILTTTAVRKIMNCG ENST00000323346 GFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRQILTTTAVRKIMNCG SINFRUP00000143039 GFPISKVGILSAVPHMVMTIVVPIGGQLADHLRSRKIMSTTNVRKLMNCG SINFRUP00000132369 GFEISKVGMLSALPHLVMTIIVPLGGQLADYLRSHNIMSTTMVRKIMNCG SINFRUP00000165121 GFEISKVGILSALPHLVMTIIVPIGGQLADYLRSRNILSTTTVRKIMNCG Q8JFT2_Brachydanio_rerio ------VGMLSALPHLVMTIIVPIGGQLADHLRSKNILSTTTVRKIMNCG ENSMUST00000032710 GFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVRKIMNCG ENSMUST00000003509 -------------------------------------------------- CG9887-RA GFKVEEAGFVGSLPHLIMTTIVPFGGMLADHLRKNGILSTTNVRKLFNCG : : :: : ::: :: . : : :: : :: SINFRUP00000158609 GFGMEATLLLVVGYSHTKGIAISFLVLAVGFSGFAISGFNVNHLDIAPRY SINFRUP00000141634 GFGMEATLLLVVGFSHTRGVAITFLVLAVGFSGFAISGFNVNHLDIAPRY ENSMUST00000020102 VVCWEMPHWKAK-FDSKRGFCANFEVLLFTLG------FNVNHLDIAPRY ENST00000323346 GFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRY SINFRUP00000143039 GFGMEATLLLVVGFSHTRAVAISFLVLAVGFSGFAISGFNVNHLDIAPRY SINFRUP00000132369 GFGMEATLLLVVGYSHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRY SINFRUP00000165121 GFGMEATLLLVVGYSHSKGMAISF-CLAVGFSGFAISGFNVNHLDIAPRY Q8JFT2_Brachydanio_rerio GFGMEATLLLIVGYSHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRY ENSMUST00000032710 GFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRY ENSMUST00000003509 -------------------------------------------------- CG9887-RA GFGMEGLFFLFVAHSSTATGAMFALTCGVAFSGFAISGYNVNHLDIAPRY . . : : : : : : SINFRUP00000158609 ASILMGISNGVGTLSGMVCPLIVGAMTKHKTREEWQYVFLIASLVHYGGV SINFRUP00000141634 ASILMGISNGVGTLSGMVCPLIVGAMTKHK-------------------- ENSMUST00000020102 ASILMGISNGVGTLSGMVCPLIVGAMTKHKTREEWQNVFLIAALVHYSGV ENST00000323346 ASILMGISNGVGTLSGMVCPLIVGAMTRHKTREEWQNVFLIAALVHYSGV SINFRUP00000143039 ASILMGISNGVGTLSGMVCPLIVGALTKHKTRLEWQNVFVIASMVHYSGV SINFRUP00000132369 ASILMGISNGVGTLSGMVCPLIVGAMTKNKTREEWQYVFLIASLVHYGGV SINFRUP00000165121 ASILMGISNGVGTLSGMVCPLIVGTMTKNKTREEWQYVFLIASLVHYGGV Q8JFT2_Brachydanio_rerio ASILMGISNGVGTLSGMVCPLIVGAMTKHKTREEWQYVFLIASLVHYGGV ENSMUST00000032710 ASILMGISNGVGTLSGMVCPIIVGAMTKNKSREEWQYVFLIAALVHYGGV ENSMUST00000003509 -------------------------------------------------- CG9887-RA ASILMGLSNGIGTLAGIIVPYALDGLIQANGAPEYT----EQSQMQQSTA ::: : : : :: : : ::: : SINFRUP00000158609 IFYGLFASGEKQPWADIEDTSEEKCGIIDEDELANETEELYRGGGQYGAM SINFRUP00000141634 -------------------------------------------------- ENSMUST00000020102 IFYGVFASGEKQDWADPENLSEDKCGIIDQDELAEET-ELNHETFVSPRK ENST00000323346 IFYGVFASGEKQEWADPENLSEEKCGIIDQDELAEEI-ELNHESFASPKK SINFRUP00000143039 IFYAIFASGEQQAWANPESTSEDKCGIIGEDELAEES-ELNSDITVAPKK SINFRUP00000132369 VFYGIFASGEKQPWADPEETSEEKCGFIDEDELAEETGDITQGYGAMGGP SINFRUP00000165121 IFYGIFASGEKQPWADPELTSEEKCGFIDEDELAEETGDITQNYGAFGGP Q8JFT2_Brachydanio_rerio IFYGIFASGEKQPWADPELTSDEKCGFIDEDELAEETGDITQSYGALGAP ENSMUST00000032710 IFYALFASGEKQPWADPEETSEEKCGFIHEDELDEETGDITQNYINYG-T ENSMUST00000003509 -------------------------------------------------- CG9887-RA ISYGATGHVANNPFAMASGAPP-----IAEEDAPPTYGDVTNPG------ : :: : SINFRUP00000158609 SQPVAGSNGGGGGGGGWVSDWDKNEEYVQPPGYNSYMY---------- SINFRUP00000141634 ------------------------------------------------ ENSMUST00000020102 KMSYGATTQNCEV---QKTEWRQQRESAFDGEEPLSYQAEG-DFSETS ENST00000323346 KMSYGATSQNCEV---QKKEWKGQRGATLDEEELTSYQNEERNFSTIS SINFRUP00000143039 --SYG-TTNNSFG---RKQGWKKKRGVTMQEEEQEEEYLENGEY---- SINFRUP00000132369 AKSYGATSQLNGG---WVQDWDKTEEYVQEP---AGKMYS-------- SINFRUP00000165121 AKTYGATTQVNGG---WASGWEKTEEYVQEEGQGAGYGYRQEEGYS-- Q8JFT2_Brachydanio_rerio AKSYGATTQLNGG---WAEGWDKREEYVQDGVEEGGYGYRQGGNYS-- ENSMUST00000032710 TKSYGATSQENGG---WPNGWEKKEEFVQEG-AQDAYTYKDRDDYS-- ENSMUST00000003509 ------------------------------------------------ CG9887-RA --QYGYTQGQMPS--------YDPQGYQQQ------------------